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Woo Seok Yang,Eunmi Lee,Tae Woong Kim,Gi-Ho Sung,Jae Youl Cho 한국버섯학회 2014 버섯 Vol.18 No.2
4-isopropyl-2,6-bis(1-phenylethyl)aniline 1 (KTH13-AD1) is a metabolite of Cordyceps bassiana that has been traditionally used to treat various inflammatory disease. Even though it has the magnificent pharmaceutical potential, there was not much understanding on its anti-inflammatory actions. Therefore, this study was aimed to determine the anti-inflammatory effects of KTH13-AD1. We found that KTH13-AD1 suppressed nitric oxide (NO) and reactive oxygen species (ROS) production in lipopolysaccharide (LPS)- or sodium nitroprusside (SNP)-treated macrophages (RAW264.7 cells). Similarly, mRNA expression of inducible NO synthase (iNOS) and tumor necrosis factor-a (TNF-a) analyzed by RT-PCR and real-time PCR was also reduced by this compound. Interestingly, KTH13-AD1 also strongly diminished the levels of NF-kB-mediated luciferase activities and nuclear translocated NF-kB family proteins. In agreement with these, KTH13-AD1 suppressed the upstream signaling pathway for NF-kB activation including IkBa, IKKa/b, AKT, p85/PI3K and Src in time- and dose-dependent manners. Therefore, these results strongly suggest that KTH13-AD1 has a strong anti-inflammatory activity via suppression of the NF-kB signaling pathway.
Impact of Recipient Age on Mortality after Liver Transplantation: A Population-Based Cohort Study
( Eunmi Gil ),( Jong Man Kim ),( Jae-won Joh ),( Gee Young Suh ),( Dong Hyun Sinn ),( Kyeongman Jeon ),( Jeong Hoon Yang ),( Jinkyeong Park ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Mortality after liver transplantation (LT) depends on many factors. Our aim was to assess short-term outcomes after first LT in a cohort of adult recipients form the national wide database in Korea and identify predictors of in-hospital mortality that could avoid futile LT. Methods: We analyzed data from Health Insurance Review and Assessment Service (HIRA) which is a government-affiliated organization that reviews claim accuracy and assess the quality for the National Health Insurance (NHI) between Aug, 2009 and July, 2014. The patients who had procedural codes of the Korea NHI concerning LT (Q8040-Q8050, Q8140-Q8150) were categorized as patients who received LT. We analyzed the effect of several risk factors on survival by multivariable logistic models. Results: Total 5375 patients had first liver transplantation in this period (1433 received from deceased donor (DD) and 3942 received form living donor (LD)). Mean age was 52.3±8.9 years old and 72.8% (n = 3913) was male. Most common underlying cause of LT was viral hepatitis (46.9 %) due to hepatitis B or C virus, with or without malignant neoplasm of liver. Total 346 patients (6.4%) were died after liver transplantation before hospital discharge. DDLT recipients’ mortality was 14.0% (n = 200) and LDLT recipients’ mortality was 3.7% (n = 146) (p < 0.001). Multiple logistic analysis identified four variables associated with patient survival: recipient age older than 65 years old, recipient on mechanical ventilation more than 3 days, recipients on perioperative hemodialysis, and vasopressor support more than 2 days. Conclusions: Our data shows recipient age, mechanical ventilation, dialysis, and shock had an ability to predict short term outcome. Our results can be used to identify futile cases in which expected outcomes is too poor to justify transplantation.
Ahn, Eunmi,Shin, Dong Wook,Yang, Hyung-kook,Yun, Jae Moon,Chun, So Hyun,Suh, Beomseok,Lee, Hyejin,Son, Ki Young,Cho, BeLong The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.9
<P>Participation in a screening program by itself may not improve clinical outcomes. Treatment gaps in the program may limit its full benefit. We evaluated statin prescription rates for subjects with sustained hypercholesterolemia to assess the treatment gaps in the National Health Screening Program (NHSP) in Korea. A retrospective, random cohort was established among National Health Insurance Corporation (NHIC) members. Finally, we examined 465,499 individuals who attended the NHSP from 2003 to 2010 without any history of dyslipidemia, statin prescription, or hospitalization for cardiovascular events until the end of 2002. The subsequent statin prescription rates were identified from the NHIC medical service claim database from 2003 to 2011. Descriptive data and odds ratio from multivariate logistic analyses on statin prescription rates and the corresponding correlations were evaluated. The NHSP detected 114,085 (24.5%) cases of newly diagnosed hypercholesterolemia. However, only 8.6% of these received statin prescription within 6 months of diagnosis. For cases of sustained hypercholesterolemia determined in the next screening visit by the NHSP, the statin prescription rate increased, but only to 12.2%. Statin prescriptions were more common among females, older individuals, and hypertension or diabetes patients. Furthermore, the statin prescription rates had increased over the study period. The NHSP exhibited low statin prescription rate which has been improving. For the NHSP to be effective, it would be worthwhile to decrease the gap between the diagnosis of hypercholesterolemia and the following treatment.</P>
( Seungkeol Yang ),( Jee Woong Choi ),( Bo Ri Kim ),( Eunmi Seo ),( Sang Woong Youn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis are not well described in Asian populations, including Koreans. Objectives: The purpose of this study was to investigate the prevalence of PsA by using the classification of psoriatic arthritis (CASPAR) criteria on the basis of physical examination only, as well as its correlation with psoriasis severity and other medical conditions including nail psoriasis. Methods: A single-center, cross-sectional observational cohort study was conducted, and the included patients were evaluated for PsA according to the CASPAR criteria. The psoriasis area severity index (PASI) and the nail psoriasis severity index (NAPSI) were calculated. Results: The prevalence of PsA in patients with psoriasis was 13.5%. Hyperlipidemia and localized pustular psoriasis were found to be significant predictors of PsA. The PASI score was significantly higher in PsA patients than in those with psoriasis alone. The mean NAPSI score was higher in patients with PsA; however, the difference was not statistically significant. Conclusion: There was a close relation between psoriasis severity and PsA. Dermatologists can diagnose PsA from current physical findings only by using the CASPAR criteria. To validate the CASPAR criteria for PsA diagnosis, the definition of nail psoriasis clinical types and severity in the criteria should be reviewed again.