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Isolation and Transcriptional Expression of CuZn Superoxide Dismutase from Codonopsis lanceolata
Lee,Kang,In,Jun-Gyo,Yu,Chang-Yeon,Yun,Song-Joong,Min,Byung-Hoon,Rho,Yeong-Deok,Kim,Moo-Sung,Yang,Deok-Chun 한국자원식물학회 2004 Plant Resources Vol.7 No.3
To investigate the defense mechanism against the abiotic stress, a cDNA clone encoding a CuZn superoxide dismutase (CuZnSOD) protein was isolated from a cDNA library prepared from tabroot mRNAs of Codonopsis lanceolata. The eDNA, designated ClSODCc, is 799 nucleotides long and has an open reading frame of 459 bp with a deduced amino acid sequence of 152 residues. The deduced amino acid sequence of ClSODCc matched to the previously reported CuZnSODs. Consensus amino acid residues (His-45, -47, -62, -70, -79, -119 and Asp-82) were involved in Cu-, Cu/Zn-, and Zn- binding ligands. The deduced amino acid sequence of ClSODCc showed high homologies (82%-86%) regardless of species. Expression of ClSODCc by oxidative stress was increased up to 1 h after treatment and declined gradually. Much earlier and stronger expression of ClSODCc was observed in the cold stress treatment.
Physical and chemical Effects on the sonication Treatment of chitosan solution
Lee, Keun Tai,Park, Seong Min,Park, Chan Kyu,Kim, Sang Moo 한국키틴키토산학회 1997 한국키틴키토산학회지 Vol.2 No.2
물리적 방법을 이용한 키토산 올리고당의 제조에 관한 기초 자료를 제시하기 위하여 키토산용액을 20kHz의 초음파로 처리하였으며, 초음파 처리 효과에 미치는 처리 조건의 영향을 조사하였다. 키토산 용액의 고유점도는 초음파 처리 5분까지는 급속하게 감소하였고 그 이후로는 서서히 감소하였다. 키토산 용액의 부피가 작을수록 초음파 처리효과는 컸으며, 키토산 용액의 온도는 초음파 처리에 별다른 효과가 없는 것으로 나타났다. 5분간 초음파 처리 후의 점도는 용매의 종류에 따라 큰 차이가 없었으나, acetate buffer의 경우 초음파 처리효과가 가장 컸다. pH가 높을수록 초음파 처리효과는 크게 나타났으며, 이온강도와 염의 종류에 따른 효과는 나타나지 않았다. 이상의 결과에서, 용액의 부피는 10~20ml, 온도는 20~30℃, 용액의 pH는 4.5, 그리고 용매의 종류는 acetate buffer로 하는 것이 최적 초음파 처리조건으로 추정된다. As the first step of studies related to production of chitooligosaccharides by physical methods, chitosan solution were sonicated with 20kHz and various treatment effects were examined to present fundamental data of sonicated chitosan solution. Intrinsic viscosity of chitosan solution sharply decreased from 3.76dl/g to 2.90dl/g until 5 minutes of sonication and then slowly decreased. With low volume of chitosan solution, sonication was very effective and temperature of chitosan solution slightly affected the efficiency of sonication. In case of changing the solvent, no significant differences were observed on the effect of sonication, however, acetate buffer had highest sonication effect among various solvents. The sonication effect was increased as the increasement of the value of pH, on the contrary, ionic strength and type of counterions showed no effect on sonication, With these results, we assumed that optimal sonication treatment would be as follows, solution volume was 10 ~20ml, temperature range was 20~30℃ , pH value of solution was 4.5 and type of solvent was acetate buffer
Lee, Hyang-Ah,Park, Joon Ha,Kim, Dae Won,Lee, Choong-Hyun,Hwang, In Koo,Kim, Hyeyoung,Shin, Myoung Cheol,Cho, Jun Hwi,Lee, Jae-Chul,Noh, Yoohun,Kim, Sung-Su,Won, Moo-Ho,Ahn, Ji Hyeon SPANDIDOS PUBLICATIONS 2018 MOLECULAR MEDICINE REPORTS Vol.17 No.3
