매복된 견치의 Tunnel을 통한 교정적 견인

전정훈,오유향,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

매복된 상악 견치를 위한 외과적 수술을 동반하는 교정치료는 주위조직에 손상을 주지 않고 치열궁내에 적절히 위치시켜야 한다. 이를 위해 매복된 치아의 위치에 따라 다양한 외과적, 교정적 방법이 소개되었으며, 그 방법으로 window procedure, apically positioned flap, closed eruption technique, tunnel traction 등이 있다. 깊은 골연하 매복에서 사용할 수 있는 방법으로 closed eruption technique 그리고 tunnel traction이 있는데, closed eruption technique은 점막 및 치은 하방으로 지나는 견인 와이어의 자극으로 염증 발생 가능성이 높으며 치은퇴축 및 부착 치은의 소실이 발생할 수 있다. 하지만, tunnel traction은 치아의 맹출이 터널을 통해서 유도되어 각화치은에 둘러싸인 채 치조골의 중앙으로 나오게 되므로 치은퇴축이나 치주부착의 소실 없이 적절한 각화치은을 얻을 수 있으며 매복치가 치조골의 중심부로 맹출함에 따라 생리적 맹출과 같은 효과 얻을 수 있다. 본 증례는 깊은 매복을 보이는 상악 견치를 tunnel traction을 이용한 치료를 보고한 것으로, 적절한 방향을 가지고 맹출하였으며 치은퇴축이나 부착치은의 소실이 발생하지 않았다. The impacted maxillary canine is a common problem of which all dental practitioners should be aware. The surgical orthodontic treatment of impacted canines is replaced correction position in dental arch without periodontal damage. Many treatment possibilities have been considered for this goal; window procedure, apically positioned flap, closed eruption technique and tunnel traction. Prognosis for these treatment may be very uncertain in many case(infraosseous impacted tooth). Other steps are required to achieve a satisfactory periodontal outcome. Satisfactory results could be expected if the physiologic eruption pattern is restored by tunnel traction, because permanent tooth erupts through the gingiva near the crest of the ridge so that periodontal damage is reduced. This article report that the surgical orthodontic treatment using tunnel traction is obtained proper position and reduced periodontal damage in facially impacted maxillary canines.

Pollen-food allergy syndrome in children

Jeon, You Hoon The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.12

Pollen-food allergy syndrome (PFAS) is an immunoglobulin E-mediated immediate allergic reaction caused by cross-reactivity between pollen and the antigens of foods-such as fruits, vegetables, or nuts-in patients with pollen allergy. A 42.7% prevalence of PFAS in Korean pediatric patients with pollinosis was recently reported. PFAS is often called oral allergy syndrome because of mild symptoms such as itching, urticaria, and edema mainly in the lips, mouth, and pharynx that appear after food ingestion. However, reports of systemic reactions such as anaphylaxis have been increasing recently. This diversity in the degree of symptoms is related to the types of trigger foods and the characteristics of allergens, such as heat stability. When pediatric patients with pollen allergy are treated, attention should be paid to PFAS and an active effort should be made to diagnose it.

Identification of major rice allergen and their clinical significance in children

Jeon, You-Hoon,Oh, Se-Jo,Yang, Hyeon-Jong,Lee, Soo-Young,Pyun, Bok-Yang The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.10

Purpose: Recently, an increase in the number of patients sensitized to rice allergen with or without clinical symptoms has been reported. This study was designed to determine the major allergens in rice and their clinical significance. Methods: Twenty-four children (15 boys and 9 girls; mean age, 16.3 months) with allergic disease, who were sensitized to rice antigen (by UniCAP) in the Pediatric Allergy Respiratory Center at Soonchunhyang University Hospital, were enrolled in this study. The allergenicity of various types of rice (raw, cooked, and heat-treated, simulated gastric fluid [SGF], and simulated intestinal fluid [SIF]) was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoglobulin E (IgE) immunoblots. The patients' medical records, including laboratory data and allergy symptoms after ingestion of rice were reviewed. Results: Patients were sensitized to an average of 13.5 food antigens and their mean total IgE was 6,888.7 kU/L. In SDS-PAGE, more than 16 protein bands were observed in the raw rice, whereas only 14-16 kDa and 31-35 kDa protein bands were observed in cooked rice. The common SDS-PAGE protein bands observed in SGF-, SIF-, and heat-treated rice were 9, 14, and 31 kDa. In a heated-rice IgE immunoblot, protein bands of 9, 14, and 31-33 kDa were found in 27.8%, 38.9%, and 38.9% of all sera, respectively, and in 50%, 50%, and 75%, of ser a from the 4 symptomatic patients, respectively. Conclusion: The 9-, 14-, and 31-kDa protein bands appeared to be the major allergens responsible for rice allergy symptoms.

