Non-Edible Plants as an Attractive Source of Compounds with Chemopreventive Potential

Seungwon Ji,Barbora Orlikova,Marc Diederich 대한암예방학회 2014 Journal of cancer prevention Vol.19 No.1

Cancer remains a lethal disease, and many scientists are currently trying to develop more effective therapies. Natural compounds are potential sources of anti-cancer therapies and are obtained from diverse sources including marine organisms, microorganisms and plants. In this paper, we evaluated natural compounds from non-edible plant sources, which is a neglected area of research despite the promising future of these compounds. In addition, we assessed the function and mechanism of action of these compounds in relation to cancer chemoprevention.

The dialkyl resorcinol stemphol disrupts calcium homeostasis to trigger programmed immunogenic necrosis in cancer

Ji, Seungwon,Lee, Jin-Young,Schrö,r, Jan,Mazumder, Aloran,Jang, Dong Man,Chateauvieux, Sé,bastien,Schnekenburger, Michael,Hong, Che Ry,Christov, Christo,Kang, Hyoung Jin,Lee, Youngjo,Han, By Elsevier 2018 Cancer letters Vol.416 No.-

<P><B>Abstract</B></P> <P>Stemphol (STP) is a novel druggable phytotoxin triggering mixed apoptotic and non-apoptotic necrotic-like cell death in human acute myeloid leukemia (AML). Use of several chemical inhibitors highlighted that STP-induced non-canonical programmed cell death was Ca<SUP>2+</SUP>-dependent but independent of caspases, poly (ADP-ribose) polymerase-1, cathepsin, or calpains. Similar to thapsigargin, STP led to increased cytosolic Ca<SUP>2+</SUP> levels and computational docking confirmed binding of STP within the thapsigargin binding pocket of the sarco/endoplasmic reticulum (ER) Ca<SUP>2+</SUP>-ATPase (SERCA). Moreover, the inositol 1,4,5-trisphosphate receptor is implicated in STP-modulated cytosolic Ca<SUP>2+</SUP> accumulation leading to ER stress and mitochondrial swelling associated with collapsed cristae as observed by electron microscopy. Confocal fluorescent microscopy allowed identifying mitochondrial Ca<SUP>2+</SUP> overload as initiator of STP-induced cell death insensitive to necrostatin-1 or cycloheximide. Finally, we observed that STP-induced necrosis is dependent of mitochondrial permeability transition pore (mPTP) opening. Importantly, the translational immunogenic potential of STP was validated by HMGB1 release of STP-treated AML patient cells. STP reduced colony and <I>in vivo</I> tumor forming potential and impaired the development of AML patient-derived xenografts in zebrafish.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Stemphol induces cell death by disrupting calcium homeostasis. </LI> <LI> Stemphol induces necrosis by mediating mPTP opening. </LI> <LI> Stemphol triggers immunogenic cell death markers ER stress and HMGB1 release. </LI> <LI> Stemphol impairs development of leukemia patient-derived zebrafish xenografts. </LI> </UL> </P>

In Vitro Inhibitory Activities of Essential Oils from Two Korean Thymus species against Antibiotic-Resistant Pathogens

Seungwon Shin,Ji Hyun Kim 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.8

The in vitro inhibitory activities of essential oils from Thymus magnus and T. quinquecostatus as well as their main constituents were evaluated against susceptible and resistant species of Streptococcus pneumoniae, Staphylococcus aureus, Salmonella enteritidis, and Salmonella typhimurium. Notably, the essential oil fraction of T. magnus and its main components displayed significant inhibitory action against both antibiotic-susceptible and resistant strains of S. pneumoniae, S. aureus, and S. typhimurium with minimum inhibitory concentrations (MICs) ranging from 0.125 to 8 mg/mL. The differential MIC values imply that the oil fraction and its main components exhibit distinct patterns of activity against the tested bacterial species. Moreover, the disk diffusion test revealed that the inhibitory activities of oil fraction and components were dosedependent. Data from the checkerboard titer test confirmed synergism between the antibiotic, norfloxacin, and T. magnus oil or thymol, particularly against the resistant strains of S. aureus.

