Muscle-specific receptor tyrosine kinase (MuSK) myasthenia gravis associated with castleman disease

Oh, Jeeyoung,Yang, Woo Ick,Cho, Jeong Hoon,Sunwoo, Il Nam The Korean Society of Clinical Neurophysiology 2017 Annals of Clinical Neurophysiology Vol.19 No.1

Muscle specific tyrosine kinase (MuSK) myasthenia gravis (MG) is a rare subtype of MG, which is immunologically distinct and differential therapeutic response. Though MG is often associated with other autoimmune disorders or malignancy, concurrence of other disease and MuSK MG has been infrequently reported. We present a patient of MuSK MG associated with multicentric Castelman disease.

Clinical spectrum and diagnosis of diabetic neuropathies

Jeeyoung Oh 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.5

Neuropathy is the most prevalent microvascular complication of diabetes mellitus; it encompasses distal symmetric polyneuropathy, autonomic neuropathy, radiculoplexus neuropathy, mononeuropathy, and treatment-induced neuropathy. The prevalence rate of diabetic neuropathy in Korea was reported to be approximately 43%, which is similar to rates in other countries. However, the precise pathogenic mechanism underlying diabetic neuropathy is still obscure, and many clinical trials have failed to develop methods to prevent or reduce the progression of diabetic neuropathy. Nevertheless, early diagnosis and proper management of diabetic neuropathy are essential to alleviate disabling symptoms and to improve the quality of life of patients. This review discusses clinical manifestations and classification of diabetic neuropathies, bedside neurological examination, and electrophysiological tests.

Clinical Usefulness of a Cell-based Assay for Detecting Myelin Oligodendrocyte Glycoprotein Antibodies in Central Nervous System Inflammatory Disorders

Seok Jin Myoung,Waters Patrick,Jeon Mi Young,Lee Hye Lim,Baek Seol-Hee,Park Jin-Sung,Kang Sa-Yoon,Kwon Ohyun,Oh Jeeyoung,Oh Jeeyoung,Park Kyung-Ah,Oh Sei Yeul,Kim Byoung Joon,Min Ju-Hong 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.1

Background: The clinical implications of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Abs) are increasing. Establishing MOG-Ab assays is essential for effectively treating patients with MOG-Abs. We established an in-house cell-based assay (CBA) to detect MOG-Abs to identify correlations with patients’ clinical characteristics. Methods: We established the CBA using HEK 293 cells transiently overexpressing full-length human MOG, tested it against 166 samples from a multicenter registry of central nervous system (CNS) inflammatory disorders, and compared the results with those of the Oxford MOG-Ab-based CBA and a commercial MOG-Ab CBA kit. We recruited additional patients with MOG-Abs and compared the clinical characteristics of MOG-Ab-associated disease (MOGAD) with those of neuromyelitis optica spectrum disorder (NMOSD). Results: Of 166 samples tested, 10 tested positive for MOG-Abs, with optic neuritis (ON) being the most common manifestation (4/15, 26.7%). The in-house and Oxford MOG-Ab CBAs agreed for 164/166 (98.8%) samples (κ=0.883, P<0.001); two patients (2/166, 1.2%) were only positive in our in-house CBA, and the CBA scores of the two laboratories correlated well (r=0.663, P<0.001). The commercial MOG-Ab CBA kit showed one false-negative and three false-positive results. The clinical presentation at disease onset differed between MOGAD and NMOSD; ON was the most frequent manifestation in MOGAD, and transverse myelitis was most frequent in NMOSD. Conclusions: The in-house CBA for MOG-Abs demonstrated reliable results and can potentially be used to evaluate CNS inflammatory disorders. A comprehensive, long-term study with a large patient population would clarify the clinical significance of MOG-Abs.

Validation of Social Responsiveness Scale for Korean Preschool Children With Autism

Jeeyoung Chun,Guiyoung Bong,Jae Hyun Han,Miae Oh,Hee Jeong Yoo 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.9

