Identification of Soluble Epoxide Hydrolase Inhibitors from the Seeds of Passiflora edulis Cultivated in Vietnam

To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4

Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.

The Relationship Between Business Resources, Outside Cooperation, Dynamic Capability, and Performance of Startup Enterprises

Dong Van VU1,Tai Van PHAM2,Ghi Nha TRAN3,Anh Phuong Thi NGUYEN4,Cong Van NGUYEN5 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.6

This study seeks to examine the relationship between business resources (through VRIN: Valuable - valuable, Rare - scarce; Inimitable - difficult to adapt, Irreplaceable - hard to replace), dynamic capability, external cooperation, and efficiency of startups operating in the seafood export sector. Research data was collected randomly and conveniently from 250 enterprises in Ba Ria-Vung Tau province, Vietnam, from October 2020 to December 2020. After excluding those ineligible, the remaining 204 enterprises meet the research conditions. With the support of SPSS-AMOS 22 dedicated software, using the 5-step Likert scale and Structural Equation Modeling (SEM), the study conducted analysis steps such as verifying convergence, discriminant value, unidirectional and scale reliability when giving the components correlated freely in the critical model by Confirmatory Factor Analysis (CFA) analysis. Results of the study have shown that the enterprise resource factor - VRIN has a positive impact on dynamic capability, and outside cooperation. However, in contrast to previous studies, we found that the relationship between enterprise resources - VRIN and performance as well as the relationship between dynamics capacity and performance is not clear. This shows that seafood exporters need to promote, exploit and effectively use this precious resource to improve business efficiency.

Predicting Financial Distress Distribution of Companies

Giang Huong VU(Giang Huong VU ),Chi Thi Kim NGUYEN(Chi Thi Kim NGUYEN ),Dang Van PHAM(Dang Van PHAM ),Diu Thi Phuong TRAN(Diu Thi Phuong TRAN ),Toan Duc VU(Toan Duc VU ) 한국유통과학회 2022 유통과학연구 Vol.20 No.10

Purpose: Predicting the financial distress distribution of an enterprise is important to warn enterprises about their future. Predicting the possibility of financial distress helps companies have action plans to avoid the possibility of bankruptcy. In this study, the author conducted a forecast of the financial distress distribution of enterprises. Research design, data and methodology: The forecasting method is based on Logit and Discriminant analysis models. The data was collected from companies listed on Vietnam Stock Exchange from 2012 to 2020. In which there are both companies suffer from financial distress and non-financial distress. Results: The forecast analysis results show that the Logistic model has better predictability than the Discriminant analysis model. At the same time, the results also indicate three main factors affecting the financial distress of enterprises at all three research stages: (1) Liquidity, (2) Interest payment, and (3) firm size. In addition, at each stage, the impact of factors on financial distress differs. Conclusions: From the results of this study, the author also made several recommendations to help companies better control company operations to avoid falling into financial distress. Adjustments to current assets, debt, and company expansion considerations are the most important factors for companies.

Blood Eosinophil Level in Asthma, COPD and Asthma - COPD Overlap Patients in University Medical Center

( Tran Thien Quan Vu ),( Diem Thu Pham ),( Quynh Mai Pham ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Purpose This study aimed to describe the blood EOS levels in patients with these diseases and state of ICS prescription in groups of COPD patients according to the blood EOS cut - offs 100 and 300 cells/μL. Materials and Method This study was a retrospective descriptive cross - sectional study and a convenience sampling of outpatients aged ≥ 18 years, diagnosed with asthma (based on medical history, symptoms, smoking < 10 pack-years and positive reversibility test), COPD (based on symptoms, smoking > 10 pack-years, and post-bronchodilator FEV1/FVC < 0.70) or ACO (COPD (age > 35, smoking > 10 pack-years, post-bronchodilator FEV1/FVC < 0.70, and positive reversibility test with FEV1 increased > 400 miL and 15%) in University Medical Center in 2019 and had blood EOS tests. 333 asthma patients, 168 COPD patients and 102 ACO patients were included. Results Of 333 asthma patients, 143 (42.9%) were male, of 168 COPD patients 158 (94.0%) were male, of 102 ACO patients, 91 (89.2%) were male. Median age +/- IQR of asthma, COPD, ACO was 53 (39-65), 67 (62-73), 62 (54-68), respectively. Medians of blood EOS in asthma patients (2.9%; 249 cells/mL) and ACO patients (2.8%; 260 cells/mL) were significantly higher than in COPD patients (2.0%; 170 cells/mL). All three groups have mainly blood EOS levels of ≥ 100 cells/μL. The ratio of COPD patients with blood EOS < 100 cells/mL using ICS accounted for 35.6%. The ratio of COPD patients with blood EOS ≥ 300 cells/mL without ICS was 63.0%, of which 35.2% were group D patients. Conclusion This descriptive study of blood EOS levels in asthma, COPD and ACO patients is a cornerstone of further studies to find out the most appropriate EOS thresholds for diagnosis and treatment of these diseases in Vietnam.

Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam

Vu Van Khien,Duong Minh Thang,Tran Manh Hai,Nguyen Quang Duat,Pham Hong Khanh,Dang Thuy Ha,Tran Thanh Binh,Ho Dang Quy Dung,Tran Thi Huyen Trang,Yoshio Yamaoka 거트앤리버 소화기연관학회협의회 2019 Gut and Liver Vol.13 No.5

Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. The search terms included the following: H. pylori infection, antibiotic (including clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug) resistance in Vietnam. The data were summarized in an extraction table and analyzed manually. Finally, Excel 2007 software was used to create charts. Ten studies (three studies in English and seven in Vietnamese) were included in this review. A total of 308, 412, 523, 408, 399, and 268 H. pylori strains were included in this review to evaluate the prevalence of H. pylori primary resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance, respectively. Overall, the primary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 15.0%, 34.1%, 69.4%, 27.9%, 17.9% and 48.8%, respectively. Secondary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 9.5%, 74.9%, 61.5%, 45.7%, 23.5% and 62.3%, respectively. In Vietnam, primary and secondary resistance to H. pylori is increasing over time and affects the effectiveness of H. pylori eradication.

Tobacco Control Policies in Vietnam: Review on MPOWER Implementation Progress and Challenges

Hoang, Van Minh,Tran, Thu Ngan,Vu, Quynh Mai,Nguyen, Thi Tuyet My,Le, Hong Chung,Vu, Duy Kien,Tran, Tuan Anh,Nguyen, Bao Ngoc,Vu, Van Giap,Nguyen, Manh Cuong,Pham, Duc Manh,Kim, Bao Giang Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1

In Vietnam, the WHO Framework Convention on Tobacco Control (WHO FCTC) took effect in March 2005 while MPOWER has been implemented since 2008. This paper describes the progress and challenges of implementation of the MPOWER package in Vietnam. We can report that, in term of monitoring, Vietnam is very active in the Global Tobacco Surveillance System, completing two rounds of the Global Adult Tobacco Survey (GATS) and three rounds of the Global Youth Tobacco Survey (GYTS). To protect people from tobacco smoke, Vietnam has issued and enforced a law requiring comprehensive smoking bans at workplaces and public places since 2013. Tobacco advertising and promotion are also prohibited with the exception of points of sale displays of tobacco products. Violations come in the form of promotion girls, corporate social responsibility activities from tobacco manufacturers and packages displayed by retail vendors. Vietnam is one of the 77 countries that require pictorial health warnings to be printed on cigarette packages to warn about the danger of tobacco and the warnings have been implemented effectively. Cigarette tax is 70% of factory price which is equal to less than 45% of retail price and much lower than the recommendation of WHO. However, Vietnam is one of the very few countries that require manufacturers and importers to make "compulsory contributions" at 1-2% of the factory price of cigarettes sold in Vietnam for the establishment of a Tobacco Control Fund (TCF). The TCF is being operated well. In 2015, 67 units of 63 provinces/cities, 22 ministries and political-social organizations and 6 hospitals received funding from TCF to implement a wide range of tobacco control activities. Cessation services have been starting with a a toll-free quit-line but need to be further strengthened. In conclusion, Vietnam has constantly put efforts into the tobacco control field with high commitment from the government, scientists and activists. Though several remarkable achievements have been gained, many challenges remain. To overcome those challenges, implementation strategies that take into account the contextual factors and social determinants of tobacco use in Vietnam are needed.

