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Histologic effects of intentional-socket-assisted orthodontic movement in rabbits
Yu, Ji-Yeon,Lee, Won,Park, Jae Hyun,Bayome, Mohamed,Kim, Yong,Kook, Yoon-Ah The Korean Association Of Orthodontists 2012 대한치과교정학회지 Vol.42 No.4
Objective: This study aimed to evaluate the effect of an intentionally created socket on bone remodeling with orthodontic tooth movement in rabbits. Methods: Eighteen male rabbits weighing 3.8 - 4.25 kg were used. An 8-mm deep and 2-mm wide socket was drilled in the bone 1 mm mesial to the right mandibular first premolar. The left first premolar was extracted to serve as an extraction socket. A traction force of 100 cN was applied to the right first premolar and left second premolar. Sections were obtained at the middle third of the moving tooth for both the drilled and extraction sockets and evaluated with hematoxylin and eosin staining and immunohistochemical analyses. The amount of tooth movement and tartrate-resistant acid phosphatase (TRAP)-positive cell count were compared between the 2 groups using the Mann-Whitney U test. Results: At week 2, the distance of tooth movement was significantly higher in the intentional socket group (p < 0.05) than in the extraction socket group. The number of TRAP-positive cells decreased in week 2 but increased in week 3 (p < 0.05). However, there were no significant differences between the groups. Furthermore, results of transforming growth factor (TGF)-${\beta}$ staining revealed no significant differences. Conclusions: The intentional socket group showed greater distance of tooth movement than did the extraction socket group at week 2. Osteoclast counts and results of immunohistochemical analyses suggested elevated bone remodeling in both the groups. Thus, osteotomy may be an effective modality for enhancing tooth movement in orthodontic treatment.
Analysis of risk factors for portal vein thrombosis after liver resection
Jae Hyun Han,Dong-Sik Kim,Young Dong Yu,Sung Won Jung,Young In Yoon,조혜성 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.96 No.5
Purpose: We evaluated the risk factors for posthepatectomy thrombosis including portal vein thrombosis (PVT) and clinical outcomes. Methods: We retrospectively analyzed 563 patients who had undergone hepatectomy from February 2009 to December 2014. Twenty-nine patients with preoperatively confirmed thrombosis and tumor recurrence-related thrombosis were excluded. We identified the location of the thrombosis as main portal vein (MPV), peripheral portal vein (PPV) and other site such as hepatic vein or inferior vena cava. Patients with MPV thrombosis and PPV thrombosis with main portal flow disturbance were treated with anticoagulation therapy. We performed operative thrombectomy before anticoagulation therapy who did combined portal vein (PV) segmental resection. Results: Of the 534 patients, 22 (4.1%) developed posthepatectomy thrombosis after hepatectomy. Among them, 19 (86.4%) had PVT. The mean duration of Pringle’s maneuver was significant longer in the PVT group than the no-thrombosis group (P = 0.020). Patients who underwent combined PV segmental resection during hepatectomy were more likely to develop posthepatectomy PVT (P = 0.001). Thirteen patients who had MPV thrombosis and PPV thrombosis with main portal flow disturbance received anticoagulation therapy immediately after diagnosis and all of them were improved. Among them, 2 patients who developed PVT at the PV anastomosis site after PV segmental resection, underwent operative thrombectomy before anticoagulation therapy and both were improved. There were no patients who developed complications related to anticoagulation therapy. Conclusion: Long duration of Pringle’s maneuver and PV segmental resection were risk factors. Anticoagulation therapy or operative thrombectomy should be considered for PVT without contraindications.
Won, Yu Deok,Kim, Jae-Min,Ryu, Je-Il,Koh, Seong-Ho,Han, Myung-Hoon,Cheong, Jin-Hwan The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.5
Objective : Hemorrhagic transformation (HT) can be occurred after acute cerebral infarction. HT can worse symptoms in severe cases and adversely affect long-term prognosis. As bone and vascular smooth muscle are composed of type 1 collagen, we aimed to identify a potential relationship between bone mineral density (BMD) and HT after acute cardioembolic stroke. Methods : As an indicator of BMD, we used mean frontal skull Hounsfield unit (HU) values on brain computed tomography (CT). Multivariative hazard ratios were calculated using Cox regression analysis to identify whether the osteoporotic condition was an independent predictor of HT after acute cardioembolic stroke. Results : This 11-year analysis enrolled 506 patients who diagnosed as acute cardioembolic infarction. The first tertile of skull HU value was an independent predictor of HT development compared to the third tertile (hazard ratio, 2.12; 95% confidence interval, 1.13-3.98; p=0.020). We observed no interactions between age and skull HU with respect to HT statistically. Conclusion : The results of this study revealed an association between osteoporotic conditions and HT development after acute cardioembolic stroke. A convenient method to measure the cancellous bone HU value of the frontal skull using brain CT images may be useful for predicting HT in patients with acute cerebral infarction.
