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Development of an electrochemical fentanyl nanosensor based on MWCNT-HA/ Cu-H3BTC nanocomposite
Maryam Akbari,Maryam Saleh Mohammadnia,Masoumeh Ghalkhani,Mohammad Aghaei,Esmail Sohouli,Mehdi Rahimi-Nasrabadi,Mohsen Arbabi,Hamid Reza Banafshe,Ali Sobhani-Nasab 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Fentanyl is a potent narcotic drug with the same effects as morphine or heroin, but it’s significantly morepotent than these drugs. That means a tiny dose can have a dangerous impact and is also lethal, so it isessential to measure it. In this work, we have developed a new electrochemical sensor to measure thisdeadly drug utilizing a nanocomposite of multi-walled carbon nanotube, hydroxyapatite, and copperbasedmetal–organic framework (MWCNT-HA/Cu-H3BTC). The nanocomposite was first examined byX-ray diffraction, field emission scanning electron, Infrared, and Raman spectroscopic techniques. Theglassy carbon electrode (GCE) modified with MWCNT-HA/Cu-H3BTC was employed to determine fentanylin aqueous solutions. The highest oxidation current was generated for fentanyl at GCE/MWCNT-HA/Cu-H3BTC compared to the GCE, GCE/MWCNT, GCE/MWCNT/HA, and GCE/Cu-H3BTC. The GCE/MWCNT-HA/Cu-H3BTC showed a linear relationship between the concentration and the oxidation current of fentanylin the 0.01 to 100 lM with a detection limit of 3 nM. Finally, the fentanyl quantification in blood serumsamples was successfully performed. The GCE/MWCNT-HA/Cu-H3BTC’s reproducibility and stability wereindeed excellent.
Elham Parsaeimehr,Mehdi Fartash,Javad Akbari Torkestani 한국지능시스템학회 2020 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.20 No.1
Named entity recognition and relation extraction are two principal tasks in most natural language processing systems. The majority of methods used in the field implement these two issues independently, thus leading to possible problems such as error propagation from one component (entity detection) to another (relation extraction). To solve such problems, we propose a new architecture for joint identification of entity mentions and their relation by employing a deep neural network framework. The model not only overcomes the error propagation challenge but also improves the detection results of both tasks owing to the cooperation with each other. Experiments on publicly available sources demonstrate that our joint model surpasses competitors in terms of accuracy. The results highlight the improvement achieved by the proposed deep neural network framework for the entity mention and relation classification tasks. Furthermore, we tested the effect of increasing the sentence length and demonstrated its negative influence on the performance.
Zare, Mohammad-Hossein,Biderang, Mehdi,Akbari, Alireza American Physical Society 2017 Physical Review B Vol.96 No.20
<P>We study the symmetry of the potential superconducting order parameter in 5d Mott insulators with an eye toward hole-doped Sr2IrO4. Using a mean-field method, a mixed singlet-triplet superconductivity, d + p, is observed due to the antisymmetric exchange originating from a quasi-spin-orbit coupling. Our calculation on ribbon geometry shows the possible existence of the topologically protected edge states, because of the nodal structure of the superconducting gap. These edge modes are spin polarized and emerge as zero-energy flat bands, supporting a symmetry-protected Majorana state, verified by evaluation of the winding number and Z(2) topological invariant. At the end, a possible experimental approach for observation of these edge states and determination of the superconducting gap symmetry is discussed based on the quasiparticle interference technique.</P>
Echocardiographic Assessment of Pulmonary Arteries Pulsatility Index in Fontan Circulation
Reza Shabanian,Mohammad Reza Mirzaaghayan,Minoo Dadkhah,Mehdi Hosseini,Mitra Rahimzadeh,Parvin Akbari Asbagh,Mohammad Ali Navabi 한국심초음파학회 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.4
Background: Late complications after Fontan procedure may be due to the absence of pump and pulsatile pulmonary blood flowin this type of palliation. Our aim was to quantify the degree of pulsation by echocardiographic method in patients with extracardiactotal cavopulmonary connection (ECTCPC) in comparison with biventricular circulation and few cases of pulsatile Fontan. Methods: In a case series study, pulsatility index (PI) derived by echocardiographic method were compared between 20 patientswith ECTCPC, 6 patients with pulsatile Fontan and 18 normal individual aged 4 to 20 years old. All patients were in New YorkHeart Association class of I and there was no report of complication. Results: In patients with ECTCPC pulmonary artery branches Doppler flow study showed lower peak and mean velocitiescompared to the pulsatile Fontan and normal groups. ECTCPC patients had PI of 0.59 ± 0.14 and 0.59 ± 0.09 for right and leftpulmonary arteries (RPA and LPA) respectively. PI was higher in patients with preserved antegrade flow (RPA PI = 0.94 ± 0.26,LPA PI = 0.98 ± 0.27) and in normal individuals (RPA PI = 1.59 ± 0.12, LPA PI = 1.64 ± 0.17) for both branches (p = 0.000). Conclusion: Using a Doppler derived index for pulsatility, patients with ECTCPC had the least pulsation. The pulmonary arteryflow pattern in patients with preserved antegrade flow showed higher pulsatility indices in both branches. Normal individualshad the greatest pulsatility index.
