다기관 전향적 임상연구를 위한 웹 데이터베이스 시스템

김혜림,최신영,유은미,박지숙 서울여자대학교 2010 정보기술논문지 Vol.8 No.-

Because many centers jointly select the subject, multi-center clinical study can promptly recruit various patient groups into the research, thus being advantageous in terms of generalization. However, prospective clinical study has difficulties in implementation, because it takes a lot of efforts to trace a large scale of subjects. The purpose of this study is to develop a web database system suitable for multi-center prospective clinical study. This study has presented three basic strategies-accurate data input, easy data tracing, and real-time data verification-to supplement the demerits of prospective clinical study. The developed system has been applied in the clinical study proceeded by the study group for Respiratory failure which is affiliated to The Korean Academy of Tuberculosis and Respiratory Diseases's Association for Research on Respiratory Failure and has been verified of its performance.

아동의 사회적 문제해결능력과 어머니의 대화형태와의 관계연구

김재림,백은주,신유림,심미경,이혜경 연세대학교 생활과학대학 1985 婦學 Vol.18 No.-

The present study investigated the relationship between the social problem solving ability of children and the language patterns of their mothers. The subjects included 193 nine year­olds (185 girls, 108 boys), and 230 twelve year­olds (115 girls, 115 boys). The instruments used were a language patterns test for the mother and IPA (Interpersonal Problem Solving Ability Test) for children. Major finding from this study were: ⑴ the correlation between the social problem solving ability of children and the language patterns of their mothers was not statistically significant, ⑵ the language patterns of the mothers were significantly different by child's sex; for boys, mother used more ordered language patterns and for girls, mothers used more ordered language patterns and for girls, mothers used more human­oriented language patterns, ⑶ the social problem solving ability of children were significantly different by child's age; 12­year­olds exhibited higher ability than 9­year­olds.

성인간호학회지 논문(1989-2000)의 내용과 경향 분석

서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4

"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.

Development of Oriental Feed Additive of Broiler Chickens for Organic Livestock

Mi-rim Park,Ho-Jo Kang,Yong-hwan Kim,Jong-su Kim,Tae-sung Jung,Hui-guen Cha,Yong-seung Shin,Gee-wook Shin,Dae-yong Han,Sung-hyun Kang,Hang-hee Yang,Gon-sup Kim 대한수의학회 2003 대한수의학회 학술대회발표집 Vol.2003 No.-

Reference Map of Soluble Protenis from Salmonella enterica Serovar Enteritidis by Two-Dimensional Electrophoresis

김곤섭,Eung-goo Lee,Yong-hwan Kim,정태성,Yong-seung Shin,Gee-wook Shin,Hui-guen Cha,Mi-rim Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Map of Soluble Proteins from Salmonella enterica Serovar Enteritidis byTwo-Dimensional ElectrophoresisMi-rim Park, Eung-goo Lee, Yong-hwan Kim, Tae-sung Jung, Yong-seung Shin, Gee-wook Shin, Hui-guen Cha and Gon-sup Kim*Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, KoreaReceived May 17, 2003 / Accepted July 23, 2003J. Vet. Sci. (2003), 4(2), 143-149JOURNAL OFVeterinaryScience*Corresponding author: Gon-sup Kim Laboratory of Veterinary Biochemistry, Collage of Veterinary Medicine, Gyeongsang National University, 900 Gazwa, Jinju 660-701 Korea Tel: +82-55-751-5823, Fax: +82-55-751-5803 E-mail: gonskim@nongae.gsnu.ac.kr

