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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
장애학생 관련 변인에 따른 비장애 학생의 통합태도 연구
오원석 ( Won Seok Oh ),남경숙 ( Kyung Sook Nam ),허명진 ( Myung Jin Huh ) 한국특수교육문제연구소 2006 특수교육저널 : 이론과 실천 Vol.7 No.3
장애학생 관련 변인에 따른 비장애 학생의 통합교육에 대한 태도 및 장애학생에 대한 친근감을 알아보기 위하여 본 연구를 수행하였으며, 연구 대상은 대구광역시 초등학교 5개교15학급 477명을 선정하였다. 연구 결과 장애학생의 통합에 대한 비장애 학생의 태도에 영향을 미치는 변인은 장애유형, 장애학생 성별, 장애학생의 청결상태이며, 영향을 미치지 않는 변인으로는 장애학생 부모의 관심도, 장애아 가정의 경제적 수준 그리고 장애학생의 학습 능력인 것으로 나타났다. The purpose of this study is to determine the attitudes for integration education and the intimacy with disabled students of Nondisabled students influenced by disabled students. For such purpose, 477 students of 15 classes from 5 elementary schools located in Daegu Metropolitan City were selected as the object of this study. Integrated Attitudes was measured through an investigation equipment by Oh Won-Seok and Seo-Yeong Ran which adapted and modified a testing document called Inclusion of Students who are Deaf or Hard of Hearing Inventory (ISDHH) invented by Hsin-Ling Hung(2005). The result indicated that the factors which influence the Attitudes of nondisabled students regarding integration with disabled students are the type of injury, the gender and the cleanness of the disabled student. The factors which do not influence the above are interests of the disabled student``s parents, economic level of the family and the learning ability of the disabled student.
Electrical quadruple hysteresis in Pd-doped vanadium pentoxide nanowires due to water adsorption
Kim, Byung Hoon,Oh, Soon-Young,Yu, Han Young,Hong, Won G,Yun, Yong Ju,Kim, Yark Yeon,Kim, Hae Jin Elsevier 2010 SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS Vol.11 No.6
<P>Humidity-dependent current–voltage (<I>I–V</I>) characteristics of Pd-doped vanadium pentoxide nanowires (Pd-VONs) were investigated. Electrical quadruple hysteresis (QH) was observed and attributed to the large amount of water molecules adsorbed on the nanowires. Using QH in Pd-VONs, the reaction of water with PdO was interpreted as the water molecules are desorbed and then dissociated with increasing bias voltage. Owing to the dissociated H<SUP>+</SUP> and OH<SUP>−</SUP> ions, PdO is reduced and oxidized. As a result, water molecules recombine as the bias voltage is decreased.</P>
임현민,이진호,김원진,오승환,서동혁,이동희,김륜나,김우병,Yim, Hyeonmin,Lee, Jinho,Kim, Won Jin,Oh, Seung-Hwan,Seo, Dong Hyeok,Lee, Donghee,Kim, Ryun Na,Kim, Woo-Byoung 한국재료학회 2022 한국재료학회지 Vol.32 No.9
A spin coating process for RRAM, which is a TiN/TiO<sub>2</sub>/FTO structure based on a PTC sol solution, was developed in this laboratory, a method which enables low-temperature and eco-friendly manufacturing. The RRAM corresponds to an OxRAM that operates through the formation and extinction of conductive filaments. Heat treatment was selected as a method of controlling oxygen vacancy (V<sub>O</sub>), a major factor of the conductive filament. It was carried out at 100 ℃ under moisture removal conditions and at 300 ℃ and 500 ℃ for excellent phase stability. XRD analysis confirmed the anatase phase in the thin film increased as the heat treatment increased, and the Ti<sup>3+</sup> and OH- groups were observed to decrease in the XPS analysis. In the I-V analysis, the device at 100 ℃ showed a low primary SET voltage of 5.1 V and a high ON/OFF ratio of 10<sup>4</sup>. The double-logarithmic plot of the I-V curve confirmed the device at 100 ℃ required a low operating voltage. As a result, the 100 ℃ heat treatment conditions were suitable for the low voltage driving and high ON/OFF ratio of TiN/TiO<sub>2</sub>/FTO RRAM devices and these results suggest that the operating voltage and ON/OFF ratio required for OxRAM devices used in various fields under specific heat treatment conditions can be compromised.
