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임소정(Sojeong Im),정경아(Jeong Kyong Ah),최병준(Byung Joon Choi),이인구(In Goo Lee),황경태(Kyung Tai Whang) 대한소아신경학회 2003 대한소아신경학회지 Vol.11 No.1
목적 : 경련성 질환 발작 후 조직 병리적 소견이 헤모시데린 침착을 주 소견으로 보여 주고 있을 뿐만 아니라, 지질 과산화가 비외상성 경련 질환에 영향을 미치면 철 함유 상태가 경련 역치에 영향을 주는 것이라 생각할 수 있겠다. 이 가설을 연구하기 위해서, 열성 질환(열성 경련 유무와 상관없이)으로 야기된 소아의 열성 경련 환아를 대상으로 철 함유 상태를 관찰하였다. 방법 : 열성 경련이 있는 만 6개월에서 만 5세 사이 환아 중 외래에서 철 지표를 확인 할 수 있던 환아 45명과 열성 경련이 없는 열성 질환 환아 50명을 대상으로 하였다. 입원을 요하거나 중추 신경계 감염, 중추 신경계 기형, 발달 지연, 국소적 혹은 전반적 신경계 결함이 있는 경우 또는 비열성 경련의 과거력이 있는 경우와 복합 열성 경련이나 간질 중첩증 등인 경우는 제외하였다. 결과 : 열성 경련 군과 열성 경련이 없는 대조군의 헤모글로빈은 11.99±0.96 gm/dL, 11.44±1.6 gm/dL이었다. 평균 적혈구 용적은 열성 경련 환아는 77.9±6.2 fL, 열성 경련이 없는 환아는 74.6±10.5 fL이었고, 평균 적혈구 혈색소량은 열성 경련 환아는 26.8±2.1 pg, 열성 경련이 없는 환아는 25.4±3.6 pg이었고, 혈소판은 열성 경련 환아는 348.6±141.4(X109/L), 열성 경련이 없는 환아는 382.3±107.3(X109/L)이었으며, 혈청 ferritin은 열성 경련 환아는 27.5±20.2 mg/L, 열성 경련이 없는 환아는 22.5±15.6 mg/L이었다. 가족 중 정신 지체력이 없는 경우를 살펴보면, 열성 경련 군과 대조군의 헤모글로빈은 12.2±0.9 gm/dL, 11.5±1.6 gm/dL이었다. 가족 중 열성 경련 과거력이 없는 경우를 살펴보면, 열성 경련 군과 대조군의 헤모글로빈은 12.0±1.0 gm/dL, 11.4±1.6 gm/dL이었다. 결론 : 본 연구에서 나타난 철 결핍과 열성 경련 감소와의 연관성은 철 유발성 지질 과산화가 열성 경련과 같은 비외상성 경련의 발생에 중요한 역할을 할 가능성이 많으며 이를 통해 철 결핍이 경련의 역치를 높일 수 있다는 연구 가설을 가능하게 한다. 따라서, 앞으로 이 가설을 증명하기 위해서는 열성 경련 빈도에 다른 항 산화제가 미치는 영향도 평가하여 고려하여야 할 것이다. Purpose : A part of seizure disorders, hemosiderin deposits are noted in epileptogenic lesions cytopathologically and iron status may affect the seizure threshold. To investigate this possibility, measures of iron sufficiency were evaluated. Methods : Children between 6 months and 5 years of age with febrile illness with (n=45) or without simple febrile seizures(n=50) were eligible for study. Children with the central nervous system(meningitis or encephalitis) infection, developmental delay, neurologic deficit, or past history of febrile seizures were excluded. Results : The hemoglobin level was 11.99±0.96 gm/dL in the febrile seizure and 11.44±1.6 gm/dL in the control group. The mean corpuscular volume was 77.9±6.2 fL in the febrile seizure group and 74.6±10.5 fL in the control group. The mean corpuscular hemoglobin was 26.8±2.1 pg in the febrile seizure group and 25.4±3.6 pg in the control group. The platelet count was 348.6±141.4(X109/L) in the febrile seizure group and 382.3±107.3(X109/L) in the control group. The ferritin was 27.5±20.2 mg/L in the febrile seizure group and 22.5±15.6 mg/L in the control group. Conclusion : A relationship between iron deficiency and a reduced risk of febrile seizures is consistent with the study hypothesis that iron deficiency may thereby raise the febrile seizure threshold. Therefore, the effects of antioxidants on the frequency of febrile seizures could be evaluated to test this hypothesis more directly. Studies using iron chelators would be necessary to delineate these possible effects.