한국 일 도서지역 인지기능과 우울간의 관계

신경림,김미영 노인간호학회 2001 노인간호학회지 Vol.3 No.1

This study was to investigate the prevalence and the affecting factors of cognitive function and depression among the elderly in an island community. The sample was collected from 116 elders who have 65 or more age. Subjects were tested for cognitive function with MMSE-K(Mini Mental State Examination- Korea) and depression with Yesavage' GDS(Geriatric Depression Scale). The main results were summarized as follows. 1. The prevalence rates of severe cognitive impairment were 19% and rate of mildly impaired was 18.1%. The mean score of depression was 5.39. 2. The variables such as sex, age, educational level, marital status had the significant differences with cognitive function impairment. The correlation between cognition level and ADL/IADL, sleep pattern showed statistical significance. 3. marital status had the significant differences with depression. The correlation between depression and ADL/IADL, physical disease showed statistical significance. 4. The correlation between cognitive function level and depression score showed negative significant relationship (r=-.258). 5. In the multiple stepwise regression, ADL/IADL age and sex were selected as highly correlated variables of cognitive function and the R² value for these variables was 48.1%. ADL/IADL and physical disease were selected as correlated variables of depression and the R² value for these variables was 11.3%. In conclusion, main variable which had close relation to the cognitive function and depression was ADL/IADL.

Impact of depression and activities of daily living on the fear of falling in Korean community‐dwelling elderly

Shin, Kyung Rim,Kang, Younhee,Kim, Mi Young,Jung, Dukyoo,Kim, Jeong Soo,Hong, Chong Min,Yun, Eun Suk,Ma, Rye Won Blackwell Publishing Asia 2010 NURSING AND HEALTH SCIENCES Vol.12 No.4

<P><B>Abstract</B></P><P>This study determined the predictors of the fear of falling (FOF) in 213 South Korean community‐dwelling elderly. The Fall Efficacy Scale, Pittsburgh Sleep Quality Index, Korean Geriatric Depression Screening Scale, and Barthel Index were used to measure the FOF, sleep quality, depression, and activities of daily living, respectively. In addition, information regarding the participants' demographic details and the number of types of medication was collected. The data were analyzed by using hierarchical regression. The general regression model, with the FOF as a dependent variable, was statistically significant. The FOF variance was partially explained. Depression and activities of daily living significantly influenced the FOF. Thus, the results indicate that the FOF in community‐dwelling elderly Koreans is affected by depression and activities of daily living. Therefore, an older adult with recognized signs of depression must be provided with more appropriate care and the allocation of specific interventional strategies in order to maintain activities of daily living should be developed to manage the FOF.</P>

F-76 : Free Paper Presentation ; Replication of Results of a Genome-wide Association Study on Lung Cancer Survival in a Korean Population

( Mi Young Kim ),( Seung Soo Yoo ),( Mi Jeong Hong ),( Hye Won Seo ),( Se Rim Oh ),( Keum Ju Choi ),( Shin Yup Lee ),( Jae Hee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Jae Yong Park 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Background: Recently, a genome-wide association study (GWAS) has identified single nucleotide polymorphisms (SNPs) which may influence the prognosis of early-stage non-small cell lung cancer (NSCLC) in Caucasians. We attempted to replicate the impact of genetic variants identified in the GWAS for lung cancer survival in a Korean population. Materials and Methods: Three hundred and sixty-three patients with surgically resected NSCLCs were enrolled. Twelve SNPs were genotyped by using SEQUENOM``s MassARRAYⓡ iPLEX assay, TaqMan assay, or a polymerase chain reaction-restriction fragment length polymorphism assay. The association between genotypes and overall survival (OS) was analyzed. Results: Among the 12 SNPs, rs6034368T>C was associated with OS. Patients with the rs6034368C allele showed better OS than the rs6034368T allele (adjusted hazard ratio=0.72, confidence interval=0.56-0.93, P=0.01). The rs12446308A>G had an effect on OS, with marginal significance (under a codominant model, adjusted hazard ratio=1.85, confidence interval=0.98-3.47, P=0.06). Conclusions: We identified that rs6034368T>C was associated with survival for early-stage NSCLC in a Korean population.Background: Recently, a genome-wide association study (GWAS) has identified single nucleotide polymorphisms (SNPs) which may influence the prognosis of early-stage non-small cell lung cancer (NSCLC) in Caucasians. We attempted to replicate the impact of genetic variants identified in the GWAS for lung cancer survival in a Korean population. Materials and Methods: Three hundred and sixty-three patients with surgically resected NSCLCs were enrolled. Twelve SNPs were genotyped by using SEQUENOM`s MassARRAYⓡ iPLEX assay, TaqMan assay, or a polymerase chain reaction-restriction fragment length polymorphism assay. The association between genotypes and overall survival (OS) was analyzed. Results: Among the 12 SNPs, rs6034368T>C was associated with OS. Patients with the rs6034368C allele showed better OS than the rs6034368T allele (adjusted hazard ratio=0.72, confidence interval=0.56-0.93, P=0.01). The rs12446308A>G had an effect on OS, with marginal significance (under a codominant model, adjusted hazard ratio=1.85, confidence interval=0.98-3.47, P=0.06). Conclusions: We identified that rs6034368T>C was associated with survival for early-stage NSCLC in a Korean population.

