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- 저자 : Weiwei Dong (검색결과 17 건)
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Weiwei Dong,Xiaowei Wu,Mi Yan 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.10
The influences of minor Y addition on the thermal stability, crystallization behavior, magnetic property and bending ductilityof Fe–Si–B amorphous ribbons have been systematically investigated. The results show that all the ribbons with Y additionare fully amorphous structure, and the introduction of Y can enhance the glass forming ability of Fe–Si–B amorphous alloy. With Y addition, crystallization temperature of the first and second phase shift to high temperature side, the temperatureinterval between the two crystallization peaks are enlarged, the third phase transitions process of Fe–Si–B amorphous alloywith Y addition corresponds to the precipitation of Fe3Bphase. The activation energy of the first and second phase calculatedby Kissinger’s formula increased with Y addition. Appropriate Y addition is beneficial for Ms. The measured coercivity Hcgradually decreased with the Y addition increased. The amorphous alloys exhibit good bending ductility in the quenchedstate. The ductile to brittle temperature increase to 300 °C with 1 at% Y addition. Furthermore, the mechanism of ductile tobrittle for amorphous alloy was discussed.
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Weiwei Jiang,Guanghui Jin,Fangfang Cai,Xiao Chen,Nini Cao,Xiangyu Zhang,Jia Liu,Fei Chen,Feng Wang,Wei Dong,Hongqin Zhuang,Zichun Hua 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Radiotherapy is a frequent mode of cancer treatment, although the development of radioresistance limits its effectiveness. Extensive investigations indicate the diversity of the mechanisms underlying radioresistance. Here, we aimed to explore the effects of extracellular signal-regulated kinase 5 (ERK5) on lung cancer radioresistance and the associated mechanisms. Our data showed that ERK5 is activated during solid lung cancer development, and ectopic expression of ERK5 promoted cell proliferation and G2/M cell cycle transition. In addition, we found that ERK5 is a potential regulator of radiosensitivity in lung cancer cells. Mechanistic investigations revealed that ERK5 could trigger IR-induced activation of Chk1, which has been implicated in DNA repair and cell cycle arrest in response to DNA double-strand breaks (DSBs). Subsequently, ERK5 knockdown or pharmacological inhibition selectively inhibited colony formation of lung cancer cells and enhanced IR-induced G2/M arrest and apoptosis. In vivo, ERK5 knockdown strongly radiosensitized A549 and LLC tumor xenografts to inhibition, with a higher apoptotic response and reduced tumor neovascularization. Taken together, our data indicate that ERK5 is a novel potential target for the treatment of lung cancer, and its expression might be used as a biomarker to predict radiosensitivity in NSCLC patients.
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Wang Weiwei,Zheng Dawen,Zhang Zhenzhen,Ye Hui,Cao Qingyun,Zhang Changming,Dong Zemin,Feng Dingyuan,Zuo Jianjun 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.11
Objective: This study was aimed to explore the efficacy of combination of endo-xylanase (Xyn) and xylan-debranching enzymes (arabinofuranosidase, Afd and feruloyl esterase, FE) in improving utilization of bran in piglet diet. Methods: In vitro experiments were firstly conducted to examine the enzymological properties of Xyn, Afd, and FE, concurrent with their effect on degradation of arabinoxylan (Abx) in bran. In vivo experiment was then implemented by allocating two hundred and seventy 35-d-old postweaning piglets into 3 groups (6 replicates/group), which received bran-containing diet supplemented with Xyn (1,600 U/kg) or its combination with Afd (0.8 U/kg) and FE (4 U/kg) or without enzyme. Results: Both Xyn, Afd, and FE are relatively stable against the changes in temperature and pH value. Combining Xyn with Afd and FE had a superiority (p<0.05) over Xyn alone and its combination with Afd or FE in promoting (p<0.05) degradation of Abx in different brans. Combined treatment with Xyn, Afd, and FE was more beneficial than Xyn alone to induce increasing trends (p<0.10) of average daily gain, final body weight and feed efficiency of piglets fed bran-containing diet. Moreover, combination of Xyn, Afd, and FE showed advantages (p<0.05) over Xyn alone in causing reductions (p<0.05) in diarrhea rate and cecal pH value, concurrent with increases (p<0.05) in cecal and colonic acetic acid and total volatile fatty acid concentrations, as well as cecal butyric acid concentration of piglets fed brancontaining diet. Conclusion: Combining Xyn with Afd and FE was more beneficial than Xyn alone in promoting degradation of Abx in bran, along with growth performance and intestinal volatile fatty acid profile of piglets received bran-containing diet. Thereby, combination of Xyn, Afd, and FE had a superior efficacy relative to Xyn alone in improving application of cereal bran in piglet diet. Objective: This study was aimed to explore the efficacy of combination of endo-xylanase (Xyn) and xylan-debranching enzymes (arabinofuranosidase, Afd and feruloyl esterase, FE) in improving utilization of bran in piglet diet.Methods: <i>In vitro</i> experiments were firstly conducted to examine the enzymological properties of Xyn, Afd, and FE, concurrent