Clinical Characteristics of Atopic Dermatitis in Korean School-Aged Children and Adolescents According to Onset Age and Severity

You Hoon Jeon,Kangmo Ahn,김지현,Meeyong Shin,Soo-Jong Hong,So-Yeon Lee,Bok-Yang Pyun,Taek Ki Min,Minyoung Jung,Jeongmin Lee,송태원,Hye-Young Kim,Sooyoung Lee,Kyunguk Jeong,Yoon-Ha Hwang,Minji Kim,Yong Ju Le 대한의학회 2022 Journal of Korean medical science Vol.37 No.4

Background: Atopic dermatitis (AD) is a heterogeneous disease with different age of onset, disease course, clinical symptoms, severity, and risk of comorbidity. The characteristics of children with AD also vary by age or country. However, little is known about the clinical characteristics of AD in Korean school-aged children and adolescents. Furthermore, there are few studies on phenotypic differences according to onset age. This study aimed to explore the clinical characteristics and phenotypes according to onset age and severity of AD in children and adolescents in Korea. Methods: AD patients aged 6–18 years who presented to 18 hospitals nationwide were surveyed. The patients were examined for disease severity by pediatric allergy specialists, and data on history of other allergic diseases, familial allergy history, onset age, trigger factors, lesion sites, treatment history and quality of life were collected. The results of the patient’s allergy test were also analyzed. The patients were classified into infancy-onset (< 2 years of age), preschoolonset (2–5 years of age), and childhood-onset (≥ 6 years of age) groups. Study population was analyzed for clinical features according to onset-age groups and severity groups. Results: A total of 258 patients with a mean age of 10.62 ± 3.18 years were included in the study. Infancy-onset group accounted for about 60% of all patients and presented significantly more other allergic diseases, such as allergic rhinitis and asthma (P = 0.002 and P = 0.001, respectively). Food allergy symptoms and diagnoses were highly relevant to both earlier onset and more severe group. Inhalant allergen sensitization was significantly associated with both infancy-onset group and severe group (P = 0.012 and P = 0.024, respectively). A family history of food allergies was significantly associated with infancyonset group (P = 0.036). Severe group was significantly associated with a family history of AD, especially a paternal history of AD (P = 0.048 and P = 0.004, respectively). Facial (periorbital, ear, and cheek) lesions, periauricular fissures, hand/foot eczema, and xerosis were associated with infancy-onset group. The earlier the onset of AD, the poorer the quality of life (P = 0.038). Systemic immunosuppressants were used in only 9.6% of the patients in the severe group. Conclusion: This study analyzed the clinical features of AD in Korean children and adolescents through a multicenter nationwide study and demonstrated the phenotypic differences according to onset age and severity. Considering the findings that the early-onset group is more severe and accompanied by more systemic allergic diseases, early management should be emphasized in young children and infants.

소아 아토피피부염의 최신 치료

전유훈 ( You Hoon Jeon ),김정희 ( Jeong Hee Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2021 Allergy Asthma & Respiratory Disease Vol.9 No.2

Atopic dermatitis is the most common chronic inflammatory skin disease in children. It usually develops in infancy and early childhood and is an entry point of ‘atopic march’, which may progress to other allergic diseases, including allergic rhinitis and asthma. Although there is no disagreement on the importance of early treatment of atopic dermatitis, it is difficult to treat children with moderate to severe atopic dermatitis due to concerns about treatment-related side effects and age restrictions for effective drugs in real world. As recent researches have extend our understanding of pathogenesis, new agents targeted key pathologic mechanisms have been developed. Therefore, it is time to establish a new paradigm of treatment for children with atopic dermatitis since new biologics have been demonstrated to be effective and safe in children. The objective of this article is to review the clinical characteristics, severity classification, pathogenesis, and treatment, in particular, biologics already approved/undergoing clinical trials for children with atopic dermatitis. (Allergy Asthma Respir Dis 2021;9:59-68)

