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Shinji Tanaka,Nana Hayashi,Shiro Oka,Kazuaki Chayama 대한소화기내시경학회 2013 Clinical Endoscopy Vol.46 No.2
Among early colorectal carcinoma, endoscopic treatment is generally indicative for cases with intramucosal to submucosal (SM) super-ficial invasion, because cases with SM deep invasion should be treated surgically due to the risk of lymph node metastasis. It is impor-tant, therefore, to distinguish between superficial and deep SM invasion in early colorectal carcinoma prior to treatment. In this review we assessed the clinical usefulness and knack of pit pattern and narrow band imaging (NBI) diagnosis using magnifying observation. VN type pit pattern, type C3 in NBI Hiroshima classification and NBI type 3 in NBI international colorectal endoscopic (NICE) classification are useful predictors of SM deep invasion. In NBI magnifying observation evaluation of both the vascular pattern and surface pattern are important. We have to use pit pattern diagnosis and NBI magnifying diagnosis as the situation demands with the knowledge of both advantage and disadvantage in each diagnostic method.
Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy
( Ryohei Hayashi ),( Yoshitaka Ueno ),( Shinji Tanaka ),( Kana Onishi ),( Takeshi Takasago ),( Masaki Wakai ),( Toshikatsu Naito ),( Kensuke Sasaki ),( Shigehiro Doi ),( Takao Masaki ),( Kazuaki Chaya 대한장연구학회 2021 Intestinal Research Vol.19 No.4
Background/Aims: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract. Some patients with this condition have been reported to present with immunoglobulin A nephropathy (IgAN), a renal complication that can cause end-stage renal failure, but the frequency of this comorbidity has not been described. Thus, the aim of this study was to investigate the frequency of IgAN in patients with IBD. Methods: This study included 620 patients with IBD (338 with ulcer-ative colitis [UC] and 282 with Crohn’s disease [CD]) from the Hiroshima University Hospital outpatient department. IgAN cases were identified from medical interviews, blood examinations (serum immunoglobulin A), and urinalyses (occult blood, proteinuria). Definitive IgAN cases were diagnosed by renal biopsies, while those detected through the clinical course and test results, but not clinically recommended for renal biopsy, were defined as suspected IgAN. Results: We analyzed 427 cases meeting the inclusion criteria (220 with UC and 207 with CD). The incidence of IgAN across all patients with IBD was 3.0%. The frequency of IgAN was significantly higher in patients with CD (11/207, 5.3%) than in those with UC (2/220, 0.9%) (P< 0.01). Moreover, a significant correlation was found between CD patients with ileostomy or colostomy and a diagnosis of IgAN. Con-clusions: Patients with IBD present a high incidence of IgAN, especially those with CD who have undergone ileostomy or co-lostomy. (Intest Res 2021;19:430-437)
Katsuhiro Hayashi,Tetsutaro Yahata,Ryota Muramoto,Norio Yamamoto,Akihiko Takeuchi,Shinji Miwa,Takashi Higuchi,Kensaku Abe,Yuta Taniguchi,Hisaki Aiba,Yoshihiro Araki,Hiroyuki Tsuchiya 대한재활의학회 2018 Annals of Rehabilitation Medicine Vol.42 No.3
Objective To analyze patient characteristics of cancer rehabilitation and outcomes at our hospital.Methods This retrospective study analyzed 580 patients, who underwent cancer rehabilitation at our hospital and rehabilitation outcome after therapy were investigated. The relationship between the initial Barthel index and discharge outcomes was investigated, with a special focus on cancer patients with bone metastasis. The Barthel index and performance status (Eastern Cooperative Oncology Group) before and after rehabilitation were analyzed, and threshold value of home discharge was calculated from a receiver operating characteristic curve (ROC). General criteria for home discharge from our hospital included independence in performing basic activities of daily living such as bathing, feeding, and toileting or availability of home support from a family member/caregiver.Results The outcomes after rehabilitation among all the patients were as follows: discharge home 59%, death 13%, and others 27%. Statistical differences were observed between the initial and final values of the Barthel index in patients with bone metastasis, who could be discharged home (p=0.012). ROC analysis of the initial Barthel index for predicting home discharge revealed a threshold value of 60, sensitivity of 0.76, and specificity of 0.72.Conclusion The patients with bone metastasis had a lower rate of home discharge and a higher rate of mortality than all the study patients who underwent cancer rehabilitation at our hospital. It is proposed that at the time of initiation of rehabilitation for patients with bone metastasis, an initial Barthel index lower than 60 might predict a worse outcome than home discharge.
