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      • Toward the Insights into Fast CO<sub>2</sub> Absorption over Novel Nanostructured MgO-Based Sorbent

        Yang, Lixia,Liu, Dan,Wang, Pingping,Seo, Hwimin,Gui, Jianzhou,Park, Yong-Ki American Chemical Society 2018 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.57 No.31

        <P>A uniform nanoplate-like MgO-based sorbents were prepared with eitelite and hydromagnesite intergrowing each other, and their CO<SUB>2</SUB> capture capacity was evaluated for fast CO<SUB>2</SUB> absorption in the thermal swing absorption process, with model wet industrial flue gas at a CO<SUB>2</SUB> concentration of 14.5 vol %, at ambient pressure. Fast absorption and desorption rate, acceptable dynamic absorption capacity, and good cyclic stability (9 wt % after recycling 100 times) have been obtained. Some theoretical work has been carried out and found eitelite was the only origin of the active MgO species for fast CO<SUB>2</SUB> uptake in TSA process. Nitrate was also demonstrated to have some promotive effect in CO<SUB>2</SUB> fast absorption on the active MgO species. The effectiveness of eitelite was close related to its special crystal structure, i.e., after calcination, the special layer assembling with the proximity of Na<SUP>+</SUP> and O<SUP>2-</SUP> at a molecular level probably contributed to the fast absorption. Meanwhile, the void space caused by decarbonization of hydromagnesite may also facilitate the absorption and diffusion of CO<SUB>2</SUB>. Therefore, this sorbent has been demonstrated to be a potential absorbent for postcombustion CO<SUB>2</SUB> capture from fossil-fuel-fired power plant.</P> [FIG OMISSION]</BR>

      • KCI등재

        閑适文化與錢默吟-論小說《四世同堂》中“錢默吟”的形象-

        楊麗霞 ( Lixia Yang ) 아시아문화학술원 2019 인문사회 21 Vol.10 No.3

        在長篇小說《四世同堂》中,作爲傳統“士”的代表,錢默吟恪守“達則兼濟天下,窮則獨善其身”的行爲准則。在這一標准引領下,他自覺認同閑适文化。而戰爭却打破固有傳統,在殘暴的侵略者面前,錢默吟幾十年秉持的生活理念脆弱不堪,他從“隱士”轉變爲“卒”,完成“家”“國”溝通。而戰爭却打破固有傳統,錢默吟從“隱士”轉變爲“卒”,他不僅是中國現代知識分子抗戰的典型,更是整個中華民族人民抗戰的心理折射與靈魂史詩。 In the long novel “The Yellow Storm”, moyin Qian, as a representative of traditional “scholar”, abided by the code conduct of “if you succeed, you can help the whole world, if you are poor, you can improve yourself”. Guided by this standard, he consciously identified with the leisure culture. However, the war broke the inherent tradition, In the face of brutal invaders, moyin Qian 's philosophy of life for decades is fragile, he changed from “hermit” to “pawn”, and completed the communication between "home" and "country". He is not only the typical representative of Chinese modern intellectuals during the anti-Japanese war, but also the psychological refraction and soul epic of the whole Chinese nation in that period.

      • KCI등재

        Genome wide methylation analysis to uncover genes related to recurrent pregnancy loss

        Lixia Zhou,Yudong Pu,Yuxun Zhou,Bin Wang,Ye Chen,Yang Bai,Shuzhen He 한국유전학회 2021 Genes & Genomics Vol.43 No.4

        Background Recurrent pregnancy loss (RPL) refers to two or more consecutive spontaneous abortion before 24 weeks of gestation, representing 1% of couples of childbearing age. Epigenetic factors including dysregulation of DNA methylation of some genes may play a role in RPL. Objective To identify RPL related genes modulated by DNA methylation expressed in decidua and blood. Methods Three decidua samples each from RPL patients and normal controls were recruited to perform genome-wide bisulfte sequencing (GWBS) and transcriptome sequencing. Based on the above results, 22.52 kb of diferential methylation regions (DMRs) from 17 genes were verifed by bisulfte sequencing PCR at specifc region (Hi-MethylSeq) in another 15 decidua (7RPL vs. 8 Controls) and 13 blood (5RPL vs. 8 Controls) samples. Results 23 genes showed signifcantly diferential cytosine methylation status and distinct expression level between PRL patients and healthy controls synergistically. Three signaling pathways were found to be shared between genes with both hypomethylated diferential methylation regions (DMR) and upregulated diferential gene expression (DGE). The results from Hi-MethylSeq showed that the hypermethylation of SGK1 in both blood and decidua samples in RPL patients, which was consistent to its lower expression in endometrium reported earlier. SGK3 and CREB5 also showed modulated methylation level in RPL decidua. Conclusion Our fnding supported that aberrant methylation of SGK1 and CREB5 could be a cause of the dysregulation of these gens in the endometrium, which is one of cause of reproductive failure. The function of SGK3 in reproduction system deserves further investigation.