Hydrogen production by steam reforming of ethanol over Ni/Al 2 O 3 -La 2 O 3 xerogel catalysts

Song, Ji Hwan,Yoo, Sangbeom,Yoo, Jaekyeong,Park, Seungwon,Gim, Min Yeong,Kim, Tae Hyeop,Song, In Kyu Elsevier 2017 Molecular catalysis Vol.434 No.-

<P>A series of nickel catalysts supported on binary Al2O3-La2O3 xerogel supports with different La/Al molar ratio were prepared via a sol-gel method and a subsequent wetness impregnation method for use in the ethanol steam reforming reaction. The effect of La/Al molar ratio on the characteristics and catalytic activities of Ni/Al2O3-La2O3 catalysts in the hydrogen production by steam reforming of ethanol was investigated. The prepared Ni/Al2O3-La2O3 catalysts were characterized by nitrogen adsorption desorption, ICP-AES (inductively coupled plasma atomic emission spectroscopy), XRD (X-ray diffraction), Al-27 MAS NMR (magic angle spinning nuclear magnetic resonance), TPR (temperature-programmed reduction), TPO (temperature-programmed oxidation), TEM (transmission electron microscopy), and TPD (temperature-programmed desorption) analyses. Physicochemical properties of the catalysts were suppressed with increasing La/Al molar ratio because of the formation of defective structure within the alumina lattice. Acidity of Ni/Al2O3-La2O3 'catalysts was weakened with increasing La/Al molar ratio, while basicity of the catalysts was strengthened. Nickel dispersion and nickel surface area increased with increasing La/Al molar ratio. On the contrary, ethanol adsorption capacity of the catalysts decreased with increasing La/Al molar ratio due to their unfavorable physicochemical properties. Hydrogen yield showed a volcano-shaped curve with respect to La/Al molar ratio, where an optimal amount of La content was required to achieve the most promising catalytic performance. The enhanced catalytic activity at an intermediate La/Al molar ratio is believed to be due to the offset of two opposite trends between nickel surface area and ethanol adsorption capacity of Ni/Al2O3-La2O3 catalysts. (C) 2017 Elsevier B.V. All rights reserved.</P>

Antifungal Activities of Essential Oils from Thymus quinquecostatus and T. magnus

Shin, Seungwon,Kim, Ji-Hyun 德成女子大學校 藥學硏究所 2004 藥學論文誌 Vol.15 No.1

The antifungal activities of essential oils from Thymus quinquecostatus and T. magnus, which are species native to Korea, were evaluated against seven common pathogenic fungi. Additionally, the effects of the oils together with ketoconazole were tested by the checkerboard titer test. Both of the two Thymus oils showed significant inhibition of the tested fungi, with minimal inhibitor concentrations (MICs) and minimal fungicidal concentrations (MFCs) in the range of 0.04-0.39 mg/mL and 0.19-0.78 mg/mL, respectively. The two Thymus oils, and thymol as well, exhibited synergism with ketoconazole against Trichophyton rubrum, which showed the highest susceptibility to these oils.

목표전개 기법을 적용한 차량개발 프로세스 및 환경개발

안지현(Ji Hyun An),유승원(Seungwon Yoo),박종찬(Jongchan Park) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.4

CNN을 활용한 골프 스윙 속도 분석 및 샤프트 추천 알고리즘 구상

김지환(Ji-hwan Kim),양승원(SeungWon Yang),이동준(DongJoon Lee),이종태(Jongtae Lee),김재현(Jae-Hyun Kim) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.11

Hydrogen production by steam reforming of ethanol over Ni–X/Al₂O₃–ZrO₂ (X=Mg, Ca, Sr, and Ba) xerogel catalysts: Effect of alkaline earth metal addition

Song, Ji Hwan,Han, Seung Ju,Yoo, Jaekyeong,Park, Seungwon,Kim, Do Heui,Song, In Kyu Elsevier 2016 Journal of molecular catalysis Chemical Vol.415 No.-

