Optimization Model of Reliable Data Storage in Cloud Environment Using Genetic Algorithm

Feng Liu,Haitao Wu,Xiaochun Lu,Xiyang Liu 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.6

Massive data storage is one of the great challenges for cloud computing service, and reliable storage of sensitive data directly affects quality of storage service. In this paper, based on analysis of data storage process in cloud environment, the cost of massive data storage is considered to be comprised of data storage price, data migration and communication; and the storage reliability consists of data transmission reliability and hardware dependability. A multi-objective optimization model for reliable massive storage is proposed, in which storage cost and reliability are the objectives. Then, a genetic algorithm for solving the model is designed. Finally, experimental results indicate that the proposed model is positive and effective.

Population Genetic Structure of Liza affinis (Eastern Keelback Mullet), Reveals High Gene Flow Inferred from Microsatellite Analysis

Lu Liu,Xiumei Zhang,Dianrong Sun,Tianxiang Gao,Na Song 한국해양과학기술원 2019 Ocean science journal Vol.54 No.2

The population genetic studies of marine fishes usually show complex patterns of genetic differentiation which were influenced by both historical process and contemporary gene flow. Genetic structure of eight different populations for eastern keelback mullet, Liza affinis, collected from the coast along eastern and southern China, was examined using six microsatellite loci. We found strong genetic similarities among most of the samples except the Dongguan population and most microsatellite variation was found within populations. All loci were characterized by high genetic variability with expected heterozygosities ranging from 0.871 to 0.928. The Bayesian cluster analysis of the microsatellite data detected four genetic groups with no relation to geographic areas. The bottleneck results also showed no significant values. Based on these data we postulated that complex marine currents and larval dispersal shaped the genetic structured of studied populations. The present study illustrated the importance of understanding the biological significance of genetic differentiation when using molecular data in identifying units for management and protection.

Esophageal/Gastric Cancer Screening in High-risk Populations in Henan Province, China

Lu, Yu-Fei,Liu, Zhi-Cai,Li, Zhong-Hong,Ma, Wen-Hao,Wang, Fu-Rang,Zhang, Ya-Bing,Lu, Jian-Bang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Objective: To summarize the endoscopic screening findings in high-risk population of esophageal and gastric carcinoma and analyze influential factors related to screening. Methods: In seven selected cities and counties with high incidences of esophageal carcinoma, people at age of 40-69 were set as the target population. Those with gastroscopy contradictions were excluded, and all who were voluntary and willing to comply with the medical requirements were subjected to endoscopic screening and histological examination for esophageal, gastric cardia and gastric carcinoma in accordance with national technical manual for early detection and treatment of cancer. Results: In three years, 36,154 people were screened, and 16,847 (46.60%) cases were found to have precancerous lesions. A total of 875 cases were found to have cancers (2.42%), and among them 739 cases had early stage with an early diagnosis rate is 84.5%. Some 715 patients underwent prompt treatment and the success rate was 81.8%. Conclusions: In a high-risk population of esophageal and gastric carcinoma, it is feasible to implement early detection and treatment by endoscopic screening. Screening can identify potential invasive carcinoma, early stage carcinoma and precancerous lesions, improving efficacy through early detection and treatment. The exploratory analysis of related influential factors will help broad implementation of early detection and treatment for esophageal and gastric carcinoma.

Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta.

Liu, Meng-Lu,Liu, Ming-Jie,Shen, Yan-Fei,Ryu, Hoon,Kim, Hyeon-Jin,Klupsch, Kristina,Downward, Julian,Hong, Seong-Tshool Cambridge University Press 2009 Journal of cell science Vol.122 No.11

<P>The cellular generation of toxic metabolites and subsequent detoxification failure can cause the uncontrolled accumulation of these metabolites in cells, leading to cellular dysfunction. Amyloid-beta protein (Abeta), a normal metabolite of neurons, tends to form toxic oligomeric structures that cause neurodegeneration. It is unclear how healthy neurons control the levels of intracellular oligomeric Abeta in order to avoid neurodegeneration. Using immunochemical and biochemical studies, we show that the Abeta-binding serine protease Omi is a stress-relieving heat-shock protein that protects neurons against neurotoxic oligomeric Abeta. Through its PDZ domain, Omi binds preferentially to neurotoxic oligomeric forms of Abeta rather than non-toxic monomeric forms to detoxify oligomeric Abeta by disaggregation. This specific interaction leads not only to mutual detoxification of the pro-apoptotic activity of Omi and Abeta-induced neurotoxicity, but also to a reduction of neurotoxic-Abeta accumulation. The neuroprotective role of Omi is further supported by its upregulation during normal neurogenesis and neuronal maturation in mice, which could be in response to the increase in the generation of oligomeric Abeta during these processes. These findings provide novel and important insights into the detoxification pathway of intraneuronal oligomeric Abeta in mammals and the protective roles of Omi in neurodegeneration, suggesting a novel therapeutic target in neurodegenerative diseases.</P>

Inhibitory effect of StCYP707A1 gene on tuberization in transgenic potato

Lu Liu,Rui-Jie Zhang,Wen-jiao Zhu,Xin-Ru Liu,Ke Shi,Min Chen,Qing Yang 한국식물생명공학회 2017 Plant biotechnology reports Vol.11 No.4

