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Myung-Sun Song(Myung-Sun Song),Young Ah Ku(Young Ah Ku),Seunghoon Kim(Seunghoon Kim),Myung Hee Chung(Myung Hee Chung),Yong Ho Kim(Yong Ho Kim),Dong Hyun Kim(Dong Hyun Kim) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.3
Purpose: To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model. Methods: In 40 male Sprague-Dawley rats, we induced alkali burn using filter paper soaked in 0.2N sodium hydroxide. The rats were then treated with topical 0.5% RCI001, 1.0% RCI001, Solcoseryl, or PDRN twice a day for 2 weeks. Corneal epithelial integrity and epithelial healing rate were measured at day 0, 3, 5, 7, 10, and 14. Histologic and immunohistochemistry findings were also assessed. Results: Both the 0.5% and 1.0% RCI001 groups showed significantly more epithelial healing compared to the control group at day 5, 7, 10, and 14 (each p < 0.05). No statistical difference was found between the 0.5% and 1.0% RCI001 groups. Neither the Solcoseryl nor the PDRN groups showed a significant difference from the control. RCI001 treatment resulted in significantly reduced stromal edema, and a trend towards less inflammatory cell infiltration. Conclusions: Topical application of RCI001 showed enhanced corneal epithelial wound healing in the murine corneal alkali burn model, presumably by suppressing inflammation. Meanwhile, Solcoseryl and PDRN did not show sufficient therapeutic effects compared to RCI001.
Kim, Tae-Hun,Kang, Jung Won,Kim, Kun Hyung,Lee, Min Hee,Kim, Jung Eun,Kim, Joo-Hee,Lee, Seunghoon,Shin, Mi-Suk,Jung, So-Young,Kim, Ae-Ran,Park, Hyo-Ju,Hong, Kwon Eui J. OCCUP. HEALTH 2012 JOURNAL OF OCCUPATIONAL HEALTH Vol.54 No.6
<P>This was a randomized controlled pilot trial to evaluate the effectiveness of cupping therapy for neck pain in video display terminal (VDT) workers.</P>
KIM, Mijung,KIM, Yongsun,LEE, Seunghoon,KUK, Minyoung,KIM, Ah Young,KIM, Wanhee,KWEON, Oh-Kyeong The Japanese Society of Veterinary Science 2016 The Journal of veterinary medical science Vol.78 No.4
<P>Allogenic adipose-derived mesenchymal stem cells (Ad-MSCs) are an alternative source for cytotherapy owing to their antioxidant and anti-inflammatory effects. Frozen-thawed allogenic Ad-MSCs can be used instantly for this purpose. However, the viability and function of frozen-thawed Ad-MSCs have not been clearly evaluated. The purpose of this study was to compare the viability and function of Ad-MSCs and heme oxygenase-1 (HO-1)-overexpressed Ad-MSCs <I>in vitro</I> after freeze-thawing. The viability, proliferation, antioxidant capacity and mRNA gene expression of growth factors were evaluated. Frozen-thawed cells showed significantly lower viability than fresh cells (77% for Ad-MSCs and 71% for HO-1 Ad-MSCs, <I>P</I><0.01). However, the proliferation rate of frozen-thawed Ad-MSCs increased and did not differ from that of fresh Ad-MSCs after 3 days of culture. In contrast, the proliferation rate of HO-1-overexpressed Ad-MSCs was lower than that of Ad-MSCs. The mRNA expression levels of <I>TGF-β</I>, <I>HGF</I> and <I>VEGF</I> did not differ between fresh and frozen-thawed Ad-MSCs, but <I>COX-2</I> and <I>IL-6</I> had significantly higher mRNA expression in frozen cells than fresh cells (<I>P</I><0.05). Fresh Ad-MSCs exhibited higher <I>HO-1</I> mRNA expression than frozen-thawed Ad-MSCs, and fresh HO-1-overexpressed Ad-MSCs exhibited higher than fresh Ad-MSCs (<I>P</I><0.05). However, there was no significant difference between fresh and frozen HO-1-overexpressed Ad-MSCs. The antioxidant capacity of HO-1-overexpressed Ad-MSCs was significantly higher than that of Ad-MSCs. Cryopreservation of Ad-MSCs negatively affects viability and antioxidant capacity, and HO-1-overexpressed Ad-MSCs might be useful to maximize the effect of Ad-MSCs for cytotherapy.</P>
Kim, Jaewon,Lee, Kyung Eun,Kim, Kyung Hwan,Wi, Sungun,Lee, Sangheon,Nam, Seunghoon,Kim, Chunjoong,Kim, Sang Ouk,Park, Byungwoo Elsevier 2017 Carbon Vol.114 No.-
<P>Graphene has been intensively adopted into boosting the electrochemical performances of battery electrode materials due to its superior nature. In the case of Li4Ti5O12 (LTO), the application of graphene has been specifically focused on ameliorating the low electronic conductivity of LTO. So far, these attempts aiming to increase the composite's electronic conductivity involved thick graphene layers, which inevitably hindered Li-ion diffusion and eventually harmed the electrochemical kinetics in LTO's surface. In this work, high quality minimum-impurity graphene oxide was prepared by means of thorough cleaning and dialysis, which enabled each single-layered graphene to successfully wrap individual LTO particles. The resulting single-layer graphene-wrapped LTO exhibits an excellent specific capacity of 130 mAh g(-1) even at a lithiation/delithiation of 30 degrees C. Such a high rate capability is one of the highest values among the reported LTO with comparable sizes (similar to 200 nm). To uncover the reasons for such high performance, electrochemical properties from varied graphene contents were juxtaposed for comparison, and as a result, number of graphene layers and the corresponding kinetic parameters were found correlated. With adequate validity, single graphene layer was revealed to be the uttermost optimum for both Li+ diffusion and electronic conduction. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Saturated Power Amplifier Optimized for Efficiency Using Self-Generated Harmonic Current and Voltage