<P>Oligodendrocytes are myelin-forming cells in the central nervous system. Research into the effects of aging on oligodendrocyte protein expression remains limited. The present study aimed to determine the alterations in oligodendrocyte-specific protein (OSP) expression in the gerbil hippocampus at 1, 2, 3, 4, 6 and 24 months of age with western blot and immunohistochemistry analyses. OSP expression levels in the hippocampus were highest at 6 months of age. OSP immunoreactivity was identified in numerous cell bodies at 1 month, although the number of OSP immunoreactive cells was different according to hippocampal subregion. The number of OSP immunoreactive cells significantly decreased at 2 months and, thereafter, numbers decreased gradually. The detection of OSP immunoreactive fibers was negligible in all layers in the hippocampal subregions until 4 months. OSP immunoreactive fibers were abundant at 6 and 24 months, although the fiber distribution patterns in the CA1-3 areas and dentate gyrus were different. The results demonstrated that OSP expression in the gerbil hippocampus was age-dependent. The detection of OSP immunoreactive cell bodies and fibers was significantly different according to the layers of hippocampal subregions, indicating that myelination may be continuously altered in the hippocampus during normal aging.</P>
( Sung Hoon Hong ),( Seok Ju Llee ),( Hyuck Moo Kwon ),( Min Koo Lee ) 한국품질경영학회 2014 한국품질경영학회 학술대회 Vol.2014 No.2
The sigma level is a performance metric that indicates how often defects are likely to occur in the business process. The higher the sigma level, the less likely a process will produce defects. In this paper, the concept of sigma level is introduced and methods of calculating sigma levels for different data types are illustrated with several examples. Four data types are considered; defects data, defective items data, normally distributed variables data, and non-normally distributed data including lifetime data. MINITAB software is used for calculating the sigma levels.
Lee, Inki,Byun, Byung Hyun,Lim, Ilhan,Kim, Byung Il,Kong, Chang-Bae,Song, Won Seok,Cho, Wan Hyeong,Koh, Jae-Soo,Lim, Sang Moo Williams & Wilkins Co 2018 Medicine Vol.97 No.37
<P><B>Abstract</B></P><P>We compared the usefulness of <SUP>99m</SUP>Tc-methyl diphosphonate (<SUP>99m</SUP>Tc-MDP) bone scintigraphy and <SUP>18</SUP>F-fluorodeoxyglucose (FDG) for positron emission tomography/computed tomography (PET/CT) in predicting histologic response in patients with osteosarcoma receiving neoadjuvant chemotherapy (NAC).</P><P>We retrospectively reviewed 62 patients with high-grade osteosarcoma who had received 2 cycles of NAC and surgery. All patients underwent <SUP>99m</SUP>Tc-MDP bone scintigraphy and <SUP>18</SUP>F-FDG PET/CT before and after NAC. <SUP>99m</SUP>Tc-MDP uptake in the primary tumor was measured quantitatively as the maximum tumor-to-nontumor ratio (T/NT<SUB>max</SUB>) and <SUP>18</SUP>F-FDG uptake was measured as the maximum standardized uptake value (SUV<SUB>max</SUB>), before and after NAC. The percent changes of T/NT<SUB>max</SUB> (percent changes of the maximum tumor-to-nontumor ratio [Δ%T/NT<SUB>max</SUB>]) and SUV<SUB>max</SUB> (percent changes of the maximum standardized uptake value [Δ%SUV<SUB>max</SUB>]) after NAC were calculated and the correlations between these parameters were evaluated. After surgery, the effects of NAC were graded histopathologically (good vs poor) and the optimum cut-off values of Δ%T/NT<SUB>max</SUB> and Δ%SUV<SUB>max</SUB> for predicting histologic response were assessed using the receiver operating characteristic (ROC) curve analysis.</P><P>Δ%T/NT<SUB>max</SUB> and Δ%SUV<SUB>max</SUB> were positively correlated with each other (<I>r</I> = 0.494, <I>P</I> < .01). Based on the ROC curve analysis, both Δ%T/NT<SUB>max</SUB> (area under the curve [AUC] = .772, <I>P</I> < .01) and Δ%SUV<SUB>max</SUB> (AUC = .829, <I>P</I> < .01) predicted good histologic response. However, there was no significant difference between the AUCs of Δ%T/NT<SUB>max</SUB> and Δ%SUV<SUB>max</SUB> (<I>P</I> = .44). The sensitivity and specificity for predicting good histologic response were 83.3% and 75.0%, for the criterion Δ%T/NT<SUB>max</SUB> <–12.5%, and 80.0% and 81.3% for the criterion Δ%SUV<SUB>max</SUB> <−49.0%, respectively.