Validation of the Short Form of Korean-Everyday Cognition (K-ECog)

Song Minji,Seo Dong Gi,Kim Seong Yoon,Kang Yeonwook 대한의학회 2023 Journal of Korean medical science Vol.38 No.44

Background: Evaluating the activities of daily living (ADL) is an important factor for diagnosing dementia. The Everyday Cognition (ECog) scale was developed to measure ADL changes that were correlated with specific neuropsychological impairments. A short form of the ECog (ECog-12) was also developed, consisting of 12 items, two from each of the six cognitive domains of the ECog. The Korean full version of ECog (K-ECog) has recently been standardized, but the need for a shortened version has been raised in clinical practice. The purpose of this study was to develop a Korean version of ECog-12 (K-ECog-12) and to verify its reliability and validity by comparing those to the full version of K-ECog. Methods: The participants were 267 cognitively normal older adults (CN), 183 patients with mild cognitive impairment (MCI), and 89 patients with dementia. The Korean-Mini Mental State Examination (K-MMSE), Korean-Montreal Cognitive Assessment (K-MoCA), and Short form of Geriatric Depression Scale (SGDS) were administered to all participants. The K-ECog and Korean-Instrumental Activities of Daily Living (K-IADL) were rated by the informants of patients. Results: K-ECog-12 was newly constructed by replacing one item for the visuospatial function in the original ECog-12 with another one through an item response theory analysis on Korean data. The internal consistencies (Cronbach’s α) of K-ECog-12 and K-ECog were 0.95 and 0.99, respectively. The test–retest reliabilities (Pearson’s r) were 0.67 for K-ECog-12 and 0.73 for K-ECog. The K-ECog-12 was significantly correlated with K-ECog as well as K-IADL, K-MMSE, and K-MoCA. The K-ECog-12 scores differed significantly between the CN, MCI, and dementia groups, as did the K-ECog scores. Receiver operating characteristic curve analyses showed that K-ECog-12, like K-ECog, could differentiate MCI and dementia patients from CN as well. Conclusion: The K-ECog-12 is as reliable and valid as the K-ECog in assessing ADL. Therefore, K-ECog-12 can be used as an alternative to the K-ECog in clinical and community settings in Korea.

A Normative Study of the Full Version of Story Memory in the Korean-Mini Mental State Examination, 2nd Edition: Expanded Version (K-MMSE-2: EV)

Song Minji,장승민,Kim SangYun,강연욱 대한치매학회 2020 Dementia and Neurocognitive Disorders Vol.19 No.4

Background and Purpose: The Mini Mental State Examination, 2nd edition: Expanded version (MMSE-2: EV) involves an immediate recall (IR) of story memory (SM). A full version of SM has been developed and standardized; it includes delayed recall (DR) and recognition tests in addition to IR to increase its clinical utility as an independent story recall test. This study was conducted to provide norms for the full version of SM in the Korean version of MMSE-2: EV for clinical use. Methods: A total of 1,168 participants (496 males and 672 females) were included in the study. The ages ranged from 19 to 90 years, and the education level ranged from illiterate to post-graduate. Regression analysis was used to evaluate the relative contributions of demographic variables (age, education, and sex) on the SM measures. Results: We stratified age into 11 groups, and categorized the education level into 6 groups. It was found that the IR, DR, and recognition scores of SM were affected by age, education level, and sex. We provided corrected means and standard deviations of the IR, DR, and recognition scores of the SM for the demographic variables. Conclusions: The results indicate the importance of considering demographic variables in interpreting the full version of SM measures. The normative data we have provided in this study should be useful in clinical and research settings for detecting the impairment in verbal memory.

Development of Detection Markers for Herbicide Glufosinate Tolerant GMOs for Food Safety Management

Minji Song,Yang Qin,Ounsung Cho,TaeSung Park,Myung-Ho Lim 한국식품영양과학회 2019 한국식품영양과학회 학술대회발표집 Vol.2019 No.10

Measurement of Subjective Cognitive Decline (SCD) Using Korean-Everyday Cognition (K-ECog) as a Screening Tool: a Feasibility Study

Song Minji,Lee Sun Hwa,Kim Seong Yoon,Kang Yeonwook 대한치매학회 2021 Dementia and Neurocognitive Disorders Vol.20 No.4