Objective This cross-cultural study aims to examine the psychometric properties of the Social Responsiveness Scale (SRS) and to determine the best-estimate-cut-off scores for the diagnosis of autism spectrum disorder (ASD) in Korean preschool children.Methods A total of 563 children was recruited from multiple sources, including Seoul National University Bundang Hospital. Participants were assessed by a multidisciplinary research team using multiple diagnostic tools based on DSM-5 diagnostic criteria. Discriminative validity was tested by comparing the difference in SRS scores between ASD and non-ASD groups. Convergent validity was tested by examining correlations between SRS scores with other diagnostic instruments. A receiver operation characteristic curve analysis was conducted to test the sensitivity and specificity of SRS and to determine the best-estimate-cut-off scores for screening ASD in Korean preschool children.Results There were significant differences in the total SRS scores between the ASD (n=242) and non-ASD group (n=321) (p<0.01, 95% confidence interval [CI]: 14.08–17.24). The differences were significant even after adjusting for age. SRS scores were significantly correlated with other prescreening diagnostic tools for ASD. The best-estimate cut-off score to screen ASD was 55 (area under curve=0.88, sensitivity 78.1%, specificity 86.6%).Conclusion The SRS is a valid and reliable instrument to screen and aid in the diagnosis of ASD in Korean preschool children. The adjusted cut-off scores, notably lower than in the original U.S. version, may yield a more accurate diagnosis by reflecting transcultural differences.

Laser-Induced Dewetting of Metal Thin Films for Template-Free Plasmonic Color Printing

Oh, Harim,Lee, Jeeyoung,Seo, Minseok,Baek, In Uk,Byun, Ji Young,Lee, Myeongkyu American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.44

<P>Plasmonic color laser printing has several advantages over pigment-based technology, including the absence of ink and toner and the production of nonfading colors. However, the current printing method requires a template that should be prepared via nanofabrication processes, making it impractical for large-area color images. In this study, we show that laser-induced dewetting of metal thin films by a nanosecond pulsed laser can be effectively utilized for plasmonic color printing. Ag, Au, and their complex films deposited on a glass substrate were dewetted into different surface structures such as droplets, rods, and ripples, depending on the incident laser energy. The resulting morphological evolutions could be explained by Rayleigh and capillary instabilities. For a bimetallic film comprising Ag nanowires coated on a Au layer, a few different plasmonic colors were generated from a single sample simply by changing the laser fluence. This provides a possible method for implementing plasmonic color laser printing without using a prepatterned template.</P> [FIG OMISSION]</BR>

Fabrication of Invisible Ag Nanowire Electrode Patterns Based on Laser-Induced Rayleigh Instability

Oh, Harim,Lee, Jeeyoung,Kim, Jin-Hoon,Park, Jin-Woo,Lee, Myeongkyu American Chemical Society 2016 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.120 No.36

<P>We here present a laser-patterning method that may solve the-visibility problem associated with silver nanowire (AgNW) transparent electrodes. In conventional methods, AgNW electrodes are patterned on a transparent substrate by either selective removal or deposition of the material. Therefore, the fabricated pattern becomes visible due to the difference in transmittance/reflectance between the regions with and without AgNWs. Our approach is to disconnect the AgNW networks in selective areas by a laser and thus make the irradiated areas electrically insulating. This method is fundamentally based on Rayleigh instability. Given that the laser-cut nanowires remain on the substrate, the electrode pattern fabricated by the method can be invisible. The feasibility of the presented approach is demonstrated by fabricating organic light-emitting diodes using patterned AgNW electrodes and then characterizing their performance capabilities.</P>

Fabrication of Ag-Au bimetallic nanoparticles by laser-induced dewetting of bilayer films

Oh, Yoonseok,Lee, Jeeyoung,Lee, Myeongkyu Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.434 No.-

<P><B>Abstract</B></P> <P>We here show that Ag-Au bimetallic nanoparticles (NPs) can be produced by dewetting an Ag/Au bilayer film coated on glass using a nanosecond-pulsed laser beam. Elemental analysis revealed that the obtained bimetallic NPs are Ag-Au alloys, with two elements well mixed over the whole volume of the particle. The composition of the produced particles was controllable by changing the relative thickness of each layer. The localized surface plasmon resonance (LSPR) peak was red-shifted with an increasing Au content and the LSPR wavelength could be tuned from 415 to 525 nm by varying the alloy composition. A film area of several square centimeters could be transformed into Ag-Au NPs by a single laser pulse of 6 ns duration. This study provides a facile and scalable route to prepare bimetallic NPs for plasmonic and other applications.</P> <P><B>Highlights</B></P> <P>Ag-Au bimetallic nanoparticles are produced by laser-induced dewetting of bilayer films.</P> <P>A film area of several square centimeters can be dewetted into nanoparticles by a single laser pulse.</P> <P>The process may be effectively utilized for the synthesis and plasmonic tuning of bimetallic nanoparticles.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Superior Cluneal Nerve Entrapment as Uncommon Cause of Buttock Pain