Tracking the establishment of local endemic populations of an emergent enteric pathogen

Holt, Kathryn E.,Thieu Nga, Tran Vu,Thanh, Duy Pham,Vinh, Ha,Kim, Dong Wook,Vu Tra, My Phan,Campbell, James I.,Hoang, Nguyen Van Minh,Vinh, Nguyen Thanh,Minh, Pham Van,Thuy, Cao Thu,Nga, Tran Thi Thu National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.43

<P><I>Shigella sonnei</I> is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese <I>S. sonnei</I> isolated over 15 y. Our data show that <I>S. sonnei</I> was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.</P>

An improvement of real-time polymerase chain reaction system based on probe modification is required for accurate detection of African swine fever virus in clinical samples in Vietnam

Tran Ha Thi Thanh,Dang Anh Kieu,Ly Duc Viet,Vu Hao Thi,Hoang Tuan Van,Nguyen Chinh Thi,Chu Nhu Thi,Nguyen Vinh The,Nguyen Huyen Thi,Truong Anh Duc,Pham Ngoc Thi,Dang Hoang Vu 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.10

Objective: The rapid and reliable detection of the African swine fever virus (ASFV) plays an important role in emergency control and preventive measures of ASF. Some methods have been recommended by FAO/OIE to detect ASFV in clinical samples, including real-time polymerase chain reaction (PCR). However, mismatches in primer and probe binding regions may cause a false-negative result. Here, a slight modification in probe sequence has been conducted to improve the qualification of real-time PCR based on World Organization for Animal Health (OIE) protocol for accurate detection of ASFV in field samples in Vietnam. Methods: Seven positive confirmed samples (four samples have no mismatch, and three samples contained one mutation in probe binding sites) were used to establish novel real-time PCR with slightly modified probe (Y = C or T) in comparison with original probe recommended by OIE. Results: Both real-time PCRs using the OIE-recommended probe and novel modified probe can detect ASFV in clinical samples without mismatch in probe binding site. A high correlation of cycle quantification (Cq) values was observed in which Cq values obtained from both probes arranged from 22 to 25, suggesting that modified probe sequence does not impede the qualification of real-time PCR to detect ASFV in clinical samples. However, the samples with one mutation in probe binding sites were ASFV negative with OIE recommended probe but positive with our modified probe (Cq value ranked between 33.12-35.78). Conclusion: We demonstrated for the first time that a mismatch in probe binding regions caused a false negative result by OIE recommended real-time PCR, and a slightly modified probe is required to enhance the sensitivity and obtain an ASF accurate diagnosis in field samples in Vietnam.

The role of rapid tissue expansion in separating xipho-omphalopagus conjoined twins in Vietnam

Tran, Thiet Son,Pham, Thi Viet Dung,Ta, Thi Hong Thuy,Vu, Duy Kien,Nguyen, Thanh Liem Korean Society of Plastic and Reconstructive Surge 2021 Archives of Plastic Surgery Vol.48 No.4

Conjoined twins are rare, and each set of conjoined twins has a unique conjoined anatomy. It is necessary to perform separation to increase the chance of patient survival. Tissue expansion is an advanced technique for providing sufficient soft tissue and skin for wound closure. We report the successful application of rapid tissue expansion in 10-month-old xipho-omphalopagus conjoined twins in Vietnam. A tissue expander was placed on the anterior body between the sternum and umbilicus with a baseline of 70 mL sterile saline (0.9% NaCl). The first injection into the tissue expander began on the 6th day after expander insertion, and injections continued every 2 days with approximately 30-70 mL per injection according to the expansion of the skin. The expander reached 335 mL after six injections and within 10 days. In order to prepare for surgical separation, expansion was completed on the 15th day after insertion. The expanded skin area was estimated to be 180 cm², which was sufficient to cover both patients' skin deficiencies. The twins presented for surgical separation 6 days following the completion of tissue expansion. Both babies were discharged in good health 1 month after separation.

Split-and-Merge Fast Level Set Methods and their application to medical image segmentation

Vu Dang Tran,Young Jun Seo(서영준),Pham Thanh Trung,Jin Young Kim(김진영),Seoung You Na(나승유) 한국지능시스템학회 2009 한국지능시스템학회 학술발표 논문집 Vol.19 No.1

The boundary evolution based Level Set Method has been widely used in medical image segmentation. In this paper, we have developed a new algorithm that extends the Fast Level Set Method. The main contributions of this work are to formulate a new level set function, define relationships between layers and use an alternative elimination criterion in interface evolution. The experimental results validate the effectiveness and efficiency of our approach, compared to the classical Level Set Method and the original Fast Level Set Method.