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Deep Recommender System Using Purchase History Data
Suji Kang,Changha Hwang 계명대학교 자연과학연구소 2017 Quantitative Bio-Science Vol.36 No.1
In this paper, we propose a deep recommender system that utilizes purchase history data of customers when ratings for products are not available at all. The purchase history data of these customers are obtained between May 2014 and July 2015 from nationwide branches of a particular supermarket chain. If the customer’s purchase cycle for a particular product is shorter than the average purchase cycle, then the preference for the product will be high. Using this idea, we generate rating data from these customers’ purchase history data. Among collaborative filtering recommender systems using rating data, we know that the restricted Boltzmann machine (RBM) shows the best performance in terms of prediction accuracy. Thus, for recommender system wepropose the use of conditional RBM, which utilizes additional information on whether or not to purchase. Through an experiment we show that conditional RBM works best in predicting the ratings for products. This recommender system is expected to be useful in future.
Blue light emission of new anthracene derivatives produced using optimized side group link positions
Kang, Seokwoo,Jung, Hyocheol,Lee, Hayoon,Lee, Suji,Jung, Mina,Lee, Jaehyun,Chul Kim, Young,Park, Jongwook Elsevier 2018 Dyes and pigments Vol.156 No.-
<P><B>Abstract</B></P> <P>Using an anthracene chromophore as a core group and a phenyl carbazole chromophore as a side group, three new emitters of blue light, 2-DCPA, 3-DCPA and 4-DCPA, were synthesized. The three compounds differed with regard to the position of the carbazole linked to the core, with 2-DCPA and 4-DCPA using carbazole nodes and 3-DCPA using the lobe position. Density functional theory calculations were performed to determine which positions of the carbazole moiety had node characteristics and which had lobe characteristics. The PL<SUB>max</SUB> values of 2-DCPA, 3-DCPA and 4-DCPA in the film state were in the blue region, at 453, 457, and 452 nm, respectively. Of these materials, 3-DCPA, i.e., that with the linkage to the lobe position, showed the highest efficiency, with a value of 2.91 cd/A, and EQE, with a value of 2.65%. In a doped device using CBP as a host material and 3-DCPA as a dopant, the EL<SUB>max</SUB> emission was observed to be in the deep blue region, at 433 nm, and with a CIE value of (0.150, 0.068).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new blue emitter was synthesized by linking different positions of a carbazole to the anthracene. </LI> <LI> The PL<SUB>max</SUB> values of 2-DCPA, 3-DCPA and 4-DCPA in the film state were in the blue region, at 453, 457, and 452 nm. </LI> <LI> 3-DCPA achieved deep blue EL performance of CIE (x, y) value of (0.150, 0.068), 1.61 cd/A, and EQE of 2.74%. </LI> </UL> </P>
A direct assay of butyrylcholinesterase activity using a fluorescent substrate
Kang, Seungyoon,Lee, Suji,Yang, Woojin,Seo, Jiwon,Han, Min Su The Royal Society of Chemistry 2016 Organic & Biomolecular Chemistry Vol.14 No.37
<P>In this study, we report a direct fluorometric assay for butyrylcholinesterase (BChE) activity and screening of its inhibitor, using a fluorescent substrate. 2-(2-(5,6-Dimethoxy-1,3-dioxoisoindolin-2-yl) acetoxy)N, N, N-trimethylethan-1-ammonium iodide (1) was hydrolyzed by BChE, and its fluorescence was quenched by an intramolecular photoinduced electron transfer process. The resulting change in fluorescence provided a facile method for real-time BChE activity testing. Remarkably, 1 was selectively hydrolyzed by BChE, even in the presence of excess acetylcholinesterase, thereby facilitating the specific monitoring of BChE activity. This assay method is also useful for screening potential BChE inhibitors. Given its simplicity, selectivity, and higher assay speed, this method may be extended to high-throughput screening of BChE inhibitors and relevant drug discovery.</P>
Smallanthus sonchifolius leaf attenuates neuroinflammation
( Suji Baek ),( Nan Hee Choi ),( Kang-pa Lee ),( Hyunjhung Jhun ),( Jisu Kim ) 한국운동영양학회 2018 Physical Activity and Nutrition (Phys Act Nutr) Vol.22 No.2
[Purpose] Yacon, Smallanthus sonchifolius, has anti-hypertensive, anti-inflammatory, and anti-cancer potential. However, its neuroprotective and anti-neu-roinflammatory effects are unknown. Moreover, activation of microglia has been considered a mechanism in the development of Alzheimer’s disease. Therefore, the aim of this study was to determine the neuroprotective effects of an ethanolic yacon leaf extract (YLE) on lipopolysaccharide (LPS)-induced neuroinflammation in vitro and in vivo. [Methods] The viability of microglial BV2 cells was tested with 2,3-bis[2-methyloxy-4-nitro-5-sulfophenyl]- 2H-tetrazolim-5-carboxanilide. The production of nitric oxide (NO) was determined by the Griess reagent. mRNA expression and protein levels of inflammatory mediators were evaluated by the real-time polymerase chain reaction and immunohistochemistry, respectively. In addition, we performed histological analysis in mice treated with an intraperitoneal injection of LPS (250 μg/ kg). [Results] Our results showed that treatment with YLE significantly reduced NO production in LPS-stimulated BV2 cells. YLE also decreased mRNA levels of the inflammatory factors tumor necrosis factor alpha, inducible nitric oxide synthase, cyclooxygenase-2, and interleukin-1 beta. In vivo, YLE (40 mg/kg daily for seven days) significantly diminished LPS-induced tissue damage in the dentate gyrus and cornu amonis regions of the hippocampus by regulating the levels of inflammatory factors. [Conclusion] Our findings support the protective effects of YLE against the development of neurodegeneration.