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정상 면역인에서 동시에 발생한 베체트병과 결핵성 림프절염 1례
이병욱 외 중앙대학교 의과대학 의학연구소 2011 中央醫大誌 Vol.36 No.1/2
Behçet's disease is an idiopathic systemic vasculitis which manifests with recurrent oral or genital ulcer, various skin lesions and ocular lesions. The strategies of treatment for Behçet's disease frequently include various immunosuppressants, such as systemic steroids, azathioprine, cyclosporine A, cyclophosphamide, and infliximab. These immunosuppressive agents attenuate the cell-medicated immunity of hosts and predispose them to the development of tuberculosis. Cases in which pulmonary tuberculosis, intestinal tuberculosis, and tuberculous meningoencephalitis are developed in Behçet's disease patients who had been taking immunosuppressive drugs, including corticosteroids, are frequently reported worldwide. However, no case has been reported in which tuberculous lymphadenitis was concurrently diagnosed with Behçet's disease, especially in a patient who is not under immunosuppressive therapy. We describe here the case of a 28-year-old woman presenting fever who was simultaneously diagnosed as having Behçet's disease and tuberculous cervical lymphadenitis.
프리캐스트 계단을 적용한 효율적인 RC 코어의 연속화 시공방법
김욱종,김록배,이도범 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
The past manpower-dependent method in the constructional industry has raised the problem of high cos - low efficiency. Especially construction of staircase by using conventional form work and concrete placement deteriorates the quality of reinforced concrete, requires many manpower and has many difficulties of work. This study introduces COSEC system(RC _Co_re _Se_quential _C_onstruction Method by Using PC stairs) to reduce the manpower and the construction time and improve quality of structure. This is the new epoch method of installing PC stair elements after the construction of core wall contrary to the existing method of installing PC stair elements before the construction of core wall or at the same time. After reinforced concrete core wall is constructed by the system form in advance, PC landings and stairs are took in and set up between core walls standing right opposite. PC landings are connected by pinned connection with the core wall and PC stairs are simply put on PC landings on both sides. This system makes installation of PC stair elements very easy and improves the quality of stairs and core wall. This study shows the effect of practical application to construction of the building in the field.
Corticotropin-releasing factor decreases IL-18 in the monocyte-derived dendritic cell
Lee, Hee Jung,Kwon, Yeon Sook,Park, Chang Ook,Oh, Sang Ho,Lee, Ju Hee,Wu, Wen Hao,Chang, Nam Soo,Lee, Min-Geol,Lee, Kwang Hoon Blackwell Publishing Ltd 2009 Experimental dermatology Vol.18 No.3
<P>Abstract: </P><P>Recent evidence suggests that crosstalk between mast cells, nerves and keratinocytes might be involved in the exacerbation of inflammatory conditions by stress, but the mechanism by which this occurs remains unclear. Corticotropin-releasing factor (CRF), which activates the hypothalamo-pituitary-adrenal (HPA) axis under stress, also has pro-inflammatory peripheral effects. However, there have been no reports about CRF receptor expression and the functional role of CRF in the dendritic cell (DC), which is considered to be the link between allergen uptake and the clinical manifestations of allergic diseases, such as atopic dermatitis. The purpose of this study was to investigate the expression of CRF receptors and the functional role of CRF in the monocyte-derived DC (MoDC) of atopic dermatitis patients and non-atopic healthy controls. In this study, mRNAs for CRF-R1&agr; and 1&bgr;, as well as the CRF-R1 protein, were detected in MoDCs. CRF-R2&agr; (but not R2&bgr; or R2&ggr;) mRNA and the CRF-R2 protein were present in MoDCs. Exposure of DCs to CRF resulted in a decrease of IL-18 in both atopic dermatitis patients and non-atopic healthy controls. However, CRF did not alter the expression of IL-6, CCL17, CCL18, and CCL22. Therefore, our results demonstrate that CRF could modulate immune responses by acting directly upon DCs.</P>
하루 4회 인슐린 투여로 과혈당을 조절한 모성 당뇨환자의 임상 분석
이호 ( Ho Lee ),김소영 ( So Young Kim ),이진교 ( Jin Kyo Lee ),이은택 ( Eun Taek Lee ),장진호 ( Jin Ho Jang ),이정헌 ( Jeong Hun Lee ),박지현 ( Jee Hyun Park ),황성욱 ( Sung Ook Hwang ),송은섭 ( Eun Seop Song ),고승권 ( Seung Kwo 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
목적: 모성 당뇨환자에서 인슐린의 투여량을 직접 결정하고 혈당치를 측정해가면서 하루 4회 인슐린 투여를 하였을 때 하루 1-3회 인슐린 투여와 비교하여 산모와 태아에 더 나은 효과가 있는지 알아보고자 한다. 연구 방법: 1998년 8월부터 2004년 4월까지 인하대학교 의과대학 산부인과를 방문한 임신한 진성 당뇨환자와 임신성 당뇨환자 29명을 대상으로 중간형 인슐린과 인슐린 lispro를 하루 4회 투여한 14예를 연구 대상군으로, 하루 1-3회 인슐린 Objective: To determine whether administrating insulin four times daily, compared to 1-3 times daily, improves maternal and perinatal outcomes of diabetes. Methods: From August 1998 to April 2004, the 14 pregnant diabetic women were treated with four time
