유기용제에 장기간 폭로된 근로자의 정신의학적 기능과 삶의 질

김석재,강순아,유지숙,국승희,윤진상,문재동,이형영 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 본 연구는 Y공단의 제조공정에서 저농도의 유기용제(solvent)에 장기간 노출된 근로자의 정신의학적 기능과 삶의 질을 평가하고자 하였다. 방법: 총 142명의 남성근로자 중 유기용제에 폭로된 군(이하 폭로군) 82명과 폭로되지 않는 군(이하 비폭로군) 60명에게 간이정신진단검사(Symptom Checklist-90-R, SCL-90-R), 인지 및 정신운동성검사 (Critical Flicker Fusion Threshold. CFFT; Choice Reaction Time, CRT;Compensatory Tracking Task, CTT;Digit-Symbol Substitution, DDS) 및 한국판 스미스클라인 비챰 삶의 질 척도(Korean version of the SmithKline Beecham 'Quality of Life' Scale, KvSBQOL) 등을 적용하였다. 두 군간의 비교는 평가치의 평균에 대해 t-검증을 하였고 또한 연령과 학력을 공변인으로한 공변량분석(ANCOVA)을 하였다. 결과: SCL-90-R의 9개 증상 차원과 3개 전체 지표 점수는 두 군이 각각 정상범위였다. 그러나 신체화 (Somatization, SOM), 우울(Depression, DEP), 적대감(Hostility, HOS), 공포불안(Phobic anx-iety, PHOB)의 증상차원과 전체심도지수(Global Severity Index, GSI), 표출증상합계(Positive Symptom Total, PST)의 전체 지표는 폭로군이 비폭로군보다 유의하게 높았다. 인지 및 정신운동성 검사와 삶의 질은 두 군간에 유의한 차이는 없었다. 결론: 이상의 결과는 유기용제가 허용치 이하일지라도 장기간 폭로되는 경우에는 정신의학적 문제를 다소 일으킬 수 있음을 시사하였다. 중심단어:유기용제·근로자·정신건강·정신운동성 기능·삶의 질. Objectives: The aim of this study was to evaluate the psychiatric function and quality of life of the chemical workers who had been exposed to long-term, low-level organic solvents in the Y industrial complex. Method: A total of 144 male workers, of whom 82 were in the exposed group and 60 in the unexposed-control group, were evaluated by using Symptom Checklist-90-R(SCL-90-R), series of neuropsychological tests(critical flicker fusion threshold, CFFT) ; choice reaction time, CRT ; compensatory tracking task, CTT) ; digit symbol substitution test, DSS), and the Korean version of the SmithKline Beecham Quality Of Life scale(KvSBQOL). For the statistical analyses, comparisons of the means of the two groups were performed for each variable with two-tailed t-test as well as ANCOVA including age and education as covariates. Results: For the SCL-90-R, the nine symptom scales and the three global indices were clinically within normal range in both groups. However, the scores on the symptom scales of 'somatization','depression','hostility' and 'phobic anxiety', and those on the global indices of 'global severity index' and 'positive symptom total', were significantly higher in the exposed group than in the unexposed group. In terms of the neuropsychological function and the quality of life, there wes no significant difference between the two groups. Conclusion: These findings suggested that the long-term eposure to mixed organic solvents, even at the low level below the permissible exposure limit, might induce some psychiatric problems. KEY WORDS: Organic solvent·Worker·Mental health·Psychomotor function·Quality of life.

Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

위장간 수술환자에서 겐타마이신의 임상약물동태

최준식,문홍섭,최인,범진필 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

The purpose of this investigation was to determine pharmacokinetic parameter of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korea normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were 0.226±0.032, 0.231±0.063 L/㎏ and 0.357± 0.024, 0.337±0.041 hr^-1 for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters. KS and VS were 0.00344±0.00049(hr·mL/min/1.73㎡)^-1 and 0.214±0.0502 L/㎏ for gastronintestinal surgical patients using NPEM method. The V and K were 0.216±0.048 L/㎏ and 0.336±0.043 hr^-1 for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetic between NLSR and Bayesian analysis in gastrointestinal surgical patient.