</P><P>The <SUP>99m</SUP>Tc-MDP bone scan and <SUP>18</SUP>F-FDG PET scan are non-inferior to each other in predicting the histologic response of osteosarcoma treatments. The <SUP>99m</SUP>Tc-MDP bone scan and <SUP>18</SUP>F-FDG PET scan showed respective advantages with differing features. Therefore, physicians should consider which scan is appropriate for their own institute based on the advantages of each scan and the circumstances of the institute.</P>
Prevalence and characteristics of isolated nocturnal hypertension in the general population
( Moo-yong Rhee ),( Je Sang Kim ),( Chee Hae Kim ),( Ji-hyun Kim ),( Jung-ha Lee ),( Sun-woong Kim ),( Deuk-young Nah ),( Namyi Gu ),( Eun-joo Cho ),( Ki-chul Sung ),( Kyung-soon Hong ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.5
Background/Aims: Ascertaining the prevalence of isolated nocturnal hypertension (INHT) in the general population and identifying the characteristics of patients with INHT may be important to determine patients who should receive 24- hour ambulatory blood pressure (BP) measurements. This study aimed to evaluate the prevalence and characteristics of INHT in the general population. Methods: Of 1,128 participants (aged 20 to 70 years), we analyzed 823 who had valid 24-hour ambulatory BP measurements and were not on antihypertensive drug treatment. Results: The prevalence of INHT in the study was 22.8%. Individuals with INHT had a higher office, 24-hour, and daytime and nighttime ambulatory systolic and diastolic BPs compared to individuals with sustained day-night normotension. INHT was more prevalent in individuals with masked hypertension (MH) than in those with sustained hypertension (59.8% vs. 15.6%, p < 0.001). Among individuals with INHT, 92.6% had MH. Among individuals with office BP-based prehypertension, 34.5% had both INHT and MH. The prevalence of INHT was highest in individuals with office BP-based prehypertension. INHT was an independent determinant of MH after adjustment for age, sex, body mass index, diabetes, low-density-lipoprotein cholesterol, 24-hour systolic and diastolic BP, systolic and diastolic BP dipping, and systolic and diastolic BP non-dipping. Conclusions: The present study showed that INHT is not uncommon and is a major determinant of MH. Our findings strongly suggest the use of 24-hour ambulatory BP measurement for individuals within the prehypertension range of office BP owing to the high prevalence of INHT and MH in this population.
A Fast Analysis on Floating Wave Energy Conversion System
Sang-moo Lee(이상무),Seoung-gun Kim(김성근) 한국해양공학회 1999 韓國海洋工學會誌 Vol.13 No.4
부유식 파랑에너지 변환시스템(Oscillating Water Column)에 대한 해석은 입력파와 챔버, 챔버내 공기의 상호작용으로 인하여 어려움이 많다. 이 논문은 이와 같은 요소를 고려하면서도 쉽고 간편한 해석법을 제시한다. 파랑에너지에 의한 자가발전은 파랑에너지를 기계적 운동으로 변환하고 이를 전기에너지로 변환함으로써 가능하다. 본 논문은 파랑에너지에서 기계적 에너지로 변환하는 과정에 집중하여 그 부분의 성능을 해석한다.<br/> 단일 진동수 규칙파가 입력되었을 때에 파에 의하여 챔버의 상하운동이 선형적으로 발생하는 것으로 보며, 이 상하운동에 챔버내의 압력 영향을 고려하였다. 상하운동과 챔버내로 투과한 파, 그리고 챔버내 압력에 의해 발생되는 파에 의해 챔버내의 상대운동을 정하고, 그 상대운동에 의한 공기의 압축 팽창과 온도상승을 근사적 열역학적 방정식으로 해석하였고 오리피스를 통한 유량을 결정하였다. 얻어진 식은 간단하면서도 관련요소의 영향을 전반적으로 표현한다. 결과에 따르면 고정식의 에너지 변환식은 부유식의 특별한 경우로서 파악되었다. 또한 고정식의 시스템을 그대로 부유식으로 바꿨을 때 그 변환효율은 적어지는 것으로 나타났다. 본 해석법은 계산이 간편하므로 설계단계에서 유용하게 활용될 수 있을 것으로 기대된다.