with their effect on degradation of arabinoxylan (Abx) in bran. <i>In vivo</i> experiment was then implemented by allocating two hundred and seventy 35-d-old postweaning piglets into 3 groups (6 replicates/group), which received bran-containing diet supplemented with Xyn (1,600 U/kg) or its combination with Afd (0.8 U/kg) and FE (4 U/kg) or without enzyme.Results: Both Xyn, Afd, and FE are relatively stable against the changes in temperature and pH value. Combining Xyn with Afd and FE had a superiority (p<0.05) over Xyn alone and its combination with Afd or FE in promoting (p<0.05) degradation of Abx in different brans. Combined treatment with Xyn, Afd, and FE was more beneficial than Xyn alone to induce increasing trends (p<0.10) of average daily gain, final body weight and feed efficiency of piglets fed bran-containing diet. Moreover, combination of Xyn, Afd, and FE showed advantages (p<0.05) over Xyn alone in causing reductions (p<0.05) in diarrhea rate and cecal pH value, concurrent with increases (p<0.05) in cecal and colonic acetic acid and total volatile fatty acid concentrations, as well as cecal butyric acid concentration of piglets fed bran-containing diet.Conclusion: Combining Xyn with Afd and FE was more beneficial than Xyn alone in promoting degradation of Abx in bran, along with growth performance and intestinal volatile fatty acid profile of piglets received bran-containing diet. Thereby, combination of Xyn, Afd, and FE had a superior efficacy relative to Xyn alone in improving application of cereal bran in piglet diet.
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Simin Liu,Weiwei Chen,Min Wang,Tong Wu,Lingli Dong,Chu Pan,Wenzhen Zhu 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.3
Objective: To evaluate the secretory function of parotid glands by dynamic magnetic resonance (MR) sialography and determine the clinical performance of this technique in diagnosing and evaluating Sjögren’s syndrome (SS) patients. Materials and Methods: This study enrolled 29 healthy volunteers (25 women and 4 men; mean age, 34.8 ± 6.3 years; age range, 26–47 years) and 25 primary SS (pSS) patients (23 women and 2 men; mean age, 37.7 ± 7.9 years; age range, 25–50 years) with decreased secretory function. The volume of the parotid gland ducts was precisely measured for both groups at single pre- and 6 post-gustatory-stimulated phases. Time-dependent volume change ratio curves were generated, four parameters were derived from the curves: the slope of the increase in the first post-stimulation phase (slope1st), the peak value, the time-to-peak, the total saliva secretion post-stimulation. All values were used to quantitatively evaluate the secretory function of the parotid gland. The repeated measurement analysis, Mann-Whitney U test and receiver operating characteristic curve were applied. Results: Time-dependent volume change ratio curves demonstrated that there is a statistically significant difference between the two groups (F = 8.750; p = 0.005). A quickly increasing curve was shown in the volunteer group, whereas a slowly increasing curve was shown in the pSS patient group. The slope1st, peak value and total saliva secretion post-stimulation of the patient group were significantly lower than those of the volunteer group (p = 0.005, p = 0.003, and p = 0.002, respectively). The timeto-peak between the two groups was not significantly different (p = 0.383). The slope1st can be used as a discriminator to diagnose SS patients (p = 0.015; odds ratio = 4.234; area under the curve = 0.726). Conclusion: Dynamic MR sialography is proven to be an effective method in evaluating salivary gland function and has a great potential in diagnosing and evaluating pSS patients.
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Shuang Sun,Weiwei Cui,Ying Dong,Qing Wang 한국고분자학회 2019 Macromolecular Research Vol.27 No.5
An organoid is a kind of three-dimensional cell culture system that is highly similar to the source tissues or organs in the body. Recently, organoid therapy has become a hot topic in the field of fundamental researches and clinical treatments. Type 1 diabetes mellitus (T1DM) is caused by the absolute lack of insulin. Exogenous insulin supplement, the only treatment currently available for T1DM, has nonideal effect due to the poor compliance. An implantable and sustainable strategy of T1DM is needed and the organoids theoretically provide the basis for treatment. However, the current structure and function of organoids are different from that of real organs or tissues. The organic scaffolds can effectively support the growth of organoids, which can increase the similarity of organoids to the real structure. In order to find suitable scaffold materials for islet β-like cells (IBCs) organoids, poly (lactic-co-glycolic acid) (PLGA) polymer films were prepared to act as induced carriers for IBCs derived from bone marrow mesenchymal stem cells (BMSCs). The surface of PLGA film was simply modified through dopamine (DA) coating (i.e., DA-PLGA) and then liraglutide (LIR) was fixed on the surface of PLGA film via the DA coating (i.e., LIR-DA-PLGA). The results proved that DA could enhance the hydrophilicity and cell proliferation and LIR-DA-PLGA was suitable to act as inducing carriers. In subsequent experiments, LIR-DA-PLGA scaffolds would be prepared to culture organoids and transplanted into the body of diabetic rat model to regulate blood glucose lever.