Anti-Toxoplasma Activities of Zea Mays and Eryngium Caucasicum Extracts, In Vitro and In Vivo
Ehsan Ahmadpour,Mohammad Ali Ebrahimzadeh,Mehdi Sharif,Sara Edalatian,Shahabeddin Sarvi,Mahbobeh Montazeri,Saeed Mehrzadi,Mohammad Akbari,Mohammad Taghi Rahimi,Ahmad Daryani 대한약침학회 2019 Journal of pharmacopuncture Vol.22 No.3
Objectives: Toxoplasmosis is a worldwide health problem that caused by intracellular apicomplexan parasite, Toxoplasma gondii (T. gondii). Considering that the available drugs for toxoplasmosis have serious host toxicity, the aim of the current study was to survey the in vitro and in vivo anti-Toxoplasma activity of Zea mays (Z. mays) and Eryngium caucasicum (E. caucasicum) extracts. Methods: Four concentrations (5, 10, 25, and 50 mg mL -1 ) of Z. mays and E. caucasicum methanolic extracts for 30, 60, 120, and 180 min were incubated with infected macrophages and then the viability of RH strain of T. gondii tachyzoites was evaluated by trypan blue staining method. Also, we evaluated the survival rate of acutely infected mice with the extracts (100 and 200 mg kg -1 day -1 ) intraperitoneally for 5 days after infection with 2× 104tachyzoites of T. gondii. Results: The anti-Toxoplasma effect of the methanolic extracts were extremely significant compared to the negative control group in all exposure times (P < 0.05). The Z. mays (10, 25 and 50 mg mL -1 ) killed 100% of the parasites after 180 and 120 min exposure, respectively. Also, high toxoplasmacidal activity was observed with E. caucasicum extract. Furthermore, treatment of experimentally infected mice with the Z. mays (100, 200 mg kg -1 day -1 ) and E. caucasicum (100 mg kg -1 day -1 ) significantly increased their survival rate compared to untreated infected control (P < 0.05). Conclusion: These extracts are promising candidates for further medicine development on toxoplasmosis. However, further investigations are necessary to clarify effective fractions of the Z. mays and E. caucasicum extracts and the mechanisms of action.
Improving the Chitinolytic Activity of Bacillus pumilus SG2 by Random Mutagenesis
( Majid Vahed ),( Ebrahim Motalebi ),( Garshasb Rigi ),( Kambiz Akbari Noghabi ),( Mohammad Reza Soudi ),( Mehdi Sadeghi ),( Gholamreza Ahmadian ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.11
Bacillus pumilus SG2, a halotolerant strain, expresses two major chitinases designated ChiS and ChiL that were induced by chitin and secreted into the supernatant. The present work aimed to obtain a mutant with higher chitinolytic activity through mutagenesis of Bacillus pumilus SG2 using a combination of UV irradiation and nitrous acid treatment. Following mutagenesis and screening on chitin agar and subsequent formation of halos, the mutated strains were examined for degradation of chitin under different conditions. A mutant designated AV2-9 was selected owing to its higher chitinase activity. To search for possible mutations in the whole operon including ChiS and ChiL, the entire chitinase operon, including the intergenic region, promoter, and two areas corresponding to the ChiS and ChiL ORF, was suquenced. Nucleotide sequence analysis of the complete chitinase operon from the SG2 and AV2-9 strains showed the presence of a mutation in the catalytic domain (GH18) of chitinase (ChiL). The results demonstrated that a single base change had occurred in the ChiL sequence in AV2- 9. The wild-type chitinase, ChiL, and the mutant (designated ChiLm) were cloned, expressed, and purified in E. coli. Both enzymes showed similar profiles of activity at different ranges of pH, NaCl concentration, and temperature, but the mutant enzyme showed approximately 30% higher catalytic activity under all the conditions tested. The results obtained in this study showed that the thermal stability of chitinase increased in the mutant strain. Bioinformatics analysis was performed to predict changes in the stability of proteins caused by mutation.
A Scoping Review of Components of Physician-induced Demand for Designing a Conceptual Framework
Marita Mohammadshahi,Shahrooz Yazdani,Alireza Olyaeemanesh,Ali Akbari Sari,Mehdi Yaseri,Sara Emamgholipour Sefiddashti 대한예방의학회 2019 Journal of Preventive Medicine and Public Health Vol.52 No.2
Objectives: The current study presents a new conceptual framework for physician-induced demand that comprises several influential components and their interactions. Methods: This framework was developed on the basis of the conceptual model proposed by Labelle. To identify the components that influenced induced demand and their interactions, a scoping review was conducted (from January 1980 to January 2017). Additionally, an expert panel was formed to formulate and expand the framework. Results: The developed framework comprises 2 main sets of components. First, the supply side includes 9 components: physicians’ incentive for pecuniary profit or meeting their target income, physicians’ current income, the physician/population ratio, service price (tariff), payment method, consultation time, type of employment of physicians, observable characteristics of the physician, and type and size of the hospital. Second, the demand side includes 3 components: patients’ observable characteristics, patients’ non-clinical characteristics, and insurance coverage. Conclusions: A conceptual framework that can clearly describe interactions between the components that influence induced demand is a critical step in providing a scientific basis for understanding physicians’ behavior, particularly in the field of health economics.