[P249] Two cases of pyogenic granuloma on a nail bed
( Yu Jin Jeon ),( Dae Young Oh ),( Young Min Jo ),( Jae Hwa Kim ),( Joong Sun Lee ),( Dae Won Koo ),( Kyung Eun Jung ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Pyogenic granuloma(PG) is a rapidly developing vascular lesion, histopathologically a lobular capillary hemangioma. The lesion is a commonly reddish papule with a smooth surface, with or without crusts and erosion. Typical locations include the cheek, forehead or gingiva but virtually any body site including the mucous membranes may be affected. An 17-year-old woman presented with a partial defect of her left first proximal nail plate of 1 week in duration. She had no history of trauma but the nail plate dissolved spontaneously. Histopathologic examination of the lesion on the nail bed revealed lobular aggregates of proliferating capillaries with edema and numerous neutrophils, which was supportive for PG. The lesion of nail was improved after surgical excision and curettage of PG, and her nail showed normal growth. A 33-year-old woman presented with painful tiny splitting of a nail plate of right thumb of 2 week in duration. She had no history of trauma. Histopathologic examination of the lesion on the nail bed revealed proliferation of small vasculatures such as capillaries, which was supportive for PG. We are under close observation for her. There have been numerous reports about PG on the finger, lips, mouth, trunk, and toes. We report this two cases because it``s rare cases of PG involving a nail bed. Dermatologist should be aware that PG on the nail bed could often cause nail dystrophy.
Erythromelanosis follicularis faciei et colli colocalized with Becker`s nevus
( Yu Ri Woo ),( Dong Ha Kim ),( Jae Hwa Kim ),( Young Min Cho ),( Kyung Eun Jung ),( Dae Won Koo ),( Joong Sun Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Erythromelanosis follicularis faciei et colli (EFFC) is characterized by hyperpigmentation, erythema and follicular papules on the face with male predominance. Becker’s nevus is a hamartoma with unilateral brownish hyperpigmentation, commonly with hypertrichosis. These lesions are frequently localized to the upper extremities and trunk. The lesions mostly occur during adolescence and are more common in males than females. An 18-year-old Korean man presented with 6-year history of asymptomatic brownish pigmented patches on his left side of the preauricular and mandibular area. During puberty, hair developed on the hyperpigmented patch. The patient was also complained of having flesh colored papules on both his mandibular areas for 13 years. Physical examination revealed the follicular keratotic papules on both side of the preauricular and mandibular areas and reddish-brown pigmented hairy patches on his left side of the lesion. The histopathological examination of the left side of the lesion revealed the follicular plugging, mild acanthosis, elongated rete ridges with flat bottoms and hyperpigmentation of the basal layer of epidermis. It was diagnosed as having EFFC colocalized with Becker``s nevus based on the clinical and histopathological findings. There are, to our knowledge, no previous reports of Becker’s nevus in the lesional skin of EFFC. We think it would be interesting to report this case for its rare clinical manifestation.
Suppression of CD4+ T-Cells in the Spleen of Mice Infected with Toxoplasma gondii KI-1 Tachyzoites
Won-Hee Kim,Eun-Hee Shin,Jae-Lip Kim,Seung-Young Yu,Bong-Kwang Jung,Jong-Yil Chai 대한기생충학열대의학회 2010 The Korean Journal of Parasitology Vol.48 No.4
Toxoplasma gondii KI-1, a recent new isolate from Korea, shows similar pathogenicity and infectivity to mice compared to the virulent RH strain. To understand characteristics of host immunity, including immune enhancement or suppression, we investigated proliferative responses and phenotypes of spleen cells. In addition, kinetics of IFN-g, a Th1 cytokine, was examined in BALB/c mice up to day 6 post-infection (PI). Intraperitoneal injection of mice with 10³ KI-1 tachyzoites induced significant decreases (P < 0.05) in proliferative responses of spleen cells. This occurred at days 2-6 PI even when concanavalin A (con A) was added and when stimulated with KI-1 antigen, suggesting suppression of the immunity. CD4+ T-cells decreased markedly at day 2 PI (P < 0.05), whereas CD8+ T-cells, NK cells, and macrophages did not show significant changes, except a slight, but significant, increase of CD8+ T-cells at day 6 PI. The capacity of splenocytes to produce IFN-g by con A stimulation dropped significantly at days 2-6 PI. These results demonstrate that intraperitoneal injection of KI-1 tachyzoites can induce immunosuppression during the early stage of infection, as revealed by the decrease of CD4+ T-cells and IFN-g.