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Skull‐stripping method for brain MRI using a 3D level set with a speedup operator
Hwang, Jinyoung,Han, Yeji,Park, HyunWook Wiley Subscription Services, Inc., A Wiley Company 2011 JOURNAL OF MAGNETIC RESONANCE IMAGING Vol.34 No.2
<P><B>Abstract</B></P><P><B>Purpose:</B></P><P>To extract the brain region from brain magnetic resonance (MR) images using a fast 3D level set method and a refinement process.</P><P><B>Materials and Methods:</B></P><P>The proposed method introduces a speedup operator to the conventional 3D level set method in order to accelerate the level set evolution. While the processing time for brain extraction is reduced by the speedup operator, the accuracy of brain extraction is also improved by adopting a refinement process.</P><P><B>Results:</B></P><P>The speedup operator yielded a 75% reduction in the total iteration numbers for the synthesized volume. The proposed method was applied to several datasets and compared with previous methods, ie, BrainVisa, BET, and FreeSurfer. The proposed method provided a Jaccard index of 0.971 ± 0.0114 for the BrainWeb dataset, 0.864 ± 0.035 for the IBSR dataset, and 0.9414 ± 0.0517 for a self‐produced dataset acquired with a 3T MRI system.</P><P><B>Conclusion:</B></P><P>Utilizing a speedup operator, the proposed method reduced the evolution time. Robust and accurate results for various datasets were obtained in experiments. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.</P>
First Report of Brain Abscess Associated with Pseudozyma species in a Patient with Astrocytoma.
Hwang, Sangsun,Kim, Juwon,Yoon, Seoyoung,Cha, Yeji,Kim, Myungsook,Yong, Dongeun,Chang, Jong Hee,Jeong, Seok Hoon,Uh, Young,Lee, Kyungwon 대한진단검사의학회 2010 Annals of Laboratory Medicine Vol.30 No.3
<P>A yeast-like strain was isolated from the brain abscess of a patient diagnosed with astrocytoma. Morphological and molecular analysis on D1/D2 domain in the 26S rRNA gene and internal transcript spacer region of the strain revealed that the strain belonged to the genus Pseudozyma. To the best of our knowledge, this is the first report on the isolation of a Pseudozyma strain from brain abscess.</P>
The Occurrence and Flow Analysis of PBDEs in Automobile Shredded Residues in Korea
( Yeji Jang ),( Yuree Kwon ),( Yong-chul Jang ),( Woo-il Kim ),( Ki-heon Kim ),( Dong-gun Hwang ) 한국폐기물자원순환학회(구 한국폐기물학회) 2018 한국폐기물자원순환학회 심포지움 Vol.2018 No.1
Approximately 400 million cars are generated annually worldwide, and about 1 billion cars are being used. A number of existing studies have found that hazardous chemicals such as lead, mercury, hexavalent chromium, PBDEs, and Deca-BDE are detected in end-of-life vehicles (ELVs). In this study, we focused on brominated flame retardants (BFRs) of automobile shredded residue (ASR) generated after recycling of ELVs. PBDEs are often used in textiles and car seat, door trims in automobiles. Such PBDEs are chemicals that may cause endocrine disruption, nervous system toxicity, liver tumors, and thyroid disorders. On the other hand, the law on circulation of waste electrical and electronic equipment and ELVs has been introduced since January 1, 2008 by adopting the EU RoHS, WEEE, and ELV guidelines. According to the criteria for containing harmful substances, the concentration of PBDEs in electrical and electronic products is limited to less than 0.1 W%, but there is no regulation of BFRs in automobiles. Therefore, this study aims to provide basic data on the occurrence of PBDEs in ASR after recycling of ELVs. In this study, 16 ASR samples were collected from eight domestic automobile shredding facilities and quantitative analysis was performed using GC/MS equipment. Material flow analysis(MFA) of ASR was conducted through statistical data and literature survey and expert consultation. Based on the analytical results of BFRs, the average concentration of PBDEs was 1036.6±1421.8 mg/kg with the highest concentration of 5,526.6 mg/kg. Most PBDEs existed as deca-BDE. As a result of MFA, approximately 115 tons-PBDEs were found in ASR as of 2016, and 79 tons (68%) in energy recovery, while about 37 tons (32%) ended up with incineration.