Ai Hasegawa,Asami Kurita,Shinji Hayashi,Takeshi Fukumoto,Hamako Sasamoto 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.2
The effects of sea salts, NaCl, KCl, MgCl2,MgSO4, and CaCl2, on the growth of protoplast cultures oftwo mangrove species, Sonneratia alba and Avicenniaalba, were investigated using 96-well culture plates. Plantsof these two species naturally grow at the seaward side of amangrove forest. Cotyledon protoplasts of S. alba showedhalophilic nature to NaCl, KCl, and MgCl2 at low concentrations(10–50 mM) when cultured in Murashige andSkoog’s (MS) medium containing 0.6 M mannitol. CaCl2at a concentration higher than 25 mM was inhibitory to cellgrowth. On the other hand, in protoplast culture of A. albasuspension cells, which were induced from cotyledontissues, in the modified amino acid (mAA) mediumcontaining 1.2 M sorbitol, tolerance to NaCl, MgCl2 andMgSO4 were observed at a wide range of concentrations upto 400 mM. CaCl2 was always inhibitory for cell divisionsin A. alba, but stimulatory for spherical enlargement ofcells. However, no difference in cell enlargement wasobserved among other salts. Similarity and difference inreactivity to salts between protoplasts and suspension cellsfrom our previous studies were discussed in relation to thesite of salt tolerance or halophilic adaptation within mangrovecells. For protoplast cultures, the site(s) for responseof S. alba and A. alba are located in the cytoplasm and/orthe cell membrane.
Hasegawa, Ai,Kurita, Asami,Hayashi, Shinji,Fukumoto, Takeshi,Sasamoto, Hamako 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.2
The effects of sea salts, NaCl, KCl, $MgCl_2$, $MgSO_4$, and $CaCl_2$, on the growth of protoplast cultures of two mangrove species, Sonneratia alba and Avicennia alba, were investigated using 96-well culture plates. Plants of these two species naturally grow at the seaward side of a mangrove forest. Cotyledon protoplasts of S. alba showed halophilic nature to NaCl, KCl, and $MgCl_2$ at low concentrations (10-50 mM) when cultured in Murashige and Skoog's (MS) medium containing 0.6 M mannitol. $CaCl_2$ at a concentration higher than 25 mM was inhibitory to cell growth. On the other hand, in protoplast culture of A. alba suspension cells, which were induced from cotyledon tissues, in the modified amino acid (mAA) medium containing 1.2 M sorbitol, tolerance to NaCl, $MgCl_2$ and $MgSO_4$ were observed at a wide range of concentrations up to 400 mM. $CaCl_2$ was always inhibitory for cell divisions in A. alba, but stimulatory for spherical enlargement of cells. However, no difference in cell enlargement was observed among other salts. Similarity and difference in reactivity to salts between protoplasts and suspension cells from our previous studies were discussed in relation to the site of salt tolerance or halophilic adaptation within mangrove cells. For protoplast cultures, the site(s) for response of S. alba and A. alba are located in the cytoplasm and/or the cell membrane.
Koinuma, Shoichi,Fujimoto, Yu,Hayashi, Yasuhiro,Shinji, Takao,Watanabe, Yosuke,Tadokoro, Masayuki The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.2
The installation of residential fuel cell systems (FCs) with photovoltaic generation systems (PVs) in residences has begun in Japan. Because of the reverse power flow from PVs, the line voltage may exceed the proper range during daytime operation. In addition, because residential PVs are connected to a single-phase distribution system, the voltage imbalance rate may increase. Here, we focus on an FC with a large available capacity during the daytime, so as to adjust the voltage by reactive power control with the available capacity of the FC. We propose a method of reactive power control that uses the available capacity of FCs to improve the voltage magnitude and voltage imbalance rate in a distribution network.