Clostridium difficile에 의한 설사의 예후인자

김준형,김희정,구남수,김영근,최준용,신소연,박윤선,김연아,김명수,정수진,최희경,송영구,이경원,김준명 대한감염학회 2007 감염과 화학요법 Vol.39 No.2

배경 : Clostridium difficile에 의한 설사(Clostridium difficile associated diarrhea; CDAD)는 임상 경과가 다양하다. 최근에 유럽과 북미에서 C. difficile 감염의 발생률이 증가하고 고전적 치료에 잘 반응하지 않으며 이환률이 증가하였고, 이러한 원인이 새로운 균주의 탄생에 기인한다고 보고되었다. CDAD의 예후에 영향을 미치는 세균성 요인과 숙주 요인을 확인하기 위해 본 연구를 진행하였다. 재료 및 방법 : 2002년 8월부터 2003년 12월까지 CDAD가 진단된 20세 이상인 환자들을 대상으로 후향적 Cohort 연구를 하였다. 세균성 요인을 확인하기 위해 cdt A, cdtB, tcd A, tcd A rep 그리고 tcd B 유전자(binary toxin)를 확인하였다. 설사가 치료 시작 후 11일 이상 지속되거나, 2달 이내에 재발하거나, 수술 혹은 다른 시술이 필요한 경우, 사망한 경우 예후가 좋지 않은 것으로 정의하였다. 결과 : 총 115예에서 toxin을 생성하는 C. difficile가 동정되었으며, Toxin A와 toxin B 모두 양성인 균이 91예, toxin B만 양성인 균이 24예였다. Toxin A 생성 여부가 예후에 영향을 미치지 않았지만, 제산제를 사용한 환자에서 그렇지 않은 환자에 비해 toxin B만 양성인 균이 많이 동정되었다(P<0.05). 예후가 좋지 않은 경우는 39예(33.9%)였고 76예(66.1%)에서 예후는 양호하였다. 단변량 분석에서 70세 이상의 고령, 남성, 증상 발현 후 사용한 항생제의 개수 사용, 증상 발현 후 carbapenem, aminoglycoside, glycopeptide 사용, 당뇨 및 뇌졸중 병력이 있는 경우, 그리고 높은 Charlson index가 불량한 예후 인자로 확인되었다. 그러나 독립적인 예후 인자를 조사했을 때에는70세 이상의 고령(odds ratio=3.378, P=0.009), 증상 발현후 carbapenem 사용(odds ratio 7.210, P<0.001)이 예후에 중요한 영향을 미치는 요소로 확인되었다. 결론 : 70세 이상의 고령과 증상 발현 후 carbapenem 사용이 CDAD 독립적인 불량한 예후인자이다. Background : Clostridium difficile associated diarrhea (CDAD) has a wide range of clinical manifestations. The prognostic factors of CDAD are not fully understood. Materialsand Methods : A retrospective cohort study of 115 patients with CDAD from Aug. 2002 to Dec. 2003 was conducted to evaluate prognostic factors of CDAD. Bacteriologic factors were determined by detecting the binary toxin gene, tcd A, tcd A rep and tcd B gene. Poor prognosis was defined as diarrhea more than 10 days even with classic treatment, recurrence, death, and moribund discharge. Results : Approximately 79% of isolated strains were toxin A+/B+ strains and 21% were toxin A-/B+ strains. There was no difference in prognosis between toxin A+ and toxin A- strains. 39 (33.9%) cases showed poor prognosis and 76 (66.1%) cases showed good prognosis. Univariate analyses revealed that the poor prognostic factors were old age over 70 years old, male, the number of antibiotics used after onset of symptom, the administration of carbapenems, aminoglycosides, glycopeptides after onset of symptom, history of DM and stroke, and high Charlson comorbidity index. Multiple logistic regression analysis identified old age over 70 years old (odds ratio=3.378, P=0.009) and the administration of carbapenems after onset of symptom (odds ratio 7.210, P<0.001) as the independent poor prognostic factors. Conclusion : Old age over 70 and the administration of carbapenems after onset of symptom were the poor prognostic factors for CDAD caused by none-binary toxin producing strains.