Flashlight into the function of unannotated C11orf52 with global and glyco- pretomic analysis
Yeji Yang,Heeyoun Hwang,Ji Eun Im,Kyungha Lee,Seong Hee Bhoo,Jong Shin Yoo,Yun-Hee Kim,Jin Young Kim 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
For an enhanced understanding of the biological mechanisms of human disease, it is essential to investigate protein functions. In a previous study, we developed a prediction method of gene ontology (GO) terms by the I-TASSER/COFACTOR result, and we applied this to uPE1 in chromosome 11. Furthermore, to validate the bioinformatics prediction of C11orf52, we utilized affinity purification and mass spectrometry to identify interacting partners of C11orf52. Using immunoprecipitation methods with three different peptide tags (Myc, Flag, and 2B8) in HEK 293T cell lines, we identified 79 candidate proteins that are expected to interact with C11orf52. The results of a pathway analysis of the GO and STRING database with candidate proteins showed that C11orf52 could be related to signaling receptor binding, cell−cell adhesion, and ribosome biogenesis. Then, we selected three partner candidates of DSG1, JUP, and PTPN11 for verification of the interaction with C11orf52 and confirmed them by colocalization at the cell−cell junctions by coimmunofluorescence experiments. In fact, cell-cell interactions and cell adhesion could be affected by glycosylation of adhesive molecules. Here, we focused on changes in protein expressions and glycosylation patterns caused by overexpression of C11orf52. Differentially expressed proetins and glycosylations were identified with TMT-based quantitative global and glyco- pretomic analysis and it will help to clarify how C11orf52 works in cells.
Hwang, Sungho,Ko, Yeji,Park, Donguk,Yoon, Chungsik British Medical Association 2018 Journal of clinical pathology Vol.71 No.1
<P>Conclusions Airborne microbe concentrations in the LMR and LRR varied greatly depending on season, and these changes were affected by environmental factors.</P>
Dietary intake of fats and fatty acids in the Korean population
Yeji Baek,Ji-Yun Hwang,Kirang Kim,Hyun-Kyung Moon,Sanghui Kweon,Jieun Yang,Kyungwon Oh,Jae Eun Shim 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.6
BACKGROUND/OBJECTIVES: The aim of this study was to estimate average total fat and fatty acid intakes as well as identify major food sources using data from the Korea National Health and Nutrition Examination Survey (KNHANES) VI-1 (2013). SUBJECTS/METHODS: Total fat and fatty acid intakes were estimated using 24-hour dietary recall data on 7,048 participants aged ≥ 3 years from the KNHANES VI-1 (2013). Data included total fat, saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), n-3 fatty acid (n-3 FA), and n-6 fatty acid (n-6 FA) levels. Population means and standard errors of the mean were weighted in order to produce national estimates and separated based on sex, age, income, as well as residential region. Major food sources of fat, SFA, MUFA, PUFA, n-3 FA, and n-6 FA were identified based on mean consumption amounts of fat and fatty acids in each food. RESULTS: The mean intake of total fat was 48.0 g while mean intakes of SFA, MUFA, PUFA, n-3 FA, and n-6 FA were 14.4g, 15.3 g, 11.6 g, 1.6 g, and 10.1 g, respectively. Intakes of MUFA and SFA were each higher than that of PUFA in all age groups. Pork was the major source of total fat, SFA, and MUFA, and soybean oil was the major source of PUFA. Milk and pork were major sources of SFA in subjects aged 3-11 years and ≥ 12 years, respectively. Perilla seed oil and soybean oil were main sources of n-3 FA in subjects aged ≥ 50 years and aged < 50 years, respectively. CONCLUSIONS: Estimation of mean fatty acid intakes of this study using nationally represented samples of the Korean population could be useful for developing and evaluating national nutritional policies.