<P><B>Abstract</B></P> <P>A series of alkaline earth metal-promoted nickel catalysts supported on Al<SUB>2</SUB>O<SUB>3</SUB>–ZrO<SUB>2</SUB> (Ni–X/AZ, X=Mg, Ca, Sr, and Ba) were prepared by an epoxide-driven sol-gel method and a subsequent co-impregnation method. For comparison and reference, promoter-free Ni/Al<SUB>2</SUB>O<SUB>3</SUB>–ZrO<SUB>2</SUB> catalyst (Ni/AZ) was also prepared by an epoxide-driven sol-gel method and a subsequent impregnation method. The effect of alkaline earth metal addition on the physicochemical properties and catalytic activities of Ni–X/Al<SUB>2</SUB>O<SUB>3</SUB>–ZrO<SUB>2</SUB> catalysts in the steam reforming of ethanol was investigated. The catalysts were characterized by nitrogen adsorption-desorption, ICP-AES, XRD, TPR, TEM, H<SUB>2</SUB>-TPD, NH<SUB>3</SUB>-TPD, and EtOH-TPD analyses. It was revealed that addition of alkaline earth metal promoters reduced acidity of the catalysts and positively influenced catalytic activity in the steam reforming of ethanol. Hydrogen yield increased with the introduction of promoter, which was attributed to enhanced nickel dispersion. Nickel surface area and ethanol adsorption capacity of the catalysts were well correlated with hydrogen yield. Hydrogen yield increased with increasing nickel surface area and with increasing ethanol adsorption capacity of the catalysts. Among the catalysts tested, Ni–Sr/AZ catalyst showed the most promising result. It was concluded that addition of alkaline earth metal promoters increased nickel surface area by acting as a spacer, leading to higher ethanol adsorption capacity and hydrogen yield.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ni–X/Al<SUB>2</SUB>O<SUB>3</SUB>–ZrO<SUB>2</SUB> (AZ) (X=Mg, Ca, Sr, and Ba) catalysts were prepared. </LI> <LI> Hydrogen was produced by steam reforming of ethanol. </LI> <LI> Hydrogen yield increased with increasing ethanol adsorption capacity of the catalysts. </LI> <LI> Hydrogen yield increased with increasing nickel surface area of the catalysts. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Steam reforming of liquefied natural gas (LNG) for hydrogen production over nickel–boron–alumina xerogel catalyst

Park, Seungwon,Yoo, Jaekyeong,Han, Seung Ju,Song, Ji Hwan,Lee, Eo Jin,Song, In Kyu Pergamon Press 2017 International journal of hydrogen energy Vol.42 No.22

<P><B>Abstract</B></P> <P>A series of mesoporous nickel–boron–alumina xerogel (<I>x</I>-NBA) catalysts with different boron/nickel molar ratio (<I>x</I> = 0–1) were prepared by an epoxide-driven sol–gel method. The effect of boron/nickel molar ratio on the catalytic activities and physicochemical properties of nickel–boron–alumina xerogel catalysts was investigated in the steam reforming of liquefied natural gas (LNG). All the mesoporous <I>x</I>-NBA catalysts showed similar surface area. Introduction of boron increased interaction between nickel and support. In addition, introduction of boron into <I>x</I>-NBA catalysts reduced methane activation energy and increased nickel surface area. Promotion of boron had a positive effect on the catalytic activity due to the increase of adsorbed methane and nickel surface area. The amount of adsorbed methane and nickel surface area exhibited volcano-shaped trends with respect to boron/nickel molar ratio. LNG conversion and hydrogen yield increased with increasing the amount of adsorbed methane and with increasing nickel surface area. Among the catalysts, 0.3-NBA, which retained the largest amount of adsorbed methane and the highest nickel surface area, showed the best catalytic performance. It was also revealed that <I>x</I>-NBA catalysts showed strong coke resistance during the steam reforming reaction.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ni–B–Al<SUB>2</SUB>O<SUB>3</SUB> (<I>x</I>-NBA) catalysts with different B/Ni molar ratio (<I>x</I> = 0–1) were prepared. </LI> <LI> Hydrogen was produced by steam reforming of liquefied natural gas (LNG). </LI> <LI> Hydrogen yield increased with increasing the amount of adsorbed methane. </LI> <LI> Hydrogen yield increased with increasing nickel surface area. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Aromatic Hybrid Foldamer with a Hydrophilic Helical Cavity Capable of Encapsulating Glucose

Hwang, Ji Young,Jeon, Hae-Geun,Choi, Ye Rin,Kim, Junyoung,Kang, Philjae,Lee, Seungwon,Jeong, Kyu-Sung THE AMERICAN CHEMICAL SOCIETY 2017 ORGANIC LETTERS Vol.19 No.20

<P>An indolocarbazole–naphthyridine hybrid oligomer capable of adopting a stable helical conformation was prepared, and its folding properties were thoroughly studied in the solid state and in solution. As a result of folding, a hydrophilic cavity was generated inside the helix wherein monosaccharides were able to be encapsulated in the order of glucose (9.6 × 10<SUP>4</SUP> M<SUP>–1</SUP>) > galactose (1.0 × 10<SUP>4</SUP> M<SUP>–1</SUP>) ≫ mannose (∼0) in 10% (v/v) DMSO/CH<SUB>2</SUB>Cl<SUB>2</SUB>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2017/orlef7.2017.19.issue-20/acs.orglett.7b02768/production/images/medium/ol-2017-02768x_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol7b02768'>ACS Electronic Supporting Info</A></P>