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Suppression of AIMP1 protects cognition in Alzheimer’s disease model mice 3xTg-AD
Jang, Sooah,Lee, Jung Ho,Sohn, Bo Kyung,Kim, Eosu,Park, Sang Gyu,Yoon, Kang Jun,Park, Minsun,Kim, Eun Woo,Jeong, Jihyeon,Lee, Jun-Young,Kim, Chul Hoon,Namkoong, Kee Wolters Kluwer Health | Lippincott Williams Wilkin 2017 NEUROREPORT - Vol.28 No.2
<P>Neuroinflammation has been raised as a candidate of unifying pathogenesis and a target of a disease-modifying strategy for Alzheimer's disease (AD). Aminoacyl-tRNA synthetase complex (ARS)-interacting multifunctional protein 1 (AIMP1) is a cytokine that is known to amplify the actions of tumor necrosis factor-a and to be involved in microglial activation and neuronal death. In this respect, AIMP1 could be a plausible target for the treatment of AD. Therefore, we aimed to examine whether anti-AIMP1 antibody could exert therapeutic effects against cognitive impairment using 3xTg-AD mice. Through the passive avoidance test, we found that an intraperitoneal injection of anti-AIMP1 antibody over 4 weeks was effective in protecting memory function in 3xTg-AD mice (16 weeks old). In addition, to address the translational implications of AIMP1, we measured blood AIMP1 levels in patients with AD (n=22), mild cognitive impairment (n=25), and normal cognition (n=23). Blood AIMP1 levels were associated negatively with global cognitive function and were significantly higher in individuals with a higher degree of medial temporal lobe atrophy, which is one of the representative clinical markers of AD. Our results suggested a possible association of AIMP1 with AD pathogenesis, as well as the potential of the anti-AIMP1 antibody as a novel therapeutic option for AD. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.</P>
Dahee Kim,Sooah Jeong,Chaewon Park,Huijeong Jeong,Beong Ou Lim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Artemisia capillaris Thunb. (ACT) is a plant of the sagebrush family and is known as a highly self-sustaining plant. It has been used as a medicine since a long time ago, and it is so effective that it is used as a treatment in many places. It helps skin elasticity, is effective in dieting, and helps to inflammation. ACT was extracted through hot water extraction method. ACT was fermented at 37°C for 24 hours using Lactococcus lactis, Streptococcus thermophilus and Lactobacillus delbrueckii. Then, the antioxidant activity was measured using the DPPH and ABTS assays. Samples of fermented ACT were treated in RAW 264.7 cells for 18 hours and then an experiment to measure cellular viability and NO production was conducted. Additionally, western blot and RT-PCR were performed to determine the expression level of anti-inflammatory-related proteins. As a result, it was verified that the fermented ACT has an antioxidant and anti- inflammatory effect. From the above results, we may suggest that fermented ACT has Antioxidant and anti-inflammatory properties. It can be used not only as a medicinal herb, but also as part of a functional food.
Effect of Fermented Lettuce Extract on Starch Retrogradation in Korean Rice Cake, Garaetteok
Eunjin Kim,Soon Yeon Jeong,Soon-Il Yun,Young-Soo Kim,Byeongjun Ji,Hyun Soo Chun,Sooah Kim 한국생물공학회 2021 KSBB Journal Vol.36 No.3
Starch retrogradation, i.e., reassociation or recrystallization of gelatinized starch, affects the flavor and texture of food. To prevent starch retrogradation, various methods such as replacement of chemically modified starch and use of hydrolytic and branching enzymes or additives have been studied. However, the relationship between fermented products and starch retrogradation has been not studied. Here, we investigated the effect of fermented lettuce extract on the retrogradation of Korean rice cake, garaetteok using Rapid Visco Analyzer (RVA), differential scanning calorimetry (DSC), texture analysis, and scanning electron microscopy (SEM). Fermented lettuce extract reduced peak viscosity, trough viscosity, breakdown, and setback of rice flour, as determined using the RVA. DSC revealed reduced onset temperature, peak temperature, and enthalpy change of cakes prepared from flour treated with fermented lettuce extract during storage compared with those of an untreated control. The change in the hardness of the treated rice cakes during storage, as determined via texture analysis, was smaller than that in the control. The surface of the fermented lettuce extract treated–rice cakes was found to be less cracked and porous than that of the control, as determined via SEM. Collectively, these findings showed that starch retrogradation during storage was retarded in fermented lettuce extract treated-rice cakes compared with untreated rice cakes. Therefore, these results suggested that fermented lettuce extract prevents starch retrogradation, improves food quality, and could be used as a food additive to retard starch retrogradation in the food industry.
Chaewon Park,Dahee Kim,Sooah Jeong,Beongou Lim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Sargassum fulvellum (SF) is a marine plant that grows in Southeast Asia and is known to have various physiologically active effects such as antioxidant, anti-inflammatory. Many natural product are reported to have increased antioxidant activity due to the fermentation of lactobacillus. Therefore, we investigated that the antioxidant activity of SF and two species of Lactobacillus fermentation extracts. Two species of Lactobacillus used for fermentation were Lactobacillus plantarum (SFP) and Lactobacillus casei (SFC), each was fermented for 24 hours and then extracted with 70% ethanol for 24 hours, 3 times. The extracts were used after filtration and concentration, and then freeze-dried. Antioxidant activity was evaluated through DPPH radical scavenging, ABTS radical scavenging, Total polyphenol and flavonoid contents, Reducing power, and DNA break repair experiments. As a result, All samples showed increased antioxidant activity in a concentration-dependent manner. From the above results, the fermented SF extract has improved antioxidant effects than SF. We suggest that the fermanted SF will become a strong natural antioxidant drug.
김정숙,김지영,김성희,김수아,우정주 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5
Lung cancer is increasing in incidence of cause of death in adult having malignant tumor. Therefore early detection of lung cancer is very important. Recently, screening chest CT scan has been used for early lung cancer detection. However, still simple chest radiograph is the most basic and important examination for detection of lung cancer. Sometimes lung cancer is overlapped with intrathoracic normal structure on chest radiograph, which makes it difficult in detection of the mass. Besides lung cancer was occured in the patient having pulmonary tuberculosis and cancer can be ignored. We have to be used to know atypical feature of lung cancer as well as well known findings on chest radiograph, and then try to decrease the chance of missing lung cancer.