Relevant Factors Affecting the Clinical implementation Competence of Dental Hygienists

Su jin Lee,Jong Hwa Yum,Hye Jin Kim 보안공학연구지원센터 2014 International Journal of Bio-Science and Bio-Techn Vol.6 No.3

Proper choice of oral hygiene devices for pantients

Yum Hyun-Ji Jung, Su-Jin Wang, Min-Suk Lee, Sook Shin, Seung-Chul Cho, Ja-won 대한임상예방치과학회 2006 International Journal of Clinical Preventive Denti Vol.2 No.1

Objectives: The authors have examined 284 Korean adults on the oral hygiene devices they used and their oral status. Methods: All adults volunteered to participate in this study. Of the total there were 115 patients who had their general oral status checked, 60 patients had bridge appliances, 61 patients had periodontal disease, and 48 patients had fixed orthodontic appliances. Correlation coefficients were calculated between the proper oral hygiene devices index which they used and such oral status as DMFT rate, s-PHP index, and CPI index on each individual. Results and Conclusion: The proper oral hygiene devices index with 10 points being a full score determined as 6.93/10.0 points in adults with their general oral status checked, 5.75/10.0 points in patients with bridge appliances, 3.42/10.0points in patients with periodontal disease and 5.80/10.0 points in patients with fixed orthodontic appliances, Oral health education was needed on the proper selection of oral hygiene devices for individuals, especially for patients with periodontal disease. Correlation coefficients were calculated as the higher index of proper oral hygiene devices, less in the s-PHP index in adults(r=-.245, p<.01.). The longer time in tooth brushing, a little bit higher PMA index(r=.188, p<.05), and the more loss of elasticity, a little bit less CPI index, (r=-.191, p<.05) in normal adults. The longer time in tooth brushing, the higher the score in s-PHP index (r=.260, p<.05) in patients with bridge appliances. Thus, frequent changing of oral hygiene devices index, the less the s-PHP index(r=-324, P<.05) in patients with periodontal disease.

Tuberostemonine에 의한 Staphylococcus aureus의 생물막 억제 효과

염수진(Su Jin Yum),김승민(Seung Min Kim),권준혁(Jun Hyeok Kwon),정희곤(Hee Gon Jeong) 한국식품과학회 2022 한국식품과학회지 Vol.54 No.2

본 연구는 S. aureus에 대한 tuberostemonine의 항균 및 항생물막 효과에 대하여 확인하였다. S. aureus에 대한 tuberostemonine의 생장 저해 효과가 없음을 확인하였으나, crystal violet 염색법과 CLSM 이미지 측정을 통해 tuberostemonine이 유의한 S. aureus 항생물막 효과 가지는 것을 알 수 있었다. S. aureus의 생물막 형성과 분해 관련 유전자인 icaA와 agrA의 발현은 tuberostemonine를 처리하였을 때 유의미하게 각각 감소 또는 증가하는 것으로 나타났다. 따라서 본 연구에서 생물막 형성 저해 및 분해 효과가 확인된 천연화합물인 tuberostemonine은 S. aureus의 내성 발생 위험이 적은 새로운 항생물막제제로서 사용가능 할 것으로 사료된다. Antibiotic resistance is a serious problem to food safety as well as human healthcare. To avoid this, there are several approaches for a new class of antibiotic agents that target only production of virulence factors such as biofilm without bacterial growth defect. The objective of this study was to investigate the antibiofilm activity of tuberostemonine in Staphylococcus aureus. Tuberostemonine significantly reduced the biofilm formation (26.07-47.02%) in the crystal violet assay whereas there were no effect on S. aureus growth. The dispersion in preformed biofilm was also observed by confocal laser scanning microscopy (CLSM). Quantification real-time PCR revealed that the icaA and agrA expression having an important role in biofilm production of S. aureus were strongly affected with tuberostemonine. These results suggest that tuberostemonine has potential for controlling biofilm formation and dispersion by effect on virulence regulation of S. aureus.

키토산 처리된 델라웨어 포도의 저장 중 품질 변화

염수진(Su Jin Yum),강지훈(Ji Hoon Kang),정승훈(Seung Hun Jung),송경빈(Kyung Bin Song) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.5