      • KCI등재

        Investigating Impacts of CoronaVac Vaccination in Males on In Vitro Fertilization: A Propensity Score Matched Cohort Study

        Wang Meng,Yang Qiyu,Zhu Lixia,Jin Lei 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.4

        Purpose: This study aimed to evaluate the influences of SARS-CoV-2 vaccination (CoronaVac) on male fertility and investigate the impact of a history of the CoronaVac vaccination in males on gamete and embryo development and in vitro fertilization (IVF) outcomes. Materials and Methods: A prospective cohort study enrolled couples undergoing IVF cycles between June and August 2021 at Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology in China. According to the history of SARS-CoV-2 vaccination in males, the participants were divided into the vaccination group and the non-vaccination group. A self-controlled study of semen analyses for males before and after CoronaVac vaccination was conducted. Baseline characteristics were matched using propensity score matching. Participants were categorized into the unexposed group (non-vaccination) and exposed group (vaccination), and the population was 271 for each. Semen parameters and IVF outcomes were the main outcomes. Results: Generally, no statistically significant differences were exhibited between the matched cohorts regarding embryo developmental parameters, including fertilization rate, cleavage rate, high-quality embryo rate, blastocyst formation rate, and available blastocyst rate, as well as clinical outcomes, such as implantation rate, biochemical pregnancy rate, and clinical pregnancy rate. Moreover, males after vaccination seemed to have fluctuating semen parameters including increased semen volume, lower motility, and decreased normal forms of sperm, while the motile sperm counts were similar. In addition, all semen parameters were above the lower reference limits. Conclusions: Our findings suggested that CoronaVac vaccinations in males may not have adverse effects on patient performance or the gamete and embryonic development potential during assisted reproductive technology (ART) treatments.

      • KCI등재

        Degradation behavior of deep UV-LEDs studied by electro-optical methods and transmission electron microscopy

        Huixin Xiu,Yang Zhang,Jiajia Fu,Zhanhong Ma,Lixia Zhao,Jijun Feng 한국물리학회 2019 Current Applied Physics Vol.19 No.1

        Degradation mechanism of 265-nm deep ultraviolet light emitting diodes (UV-LEDs) has been investigated by means of electroluminescence, current-voltage measurement, capacitance-voltage measurement, and transmission electron microscopy (TEM) equipped with energy dispersive X-ray spectrometer (EDAX). It is revealed that a major degradation mode of UV-LEDs may be the leakage current induced optical degradation. The current pathway is demonstrated by TEM with EDAX, indicating that the contact metals can partially interact with ptype materials, which accelerate the degradation of LEDs. The presented results can help to understand the degradation mechanisms and improve the reliability of deep UV-LEDs.

      • SCIESCOPUSKCI등재

        Capacitors Energy Strategy Based Cascaded H-Bridge Converter for DC Port Failures

        Peng, Xu,Liu, Xiaohan,Yang, Guolong,Liu, Xijun,Gao, Lixia,Zhu, Xinyu The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.5

        In this paper, a capacitors energy strategy based Cascaded H-bridge Converter (CHBC) for steady DC link voltage is proposed, which allow the CHBC to work while DC power fails. The topology of the CHBC is analyzed to construct the proposed strategy. The capacitors energy strategy is deduced based on the principle that the DC link voltage should be steady, the switch state should be smooth and the switch frequency should be normal. Experiments based on a three-module prototype, including static experiment, start experiment and step change experiment, proves the correctness of the strategy. They also verified the excellent fault tolerance ability and good dynamic performance of the proposed strategy.

