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      • KCI등재

        단안증에 다발성선천성기형을 동반한 기형아의 1 예

        오혜숙(HS Oh),나주환(JH Na),황병철(BC Whang),박지홍(JH Park) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.9

        단안증에 다발성선천성기형을 동반한 기형아의 1 예 Cyclopia is a rare congenital fetal ocular anomaly in which the eyes are fused together and located in a single orbit It is commonly associated with other congenital anomalies such as omphalocele anencephalus polydactyly and etc and these serious malformations make it inadequate to survive We presented a case of cyclopia associated with multiple congenital anomalies with a brief review of the literature.

      • KCI등재

        얇은 자궁내막을 갖은 환자에 있어서 과배란 유도시 에스트라디올 추가요법의 효용성

        오기석,조동제,김세광,권혁찬,양현원,장기홍,황경주,유정현,이치형 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.3

        1994년 11월 1일부터 1997년 8월 31일까지 본원 불임크리닉에서 체외수정 및 배아이식술을 시술받은 491주기를 대상으로 hCG 투여시에 내막의 두께에 따라 체외수정 및 배아이식술의 결과를 분석하고 얇은 자궁내막을 가진 환자군에서 배아를 바로 이식하지 않고 동결 보존 후 해빙 배아이식술을 시행한 군과 과배란 유도 과정 중 에스트라디올 추가요법을 시행한 군에서 자궁내막의 반응과 그에 따른 임신율을 분석하여 다음과 같은 결론을 얻었다. 배란유도 중 hCG 투여시 자궁내막 두께가 7 mm 미만인 경우 배아를 동결시키고 이후 에스트로젠의 투여기간을 연장한 자궁내막에 이식을 하며 이전 주기 혹은 불임기초검사 중에 배란기 내막 상태가 7 mm 미만인 경우 GnRHa 장기투여법에 estradiol valerate를 추가하는 것이 효과적이라고 사료된다. It is known that adequate endometrial thickness is an important prognostic factor for implantation in natural cycles, in assisted conception cycles employing ovulation induction and ovum recipient cycles using hormone replacement therapy. Recently the thickness of the endometrium has been highly correlated with histological maturation, and in patients with thin endometrium increased dosage and duration of estradiol supplementation has led to increased endometrial maturation thus stressing the importance of endometrial thickness. In this study, the results of estradiol supplementation in patients with abnormally thin endometrium who are undergoing IVF-ET was observed and to evaluate the endometrial response and to compare the pregnancy outcome. From November 1st, 1994 to August 31st, 1997, 491 IVF-ET cycles were studied, which were divided into several groups. The first group was 451 cycles where the endometrial thickness was more than 7mm at the time of hCG injection, the second group was 15 cycles where the endometrial thickness was less than 7mm at the time of hCG injection, the third and fourth group was where the endometrial thickness was less than 7mm from the previous cycle to the time of hCG injection, in which the third group was 12 cycles where embryo transfer was not completed immediately but later after freezing, and in which the fourth group was 13 cycles which received estradiol supplementation during ovulation induction. The endometrial thickness averaged 10.0±0.1 mm in Group 1 and only 5.8±0.1mm in Group 2, but after estradiol supplementation which resulted in longer endometrial exposure to estrogen, 7.9±0.5 days in Group 2, 19.8±0.7 days in Group 3, 16.7±0.9 days in Group 4, showing significant increase[p<0.05]. In Group 3, 11 of 12 cases, and 10 of 13 cases in Group 4 the endometrial thickness improved to more than 7mm, along with the average thickness which increased to 7.1± 0.5 mm and 8.3±0.5 mm, respectively. There was no significant difference with regard to number of embryos transferred, cumulative embryo score, number of embryos of more than Grade II-1 between the groups. The clinical pregnancy rate and ongoing pregnancy 27.7% and 22.3% respectively, but in Group 2 the clinical pregnancy rate was only 6.6%. However, in Group 3 and Group 4 where estradiol supplementation was administered, the clinical pregnancy rates were 25.0% and 38.5% respectively, and the pregancy rates beyond 12 weeks of gestation reached 25.0% and 30.8% respectively. In conclusion, in cases where thin endometrium is observed at the time of hCG injection during IVF-ET it is recommended to freeze the embryo and then conduct the transfer after prolonging the length of estradiol administration, but in cases where the the endometrium is not adequate in the previous cycle or during basic infertility work-up, it is suggested that estradiol supplementation to long protocol GnRHa is effective.

