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Food Intake and Thermogenesis in Adipose Tissue
Tsuyoshi Goto,Minji Kim,Haruya Takahashi,Nobuyuki Takahashi,Teruo Kawada 대한비만학회 2016 The Korean journal of obesity Vol.25 No.3
Brown adipose tissue (BAT) is regarded as a key target for developing interventions to prevent and treat obesity and age-related diseases. In addition, uncoupling pro tein 1 (UCP1) - expressing “brown-like” adipocytes, known as beige cells, that develop in white adipose tissue (WAT) under certain physiological conditions and pharmacological stimuli. The effects of ageing on BAT atrophy and functional decline further strengthen the notion that healthy eating habits and food choices play an extremely vital role against reduction in the number of BAT and beige cells as people approach middle age. This review aims to cover recent progress in food items and pharmaceuticals that activate or induce BAT and UCP1.
Goto, Tsuyoshi,Hirata, Mariko,Aoki, Yumeko,Iwase, Mari,Takahashi, Haruya,Kim, Minji,Li, Yongjia,Jheng, Huei-Fen,Nomura, Wataru,Takahashi, Nobuyuki,Kim, Chu-Sook,Yu, Rina,Seno, Shigeto,Matsuda, Hideo,A American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.22
<P>Obesity causes excess fat accumulation in white adipose tissues (WAT) and also in other insulin-responsive organs such as the skeletal muscle, increasing the risk for insulin resistance, which can lead to obesity-related metabolic disorders. Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is a master regulator of fatty acid oxidation whose activator is known to improve hyperlipidemia. However, the molecular mechanisms underlying PPAR alpha activator-mediated reduction in adiposity and improvement of metabolic disorders are largely unknown. In this study we investigated the effects of PPAR alpha agonist (fenofibrate) on glucose metabolism dysfunction in obese mice. Fenofibrate treatment reduced adiposity and attenuated obesity-induced dysfunctions of glucose metabolism in obese mice fed a high-fat diet. However, fenofibrate treatment did not improve glucose metabolism in lipodystrophic A-Zip/F1 mice, suggesting that adipose tissue is important for the fenofibrate-mediated amelioration of glucose metabolism, although skeletal muscle actions could not be completely excluded. Moreover, we investigated the role of the hepatokine fibroblast growth factor 21 (FGF21), which regulates energy metabolism in adipose tissue. In WAT of WT mice, but not of FGF21-deficient mice, fenofibrate enhanced the expression of genes related to brown adipocyte functions, such as Ucp1, Pgc1a, and Cpt1b. Fenofibrate increased energy expenditure and attenuated obesity, whole body insulin resistance, and adipocyte dysfunctions in WAT in high-fat-diet-fed WT mice but not in FGF21-defi-the fenofibrate-mediated improvement of whole body glucose metabolism in obese mice via the amelioration of WAT dysfunctions.</P>
Over-expression of PPARα in obese mice adipose tissue improves insulin sensitivity
Takahashi, Haruya,Sanada, Kohei,Nagai, Hiroyuki,Li, Yongjia,Aoki, Yumeko,Ara, Takeshi,Seno, Shigeto,Matsuda, Hideo,Yu, Rina,Kawada, Teruo,Goto, Tsuyoshi Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Peroxisome proliferator-activated receptor α (PPARα) is important in the regulation of lipid metabolism and expressed at high levels in the liver. Although PPARα is also expressed in adipose tissue, little is known about the relationship between its activation and the regulation of glucose metabolism. In this study, we developed adipose tissue specific PPARα over-expression (OE) mice. Metabolomics and insulin tolerance tests showed that OE induces branched-chain amino acid (BCAA) profile and improvement of insulin sensitivity. Furthermore, LC-MS and PCR analyses revealed that OE changes free fatty acid (FFA) profile and reduces obesity-induced inflammation. These findings suggested that PPARα activation in adipose tissue contributes to the improvement of glucose metabolism disorders via the enhancement of BCAA and FFA metabolism.</P>
An attempt at soil profiling on a river embankment using geophysical data
Takahashi, Toru,Yamamoto, Tsuyoshi Korean Society of Earth and Exploration Geophysici 2010 지구물리와 물리탐사 Vol.13 No.1
The internal structure of a river embankment must be delineated as part of investigations to evaluate its safety. Geophysical methods can be most effective means for that purpose, if they are used together with geotechnical methods such as the cone penetration test (CPT) and drilling. Since the dyke body and subsoil in general consist of material with a wide range of grain size, the properties and stratification of the soil must be accurately estimated to predict the mechanical stability and water infiltration in the river embankment. The strength and water content of the levee soil are also parameters required for such prediction. These parameters are usually estimated from CPT data, drilled core samples and laboratory tests. In this study we attempt to utilise geophysical data to estimate these parameters more effectively for very long river embankments. S-wave velocity and resistivity of the levee soils obtained with geophysical surveys are used to classify the soils. The classification is based on a physical soil model, called the unconsolidated sand model. Using this model, a soil profile along the river embankment is constructed from S-wave velocity and resistivity profiles. The soil profile thus obtained has been verified by geotechnical logs, which proves its usefulness for investigation of a river embankment.