영아기 아토피피부염 환자의 천명발생 위험인자에 대한 연구

전유훈 ( You Hoon Jeon ),양현종 ( Hyeon Jong Yang ),편복양 ( Bok Yang Pyun ) 대한소아알레르기 및 호흡기학회 2007 소아알레르기 및 호흡기학회지 Vol.17 No.2

국내 소아 지역획득폐렴의 치료

전유훈 ( You Hoon Jeon ),김정희 ( Jeong Hee Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.4

Community-acquired pneumonia is the leading cause of pediatric morbidity and mortality. However, there is a lack of data on the epidemiology of pneumonia in Korean children. In this review, we aimed to summarize pneumonia studies in Korea and suggest diagnostic methods and treatment for Korean children who were referred based on the foreign guidelines for pediatric community-acquired pneumonia. A Korean guideline for pediatric pneumonia in tune with domestic circumstances is needed. (Allergy Asthma Respir Dis 2017;5:177-184)

소아 천식환아에서 흡입용 fluticasone 및 tulobuterol의 병합치료와 두 배 용량 흡입용 fluticasone 치료의 효과 및 안전성 비교에 대한 다기관 연구

전유훈 ( You Hoon Jeon ),양현종 ( Hyeon Jong Yang ),유영 ( Young Yoo ),김영호 ( Young Ho Kim ),정지태 ( Ji Tae Jeong ),이혜란 ( Hae Ran Lee ),편복양 ( Bok Yang Pyun ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.2

목적: 소아 천식 치료에서 흡입용 스테로이드의 용량을 증가시키는 것과 기존 용량의 흡입용 스테로이드에 기관지 확장제인 tulobuterol을 추가하는 것을 효과와 안전성 면에서 비교해 보고자 하였다. 방법: GINA 가이드라인에 따라 2단계(경증지속성) 천식으로 진단받고 하루 50-100 μg의 저용량 흡입용 스테로이드(fluticasone)로 유지치료를 받고 있는 4-8세의 소아천식 환자 중에서 step-up 치료를 고려하는 53명을 대상으로 하였다. 이들을 무작위로 기존의 흡입용 fluticasone용량(50-100 μg/일)에 tulobuterol (Hokunalin(R) patch 1 mg)을 추가한 군 (Flt+Hk군)과 흡입용 fluticasone을 두 배 용량(100-200 μg/일)으로 늘린 군 (Flt군)으로 나누었다. 이들을 각각 4주간 치료하였으며 이후 치료의 효과와 부작용을 보기 위해 추적관찰하였다. 두 군에서 치료시작전과 치료 4주 후의 천식 증상 점수의 변화, 일중 최대호기유속의 변화, 야간 증상으로 잠을 깬 횟수, 증상완화제의 사용 횟수를 비교하였고 치료에 대한 보호자의 전체적인 만족도, 이상 반응의 횟수를 조사하였다. 결과: 추적관찰이 된 환자는 Flt+Hk 군, Flt군 각각 24명이었다. 치료시작전과 치료 4주 후 두 군간의 전체적인 천식증상점수 변화는 Flt+Hk 군에서 -0.01±0.24 , Flt 군에서 -0.05±0.17로 두 군 간에 통계적으로 유의한 차이는 없었다.(P=0.54) 아침 최대호기유속의 평균변화와 저녁 최대호기유속의 평균 변화는 통계적으로 큰 차이를 보이지 않았다.(P=0.83, P=0.83) 야간 증상으로 잠을 깬 횟수나 증상완화제의 사용 횟수, 치료에 대한 보호자의 전체적인 만족도도 두 군 간에 차이가 없었다.(P=0.17, P=0.32, P=0.63) 치료 중의 이상증상의 경험 빈도 역시 통계학적으로 유의한 차이를 보이지 않았다.(P=1.00) 결론: 소아천식환아에서 흡입용 fluticasone propionate및 tulobuterol의 병합치료는 두 배 용량의 흡입용 fluticasone propionate 단독치료만큼 효과가 있으며 안전성도 비슷한 것으로 나타났다. 스테로이드 치료에 대한 거부감이나 잠재적 부작용에 대한 두려움을 가지고 있는 환자에서 흡입용 스테로이드의 용량을 늘리는 치료에 대한 대체치료로 tulobuterol의 병합치료를 고려할 수 있겠다. Purpose: We aim to compare the effectiveness and safety of fluticasone propionate (Flt) plus tulobuterol (Hk) versus high-dose Flt alone in controlling asthma in children. Methods: Fifty three children aged 4 to 8 years, who were diagnosed with mild persistent asthma and underwent maintenance therapy with a low dose of inhaled corticosteroid (Flt) of 50-100 μg/day were randomized to receive Flt plus Hk (Hokunalin(R) patch 1 mg, Abbott Japan, Tokyo, Japan), or Flt alone at twice the dosage. Patients underwent new treatment for 4 weeks. Asthma symptom scores, mean changes in morning and evening peak expiratory flow (PEF), the frequency of night awakenings, the use of reliever medication, caregiver`s overall satisfaction and safety were evaluated and compared in each group. And they were followed-up again 4 week after treatment course for the evaluation of treatment-emergent adverse event (TEAE). Results: No significant difference was found between the groups in terms of mean changes in the morning and evening PEF, the frequency of night awakening, the use of rescue medication and caregiver`s overall satisfaction (P=0.83, P=0.83, P=0.17, P=0.32 and P=0.63). Furthermore, no statistically significant difference was observed between 2 groups in the incidence of any TEAE (P=1.00). Conclusion: This study demonstrated that a combination of Flt and Hk was as effective as a high-dose Flt therapy in the management of mild persistent asthma in children. The results of this study suggest that tulobuterol add-on therapy can be considered as a reasonable substitute to an increase in the dosage of steroid in the patients with steroid-phobia and it might be used to reduce the risk of high dose steroid therapy. [Pediatr Allergy Respir Dis(Korea) 2009;19:125-136]