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Two New Bibenzyl Glucosides from Dendrobium chrysotoxum
Fa-Wu Dong,Huai-Rong Luo,Qin-Li Wan,Feng-Qing Xu,Weiwei Fan,Kai-Jin Wang,Ning Li,Jiang-Miao Hu 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.7
Two new bibenzyl glucosides, 3,3',4',5-tetramethoxybibenzyl-4-O-β-D-glucopyranoside (1) and 3,4,4',5- tetramethoxybibenzyl-3'-O-β-D-glucopyranoside (2), together with five known ones, chrysotobibenzyl (3), erianin (4), chrysotoxine (5), gigantol (6) and tristin (7) were isolated from the stems of Dendrobium chrysotoxum. The structures of those compounds were elucidated by extensive spectroscopic analysis. Moreover, compounds 1-7 were assessed for inhibitory activity of two enzymes-AChE (acetylcholine esterase) and BChE (butyrylcholine esterase).
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Screen printing of silver nanoparticle suspension for metal interconnects
Sung Min Cho,Weiwei Yin,Dong-Hyun Lee,Jaesoo Choi,박진호 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.6
Silver nanoparticle suspensions were synthesized by chemical reduction method using a formaldehyde reductant. Polyvinyl pyrrolidone (PVP) of two different molecular weights (M.W.=8,000 and 29,000) was used as a stabilizer for the suspensions. PVP of a smaller molecular weight could produce silver suspensions of nanoparticle size around 20 nm. Water-based conductive silver inks with different silver concentrations were prepared and tested for suitability for screen printing. We have successfully printed silver metal lines on glass substrates using a 400 mesh screen-mask with 60wt.% silver ink prepared in this study. Curing at a low temperature of 200 oC for an hour was found sufficient to reach the lowest resistivity value with the synthesized ink. For a line with a width and thickness of 0.5 mm and 2.12 μm, respectively, it exhibited a resistivity of 3.3×10−5 Ω·cm, which could serve as conducting lines for various electronic applications.
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Zhang, Xiuling,Xu, Weiwei,Duan, Dongzhi,Park, Dong-Wha,Di, Lanbo IEEE 2018 IEEE transactions on plasma science Vol.46 No.8
<P>Atmospheric pressure (AP) oxygen cold plasma was adopted to synthesize Au/TiO<SUB>2</SUB> catalysts with the assistance of a simple modified incipient wetness impregnation process. Discharge voltages of 25.0, 29.0, and 35.0 kV and discharge time of 1, 2, and 4 min are selected to investigate the effects of discharge voltage and discharge time on the property of the Au/TiO<SUB>2</SUB> catalysts. The results of carbon monoxide (CO) oxidation activity testing show that AP oxygen cold plasma is beneficial to enhance the activity of the Au/TiO<SUB>2</SUB> catalysts, and the optimal discharge voltage and time are 29.0 kV and 1 min, respectively. CO conversion of the Au/TiO<SUB>2</SUB>-29-1 catalyst at 30 °C is 1.42 times as that of the Au/TiO<SUB>2</SUB>-As catalyst without plasma treatment. The UV-Vis diffuse reflectance spectroscopy and X-ray photoelectron spectroscopy characterizations indicate that AP oxygen cold plasma not only can decompose the gold species formed by the modified impregnation process to form metallic gold species but also can remove some of the oxygen species on the surface of the TiO<SUB>2</SUB> support. The discharge time of 1 min at 29.0 kV is enough to decompose the gold species formed by the modified impregnation process, and to keep much active hydroxyl groups. Moreover, there is little difference in the size of gold nanoparticles in the Au/TiO<SUB>2</SUB> catalysts. Therefore, Au/TiO<SUB>2</SUB>-29-1 catalyst exhibits higher CO oxidation activity than Au/TiO<SUB>2</SUB>-As, and 1 min is the optimal discharge time. Thanks to the AP oxygen cold plasma method, high-performance Au/TiO<SUB>2</SUB> catalysts can be synthesized simply in a short time.</P>
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