Optical properties of GaS:Ho3+ and GaS:Tm3+ single crystals

Moon-Seog Jin,김창대,김화택 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.4

A Study on the Measurement of Dynamic Visual Acuity according to the Change of Accommodative Stimulus

Moon-Seog Jin,In-Chul Jeon 대한시과학회 2018 대한시과학회지 Vol.20 No.4

목적: 본 연구는 근거리 동체시력(Dynamic visual acuity) 측정장치를 이용하여 측정된 근거리 동체시력과 원거리에서 측정된 동체시력과의 차이를 알아보고, 플러스렌즈 가입에 의한 조절자극의 변화가 동체시력에 미치는 영향을 알아보고자 하였다. 방법: 대상은 전신질환 및 안질환이 없고, 시력이 1.0 이상인 성인 남·여 40명(22.84±2.43세)으로 선정 하였다. 원거리와 근거리 동체시력의 비교, 플러스렌즈 가입(+0.50D, +1.00D, +1.50D)으로 유도된 동체시력의 변화를 알아보았다. 결과: 완전교정상태에서 원거리 동체시력과 근거리 동체시력은 각각 78.86 ±19.46 deg/sec, 76.90±18.05 deg/sec로 원거리 동체시력이 약간 높게 나타났다(p=0.04). 원거리 동체시력이 높을수록 근거리 동체시력이 높은 양의 상관관계를 보여 원거리 동체시력이 우수한 사람이 근거리 동체시력도 우수한 것으로 나타났다 (r=0.95, p=0.00, Fig. 4). 조절자극변화에 따른 근거리 동체시력은 완전교정상태에서 75.95±18.85 deg/sec 이었고 +0.50D 구면도수를 가입한 상태에서 동체시력은 76.95±16.45 deg/sec로 통계적으로 유의한 차이가 없었으나(p>0.05), +1.00D를 가입한 상태는 79.02±13.51 deg/sec로 약간 높게 나타났으며, +1.50D를 가입한 상태에서는 84.28±18.96 deg/sec로 통계적으로 유의한 차이가 있었다(p<0.05). 결론: 원거리와 근거리의 동체시력의 차이는 없지만 원거리 동체시력이 우수한 경우 근거리 동체시력도 우수하며, 조절자극 변화를 위해 플러스렌즈가 가입됨에 따라 동체시력이 증가함을 알 수 있었다. Purpose : The purpose of this study was to investigate the difference in the dynamic visual acuity between (DVA) the distance and near and the effect of change of accommodative stimulus on the dynamic visual acuity by the addition of the plus lens. Methods : The study involved 40 male and female adults (22.84 ± 2.43 years old) with over 1.0 of visual acuity and without systemic disease or ocular disease. We compared the distance and near DVA and the change of DVA induced by the addition of the plus lens(+0.50D, +1.00D, +1.50D). Results : The distance DVA and near DVA are 78.86±19.46 deg/sec and 76.90±18.05 deg/sec respectively. The distance DVA was slightly higher(p=0.04). The higher the distance DVA, the higher the positive correlation with the near DVA and distance DVA, and distance DVA was higher in those who had higher the near DVA(r=0.95, p=0.00, Fig. 4). The near DVA according to the change of accommodative stimulus was 75.95±18.85 deg/sec in full correction and the near DVA with +0.50D spherical power was 76.95±16.45 but there was no statistically significant differences(p>0.05). However, the near DVA with +1.00D spherical power was 79.02±13.51 deg/sec and it was slightly higher. Also, the near DVA with +1.50D spherical power was 84.28±18.96 deg/sec, there and it was statistically significant difference(p<0.05). Conclusion : There is no difference between distance and near DVA, but near DVA is also excellent if distance DVA is good. The DVA increases as added a plus lens for controlled accommodative stimulation changes.

Photoluminescence of Hexagonal Boron Nitride (h-BN) Film

Moon-Seog Jin,Nam-Oh Kim 대한전기학회 2010 Journal of Electrical Engineering & Technology Vol.5 No.4

Hexagonal boron nitride (BN) films were prepared. The process involved, spraying BN powder-dispersed H₃BO₄-BCl₃-ethyl alcohol solution on quartz plates, and the drying off quartz plates before, and annealing at 1070 ℃ in a nitrogen atmosphere. The optical energy band gap of the BN films was 5.28 eV. Photoluminescence peaks with energies of 3.44, 3.16, 2.97, and 2.35 eV at 10 K were observed and analyzed. Accordingly, these have resulted from donor-acceptor pair recombinations.

Photoluminescence of Hexagonal Boron Nitride (h-BN) Film

Jin, Moon-Seog,Kim, Nam-Oh The Korean Institute of Electrical Engineers 2010 Journal of Electrical Engineering & Technology Vol.5 No.4

Hexagonal boron nitride (BN) films were prepared. The process involved, spraying BN powder-dispersed $H_3BO_4-BCl_3$-ethyl alcohol solution on quartz plates, and the drying off quartz plates before, and annealing at $1070^{\circ}C$ in a nitrogen atmosphere. The optical energy band gap of the BN films was 5.28 eV. Photoluminescence peaks with energies of 3.44, 3.16, 2.97, and 2.35 eV at 10 K were observed and analyzed. Accordingly, these have resulted from donor-acceptor pair recombinations.