[P044] A case of pretibial thyroid dermopathy

( Jeong Won Jo ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Pretibial myxedema(PM) is a dermatological manifestation of Graves` disease, which commonly presents as diffuse, non-pitting edema of shins and less often as plaques, nodules, or elephantiasis lesions mimicking lymphedema. Most common site is pretibial area and localized thickening of the pretibial skin causes deposition of acid mucopolysaccharides. There are 7 cases of pretibial myxedema reported in domestic dermatology literature. The only four of cases occurred after treatment of hyperthyroidism like that our case. Herein, we report a case of pretibial myxedema with Grave`s disease and Grave`s ophthalmopathy. A 51-year-old male visited our department with multiple erythematous patches and nodules on Lt. pretibial area. He had been diagnosed with Grave`s disease 6 months ago and Grave`s ophthalmopathy 3 months ago. The incisional biopsy on Lt. pretibial area showed mucinosis in dermis with perivascular lymphocytic infiltration. The lesions improved after steroid intralesional injection. For persisted local lesions despite improvement of systemic symptoms, we propose that the steroid intralesional injection may be an alternative to treatment.

Notes : Transformation of Leuconostoc mesenteroides SY1, a Strain Isolated from Kimchi

( Seon Ju Jeong ),( Jae Yong Park ),( Jong Hwan Kim ),( Gyeong Min Kim ),( Ji Yeon Chun ),( Jong Hoon Lee ),( Dae Kyun Chung ),( Jeong Hwan Kim ) 한국미생물 · 생명공학회 2006 Journal of microbiology and biotechnology Vol.16 No.1

Colonization of Beauveria bassiana ERL836 on damaged logs of pine tree reduced emergences of Japanese pine sawyer beetles

Jeong Seon Yu,So Eun Park,Ye Ram Im,In Soo Jeon,Yu Lim Park,Yu Jin Jeong,Sue Yeon Lee,Woo Jin Kim,Se Jin Lee,Jae Su Kim 한국농약과학회 2021 한국농약과학회 학술발표대회 논문집 Vol.2021 No.5

P098 A clinical study on herpes zoster during the last 5-year-period (2011-2015)

( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Herpes zoster is a common dermatologic disease. But there has not been any report on the clinical characteristics of herpes zoster in the Province of Gyeongsangnam-do. Objectives: The purpose of this study was the elucidation of the clinical characteristics of herpes zoster in the Province of Gyeongsangnam-do. Methods: The study was conducted between 2011 and 2015 at our hospital outpatients. 901 patients with herpes zoster were evaluated in regard to age, sex, dermatomic distributions, associated diseases and complications. Results: Out of 901 cases, 396 were males and 505 were females. The maximum incidence was in the over 70 year-old group (26.4%). The most frequent involved dermatome was the trigeminal dermatome (28.7%). Associated diseases were observed in 679 patients (75.3%), which included hypertension (21.2%), malignancy (11.4%) and so on. Out of 901 patients, 443 (49.2%) developed complications. The most common complication was postherpetic neuralgia (27.1%). It is noteworthy that skin edema was accompanied from 43 patients (4.8%). Fourty patients showed edematous change on herpes zoster lesion. But other 3 patients showed facial edema in spite of involving herpes zoster in other area. Conclusion: Most of the results are similar to those previously reported, except for a higher incidence in trigeminal dermatome. The most interesting part of this study is herpes zoster can cause skin edema. We need to take further studies in future by others to explain causes in detail.

P191 The clinicopathologic study of multiple dermatofibroma

( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Dermatofibromas are common, benign, painless dermal nodules. Although cases of solitary dermatofibromas are common, multiple dermatofibromas are rare and there is no explainable theory in healthy people. Objectives: This study was conducted to obtain better understanding of the clinicopathologic features of multiple dermatofibroma. Methods: This is a retrospective study of multiple dermatofibroma pathologically diagnosed at our hospital over a 12-year period (2004~2015). Clinicopathologic features of 22 patients, 108 lesions were evaluated. The sex, age, number of lesions, site, symptoms and histopathological finding are included. Results: Of the 22 patients, sixteen (72.7%) were female and six (27.3%) were male. mean age was 39.1(±11.5) years old. The number of lesions ranged 2 to 20 and the mean was 4.9. The most common predilection sites were lower extremities (42.6%). All cases treated by excisional biopsy. According to the histopathological finding, the most common histological subtype was fibrocollagenous (66.7%). Most of the cases were extended dermis (62.5%) layer. Mitotic activity was not definite in majority of cases. The major infiltrated inflammatory cells were lymphocyte (75.2%). Conclusion: Multiple and solitary dermatofibroma have clinical and pathological consistency except for numbers of lesions.

