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Activatable Polymersome for Oral Delivery of Vaccines
Yurim AHN,Seojin KIM,Minse KIM,Jaewon CHOI,Jiyeon PARK,HakSeon KIM,Hyun-Ouk KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Vaccination is widely regarded as the only exit strategy for emerging, re-emerging viral diseases currently spreading around the world. Vaccines are important as the only way to defend our bodies from viral diseases. Accordingly, it is necessary to study a delivery system that can increase the efficiency of a vaccine to prevent a threatening emerging, re-emerging viral diseases. In this study, we produced Activatable polymersome, a vaccine formulation for oral administration that has its own driving force according to the in vivo environment using nanostructures. We confirmed the synthesis and effectiveness of Activatable polymersome using DLS, TEM and CLSM. In addition, the stability of this polymersome was evaluated over several months. These polymersome have a driving force by generating hydrogen gas in the intestinal environment, as well as releasing an inherent vaccine. Therefore, this system is a vaccine formulation for oral administration and can lead to an efficient immune response by resolving a feeling of resistance to pain and maximizing the activation of mucosal immunity. Therefore, our study can be developed as an efficient vaccine delivery platform using in vivo environment.