      • KCI등재

        지속임신에서 시행한 경복식 융모막채취법

        오보훈,임재훈,이동호 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.6

        1990년 4월부터 1991년 1월까지 경희대학병원 산부인과에 내원한 임신 10~18주사이의 임산부 24명을 대상으로 freehand 초음파유도하에 single needle을 삽입하여 경복식 융모막채취법(TA-CVS)을 시행한 바 다음과 같은 결과를 얻었다. 1. 총 대상 24례중 22례에서 TA-CVS가 성공하여 융모막채취 성공률은 91.7%이었는데 임신초기에는 21례중 19례(90.5%)에서 성공하였고 임신중기에 시행한 3례에서는 모두 성공하였다. 2. 총 대상 24례에서 바늘삽입횟수는 평균 1.3 0.4회이었으며 TA-CVS가 성공한 22례중 1회 바늘 삽입으로 성공한 경우가 17례(77.3%)이었다. 3. 총 대상 24례중 태반의 위치가 자궁전벽에 있었던 경우가 16례(66.7%), 자궁후벽에 위치한 경우가 4례(16.7%), 자궁저부에 위치한 경우가 4례(16.7%)이었다. 4. TA-CVS가 성공한 22례에서 채취된 융모막 양은 평균 10.2 6.9 mg이었는데 임신초기에 18 gauge바늘을 사용한 19례에서는 평균 11.4 6.8 mg, 임신중기에 20 gauge 바늘을 사용한 3례에서는 평균 3 mg이었다. 5. TA-CVS가 성공한 22례중 5 mg이상의 충분한 융모막을 채취하여 직접법과 배양법을 동시에 시행할 수 있었던 경우가 15례(68.2%)이었고, 5 mg미만을 채취하여 배양법만을 시행한 경우가 7례(31.8%)이었다. 6. TA-CVS를 시도한 24례중 현재까지 태아손실은 한 예도 없었다. 결론적으로 TA-CVS는 경질식 융모막채취법(TC-CVS)과 더불어 임신초기의 산전진단에 유용하게 시행할 수 있을 뿐만 아니라 TC-CVS가 불가능한 때에도 TA-CVS를 시행할 수 있는 경우가 있으므로 전반적인 융모막채취 성공률을 높일 수 있을 것으로 사료된다. Transabdominal chorionic villus sampling(TA-CVS) has been carried out in twenty-four pregnant women at Kyung Hee University Hospital from April, 1990 to January, 1991. We present here our technique and clinical experience with TA-CVS. We have performed TA-CVS using a single aspiration needle under the freehand ultrasound guidance. Twenty-four pregnant women underwent TA-CVS between 10 and 18 weeks of gestation. Sampling was usually carried out at the tenth or eleventh weeks of gestation. TA-CVS was successful in 22 of 24 pregnant women, a success rate of 91.7%. The amount of chorionic villi obtained by TA-CVS was 10.2 6.9 mg and sufficient chorionic villi( 5 mg) were obtained from 15(68.2%) of the 22 successful TA-CVS cases. The mean number of needle insertion was 1.3 0.4 and in 77.3%(17/22) of the successful sampling only a single needle passage was required. To date, no fetal loss was observed in this TA-CVS program. We conclude that TA-CVS is a potentially useful technique in case of unfavorable anatomic and clinical conditions for safe transcervical chorionic villus sampling.

      • Management of gastric lymphoma with chemotherapy alone

        Oh, DY,Choi, IS,Kim, JH,Rhu, MH,Kim, TY,Heo, DS,Bang, YJ,Kim, NK Taylor Francis 2005 Leukemia & lymphoma Vol.46 No.9

        <P>Purpose . The optimal therapy for gastric lymphoma except MALToma has not yet been established. This study was undertaken to investigate whether gastric lymphoma can be managed effectively and safely with chemotherapy alone. Patients and methods . A total of 58 patients (median age 56 years) with newly diagnosed gastric lymphoma between 1989 – 2001 at Seoul National University Hospital and who were initially managed with chemotherapy alone were evaluated. MALToma was excluded from the pathologic review. Results . All patients received initially anthracycline-containing chemotherapy. ECOG performance scale 0 – 1 was 88% and B symptoms were present in 41.4%. Diffuse large B cell type was the most common (74.1%). Stage IE, II1E accounted for 51.7% and II2E, IIIE, IV for 48.3%. The international prognostic index (IPI) of risk was low in 39.7%, low-intermediate in 22.4%, high-intermediate in 15.5% and high in 22.4%. The complete response rate after first-line chemotherapy was 71.4% and the partial response rate was 12.2%. (overall response rate: 83.6%). Among patients who did not reach the complete response, a further complete response was achieved by second-line chemotherapy including etoposide-based regimen. Ultimately, the maximum complete response rate by chemotherapy was 83.7% (92% in stage IE, II1E, 75% in stage II2E, IIIE, IV). Median overall survival was 47.4 months (84.7 months in stage IE, II1E, 32.5 months in stage II2E, IIIE, IV) and the 5-year survival rate was 46%. Bleeding as a complication occurred in 3 of 58 patients (5.6%) and these cases were controlled by embolization or conservative management. No perforation episode occurred and surgical intervention due to complication was not necessary. Organ preservation was possible in 57 of 58 patients (98%). The one gastrectomy was performed due to a partial clinical response to chemotherapy but the specimen showed pathologic CR. Multivariate analysis revealed that only IPI had a significant influence on survival. Conclusions . Gastric lymphoma except MALToma can be managed effectively and safely with chemotherapy alone.</P>