[P336] Generalized cutaneous angiosarcoma associated with multiple myeloma

( Jeong Won Jo ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Cutaneous angiosarcoma is a rare, malignant, vascular neoplasm of the skin commonly diagnosed in the head and neck regions. It arises infrequently in the lower extremity. In most cases, the exact etiology of cutaneous angiosarcoma is unclear. Recently, gene amplifications, especially MYC gene, have been identified as a new etiopathogenesis of angiosarcoma. MYC amplification may induce aberrant angiogenic phenotypes allowing the onset of the malignancy. Meanwhile, in multiple myeloma, MYC is activated and contributes to the malignant phenotype. Therefore, there is a possibility that MYC gene might be the common cause of angiosarcoma and multiple myeloma. Herein, we present the rare case of cutaneous angiosarcoma on lower extremity accompanied by multiple myeloma. An 85-year-old woman visited our department with multiple brownish to black colored nodules with hyperkeratotic crust, which were 0.3 to 0.8 cm in diameter, on the both feet and toes. The excisional biopsy was performed and a diagnosis of cutaneous angiosarcoma was made. At the time of visit, anemia, azotemia, proteinuria and hematuria were found. Immunofixation electrophoresis and bone marrow were performed, so multiple myeloma was diagnosed. We suspected carefully that MYC gene might be the common cause of angiosarcoma and multiple myeloma.

A survey of knowledge and behavior regarding self examination of skin cancer

( Jeong Won Jo ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: The recognition of self examination of cancer has increased more than before. Although skin cancers are almost always curable when found and removed early, most patients are little known about general awareness of skin cancer. Objectives: In this study, we survey on satisfaction of clinic education to the 40 patients treated with skin cancer and affection to behavioral change. Methods: We reviewed a written questionnaire and patients’ self-examination records including patients’ age, method of self-examination, and skin check point. Results: The most patients replay (90%, 36/40) and want to know the warning signs of skin cancer and what to look for during the self-examination (88%, 32/36). The results show the most of patients want to help you make the next your dermatologist’s appointment (81%, 29/36). At time of check self-examination, the patients use the record paper prepared from our clinic (69.4%, 25/36). Conclusion: Although the patients treated with precancer and cancer area aware that the risk of skin cancer and they want to know about self-examination of skin cancer. Therefore, most popular skin cancer education and prevention program include self-skin examination is more required and dermatologist should play a major role in this action.

P064 The effect of excess caffeine exposure on human umbilical vein endothelial cells and head and neck squamous cell carcinoma

( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Caffeine intake and consumption of coffee were estimated from food frequency questionnaires results these are increasing. Caffeine may repair skin damage induced by excessive exposure to ultraviolet light. In previous report of the associations between coffee consumption and incidence of these skin cancers, the result that the consumption of neither caffeinated nor decaffeinated coffee was associated with basal cell carcinoma and squamous cell carcinoma (SCC). Objectives: In this study, our aim is to describe the mechanisms of the anti-angiogenic effect of caffeine in human umbilical vein endothelial cells (HUVECs) and head and neck squamous cell carcinoma (HNSCC). Methods: Matrigel assays were used to investigate the effect of caffeine on angiogenesis at cell migration and wound healing and proliferation assays using HUVECs and HNSCC. Results: Caffeine was found to inhibit blood vessel formation dose-dependently and to inhibit the proliferation of HUVECs time- and dose-dependently. The apoptosis examination was used by western blotting and immunofluorescence staining. Conclusion: Caffeine was found to inhibit blood vessel formation dose-dependently and to inhibit the proliferation of HUVECs on the same manners. There is no satisfactory enhancement and/or inhibition on proliferation of HNSCC.

Cloning of Fibrinolytic Enzyme Gene from Bacillus subtilis Isolated from Cheonggukjang and Its Expression in Protease-deficient Bacillus subtilis Strains

( Seon Ju Jeong ),( Gun Hee Kwon ),( Ji Yeon Chun ),( Jong Sang Kim ),( Cheon Seok Park ),( Dae Young Kwon ),( Jeong Hwan Kim ) 한국미생물생명공학회 2007 Journal of microbiology and biotechnology Vol.17 No.6