Caffeine prevents human prion protein-mediated neurotoxicity through the induction of autophagy

MOON, JI-HONG,LEE, JU-HEE,PARK, JIN-YOUNG,KIM, SUNG-WOOK,LEE, YOU-JIN,KANG, SEOG-JIN,SEOL, JAE-WON,AHN, DONG-CHOON,PARK, SANG-YOUEL Spandidos Publications 2014 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.34 No.2

<P>The human prion protein (PrP) fragment PrP(106?126) possesses the majority of the pathogenic properties associated with the infectious scrapie isoform of PrP, known as PrPSc. The accumulation of PrPSc in the brain of humans and animals affects the central nervous system. Recent epidemiological studies have suggested that caffeine, one of the major components of coffee, exerts protective effects against the development of neurodegeneration. However, the protective effects of caffeine against prion disease have not been reported to date. In this study, we therefore investigated the effects of caffeine on PrP-mediated neurotoxicity. The protein expression of the autophagosomal marker, LC3-II, was increased by caffeine in a dose-dependent manner, and the autophagy induced by caffeine protected the neuronal cells against PrP(106?126)?induced cell death. On the contrary, the downregulation of LC3-II using the autophagy inhibitors, 3-methyladenine (3-μα) and wortmannin, prevented the caffeine-mediated neuroprotective effects. To the best of our knowledge, the present study provides the first evidence that treatment with caffeine protects human neuronal cells against prion?mediated neurotoxicity and these neuroprotective effects are mediated by caffeine-induced autophagy signals. Our data suggest that treatment with caffeine may be a novel therapeutic strategy for prion peptide?induced apoptosis.</P>

Temperature Dependence of the Optical Energy Gap of a Tl2GeS3 Single Crystal

Moon-Seog Jin 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.4

Tl2GeS3 single crystals belonging to a chalcogenide compound were grown by using the chemical transport reaction method with iodine as a transport agent. The Tl2GeS3 single crystal was crystallized into a triclinic structure. The optical energy gap of the single crystal was found to be 2.529 eV at 13 K. The temperature dependence of the optical energy gaps in the temperature range of 13 298 K was well fitted with the Varshni equation.s

CuAl₁_xGa xSe₂ 및 CuAl₁_xGa xSe₂ : CO²+ 단결정의 광학적 특성

진문석(Moon-Seog Jin),김화택(Wha-Tek Kim) 한국진공학회(ASCT) 1994 Applied Science and Convergence Technology Vol.3 No.3

삼원화합물 반도체, CuAlSe₂ 및 CuGaSe₂ 단결정의 solid solution인 CuAl_(1-x)Ga_xSe₂ 및 cobalt를 2.0 mol% 첨가한 CuAl(1-x)Ga_xSe₂:Co^(2+) 단결정을 iodine을 수송물질로 사용한 화학수송법으로 성장시켰다. source material로는 CuAl_(1-x)Ga_xSe₂의 화학조성비에서 Se를 3.0mol% 과잉으로 첨가하여 합성한 ingot를 사용하였으며, 불순물이 첨가된 CuAl_(1-x)Ga_xSe₂:Co^(2+) 단결정 성장시에는 source material 에 cobalt 분말을 2.0mol% 첨가하였다. X-선 회절무늬로부터 성장된 단결정들이 chalcopyrite 결정구조를 하고 있음을 확인하였으며 격자상수를 구하였다. 광흡수 spectra 측정으로부터 성장된 단결정의 optical energy gap 조성의존성을 규명하였고, 결정장 이론을 적용하여 CuAl_(1-x)Ga_xSe₂:Co^(2+) 단결정에서 나타나는 cobalt 불순물에 의한 광흡수 peak가 T_d 대칭점에 위치한 Co^(+2) 이온의 에너지 준위들간 전자전이에 의해 나타남을 규명하였다. The solid solution, CuAl_(1-x)Ga_xSe₂ single crystals of ternary compound semiconductors, CuAlSe₂ and CuGaSe₂, and CuAl(1-x)Ga_xSe₂:Co^(2+) single crystals doped with 2.0 mol% of cobalt as an impurity were grown by the chemical transport reaction method using iodine as the transport agency. Then, CuAl_(1-x)Ga_xSe₂ ingot synthesized from stoichiometric eleemnts, Cu, AI, Ga and Se with excess Se of 3.0 mol% was used as a source material. To grow CuAl_(1-x)Ga_xSe₂:Co^(2+) single crystal, cobalt powder of 2.0 mol% was added to the source matera1. The grown single crystals were crystalized in the chalcopyrite structure and lattice constants were obtained from X-ray diffraction. From the analysis of optical absorption spectra, the composition dependence of the optical energy gap was decided. Applying the crystal field theory to impurity optical absorption peaks in CuAl_(1-x)Ga_xSe₂:Co^(2+) single crystals, it was identified that the impurity optical absorption are originated in the electron transition between the energy levels of Co^(2+) ion sited at T_d symmetry point in the host crystals.