Jeeyoung Jun,Jinyoung Oh,Dahee Park 대한통증연구학회 2021 International Journal of Pain Vol.12 No.1

The superior cluneal nerve is a pure sensory cutaneous nerve and dominates sensation in the low back and buttock area. Entrapment of superior cluneal nerve around the iliac crest, superior cluneal neuropathy, is one of the etiology of low back pain or buttock pain, but diagnosis and treatment are still challenging. Here, we report a case that the buttock pain from cluneal nerve entrapment was diagnosed and treated by percutaneous interventions. Our patient, in this case, complained of chronic buttock pain that lasted for 6 months, and there was no response to the epidural block, medial branch block, and sacroiliac joint block, but the pain was relieved through the superior cluneal nerve block, and it was diagnosed as superior cluneal nerve entrapment neuropathy. The pain could be treated through nerve block and pulsed radiofrequency therapy. Buttock pain can be induced in many diseases, and accurate diagnosis cannot be made only by imaging studies and physical examination. Two or more diseases can simultaneously cause similar symptoms. Although superior cluneal nerve entrapment causes severe buttock pain, among several causes, it is difficult to diagnose superior cluneal nerve entrapment as the cause first. It is suggested that superior cluneal entrapment neuropathy could be considered as one of the causes in patients with buttock pain.

Transformation of silver nanowires into nanoparticles by Rayleigh instability: Comparison between laser irradiation and heat treatment

Oh, Harim,Lee, Jeeyoung,Lee, Myeongkyu Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.427 No.2

<P><B>Abstract</B></P> <P>We comparatively study the morphological evolutions of silver nanowires under nanosecond-pulsed laser irradiation and thermal treatment in ambient air. While single-crystalline, pure Ag nanospheres could be produced by laser-driven Rayleigh instability, the particles produced by heat treatment were subject to oxidation and exhibited polyhedron shapes. The different results are attributed to the significantly different time scales of the two processes. In this article, we also show that bimetallic Ag-Au nanospheres can be synthesized by irradiating Ag nanowires coated with a thin Au film using a pulsed laser beam. This may provide a facile route to tune the plasmonic behavior of metal nanoparticles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ag nanowires can be transformed into single-crystalline nanospheres by laser-driven Rayleigh instability. </LI> <LI> Ag-Au alloy nanospheres are also produced by irradiating Ag nanowires coated with a thin Au film. </LI> <LI> The process may be effectively utilized for the synthesis and plasmonic tuning of bimetallic nanoparticles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

재고를 고려한 국제원유가격변동에 따른 휘발유 가격의 비대칭성 연구

배지영 ( Jeeyoung Bae ),김수현 ( Soo Hyeon Kim ),김문정 ( Moon Jung Kim ),오수민 ( Soo Min Oh ),허은녕 ( Eunn Yeong Heo ) 한국환경경제학회·한국자원경제학회(구 한국환경경제학회) 2013 자원·환경경제연구 Vol.22 No.4

본 연구에서는 국제 원유가격의 변동에 따른 휘발유 가격의 조정 과정에 원유 재고량이 미치는 영향을 오차수정모형을 통해 분석하였다. 분석에는 미국시장의 자료를 이용하였으며, 분석기간은 1988년 1월부터 2012년 12월까지이며 전체기간에 대한 분석과 더불어 5년 단위로 구간을 나누어 구간별 비대칭성의 여부와 정도의 변화에 대해 원유 재고가 미치는 영향을 분석하였다. 분석 결과, 전체 기간에서는 재고변수 도입 여부와 관계없이 모두 대칭성이 나타났으나 구간별로는 공적분 관계를 가지는 경우에 한하여 원유와 재고 간 유의한 관계가 성립하였다. 또한 구간별로 비대칭적 조정이 다르게 나타났으며, 재고 변수 도입 여부에 의해 비대칭성의 정도가 다름도 확인하였다. 본 연구의 분석결과는 향후 비대칭성 연구에 있어서 재고 변수를 고려하여 구간별 유가의 변동성을 분석할 필요가 있음을 보여준다. This study analyzed the impact of crude oil inventory while gasoline price adjusts to international crude oil price(WTI) fluctuations. We mainly focused on asymmetric relationship between crude oil and petroleum product prices and added oil inventory as an variable, using the error correction model which is based on Borenstein et al.(1997). This paper selected the sample period from January 1988 to December 2012, analyzed the asymmetry of each intervals and the influence of crude oil inventory to the degree of asymmetry changes, both full period and five years period respectively. The results showed that when considering crude oil inventory, existence and degrees of time;amount asymmetry varies.