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Woo Yu Ri,Choi Arum,송서원,김수연,손상욱,Cho Sang Hyun,Kim Sukil,김정은 대한피부과학회 2024 Annals of Dermatology Vol.36 No.2
Background: Cyclosporine (CS) is a first-line immunosuppressive agent used to manage mod- erate to severe atopic dermatitis (AD). To date, the risk of developing hypertension associated with the long-term use of low-dose CS in AD patients is understudied. Objective: To determine the cumulative dose-dependent effect of CS on the risk of developing hypertension in patients with AD. Methods: A nationwide population-based retrospective cohort with 1,844,009 AD patients was built from the Korean National Health Insurance System database from 2005 to 2009. A Cox proportional-hazard regression analysis was performed according to patients’ CS treatment histor y adjusted for potential confounders. Results: Current use of CS was associated with an increased risk of developing hypertension (adjusted hazard ratio, 4.442; 95% confidence inter val, 3.761–5.247). Among the current CS users, a higher cumulative dose of CS (≥39,725 mg) or longer cumulative use of CS (≥182 days), was significantly associated with an increased risk of developing hypertension. Conclusion: The incidence of CS-associated hypertension is ver y low when using low-dose treatment regimens for AD. However, the current use or a high cumulative dose of CS for treating patients with AD increases the risk of developing hypertension. Precaution is needed when prescribing CS for long-term treatment of AD.
Woo, Yu Ri,Kim, Jong Sic,Lim, Ji Hong,Hwang, Sewon,Kim, Miri,Bae, Jung Min,Park, Young Min,Min, Chang-Ki,Kim, Dong-Wook,Park, Hyun Jeong Elsevier 2018 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY - Vol.78 No.3
<P><B>Background</B></P> <P>Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of a clonal proliferation of tumor cells. Cutaneous involvement of MM is very rare and remains poorly understood.</P> <P><B>Objective</B></P> <P>The aim of this study was to examine the clinical and histopathologic characteristics of cutaneous involvement in MM and identify factors associated with overall survival of MM with cutaneous involvement.</P> <P><B>Methods</B></P> <P>The medical records of 1228 patients with MM were retrieved and analyzed. Of those patients, 14 with cutaneous involvement of MM (1.14%) were further evaluated for their clinical and histopathologic findings.</P> <P><B>Results</B></P> <P>Patients with cutaneous involvement showed significantly reduced overall survival compared with those without cutaneous involvement (median, 28 vs. 57 months; hazard ratio, 1.929; 95% confidence interval, 1.030-3.613). In subgroup analyses of patients with MM with cutaneous involvement, erythematous nodules (<I>P</I> = .004), multiple cutaneous lesions (<I>P</I> = .002), and absence of a grenz zone (<I>P</I> = .004) were clinicopathologic features associated with reduced overall survival after Bonferroni correction.</P> <P><B>Limitations</B></P> <P>The retrospective design and the small sample size are the limitations.</P> <P><B>Conclusion</B></P> <P>Cutaneous involvement accounted for about 1.14% of patients with MM and was associated with reduced overall survival.</P>
Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition
Woo, Yu Ri,Lim, Ji Hong,Cho, Dae Ho,Park, Hyun Jeong MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.9
<P>Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid toward better comprehending its complex pathogenesis.</P>
( Yu Ri Woo ),( Jong Sic Kim ),( Ji Hong Lim ),( Sewon Hwang ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Acanthosis nigricans (AN) is a cutaneous eruption characterized by hyperpigmention and velvety skin texture, and primarily involves the intertriginous areas such as axillae, posterior neck and inframammary folds. Unilateral linear AN is a rare form of AN, characterized by localized linear lesions or a solitary lesion following Blaschko`s line. A 15-year-old male presented with an asymptomatic, linear, localized velvety brownish plaque on his neck that had been present for 5 months. He obtained a linear scratch mark on the anterior neck 6 months prior after climbing over a fence. In addition, symmetrically distributed, velvety, gray-brown, hyperpigmented patches on both axilla were observed. Skin biopsies were performed of the anterior neck and axillae, respectively. Histopathological examination of both lesions revealed papillomatosis, hyperkeratosis, and mild acanthosis of the epidermis. In this case, the patient already had hyperpigmented patches on the axillae before the appearance of the linear AN on the neck, implying that in patients with benign AN, the linear form of AN can occur in association with the Koebner phenomenon. We hypothesize that trauma might act as a trigger of AN, resulting in abnormal growth factor signaling pathways. Therefore, we suggest that in patients with AN, careful examination and regular follow-up are needed and the patient should avoid further trauma because this could trigger the development of AN