데페록사민 전처치가 토끼 심근경색 크기의 감소에 미치는 효과

양관모,오동렬,박승현,박규남,이원재,김형국,황두영,최승필,채장성 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4

Background: Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical mediated tissue injury. Iron may liberate during ischemia and we hypothesized that administration of the iron chelator, deferoxamine during ischemia would result in improved recovery after postischemic reperfusion. Purpose: To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, deferoxamine was administered to block iron catalyzed hydroxyl radical formation in rabbits. Methods: Eleven rabbits were divided into two groups : control group (n=5) and deferoxamine pretreatment group (n=6). The left circumflex coronay artery was ligated for 30 minutes and reperfused for 180 minutes. Area at risk (AR) was measured by non-stained area with methylene blue injection into left atrium after left circumflex coronary artery ligation. Infarct size was measured by weighing after triphenyltetrazolium chloride staining. Heart rate was measured using electrocardiographic recording and systemic blood pressure was monitored by pressure transducer connected to the catheter in the left ventricle. Results: 1. There was no significant difference of heart rate and blood pressure in deferoxamine pretreatment group compared with control group. 2. There was significant decrease of serum iron concentration after continuous infusion of deferoxamine compared with serum iron concentration before ligation of coronary artery(P<0.05). 3. There was no significant difference of area at risk between control and deferoxamine pretreatment group. 4. Area at necrosis to area at risk was significantly reduced in deferoxamine pretreatment group compared with control group(P<0.05). The results suggest that deferoxamine infusion prior to coronary artery occlusion has a significant benefit in reducing infarct size in this model.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

하악골 후방이동시 중안면부 연조직의 변화양상에 대한 임상통계학적 연구

한대희,김수남,민승기,김태성,성헌모 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Prediction of the soft tissue changes following hard tissue movement is very important from the esthetic view point for patients who have orthognathic surgery. There are many cephalometric analysis of facial bone and soft tissue on the lower lip and chin region but few soft tissue analysis on the midface after mandibular setback surgery. This study was performed to obtain whether the mandibular posterior movement has influence on the midface and the predictable ratio of post-operative measurement values of the soft tissue changes following mandibular setback surgery. Fifteen patients (8 males and 7 females) who had undergone mandibular setback surgery were selected and analyzed the soft tissue movement on the upper lip and the cheek region. Post-operative changes of the soft tissue measurements after mandibular surgery were examined on pre- and post-operative cephalo-metrics and the ratio of changes were analyzed after drawing the reference line on the face with the barium sulfate solution. The reference lines were perpendicular to the intercanthal line from infraorbital foramen and lateral canthus. The results obtained were as follows : 1.There were tendancy of anterior movement of soft tissue adjacent the nose after mandibular surgery 2.There were incerased tendancy of the amount of anterior movement from the nasal crease to the cheek region. 3.The amount of anterior movement of the soft tissue was larger below the palatal plane compared with above the palatal plane in the cheek region. 4.The upper lip length was increased and moved posterior direction after mandibular setback surgery 5.The lower lip was moved posterior direction by posterior movement of the mandibular structure 6.Soft tissue of the midface around the nose moved anterior direction after mandibular setback surgery but there was no correlation between the amount of mandibular setback and the amount of the soft tissue changes

Quantifying Uncertainty in the Measurement of Heavy Metals in the Soil

Seung Mo Nam,Jeongsik Park,Jong Kook Kwon,Hongseok Kim 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Characteristics and Treatment Outcome of Intracranial Aneurysms in Children and Adolescents

Nam, Sun Mo,Jang, Donghwan,Wang, Kyu-Chang,Kim, Seung-Ki,Phi, Ji Hoon,Lee, Ji Yeoun,Cho, Won-Sang,Kim, Jeong Eun,Kang, Hyun-Seung The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.5