      • KCI등재

        Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse

        Xinyu Wan,Xiaomin Yang,Fan Yang,Tianyi Wang,Lixia Ding,Lili Song,Yan Miao,Xiang Wang,Yani Ma,Chengjuan Luo,Jingyan Tang,Longjun Gu,Jing Chen,Yanjing Tang,Jun Lu,Benshang Li 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3

        PurposeAnti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect of CAR-T therapy in B-ALL patients with extramedullary relapse are rarely issued even disqualified in some clinical trials. Here, we examined the efficacy of 19CAR-T in patients with both bone marrow and extramedullary involvement.Materials and MethodsCAR-T cells were generated by transfection of primary human T lymphocytes with a lentiviral vector expressing anti-CD19 single chain antibody fragments (scFvs) with the cytoplasmic domains of 4-1BB and CD3ζ, and used to infuse patients diagnosed as having r/r B-ALL with extramedullary origination. Clinical responses were evaluated by the use of bone marrow aspiration, imaging, and flow cytometry. ResultsEight patients received 19CAR-T infusion and all attained complete remission (CR). Only one patient was bridged to hematopoietic stem cell transplantation (HSCT). Although three patients relapsed after infusion, they received 19/22CAR-T infusion sequentially and attained a second remission. To date, five patients are in continuous CR and all eight patients are still alive. The mean follow-up time was 21.9 months, while the 24-month estimated event-free survival is 51.4%. Conclusion19CAR-T therapy can lead to clinical remission for extramedullary relapsed pediatric B-ALL patients. However, the problem of CD19+ relapses after CAR-T remained to be solved. For patients relapsing after CAR-T, a second CAR-T therapy creates another opportunity for remission for subsequent HSCT.

      • KCI등재

        An Inter-Ethnic Comparison Study of Ziprasidone Plasma Levels, Dosage and Clinical Response in Patients with Schizophrenia

        Dongsheng Lv,Meirong Zhao,Lixia Chen,Dongsheng Yu,Xiaobin Yun,Qing Yang,Xiaojun Huang 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.3

        Objective: The aim of this study was to investigate ziprasidone plasma concentration, daily dose and clinical efficacy and safety in Han Chinese and Mongolian patients with first-episode schizophrenia. Methods: A total of 123 inpatients affected by schizophrenia were recruited from the Mental Health Center of Inner Mongolia in China. Ziprasidone plasma concentration, clinical efficacy and side effects were systematically evaluated at baseline, and at 1, 2, 4, and 6 weeks. Metabolic measures such as changes in weight, body mass index (BMI), fasting blood glucose (FBG), triglycerides, and cholesterol, were also recorded. Results: 90 patients completed the study. Compared with Han patients, on average, Mongolian patients received a significantly higher ziprasidone dosage for adequate symptom control during the 6-week period and had a lower plasma concentration-to-dose ratio. The Mongolian patients also experienced greater increases in weight and BMI. No significant differences between the two ethnic groups were found in the rate of reduction in the Positive and Negative Syndrome Scale (PANSS) score, Treatment Emergent Symptom Scale (TESS) total score, FBG, triglycerides, cholesterol or Q-Tc interval. Conclusion: Compared to Han Chinese patients, Mongolian patients appeared to have increased ziprasidone clearance and require higher doses to achieve effective treatment for schizophrenia.

      • KCI등재

        Identification and differential expression of microRNAs in Madin–Darby canine kidney cells with high and low tumorigenicities

        Wang Jiamin,Liu Lixia,Yang Di,Zhang Li,Abudureyimu Ayimuguli,Qiao Zilin,Ma Zhongren 한국유전학회 2022 Genes & Genomics Vol.44 No.2

        Background: Madin-Darby canine kidney (MDCK) cells are widely used for vaccine production, however, the safety of MDCK cells needs to be considered seriously because of high tumorigenicity. Micro RNAs (miRNAs) that are involved in the tumorigenicity of MDCK cells have been never been reported. Objective: To reveal the role of miRNA in the tumorigenic phenotype of MDCK cell line. Methods: The miRNA expression profiles of two monoclonal MDCK cells (M09CL and M35CL) with low tumorigenicity and one MDCK cell line (M73P) with high tumorigenicity were characterized and investigated by using small RNA-seq technology. Results: A total of 5 known miRNAs and 5 novel miRNAs were highly expressed in M73P. In addition, 4 known miRNAs and 4 novel miRNAs were highly expressed in M09CL and M35CL. The target genes of the differentially expressed miRNAs were significantly enriched in several biological processes, and the majority of these genes were involved in pathways in cancer and the MAPK signaling pathway. Through interaction analysis, 4 up-regulated miRNAs (cfa-miR-452, cfa-miR-8826, cfa-miR-224, and cfa-miR-2387) and their crucial target genes related to the tumor regulation network were identified. Results indicated these 4 miRNAs might play crucial roles in the tumorigenesis of MDCK cells. Conclusion: Our findings, which were based on the functional prediction of miRNAs and target genes, suggested that miRNAs might influence the tumorigenicity of MDCK cells by regulating target genes. Moreover, the results provided important data for understanding the miRNA-mediated regulatory networks that control the tumorigenicities of MDCK cells.

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