상악 유중절치 외상의 처치: 임상증례

전정훈 ( Jeong Hoon Jeon ) , 오유향 ( You Hyang Oh ) , 박종휘 ( Jong Whi Park ) , 이상호 ( Sang Ho Lee ) 조선대학교 구강생물학연구소 2004 Oral Biology Research (Oral Biol Res) Vol.28 No.1

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Mechanistic Insight into the Conversion Chemistry between Au-CuO Heterostructured Nanocrystals Confined inside SiO₂ Nanospheres

Jeon, Ki-Wan,Lee, Dong-Gyu,Kim, You Kyung,Baek, Kangkyun,Kim, Kimoon,Jin, Taewon,Shim, Ji Hoon,Park, Jeong Young,Lee, In Su American Chemical Society 2017 Chemistry of materials Vol.29 No.4

<P>By taking advantage of a nanospace-confined nanocrystal conversion protocol via high-temperature solid-state reaction within the SiO2 nanosphere, an in-depth study was conducted into the unique transformation behavior of the Au-CuO heterostructured nanocrystals (HNCs), which was discovered during the oxidative annealing of the embedded AuCu alloy nanocrystal (NC). The type of heterojuction structure of the oxidized AuCu NCs, between core(a)shell and heterodimer, could be determined by modulating either the annealing temperature (T-ann) or Cu contents (P-cu) in AuCu NCs; Au@CuO was generated only either at low temperature (T-ann <= 250 degrees C) or with very low Cu contents P-cu = 2.1), whereas the Au/CuO heterodimer was obtained as a major product in most of the cases at relatively high heat treatment (>250 degrees C). The systematic investigation of the conversion between HNCs could elucidate the distinct evolution pathway of the Au/CuO heterodimer via the kinetically accessed Au@CuO, revealing the escaping motion of the encapsulated Au core, which is more facilitated through a thicker CuO shell. This also demonstrated the high thermal stability of the Au@CuO with a very thin shell thickness due to the insufficient compressive lattice stain on the CuO shell to drive the morphological transformation into the heterodimer. Moreover, the higher operational stability could be detected for the Au@CuO with the lowest Cu content during catalytic CO oxidation, which correlates with its resistance against the thermal deformation.</P>