Min-Koo Choi,Sojeong Jin,Ji-Hyeon Jeon,Woo Youl Kang,Sook Jin Seong,Young-Ran Yoon,Yong-Hae Han,Im-Sook Song 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2
Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides,including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginsengextract in human beings. Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to15 healthy Korean people. After single and repeated administration of red ginsengextract, blood samplecollection, measurement of blood pressure and body temperature, and routine laboratory test wereconducted over 48-h test periods. Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did notproduce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1,Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC)values after 15 days of repeated administration. Their AUC values after repeated administration of redginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, theplasma concentrations of Rd and compound K showed large interindividual variations but correlatedwell between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeatedadministration of red ginseng extract. Conclusion: A good correlation between the AUC values of Rd and compound K might be the resultof intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, ratherthan the intestinal permeability of these ginsenosides. A strategy to increase biotransformation orreduce metabolic intersubject variability may increase the plasma concentrations of Rd and compoundK.
Choi, Min-Koo,Jin, Sojeong,Jeon, Ji-Hyeon,Kang, Woo Youl,Seong, Sook Jin,Yoon, Young-Ran,Han, Yong-Hae,Song, Im-Sook The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2
Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings. Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods. Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract. Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K.
요양병원 호스피스·완화의료 서비스 현황 및 종사자들의 인식 조사
조현(Hyun Cho ),심은경(Eunkyung Sim),임희영(Heeyoung Im),이소정(Sojeong Lee),전효정(Hyojeong Jeon),허현점(Hyeonjeom Heo),오수미(Sumi Oh) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.3
본 연구는 B 광역시와 K시에 소재하는 요양병원 종사자들의 호스피스·완화의료 서비스에 대한 인식 및 활성화 방안의 조사에 목적이 있다. 13개 요양병원의 종사자들 183명 대상으로 조사를 실시하였다. 2016년 7월 1일부터 7월 30일까지 한 달 동안 연구자들이 기관을 방문하여 관련 자료를 직접 조사하였고 조사대상자들의 인식 및 활성화 방안은 설문조사를 실시하였다. 회수된 설문지는 SPSS 21.0을 활용하여 기초적인 자료를 분석하였다. 연구결과 조사기관 13개 중 호스피스·완화의료 교육은 9개 기관에서 실시하고 있었으며 한 해 1회 실시되고 있었다. 183명 대상으로 조사한바 호스피스·완화의료 교육 이수자는 저조하였으며(20.9%) 주로 병원프로그램의 한 유형으로 시행하였다고 응답하였다. 대부분의 종사자들은 호스피스·완화의료의 개념은 인지하고 있었고 좋은 프로그램이라 생각하며 시행되기를 바란다고(81.9%) 응답하였다. 그러나 호스피스·완화의료가 시행되지 못하는 이유는 ‘수행할 인력이 부족하다(50.8%)’, ‘호스피스 · 완화의료 프로그램을 잘 몰라서(25.4%)’ 등으로 나타났고 이에 개선방안 및 활성화로 ‘보험수가 도입(15.8%)’, ‘서비스 교육(15%)’ 그리고 ‘정부의 재정적 지원(14%)’의 순으로 나타났다. The purpose of this study is to investigate the study subjects’ awareness on hospice & palliative care service; and explore its activation methods of Long-term care hospitals located in the metropolitan cities B and K. The total of returned survey was answered from 183 employees on Long-term care hospitals which it was selected 13 institutions. One month to study during from July 1 to July 30, 2016 the researchers visited to investigate relevant data and surveyed to examine their awareness and activation methods. The returned survey questionnaires were processed with SPSS 21.0 for basic data analysis. The results of the 13 institutions under this research, 9 institutions provided hospice & palliative care education once a year. Most of the staff members were found to be aware of the idea of hospice & palliative care, think of it as a good program, and wish it to be implemented(81.9%). They answered that the reason of not implementing the hospice&palliative care was the ‘lack of personnel(50.8%)’, ‘lack of knowledge on hospice&palliative care program; and presented activation method was ’insurance fee introduction(15.8%)’ followed by ‘service education(15%)’ and ‘governmental financial support(14%)’.