Jungjoon Kim,Jangheon Kim,Junghwan Moon,Jungwhan Son,Ildu Kim,Seunghoon Jee,Bumman Kim IEEE 2011 IEEE transactions on microwave theory and techniqu Vol.59 No.8
<P>A saturated power amplifier (PA) optimized for efficiency is described. As a PA is driven into saturated operation, the current source of the device generates a large third harmonic current, which creates a quasi-rectangular current waveform. The large nonlinear output capacitor of the transistor generates a second harmonic voltage with a very small third harmonic component. The second harmonic voltage is in-phase with the fundamental voltage, making a half-sine wave voltage waveform with voltage peaking. These waveforms are similar to those of a class F<SUP>-1</SUP> . The fundamental load at the intrinsic device is resistive with the output capacitance tuned out, which is identical to the class F<SUP>-1</SUP> case. However, the required harmonic impedances are just larger than the impedance levels of the output capacitance for both the second and third harmonics. Therefore, the circuit topology is similar to that of a class E amplifier, which is very simple. The PA implemented using a GaN HEMT delivers the expected good performance using the simple circuit topology.</P>
Lee, Changho,Kim, Kyungun,Han, Seunghoon,Kim, Sehui,Lee, Jun Hoon,Kim, Hong Kyun,Kim, Chulhong,Jung, Woonggyu,Kim, Jeehyun SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS 2014 JOURNAL OF BIOMEDICAL OPTICS Vol.19 No.3
<P>An intraoperative surgical microscope is an essential tool in a neuro- or ophthalmological surgical environment. Yet, it has an inherent limitation to classify subsurface information because it only provides the surface images. To compensate for and assist in this problem, combining the surgical microscope with optical coherence tomography (OCT) has been adapted. We developed a real-time virtual intraoperative surgical OCT (VISOCT) system by adapting a spectral-domain OCT scanner with a commercial surgical microscope. Thanks to our custom-made beam splitting and image display subsystems, the OCT images and microscopic images are simultaneously visualized through an ocular lens or the eyepiece of the microscope. This improvement helps surgeons to focus on the operation without distraction to view OCT images on another separate display. Moreover, displaying the OCT live images on the eyepiece helps surgeon's depth perception during the surgeries. Finally, we successfully processed stimulated penetrating keratoplasty in live rabbits. We believe that these technical achievements are crucial to enhance the usability of the VISOCT system in a real surgical operating condition.</P>
Proteogenomic Characterization of Human Early-Onset Gastric Cancer
Mun, Dong-Gi,Bhin, Jinhyuk,Kim, Sangok,Kim, Hyunwoo,Jung, Jae Hun,Jung, Yeonjoo,Jang, Ye Eun,Park, Jong Moon,Kim, Hokeun,Jung, Yeonhwa,Lee, Hangyeore,Bae, Jingi,Back, Seunghoon,Kim, Su-Jin,Kim, Jieun Cell Press 2019 Cancer Cell Vol. No.
<P><B>Summary</B></P> <P>We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and <I>N</I>-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mutation-phosphorylation correlation suggests possible signaling interplays in EOGCs </LI> <LI> mRNA-protein correlation suggests genes with high association with patient survival </LI> <LI> Integrated analysis of mRNA and protein data identified four subtypes </LI> <LI> Phosphorylation data provide cellular signaling pathways underlying the subtypes </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Sung-Sik Kang,Sang-Rae Cho,Ui-Hyung Kim,Yonghwan Kim,Seok-Dong Lee,Myung-Suk Lee,Eunju Kim,Jeong-Il Won,Shil Jin,Hyoun-Ju Kim,Sungwoo Kim,Sun-Sik Jang,Seunghoon Lee The Korean Society of Animal Reproduction and Biot 2024 한국동물생명공학회지 Vol.39 No.1
Background: Sperm quality and the number of sperm introduced into the uterus during artificial insemination (AI) are pivotal factors influencing pregnancy outcomes. However, there have been no reports on the relationship between sperm concentration at AI and sperm quality in Hanwoo cattle. In this study, we examined sperm quality and pregnancy rates after AI using sperm inseminated at different concentrations. Methods: We evaluated the motility, viability, and acrosomal membrane integrity of sperm at different concentrations (10, 15, 18, and 20 million sperm/straw) in 0.5-mL straws. Subsequently, we compared the pregnancy rates after AI with different sperm concentrations. Results: After freeze-thawing, sperm at the assessed concentrations showed similar viability and acrosomal membrane integrity. After AI, cattle in the 10 million group had significantly lower pregnancy rates compared to those in the 18 and 20 million groups. Conversely, there were no statistically significant variances observed between cattle in the 10 and 15 million groups. Conclusions: Sperm at concentrations of 10, 15, 18 and 20 million per straw exhibited comparable motility, viability, and acrosomal membrane integrity. However, a concentration of at least 18 million sperm per straw is required to achieve a consistent rate of pregnancy rate in Hanwoo cattle after AI.