Comparison of antigenic proteins from <i>Lactococcus garvieae</i> KG (−) and KG (+) strains that are recognized by olive flounder (<i>Paralichthys olivaceus</i>) antibodies

Shin, Gee-Wook,Nho, Seong-Won,Park, Seong-Bin,Jang, Ho-Bin,Cha, In-Seok,Ha, Mi-Ae,Kim, Young-Rim,Dalvi, Rishikesh S.,Joh, Seong-Joon,Jung, Tae-Sung Elsevier 2009 Veterinary microbiology Vol.139 No.1

<P><B>Abstract</B></P><P><I>Lactococcus garvieae</I> is an important etiological agent of lactococcosis in various fish species including olive flounder (<I>Paralichthys olivaceus</I>). In this study, proteomic and immunoproteomic analyses were employed to compare the antigenic profiles of strains KG9408, MS93003, and NSS9310 strains of <I>L. garvieae</I>. Proteomic analysis using two-dimensional gel electrophoresis (2-DE) revealed differences in five protein spots among the different <I>L. garvieae</I> strains. In immunoproteomic analysis, there was a significant difference in the 2-DE immunoblot profiles of the <I>L. garvieae</I> strains using sera collected from fish surviving infection with either <I>L. garvieae</I> strains KG9408 or NSS9310. These sera reacted with 8 and 7 unique antigenic protein spots, respectively. Heat shock protein (HSP) 70 and DNA-directed RNA polymerase were among the specific antigens recognized by the anti-NSS9310 serum. In addition, the anti-NSS9310 and anti-KG9408 olive flounder sera reacted with 25 common antigenic protein spots of all the <I>L. garvieae</I> strains, which included elongation factor (EF)-Tu, arginine deiminase (AD), inosine-5′-monophosphate dehydrogenase (IMPD), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphomannomutase (PMM), <SMALL>L</SMALL>-lactate dehydrogenase (<SMALL>L</SMALL>-LDH), 6-phosphofructokinase and UDP-galactose 4-epimerase (UDP-galactose). Based on the present results, the 8 antigens recognized by the anti-KG9408 serum and the 25 common antigens recognized by both sera may serve as potential markers for developing an effective vaccine against this bacterium.</P>

Isolation and Identification of Entomopathogenic Fungus from the Pine Wilt Disease Vector, Monochamus alternatus Hope(Coleoptera: Cerambycidae) in Korea

Shin, Tae-Young,Choi, Jae-Bang,Bae, Sung-Min,Cha, Ye-Rim,Oh, Jeong-Mi,Koo, Hyun-Na,Woo, Soo-Dong Korean Society of Sericultural Science 2009 International Journal of Industrial Entomology Vol.18 No.2

Entomopathogenic fungi were isolated directly from a cadaver of adult Monochamus alternatus supporting fungal sporulation, using a semi-selective medium and then screened several fungal colonies. The pathogenicity of each fungus was tested using oak longicorn beetle, Moechotypa diphysis, as substitutive insect. As the result, only one of them showed high pathogenicity against M. diphysis, with up to 100% mortality within 21 days of inoculation. Selected fungus was named as MaW1 and identified by Beauveria bassiana using microscopic examination and DNA analysis. Pathogenicity was also evaluated to M. alternatus.