수확 후 델라웨어 포도의 미생물학적 안전성 확보와 품질 유지를 위해 키토산 처리 후 low density polyethylene film에 포장하여 4°C와 20°C에 각각 저장하면서 저장 기간에 따른 효모 및 곰팡이 수와 품질 변화를 측정하였다. 저장온도에 상관없이 키토산 처리 후 델라웨어 포도의 초기 효모 및 곰팡이 수는 1.88 log CFU/g의 감소를 나타냈으며, 저장 12일 후 4°C에 저장한 키토산 처리구는 1.35 log CFU/g으로 대조구와 비교하여 4.35 log CFU/g의 미생물 수 감소를 보여 20°C 저장보다 미생물 저감화 효과가 높게 유지되었다. 포장재 내 O₂ 농도는 저장 중 모든 처리구가 감소하는 추세를 보였고, CO₂ 농도는 모든 처리구에서 증가하는 경향을 나타냈으며 전반적으로 4°C 저장 시 적은 변화를 보였다. 그리고 키토산 처리구의 O₂ 및 CO₂ 농도가 모든 저장 온도에서 낮은 변화 경향을 나타냈다. 경도에 있어서는 모든 처리구가 감소하는 추세를 보였으나 4°C 저장이 더 낮게 감소하였으며, pH와 당도는 4°C 저장에 비해 20°C에서 높은 증가 추이를 보였다. 또한 키토산 처리는 대조구와 비교하여 저장 중 델라웨어 포도의 Hunter 색도 값에도 부정적인 영향을 미치지 않았다. 따라서 본 연구 결과 수확 후 델라웨어 포도에 키토산 처리 후 4°C에서의 저온 저장이 델라웨어 포도의 품질 변화를 최소화하면서 미생물학적 안전성을 확보할 수 있는 효과적인 품질관리 기술이라고 판단된다. To maintain quality of Delaware grapes during storage, grape samples were treated with 0.1% chitosan dissolved in 0.5% acetic acid, packaged with low density polyethylene film, and stored at 4 or 20°C for 12 days. Chitosan treatment reduced initial populations of yeast and molds in grapes by 1.86 log CFU/g compared to that of the control. During storage, oxygen contents in packages of samples decreased, whereas carbon dioxide contents increased. In addition, regardless of storage temperature, changes in oxygen and carbon dioxide concentrations of grapes treated with chitosan were lower than those of the control. Hardness of samples decreased, and Hunter L, a, and b values were not significantly different among treatments. Regarding pH and total soluble content, grapes stored at 4°C maintained pH and had greater total soluble content than those stored at 20°C. These results suggest that chitosan treatment and low temperature storage can be useful for maintaining microbiological safety and quality of Delaware grapes during storage.

Corosolic acid에 의한 Staphylococcus aureus의 생장 및 생물막 형성 저해

염수진(Su-Jin Yum),김승민(Seung Min Kim),유연철(Yeon-Cheol Yu),정희곤(Hee Gon Jeong) 한국식품과학회 2017 한국식품과학회지 Vol.49 No.2

본 연구에서는 지금까지 거의 보고된 바 없는 corosolic acid의 항균활성에 대해 대표적 식중독균 중 하나인 S. aureus를 대상으로 연구하였다. 대수기의 S. aureus에 corosolic acid를 처리하여 생장 저해 여부를 확인하였고, broth micro-dilution 방법과 agar disc diffusion 방법을 통해 corosolic acid의 S. aureus에 대한 항균 활성을 측정해본 결과, corosolic acid의 농도에 비례하여 S. aureus 의 생장이 저해되는 것으로 확인되었다. 또한 corosolic acid의 존재 조건에서 S. aureus의 바이오필름 형성능이 MIC 보다 높은 농도뿐 아니라 낮은 농도에서 역시 저해되는 것으로 관찰되었다. 따라서 천연물질인 corosolic acid는 S. aureus에 의한 식품 오염을 억제하고 식중독 예방 및 잠재적 치료제로서 개발 될 가능성이 있는 것으로 판단되며, 나아가 다른 종류의 식중독균들에 대한 적용 가능 연구가 필요할 것으로 사료된다. Staphylococcus aureus is a pathogenic bacterium that causes food poisoning, exhibits a strong capacity to form biofilm, and is highly resistant to antimicrobial agents. The purpose of this study was to investigate the antimicrobial characteristics of corosolic acid against S. aureus. S. aureus showed high susceptibility to corosolic acid in a concentration-dependent manner. The minimum inhibitory concentration and colony-forming ability determined by the broth microdilution method showed that corosolic acid had strong antimicrobial activity against the bacteria. The diameters of the inhibition zone and numbers of colony forming units at each concentration of corosolic acid were also measured. In addition, corosolic acid displayed potent biofilm inhibition activity against S. aureus at concentrations below its minimum inhibitory concentration. These results suggest that corosolic acid can be used to effectively prevent biofilm formation by S. aureus, thereby making S. aureus more susceptible to the action of antimicrobials.

차량 범퍼 형태가 차량 충돌 안전성에 미치는 영향

박수남(Su Nam Park),김재민(Jae Min Kim),김진겸(Jin Kyum Kim),김민수(Min Su Kim),전종윤(Jong Yum Jeon) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.4

결핵성 림프절염에 의한 담관 폐쇄 및 문맥압항진증 1 예

김진일,김영수,양진모,이정민,김선명,송동섭,박두호,박진노,장은덕,방춘상,권낙기,오귀염 대한소화기학회 1999 대한소화기학회지 Vol.33 No.3

Common causes of biliary tract obstruction are mostly choledocholithiasis and neoplastic diseases. Enlargement of adjacent lymph nodes due to malignant tumors or lymphoma can occasionally ob struct the biliary duct, but obstructive jaundice and portal hypertension produced by periportal tuber culous lymphadenitis are quite rare. Its diagnosis is difficult because symptoms and signs are non specific and clinical tests are not conclusive. Additionally, the lesion mimic a malignancy clinically and radiologically. However, it is important to differentiate it from malignancy. We describe a patien who presented with jaundice and portal hypertension caused by biliary obstruction due to tuberculous lymphadenitis involving distal portion of the common bile duct.