Baumann Skin Type in the Korean Male Population
( Young Bin Lee ),( Sung Ku Ahn ),( Gun Young Ahn ),( Hana Bak ),( Seung Phil Hong ),( Eun Jung Go ),( Chang Ook Park ),( Sang Eun Lee ),( Weon Ju Lee ),( Hyun-Chang Ko ),( Jee-Bum Lee ),( Hyung Joo K 대한피부과학회 2019 Annals of Dermatology Vol.31 No.6
Background: Research into the Baumann skin type (BST) has recently expanded, with growing interest in the development of an efficient and effective skin type classification system for better understanding of this skin condition. Objective: We aimed to identify male-specific skin type characteristics with investigation into the distribution of BST by age and region in the Korean male population and to determine the intrinsic and extrinsic factors related to skin type. Methods: A questionnaire was administered to collect information about age, region, working behavior, drinking behavior, smoking behavior, usual habit of sun protection, medical history, and the BST which consisted of four parameters; oily (O) or dry (D), sensitive (S) or resistant (R), pigmented (P) or non-pigmented (N), and wrinkled (W) or tight (T). Results: We surveyed 1,000 Korean males aged between 20 and 60 years who were divided equally by age and region. Of the total re- Background: Research into the Baumann skin type (BST) has recently expanded, with growing interest in the development of an efficient and effective skin type classification system for better understanding of this skin condition. Objective: We aimed to identify male-specific skin type characteristics with investigation into the distribution of BST by age and region in the Korean male population and to determine the intrinsic and extrinsic factors related to skin type. Methods: A questionnaire was administered to collect information about age, region, working behavior, drinking behavior, smoking behavior, usual habit of sun protection, medical history, and the BST which consisted of four parameters; oily (O) or dry (D), sensitive (S) or resistant (R), pigmented (P) or non-pigmented (N), and wrinkled (W) or tight (T). Results: We surveyed 1,000 Korean males aged between 20 and 60 years who were divided equally by age and region. Of the total respondents, OSNW type accounted for the largest percentage and ORPW type the lowest. In terms of Baumann parameters, O type was 53.5%, S type was 56.1%, N type was 84.4% and W type was 57.5%. Several behavioral factors were found to have various relationships with the skin type. Conclusion: The predominant skin type in the Korean male respondents was OSNW type, and the distribution of skin types with regards to age and region was reported to be distinct. Therefore, skin care should be customized based on detailed skin types considering the various environmental factors. (Ann Dermatol 31(6) 621∼630, 2019)
한국어판 알코올 사용장애 진단 검사(AUDIT:Alcohol Use Disorders Identification Test)의 개발:신뢰도 및 타당도 검사
이병욱(Byung Ook Lee),이충헌(Choong Heon Lee),이필구(Pil Goo Lee),최문종(Moon Jong Choi),남궁기(Kee Namkoong) 한국중독정신의학회 2000 중독정신의학 Vol.4 No.2
Objectives:This study was designed to develop the Korean version of Alcohol Use Disorders Identification Test (AUDITK) and AUDIT Alcohol Consumption Questions (AUDIT-CK) which is composed of the first 3 questions of AUDIT, a screening tool for the alcohol use disorder. Methods:The translation, including back translation procedure, was carried out, keeping the basic structure of AUDIT. AUDIT-K, AUDITC-K, Korean version of Michigan Alcoholism Screening Test (MAST-K), Korean version of CAGE (CAGE-K) and clinical diagnosis were administered to 43 alcohol use disorder patients and 43 non-alcohol use disorder control subjects. The reliability and validity of AUDIT-K and AUDIT-C-K were evaluated. The sensitivity and specificity for each cut-off point of AUDITK and AUDIT-C-K were calculated and the Receiver Operating Characteristic (ROC) curve analysis was done to get their optimal cut-off points. Diagnostic efficiency of AUDITK and AUDIT-C-K was evaluated by ROC curve analysis. Results:AUDIT-K was found to have significantly high internal consistency, and test-retest reliability. The correlation coefficients of AUDIT-K with MAST-K and CAGE-K were 0.86 and 0.80, respectively, and significant correlation was shown. Its optimal cut-off point was estimated as 12, and the sensitivity and specificity were 0.84 and 0.86, respectively. The correlation coefficients of AUDIT-C-K with MAST-K and CAGE-K were 0.60 and 0.56, respectively. Its optimal cut-off point was estimated as 8, and the sensitivity and specificity were 0.95 and 0.77, respectively. The ROC curve analysis indicated that the diagnostic efficiency of AUDIT-K and AUDIT-C-K was comparable with that of MAST-K and superior to that of CAGE-K. Conclusion:AUDIT-K and AUDIT-C-K have not only high reliability and validity, but also usefulness as a screening instrument for alcohol use disorder.