Tuber formation of potato is a complex biological process and is regulated by many factors including phytochrome, hormones, transcription factors, RNAs, microRNAs, etc. In our previous study, CYP707A1, an ABA 80-hydroxylase gene, was down-regulated in the StCOL antisense transgenic potato stolons, but its relation with potato tuberization has not been studied yet. In this study, to investigate the role of this gene in potato tuberization, we cloned a CYP707A1 gene from potato cultivar De ´sire ´e and constructed the StCYP707A1 over-expression and anti-sense potato lines by Agrobacterium-mediated transformation. In total, four over-expression transgenic lines and nine anti-sense transgenic lines were confirmed by PCR analysis. Semi-quantitative RT-PCR and qRTPCR analysis showed that the level of StCYP707A1 transcripts was significantly higher in the over-expression lines (A7 and A9) and lower in the anti-sense lines (F2 and F8), compared to the wild-type control. We further analyzed tuber formation in the transgenic lines and the wild-type control. The result showed that tuber yield per plant and average tuber weight were decreased in A7 and A9 and increased in F2. We also measured the content of ABA and GA3 in transgenic lines. ABA level was reduced in A7 and A9 and increased in F2. Contrariwise, the concentration of GA3 was higher in A7 and A9, and lower in F2 than in wild-type control. These results indicate that StCYP707A1 negatively affects potato tuberization through ABA regulation on gibberellic acid concentration.

Theoretical Study on Interactions between N-Butylpyridinium Nitrate and Thiophenic Compounds

Lu, Renqing,Liu, Dong,Wang, Shutao,Lu, Yukun Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.6

By using density functional theory calculations, we have performed a systemic study on the electronic structures and topological properties of interactions between N-butylpyridinium nitrate ($[BPY]^+[NO_3]^-$) and thiophene (TS), benzothiophene (BT), dibenzothiophene (DBT), naphthalene (NAP). The most stable structure of $[BPY]^+[NO_3]^-$ ion pair indicates that hydrogen bonding interactions between oxygen atoms on $[NO_3]^-$ anion and C2-H2 on pyridinium ring play a dominating role in the formation of ion pair. The occurrence of hydrogen bonding, ${\pi}{\cdots}$H-C, and ${\pi}{\cdots}{\pi}$ interactions between $[BPY]^+[NO_3]^-$ and TS, BT, DBT, NAP has been corroborated at the molecular level. But hydrogen bonding and ${\pi}{\cdots}{\pi}$ interactions between $[BPY]^+[NO_3]^-$ and NAP are weak in terms of structural properties and NBO, AIM analyses. DBT is prior to adsorption on N-butylpyridinium nitrate ionic liquid.

A Review of Industrial MIMO Decoupling Control

Lu Liu,Siyuan Tian,Dingyu Xue,Tao Zhang,YangQuan Chen,Shuo Zhang 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5

In recent decades, MIMO (Multi-Input-Multi-Output) systems become more and more widely used inindustrial applications. A variety of decoupling control algorithms have been studied in the literature. Therefore,a review of the most extensively applied coupling interaction analysis and decoupler design methods for industrialprocesses is necessary to be carried out. In this paper, in order to benefit researchers and engineers with differentacademic backgrounds, the scattered coupling interaction analysis and decoupling algorithms are collectedand divided into different categories with their characteristics, application domains and informative comments forselection. Moveover, some frequently concerned problems of decoupling control are also discussed.

Study on Importance Function for Particle Filter

Liu Lu,Meng Yang,Shu Geng,Shu-fen Wang,Yong-hui Wang 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.2

As an important nonlinear filter theory, particle filter is a heated issue in domestic and foreign researches. The option of importance density is one of the key steps of particle filter algorithm. The proper option of importance density can minish the negative influence of filter algorithm caused by degeneracy problem. This paper introduces several widely-used options of importance density systemically, and analyzes their features and applied perspectives respectively. The paper also advances a comprehensive method of importance density, analyzes its technical features, explores the adjudgement and improvement of this method based on various performance, and finally puts forward the necessary further study according to the engineer requirements.

Circ_0026359 induces HOXA9 to regulate gastric cancer malignant progression through miR‑140‑3p

Lu Shuirong,Lu Jinlai,Liu Lang,Sun Yilong,Zhao Yixuan,Tan Xi,Li Jingze 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.4

Recent researches indicate the key role of circRNA in gastric cancer (GC) progression. However, the role of circ_0026359 in GC progression remains unclear. This study aims to analyze the role of circ_0026359 in GC development and the underlying mechanism. The results showed that compared with controls, GC tissues and cells displayed high circ_0026359 and HOXA9 expression, and low miR-140-3p expression. Depletion of circ_0026359 repressed cell proliferation, migration, invasion and glycolysis, and induced cell apoptosis. Circ_0026359 knockdown inhibited neoplasm growth in vivo. Under-expression of miR-140-3p, a target miRNA of circ_0026359, relieved the effects of circ_0026359 knockdown on GC progression. Additionally, HOXA9 was regulated by the circ_0026359/miR-140-3p axis. Thus, circ_0026359 absence inhibited GC progression by miR-140-3p/HOXA9 pathway, which provided an effective therapeutic target for GC.

Effect of nano-composite materials on repair of ligament injury in sports detoxification

Lu, Chunxia,Lu, Gang,Dong, Weixin,Liu, Xia Techno-Press 2022 Advances in nano research Vol.13 No.3

Extraordinary properties of nanocomposites make them a primary replacement for many conventional materials. Anterior cruciate ligament (ACL) reconstruction, which is a frequent surgery in sport activities, is one of the fields in which nanocomposites could be utilized. In the present study, the mechanical properties of different porous scaffolds made from graphene nano-composites are presented ad load bearing capacity of these materials is calculated using finite element method. The numerical results are further compared with experimental published data. In addition, several geometrical and material parameters are analyzed to find the best configuration of nanocomposite scaffolds in reconstruction of ACL. Moreover, coating of detoxification chemicals are extremely easier on the nano-structured materials than conventional one. Detoxification potential of nano-composites in the injured body are also discussed in detail. The results indicated that nano-composite could be successfully used in place of auto- and allografts and also instead of conventional metallic screws in reconstruction of ACL.