채식자와 비채식자에서 혈청 지질, 지단백 및 총 항산화능의 비교

김수길(Su Gil Kim),김현일(Hyun Il Kim),엄민섭(Min Sup Yum),조호(Ho Jo),오용열(Yong Yeol O),권한진(Han Jin Kwan),조욱현(Wook Hyun Cho),박정식(Jeong Sik Park) 대한내과학회 2000 대한내과학회지 Vol.58 No.2

N/A Background : Previous studies have demonstrated that modified or oxidized lipoproteins play a key role in the process of atherogenesis, particularly in hyperlipidemic individuals. Low density lipoprotein(LDL) is modified by oxygen free radical from damaged tissue or inflammatory cells. Further changes in the LDL molecule lead to an oxidized form (oxidized LDL), which is recognized by the macrophage scavenger receptor. Scavenger receptors on macrophages recognize and bind oxidized LDL. As uptake continues, the macrophages change to lipid-laden foam cells, the components of the fatty streak, which is the precursor atherosclerotic lesion. Antioxidants are known to prevent modification of LDL by free radicals and possibly also atheroma formation. This study was designed to compare the total antioxidant status and other lipid profiles in vegetarian and non-vegetarian groups in Korean adults to see the effect of diet modification on antioxidant status. Methods : 174 vegetarian and 150 non-vegetarian male adults were recruited for lipid test including total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, lipoprotein(a), and total antioxidant status during annual routine physical examination. Result : 1) Total antioxidant status was significantly high in vegetarian group(1.390±0.288 mmol/L) compared to non-vegetarian group(1.155±0.290 mmol/L)(p<0.001). 2) In non-vegetarian group, total antioxidant status was significantly low in smokers(1.041±0.288 mmol/L) compared to non-smokers(1.227±0.328 mmol/L)(p<0.001). 3) Correaltions between lipid profiles and total antioxidant status in vegetarian and combined groups were not significant. Conclusion : Total antioxidant status in vegetarian group was significantly higher compared to non-vegetarian group. Among non-vegetarian group, smoker group showed lower total antioxidant status compared to non-smoker group. And there was no significant correlations between lipid profiles and total antioxidant status.(Korean J Med 58:197-203, 2000)

Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates

Kim, Jin Yong,Yoon, Ji-Seon,Kang, Bo Mi,Yum, Hyein,Park, Hi-Jung,Cho, Doo-Wan,Yang, Young-Su,Han, Su-Cheol,Koh, Wooseok,Lee, Jae-Il,Jung, Kyeong Cheon,Kim, Kyu Han,Kwon, Ohsang Elsevier 2017 The Journal of investigative dermatology Vol.137 No.2

Risk Factors of Outcomes of COVID-19 Patients in Korea: Focus on Early Symptoms

Jang Su Yeon,Seon Jeong-Yeon,Eun Baik-Lin,Koh Seong-Beom,Yoo Jin-Hong,Lee Woo Yong,Yum Ho-Kee,Yoon Seok-Jun,오인환,Bae Sang-Cheol,Chang Sung-Goo 대한의학회 2021 Journal of Korean medical science Vol.36 No.18

Background: Coronavirus disease 2019 (COVID-19) has spread around the globe, and it is important to determine the risk factors of death in the general population. Our study aimed to determine the risk factors of death and severe illness requiring supplemental oxygen therapy based on the demographic and clinical characteristics of COVID-19 patients in Korea. Methods: In this study, we used data provided by the Korea Disease Control and Prevention Agency (KDCA) and analyzed a total of 5,068 patients with COVID-19, excluding 19 pregnant women and 544 individuals with missing data. We performed logistic regression analysis to determine the impact of early symptoms on survival and severe disease. Logistic regression models included sex, age, number of comorbidities, symptoms on admission, blood pressure, heart rate, and body temperature as explanatory variables, and death and oxygen therapy as outcome variables. Results: Logistic regression analyses revealed that the male sex, older age (≥ 60 years), higher number of comorbidities, presence of symptoms on admission, heart rate ≥ 120 bpm, and body temperature ≥ 37.5°C presented with higher risk of in-hospital death and oxygen therapy requirement. Conversely, rhinorrhea and headache were associated with a low risk of death and oxygen therapy requirement. The findings showed that cough, sputum, and fever were the most common symptoms on admission, while 25.3% of patients with COVID-19 were asymptomatic. Conclusion: COVID-19 patients with high-risk early symptoms on admission, such as dyspnea and altered mental status, and those without low-risk symptoms of rhinorrhea and headache should be included in priority treatment groups.