Objective : Intracranial aneurysms are not common in young age patients. We sought to find the characteristics of the intracranial aneurysms in patients under 20 years of age. Methods : We reviewed 23 consecutive patients ${\leq}20$ years of age treated for their intracranial aneurysms during the period from 1995 to 2017. From medical records and imaging studies, we gathered data on age, sex, presentation, associated medical condition, location and characteristics of aneurysms, treatment and clinical outcomes. Results : The patients' ages ranged from 13 months to 20 years (median, 14 years). There were 16 males and seven females (male to female ratio, 2.3 : 1) with 31 aneurysms. Clinical presentations included sudden severe headache in 61%, followed by altered mentality in 17% and seizure in 17%. More than one-fourth patients had specific medical conditions related to the development of the cerebral aneurysms. The majority of aneurysms occurred in the anterior circulation (71%), and were saccular (71%). There were each three patients with false aneurysms (13%) and giant aneurysms (13%), and only one patient with multiple aneurysms (4%). We treated 22 patients : 21 aneurysms with the endovascular methods, three with open surgery, and one with combined treatment. Good functional outcome could be achieved in 86% during the follow-up period. Conclusion : In this series, the young-age patients with intracranial aneurysms were characterized by male predominance, related specific medical conditions, low incidence of multiple aneurysms, high incidence of giant aneurysms and good functional outcome after treatment.

제3차 대한간학회 춘계학술대회 초록집 : 포스터연제 토의 ; 간경변증 및 식도정맥류 출혈이 합병된 Wilson병에서 간의 조직 괴사로 인해 다수의 공간점유병변을 보였던 증례 보고

남승모 ( Nam Seung Mo ),김성배 ( Kim Seong Bae ),이상원 ( Lee Sang Won ),곽진영 ( Gwag Jin Yeong ),최병국 ( Choe Byeong Gug ),김성환 ( Kim Seong Hwan ),정숙향 ( Jeong Sug Hyang ),김유철 ( Kim Yu Cheol ),김창민 ( Kim Chang Min ) 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.2(S)

전자금융거래의 안전성 강화를 위한 종단간 암호화

성재모(Seung, Jae-Mo),이수미(Lee, Su-Mi),안승호(Ahn, Seung-Ho),노봉남(Noh, Bong-Nam) 한국산학기술학회 2009 한국산학기술학회논문지 Vol.10 No.8

‘05. 6월 인터넷 뱅킹으로 인한 최초 사고는 전자금융거래 보호를 위한 보안프로그램 기능을 중지하고, 이용 자가 입력한 주요 금융거래정보 즉 공인인증서 비밀번호, 계좌비밀번호, 보안카드 비밀번호 등을 수집하여 이를 전자 금융거래에 사용하였다. 이처럼 백신 프로그램이나 개인 방화벽과 같은 보안프로그램의 기능을 우회하는 해킹 툴에 의해 금융정보를 갈취하는 행위는 계속해서 시도되고 있다. 따라서 전자금융거래에 있어 이용자 단말기에서부터 금융 기관의 금융거래서버까지 이용자가 입력한 금융거래정보를 안전하게 보호하는 것을 목적으로 전자금융시스템을 구성 해야 한다. 본 논문에서는 전자금융거래에서 발생된 위협에 대해 원인을 분석하고, 이를 기반으로 현 전자금융거래인 인터넷뱅킹, 금융자동화기기, 모바일뱅킹에서 보안성 향상을 위해 고려해야 할 보안사항에 대해 기술한다. `05. June, the first Internet banking accident occurred by the malignant cord. It discontinued security programs for protecting important financial informations. A computer hacker had made a collation of password, OTP(One Time Password) values etc and illegally withdraw one´s savings from the bank using the financial information. The attackers are continuously attempted with the hacking tool under bypass security programs as the vaccine program or the personal fire-wall. Therefore, an electronic financial system should be composed with the goal which is to protect financial informations from user's terminal to a banking server. In this paper, we make an analysis of menaces in electronic financial transactions and explain considerable security issues to enhance safety in Internet banking, CD/ATM and mobile banking.

RUG-Ⅲ를 이용한 노인환자군분류의 타당성검증

이지전 ( Jee Jeon Yi ),유승흠 ( Seung Hum Yu ),오희철 ( Hee Chul Ohrr ),남정모 ( Chung Mo Nam ),박은철 ( Eun Chul Park ),이윤환 ( Yoon Whan Lee ) 한국병원경영학회 2001 병원경영학회지 Vol.6 No.3