Background and Purpose: Everyday Cognition (ECog) has been widely used to differentiate individuals with mild cognitive impairment (MCI) and dementia from normal elderly individuals. It has also been used to assess subjective cognitive decline (SCD). This study investigated the feasibility of using ECog as a screening measure for SCD in community-dwelling elderly individuals. Methods: The participants included 84 older adults with and 93 without SCD living in the community. These 2 groups were classified based on their response (“yes” or “no”) to the question “Do you perceive memory or cognitive difficulties?” All participants were evaluated using the Korean-Mini Mental State Examination (K-MMSE), Short form of the Geriatric Depression Scale (SGDS), and the Korean version of Everyday Cognition (K-ECog). Results: The scores of all participants were within the normal range on the K-MMSE and SGDS. The total K-MMSE score did not differ significantly between the 2 groups after controlling for age, education, and depression. The scores of SCD group were significantly higher than those of the non-SCD group for memory, language, and executive function: planning domains, as well as K-ECog total score. Receiver operating characteristic curve analysis revealed that the K-ECog total score was effective in moderately differentiating between subjects with and without SCD (area under the curve: 0.73). Conclusions: ECog is a feasible and useful screening measure for SCD in older adults living in the community, and can be used to assess the full spectrum of cognitive and functional deficits, ranging from SCD to MCI and dementia.

Development and Validation of the Full Version of Story Memory in the Korean-Mini Mental State Examination, 2nd Edition: Expanded Version (K-MMSE-2: EV)

Minji Song,Sun Hwa Lee,유경호,강연욱 대한치매학회 2019 Dementia and Neurocognitive Disorders Vol.18 No.3

Background and Purpose: The Korean version of Story Memory (SM) in the Korean-Mini Mental State Examination, 2nd Edition: Expanded Version (K-MMSE-2: EV) was developed. Based on the SM, we additionally developed a full version of SM including delayed recall (DR) and recognition adding to immediate recall (IR). This study aimed to examine the reliabilities and validities of the newly developed SM in the K-MMSE-2: EV and its full version. Methods: Ninety-five healthy elderly individuals (HE), 90 patients with amnestic mild cognitive impairment (aMCI), and 53 patients with dementia of the Alzheimer's type (DAT) participated in the study. They were administered the full version of SM with the Seoul Verbal Learning Test-Elderly's version (SVLT-E) and Rey Complex Figure Test (RCFT). In addition, the SM was re-administered to 51 participants after a 5-week interval. Two clinical neuropsychologists independently rated the performance of 50 participants. Results: The test-retest reliabilities of the IR, DR, and recognition of the SM were statistically significant. The inter-rater reliabilities (Cohen's kappa) were high (0.87–1.00) for all the measures. The IR, DR, and recognition of SM had significant positive correlations with those of the SVLT-E and RCFT. Significant group differences in IR and DR of SM were found among the HE, aMCI, and DAT groups. The recognition scores were significantly different between the aMCI and DAT groups, but not between the HE and aMCI groups. Conclusions: The newly developed full version of SM in the K-MMSE-2: EV was proven to be a reliable and valid memory measure for clinical use.

CREAMS를 이용한 비영농기 논 배출부하량 추정

김민지 ( Minji Kim ),강문성 ( Moon Seong Kang ),송인홍 ( Inhong Song ),김계웅 ( Kyeung Kim ),송정헌 ( Jung-hun Song ),장정렬 ( Jeong Ryeol Jang ) 한국농공학회 2015 한국농공학회 학술대회초록집 Vol.2015 No.-

수질오염총량제가 실시됨에 따라 정확한 오염부하량 산정을 위해, 토지이용별 정확한 원단위를 추정하는 것이 중요하게 되었다. 논은 우리나라 총 면적의 약 9.3%를 차지하고 있어, 오염총량을 추정하는데 있어 큰 비중을 차지하고 있다. 그러나 논 배출부하와 관련된 연구는 영농활동이 이루어지는 5월 ~ 9월까지 집중되어 있으며, 상대적으로 1년의 약 50%를 차지하는 비영농기에 대한 배출부하 연구는 미흡하게 이루어지고 있어, 연 단위의 배출부하를 추정하는 것에는 어려움이 있다. 본 연구에서는 농업지역 포장단위 모형인 CREAMS(Chemicals, Runoff, and Erosion From Agricultural Management Systems)를 이용하여, 비영농기 동안 논에서의 배출부하를 모의하고, 논에서의 연 단위 배출부하를 추정하고자 한다. 대상지구로는 영농기 동안 수문·수질 모니터링이 실시된 전라북도 익산시 춘포면의 논포장을 대상으로 하였으며, 모형의 구동에 필요한 토양 특성 자료는 서울대학교 농업생명과학공동기기원 (NICEM)에 위탁하여 분석된 자료를 이용하였다. 기상 자료는 포장과 인접한 전주 기상대의 일사량 및 평균기온과 대상 지구에서 관측한 일강우량 자료를 사용하였다. 본 연구의 결과는 비영농기를 고려한 연 단위의 논 배출부하를 추정하는데 도움이 될 것으로 사료된다.