Cho, Joon-Hyung,Jeon, Soo-Bin,Kang, Min-Kyoung,Kim, Jin-Seop,Cho, Sang-Won,Oh, Kwang-Joong Elsevier 2017 Separation and purification technology Vol.184 No.-
<P><B>Abstract</B></P> <P>Ion exchange technology is the most effective and economical to remove heat stable salts (HSS) in CO<SUB>2</SUB> absorption processes. However, the disadvantage of high waste generation remains an unsolved problem. This study attempted to reduce the amount of waste generated during the Zr(OH)<SUB>5</SUB> <SUP>−</SUP> regeneration process through resource recovery by using ZrCl<SUB>4</SUB> coagulant, then recycling the recovered Zr(OH)<SUB>4</SUB> precipitate to produce Zr(OH)<SUB>5</SUB> <SUP>−</SUP> regenerant. The experimental results showed a waste coagulant efficiency of about 75%. The coagulation mechanism was suggested based on the conductivity and zeta potential analysis. The recovered Zr(OH)<SUB>4</SUB> had no differences in terms of chemical composition and regeneration efficiency, when compared with virgin material. These results indicate that the recovery and recycling of Zr(OH)<SUB>4</SUB> from the waste stream using ZrCl<SUB>4</SUB> as a coagulant reduced a large amount of the waste generated from the ion exchange process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Reduction efficiency using ZrCl<SUB>4</SUB> coagulant from ion exchange waste is about 75.0%. </LI> <LI> Coagulation mechanism of four stages with respect to the coagulant dose is proposed. </LI> <LI> Recovery efficiency of hydroxide, as Zr(OH)<SUB>4</SUB>, from the waste is about 99.2%. </LI> <LI> The recovered Zr(OH)<SUB>4</SUB> has no difference in regeneration efficiency of virgin material. </LI> </UL> </P>
Won Sung Min,Lee Na Young,Oh Ki-Kwang,Gupta Haripriya,Sharma Satya Priya,Kim Kyung Hwan,Kim Byoung Kook,Joung Hyun Chae,Jeong Jin Ju,Ganesan Raja,Han Sang Hak,Yoon Sang Jun,Kim Dong Joon,Suk Ki Tae 한국미생물학회 2023 The journal of microbiology Vol.61 No.2
The progression and exacerbation of liver fibrosis are closely related to the gut microbiome. It is hypothesized that some probiotics may slow the progression of liver fibrosis. In human stool analysis [healthy group (n = 44) and cirrhosis group (n = 18)], difference in Lactobacillus genus between healthy group and cirrhosis group was observed. Based on human data, preventive and therapeutic effect of probiotics Lactobacillus lactis and L. rhamnosus was evaluated by using four mice fibrosis models. L. lactis and L. rhamnosus were supplied to 3,5-diethoxycarbonyl-1,4-dihydrocollidine or carbon tetrachloride-induced liver fibrosis C57BL/6 mouse model. Serum biochemical measurements, tissue staining, and mRNA expression in the liver were evaluated. The microbiome was analyzed in mouse cecal contents. In the mouse model, the effects of Lactobacillus in preventing and treating liver fibrosis were different for each microbe species. In case of L. lactis, all models showed preventive and therapeutic effects against liver fibrosis. In microbiome analysis in mouse models administered Lactobacillus, migration and changes in the ratio and composition of the gut microbial community were confirmed. L. lactis and L. rhamnosus showed preventive and therapeutic effects on the progression of liver fibrosis, suggesting that Lactobacillus intake may be a useful strategy for prevention and treatment.
Oh, You-Chang,Jeong, Yun Hee,Cho, Won-Kyung,Lee, Kwang Jin,Kim, Taesoo,Ma, Jin Yeul Medknow PublicationsMedia Pvt Ltd 2014 Pharmacognosy magazine Vol.10 No.39
<P><B>Background:</B></P><P>Hwangryunhaedoktang (HR) has been traditionally used in oriental medicine as a drug for the treatment of melena, hemoptysis, and apoplexy.</P><P><B>Objective:</B></P><P>We investigated whether HR and lactobacilli-fermented HRs have an inhibitory effect on the production of proinflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells.</P><P><B>Materials and Methods:</B></P><P>The investigation was focused on whether HR and fermented HRs could inhibit the production of prostaglandin (PG)E<SUB>2,</SUB> nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-6, cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and mitogen-activated protein kinases (MAPKs) in LPS-stimulated RAW 264.7 cells.</P><P><B>Results:</B></P><P>We found that HR weakly inhibited various inflammatory mediators induced by LPS. However, fermentation with lactobacilli significantly increased the inhibitory effect of HR on most of the inflammatory mediator expression. Furthermore, fermented HRs exerted a stronger inhibitory effect on MAPKs phosphorylation than that by non-fermented HR.</P><P><B>Conclusions:</B></P><P>These results suggest that lactobacilli-fermented HRs contains elevated potent anti-inflammatory activity that is mediated by inhibiting MAPKs pathway in macrophages.</P>