      • KCI등재

        고도 정제된 인간의 FSH[highly purified FSH , FSH-HP]를 사용한 단순화된 체외수정 및 배아이식술의 효용성

        오기석,권혁찬,장기홍,황경주,김지영,유정현,이치형 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.5

        1994년 12월 1일부터 1997년 8월 31일까지 본원 불임크리닉에서 체외수정 및 배아이식을 받은 504주기의 환자를 대상으로 FSH-HP를 사용한 단순화된 과배란유도법과 다른 약제를 사용한 단순화된 과배란유도법 사이의 과배란 유도의 특성, 난자 및 배아의 발달 및 임신 결과를 비교하고자 본 연구를 수행하였다. FSH-HMG 투여법[84 주기], GnRH agonist 단기 투여법[142 주기] 및 장기 투여법[175 주기]과 FSH-HP 투여법[103 주기]을 사용한 단순화된 체외수정 및 과배란유도법을 시행한 결과 FSH-HP를 사용한 과배란유도 방법은 GnRH agonist 장기투여법에 비하여 과배란유도기간[7.6±0.2일 vs 9.0±0.1일] 및 과배란유도제제 투여 총량[26.4±1.1개 vs 34.8±1.2개]은 유의하게 적으면서 조기황체화, 취소율 및 난소 과자극증후군의 발병 빈도는 그다지 높지 않 았다. 자궁내막의 반응 또한 좋았으며 혈중 에스트라디올 농도가 GnRH agonist 장, 단기투여법에 비하여 유의하게 낮았으나[p$lt;0.05] 난자 및 배아의 발달은 정상적으로 이루워졌으며, 통계학적 유의성은 없었으나 오히려 다소 높은 착상율과 낮은 유산율로 높은 지속 임신율을 유지할 수 있었다. 또한 환자 스스로 피하주사 할 수 있어 체외수정 및 배아이식술의 전과정을 최대한 단순화시켜 의료진과 환자 모두에게 효율적이며 편리하게 할 수 있었다. 따라서 FSH-HP를 이용한 단순화된 체외수정 및 과배란 유도 방법은 기존의 과배란 유도법을 대체할 수 있는 좋은 방법으로 사료된다. Objectives : To compare simplified ovulation induction employing FSH-HP with that of simplified ovulation induction employing other pharmacologic agents with regard to ovulation induction characteristics, oocyte and embryo development, and pregnancy outcome. Methods : From December 1, 1994 to August 31, 1997, those cycles who underwent in vitro fertilization and embryo transfer with FSH-HMG [84 cycles], GnRH agonist short protocol [142 cyclse] and long protocol [175 cycles] and FSH-HP [103 cycles], totalling 504 cycles. Results : The duration of ovulation induction with FSH-HP was 7.6±0.2 days, which was significantly shorter than the 9.0±0.1 days when GnRH agonist was used, and the total dose of agents were also significantly less [26.4±1.1 ampules vs 34.8±1.2 ampules]. The incidence of premature luteinization, cycle cancellation rate, and OHSS development was similar between the two groups. In the FSH-HP group good endometrial response was observed. The serum estradiol concentrations were significantly lower than the GnRH agonist short and long protocols [p$lt;0.05], but there was normal oocyte and embryo development. Rather, although there was no statistical significanse, the implantation rate was relatively higher whereas the abortion rate was relatively lower, leading to higher ongoing pregnancy rate overall. Conclusion : Ovulation induction with FSH-HP enables subcutaneous drug administration by the patient herself, therefore simplifying as much as possible the in vitro fertilization and embryo transfer process and affording conveniency for both the patient and the hospital. It is therefore suggested that simplified protocols in IVF-ET with highly purified FSH [FSH-HP] for ovulation induction is an efficient alternative to current standard protocols.

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