Clinical Outcomes of Intrascleral Fixation of Intraocular Lens Compared to Ciliary Sulcus Implantation and Transscleral Fixation

Eun Gyu Yoon(Eun Gyu Yoon),Youngsub Eom(Youngsub Eom),Minji Woo(Minji Woo),Hyun Sun Jeon(Hyun Sun Jeon),Seong-Jae Kim(Seong-Jae Kim),Jong Suk Song(Jong Suk Song),Hyo Myung Kim(Hyo Myung Kim) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2

Purpose: To compare the clinical outcomes of intrascleral fixation of the three-piece intraocular lenses (IOLs) 2.5 mm posteriorto the limbus with ciliary sulcus implantation and transscleral fixation 2.5 mm posterior to the limbus. Methods: Sixty-five eyes of 65 patients who underwent ciliary sulcus implantation or transscleral or intrascleral fixation ofthe AMO Sensar AR40e IOL were retrospectively reviewed. The postoperative refractive prediction error, back-calculatedeffective lens position (ELP), corrected distance visual acuity (CDVA), and postoperative residual cylinder were compared. Results: There were significant differences in the median (interquartile range) postoperative refractive prediction error (diopters[D]) among the three groups (p < 0.001): for ciliary sulcus implantation (33 eyes), −0.89 D (−1.21 to −0.56 D); for transscleralfixation (10 eyes), −0.40 D (−0.78 to −0.22 D); and for intrascleral fixation (22 eyes), 0.01 D (−0.28 to 0.34 D). Significantdifferences (p < 0.001) were observed in the median back-calculated ELP: for ciliary sulcus implantation, 4.35 mm (3.95 to4.55 mm); for transscleral fixation, 4.51 mm (4.34 to 4.76 mm); and for intrascleral fixation, 4.90 mm (4.56 to 5.35 mm). Therewere no differences in the median postoperative CDVA (0, 0.10, and 0 logarithm of the minimum angle of resolution, respectively;p = 0.083) and the residual cylinder (−0.75, −1.50, and −0.63 D, respectively; p = 0.074) among three groups. Conclusions: Intrascleral fixation showed no myopic shift and the most posterior lens position, while ciliary sulcus implantationinduced the greatest myopic shift and the most anterior lens position. However, there was no significant difference in thepostoperative CDVA or astigmatism among the eyes with different IOL insertion methods, demonstrating good IOL stabilityand vision outcomes.

Hypolipidemic Effects of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) Fruit-Added Functional Rice Cookie in High-Fat Diet-Fed Mice

Minji Woo,Hong Sun Hee,Jeong Sook Noh,Yeong Ok Song 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10

High Resolution Manometry versus Video Fluorography for Evaluating Dysphagia in Patients with Inflammatory Myopathy: A Pilot Study

Minji Jung,Kyoung Hyo Choi,Kyeong Joo Song,Kee Wook Jeong,Yong-Gil Kim 대한연하장애학회 2020 대한연하장애학회지 Vol.10 No.1

Objective: Dysphagia has been reported to occur in patients with inflammatory myopathy (IM). Although high-resolutionimpedance manometry (HRIM) provides precise information regarding the pharyngeal pressure, it has not yetbeen used for assessing dysphagia in routine clinical practice. This study determined whether the results of HRIMfor evaluating deglutition disorders in patients with IM could reflect an abnormality that can’t be identified by avideo fluoroscopic swallowing study (VFSS). Methods: We reviewed both VFSS and HRIM results of nine patients with IM, four of whom presented with globussensation. Results: Cricopharyngeal muscle dysfunction was noted in all four patients with globus sensation, and the upperesophageal sphincter residual pressure (UESRP) was higher (≥8 mmHg) in the patients with pharyngeal residue. Using VFSS and HRIM, we demonstrated that dysphagia in patients with IM may arise owing to failed relaxation ofUES or decreased hyolaryngeal excursion. Conclusion: In conclusion, UES-RP values of ≥8 mmHg indicate the presence of pharyngeal residue and globussensation in patients with IM. HRIM provided a comprehensive assessment of the mechanisms of dysphagia, andHRIM facilitated recognizing subtle abnormalities in pharyngeal contraction and UES function. HRIM can overcome thelimitations of VFSS by allowing clinicians to perform objective measurements in patients with IM.

Kimchi Attenuate Atherosclerosis and Alzheimer’s Disease via Suppression of Endoplasmic Reticulum Stress

Minji Woo,Yeong Ok Song 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10