The purpose of this study is to classify elderly patient in long-term care facilities using RUG(Resource Utilization Group)-Ⅲ. It is designed by measuring patient medical characteristics and medical staff time. Elderly patients are classified into 7 categories by clinical(medical and behavioral) hierarchical typology of patients. Through the tertiary split, all 44 groups are formulated. This classification is explained by each patient resource(staff time) utilization level which is called CMI(Case-Mix Index). Major findings are as follows ; 1. The objects in this study were classified into 35 groups out of 44 groups. The most frequent category is clinical complex category(CCC; 38.9%). And extensive service category(ESC; 18.8%), reduced physical function category(RPC; 13.1%), special rehabilitation category(SRC; 12.8%), and impaired cognitive category(ICC; 0.96%) are followed. 2. The mean of total CMI was 1.02±0.36, ranging from 0.68 to 1.44(1 vs 2.12). The mean of CMI of SRC is only 1.17 which should be the highest. The means of ESC and SCC are equally 1.20. The means of CMI of CCI, ICC, BPC, and RPC were 0.90, 0.75, 0.83 and 0.96, respectively. 3. The validity of this classification was tested. Trend-test using Regression Analysis was done in the secondary split level. SCC, CCC, ICC, and RPC which covered 68.4% of this research objects showed linear trend of CMI in interim classification. This results were statistically significant. 4. In clinical hierarchy, the trend were showed linearity. But the multiple comparison of categories using Scheffe-test showed that SRC, ESC and SCC had same level of CMI means and CCC and ICC, too. This results were statistically significant. Classifying elderly patients with RUG-Ⅲ, the results showed partly linear trend in clinical hierarchy and in interim classification in conclusion. But, in clinical hierarchy, it was failed to show the consistent order of CMI. It can be explained by two reasons. One is that this research subjects were overlapped in each clinical hierarchy group. And the other is that the some of the characteristics for clinical hierarchy is not appropriate for them. For the further study, it needs to have proper sample size and to modify RUG-Ⅲ to K-RUG to consider our medical environment.

PCNA Expression and Electron Microscopic Study of Acinus - Forming Hepatocytes in Chronic Hepatitis B

(Nam Ik Han),(Young Sok Lee),(Hwang Choi),(Jong Young Choi),(Seung Kyu Yun),(Se Hyun Cho),(Jun Youl Han),(Jin Mo Yang),(Byung Min Ahn),(Sang Wook Choi),(Chang Don Lee),(Sang Bok Cha),(Hee Sik Sun),(Do 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.2

N/A Background: One of the major morphologic characteristics of hepatitis B is a hepatocellular regeneration which is induced by massive hepatocyte necrosis and associated with proliferative activity of hepatocytes. The purpose of this study is to document the proliferative activity of hepatocytes in various types of hepatitis B by immunohistochemical staining for proliferative cell nuclear antigen-labelling index (PCNA-LI) and electron microscopy. Methods: We studied 83 patients with hepatitis B; 11 cases of acute viral hepatitis, 24 cases of mild chronic hepatitis, 34 cases of severe chronic hepatitis with early cirrhosis and 14 cases of severe chronic hepatitis. The PCNA was tested by immunohistochemical staining using anti-PCNA antibody. Furthermore we evaluated the ultrastructure of acinus-forming hepatocytes (AFH) by electron microscopy. Results : The expression rate and labelling index of PCNA were 27.3% and 5.3±0.9% in acute viral hepatitis, 62.5% and 22.9 ±31.7% in mild chronic hepatits, and then 47.1% and 14.1± 24.2% in severe chronic hepatitis with early cirrhosis, respectively (Figure 1). By contrast, no detectable PCNA expression was noted in AFH. Electron microscopic findings showed that hepatocytes forming a rosette underwent marked degenerative changes with sinusoidal capillarization and increased fine strands of collagen fiber in portal area. Conclusion: The proliferative acitivity of hepatitis B was significantly decreased in severe chronic hepatitis containing AFH. This result suggested that differences in proliferative activity was associated with hepatic cell necrosis and AFH.

Fertilizer N uptake of paddy rice in two soils with different fertility under experimental warming with elevated CO2

Nam, Hong-Shik,Kwak, Jin-Hyeob,Lim, Sang-Sun,Choi, Woo-Jung,Lee, Sun-Il,Lee, Dong-Suk,Lee, Kwang-Seung,Kim, Han-Yong,Lee, Sang-Mo,Matsushima, Miwa Springer-Verlag 2013 Plant and soil Vol.369 No.1