Takahashi Yoshiaki,Kato Tsuyoshi The Korean Society of Rheology 2005 Korea-Australia rheology journal Vol.17 No.3
Coalescence process of binary immiscible fluid mixtures having bimodal size distributions, prepared by mixing two pre-sheared samples at different shear rates, ${\gamma}_{pre1}\;and\;{\gamma}_{pre2}$, under shear flow at a final shear rate, ${\gamma}_f$, are examined by transient shear stress measurements and microscopic observations in comparison with the results for simply pre-sheared samples having narrow size distributions (unimodal distribution samples). Component fluids are a silicone oil (PDMS) and a hydrocarbon-formaldehyde resin (Genelite) and their viscosities are 14.1 and 21.0 $pa{\cdot}sec$ at room temperature $(ca.\;20^{\circ}C)$, respectively. The weight ratio of PDMS: Genelite was 7:3. Three cases, $({\gamma}_{pre1}=7.2sec^{-1},\;{\gamma}_{pre2}=12.0sec^{-1}\;and\;{\gamma}_f=2.4sec^{-1}),\;({\gamma}_{pre1}=0.8sec^{-1},\;{\gamma}_{pre2}=4.0sec^{-1}\;and\;{\gamma}_f=2.4sec^{-1}),\;and\;({\gamma}_{pre1}=7.2sec^{-1},\;{\gamma}_{pre2}=12.0^sec^{-1}\;and\;{\gamma}_f=7.2sec^{-1})$ the first case, transient shear stress did not show any significant difference but domains larger than the initial state are observed at short times. In the latter cases, there exist undershoot of shear stress, reflecting existence of deformed large domains, which is confirmed by the direct observation. It is concluded that coalescence between large and small domains more frequently occur than coalescence between the domains with similar size in the bimodal distribution samples.
Yoshiaki Takahashi,Tsuyoshi Kato 한국유변학회 2005 Korea-Australia rheology journal Vol.17 No.3
Coalescence process of binary immiscible fluid mixtures having bimodal size distributions, prepared by mixing two pre-sheared samples at different shear rates, pre1 and pre2, under shear flow at a final shear rate, f, are examined by transient shear stress measurements and microscopic observations in comparison with the results for simply pre-sheared samples having narrow size distributions (unimodal distribution samples). Component fluids are a silicone oil (PDMS) and a hydrocarbon-formaldehyde resin (Genelite) and their viscosities are 14.1 and 21.0pasec at room temperature (ca. 20oC), respectively. The weight ratio of PDMS: Genelite was 7:3. Three cases, (pre1=7.2sec1, pre2=12.0sec1 and f=2.4sec1), (pre1=0.8sec1, pre2 =4.0sec1 and f=2.4sec1), and (pre1=7.2sec1, pre2=12.0sec1 and f=7.2sec1) are examined. In the first case, transient shear stress did not show any significant difference but domains larger than the initial state are observed at short times. In the latter cases, there exist undershoot of shear stress, reflecting existence of deformed large domains, which is confirmed by the direct observation. It is concluded that coalescence between large and small domains more frequently occur than coalescence between the domains with similar size in the bimodal distribution samples.
Evaluation of Voltage Control Effect for Data Acquisition Period Length from SCADA with IT Switches
Udagawa, Tsuyoshi,Yasuhiro, Hayashi,Takahashi, Naoyuki,Matsuura, Yasuo,Morita, Tomohiko,Minami, Masahiro The Korean Institute of Electrical Engineers 2013 The Journal of International Council on Electrical Vol.3 No.2
Measured data from IT switches are utilized in order to control voltage in Japanese distribution systems with photovoltaic generation systems. However, length of period from the data measurement to the data acquisition from IT switches by SCADA affects voltage control ability in a distribution automation system. In this paper, the effect of the length of the data acquisition period for voltage control by LRT and SVR is evaluated through numerical simulations in a distribution system model. Furthermore, the optimal length of the data acquisition period is determined according to PV penetration rate.
Foxf2 represses bone formation via Wnt2b/β-catenin signaling
Tanaka Tomoyuki,Takahashi Akira,Kobayashi Yutaka,Saito Masanori,Xiaolong Sun,Jingquan Chen,Ito Yoshiaki,Kato Tsuyoshi,Ochi Hiroki,Sato Shingo,Yoshii Toshitaka,Okawa Atsushi,Carlsson Peter,Inose Hiroyu 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Differentiation of mesenchymal stem cells (MSCs) into osteoblasts is a critical process for proper skeletal development and acquisition/maintenance of bone mass. However, since this regulatory mechanism has not yet been fully elucidated, the treatment of severe osteoporosis and fractures is a challenge. Here, through a comprehensive analysis of gene expression during the differentiation of MSCs into osteoblasts, we show that the forkhead transcription factor Foxf2 is a crucial regulator of this process. Foxf2 expression transiently increased during MSC osteoblastic differentiation. Overexpression of Foxf2 in MSCs inhibited osteoblastic differentiation, and conversely, knockdown of Foxf2 expression promoted this process. Osteoprogenitor-specific Foxf2 knockout mice developed a high bone mass phenotype due to increased bone formation. RNA-seq analysis and molecular experiments revealed that Foxf2 regulation of bone formation is mediated by Wnt2b. Knockdown of Foxf2 in mouse femurs enhanced bone regeneration in vivo. FOXF2 expression was correlated with hip bone mineral density in postmenopausal women with low bone mass. Finally, inhibition of FOXF2 promoted osteoblastic differentiation of human MSCs. This study uncovers a critical role of Foxf2 in the differentiation of MSCs into osteoblasts and provides insight into the pathogenesis associated with bone-related diseases such as osteoporosis and nonunion after fracture