¹³¹I-labeled chitosan hydrogels for radioembolization: A preclinical study in small animals

Hwang, H.,Kim, K.I.,Kwon, J.,Kim, B.S.,Jeong, H.S.,Jang, S.J.,Oh, P.S.,Park, H.S.,Lim, S.T.,Sohn, M.H.,Jeong, H.J. Pergamon Press 2017 Nuclear medicine and biology Vol.52 No.-

<P>Advances in knowledge: Transarterial embolization is a conceivable treatment option for patients with inoperable liver cancer to mitigate the disease progression. Recently, we have developed chitosan-based hydrogel microparticles. In the present study, the hydrogel microparticles were radiolabeled with I-131 for treatment of liver cancer. Our results demonstrated that a hepatic arterial injection of I-125 -labeled Chi resulted in substantial liver accumulation, which was accompanied by virtually no extrahepatic deposition. The results of the present study also showed that administration of I-131 Chi markedly suppressed tumor growth, compared to controls and to animals receiving unlabeled Chi. I-131 -labeled chitosan hydrogel microparticles represent a new therapeutic approach for treatment of liver cancer. (C) 2017 Elsevier Inc. All rights reserved.</P>

I발표장 : 촉매 및 반응공학2 ; I-54 : 일산화탄소의 선택산화반응용 CuO-CeO2 촉매의 활성에 미치는 귀금속 첨가 효과

정창렬 ( C. R. Jung ),한종희 ( J. Han ),남석우 ( S. W. Nam ),임태훈 ( T. -h. Lim ),홍성안 ( S. -a. Hong ),이호인 ( H. -i. Lee ) 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1

Performance evaluation for dual circulating fluidized-bed steam gasifier of biomass using quasi-equilibrium three-stage gasification model

Ngo, S.I.,Nguyen, T.D.B.,Lim, Y.I.,Song, B.H.,Lee, U.D.,Choi, Y.T.,Song, J.H. Applied Science Publishers 2011 APPLIED ENERGY Vol.88 No.12

The effects of gasification temperature (T<SUB>G</SUB>) and steam to fuel ratio (γ) on product gas composition and yield were experimentally investigated for steam gasification of pine woodchips in a bench-scale circulating fluidized-bed (CFB) gasifier with external heat supplier. To evaluate process performance in a dual circulating fluidized-bed (DFB) with heat carrier (silica sand), a quasi-equilibrium three-stage gasification (qETG) model was developed and validated with experimental data of biomass steam gasification. The model was divided into three stages including biomass pyrolysis, char-gas reactions, and gas-phase reactions. Carbonic and methane formation ratios were considered at the pyrolysis stage under the assumption of spontaneous decomposition. At the second and third stages, char-gas and gas-phase equilibrium reactions were corrected by two empirical equations concerning the steam participation ratio and the non-equilibrium factor, respectively. Using the qETG model, parametric study on T<SUB>G</SUB> and γ was performed to predict final gas composition, carbon conversion, char residue, gas yield, lower heating value, additional fuel ratio, solid circulation ratio, heat recovery and H<SUB>2</SUB> to CO molar ratio. Focusing on the solid circulation ratio and H<SUB>2</SUB>/CO molar ratio, several effective operating conditions were suggested from the contour of performance criteria.

14.6 A GeV ^28Si 중이온이 원자핵건판내에서 발생시킨 핵반응에서 생성된 2차입자의 발생각 분포

김종오,김태연,남신우,신택수,우종관,이세병,임계엽,장세덕,조재희,천병구,임인택,김기영 慶尙大學校 기초과학연구소 1990 基礎科學硏究所報 Vol.6 No.-

14.6A GeV^28Si 중이온이 원자핵 건판내에서 발생시킨 N_h=1인 핵반응에서 생성된 47개의 파쇄 α 입자와 537개의 단일하전 2차입자의 발생각들을 측정하여 변수 exp(γ-η_b)의 포괄적 분포를 회귀함수 dN=exp[a+χ{exp(γ-η_b)d{exp(γ-η_b)}로 적합시켰다. 여기서 의사신속도 γ=arctanh(cosθ)=-ln tan(θ/2)이고, 입사 중이온의 신속도 η_b=3.445이다. 그 적합결과 파쇄 α입자의 경우 χ=-0.052±0.011이고, 파쇄 p입자의 경우 χ=-0.141±0.015이었다. For LS emission angles of 47 α fragments and 537 single-charged shower particles, produced by the N_h (the number of heavyprongs)=1 interactions of 14.6 A GeV^28Si nuclei in the nuclear emulsion, the distribution of the parameter exp(γ-η_b) is well expressed by dN=exp[a+χ{exp(γ-η_b)d{exp(γ-η_b)}with χ=-0.052±0.011 for αfragments and χ=-0.141±0.015 for p 'fragments', where the pseudorapidity of secondaries γ=arctanh(cosθ)=-ln tan(θ/2) and the rapidity of incident heavy ions, η_b=3.445.

1.88A GeV ^56Fe 중이온에 의해 원자핵건판 내에서 회절들뜸 및 준회절들뜸 기구로 생긴 다중발생

김종오,김태연,천병구,박인곤,송진섭,윤천실,박상렬,이경언,김재률,김태익,박명렬,임인택,장한일,박복남 慶尙大學校 기초과학연구소 1990 基礎科學硏究所報 Vol.6 No.-

원자핵건판 내에서 1.88A GeV의 에너지를 갖는 ^56Fe 중이온(heavy ion)의 평균자유행로는 비적추적법(along-the-track scanning method)을 사용하여 8.01±0.27㎝로 측정되었다. ^56Fe 주이온에 의한 회절들뜸반응을 KHP 판정법으로 찾아내었으며, 회절들뜸반응에 대한 평균자유행로는 0.86±0.10m로 측정되었다. 입사중이온의 정지계 내에서 ^56Fe 중이온에 의한 80개의 회절들뜸 및 준회절들뜸반응에 대한 알파입자와 단일하전 입자의 의사신속도 분포는 각각 (γ_a-η_b)_max=3.31, (γ_a-η_b)_max=2.30에서 최대값을 갖는 가우스분포함수 형태를 이루었다. By employing the method of along-the -track scanning. the mean free path of inelastic collisions for 1.8A GeV^56Fe heavy ion in nuclear emulsion is measured to be 8.01±0.27㎝. "Diffractive Excitation" events are identified by using the KHP method and the mean free path of diffractive excitation is measured to be 0.86±0.10m. The distributions of pseudorapidities of alpha and singly-charged fragments for diffractive excitation of 1.88A GeV ^Fe heavy ion are well fitted by Gaussian distribution function with peaks having (γ_a-η_b)_max=3.30 and (γ_p-η_b)_max=2.24.

200 GeV/핵자 유황이온과 핵건판핵의 충돌에 의해 생성된 헬륨 파쇄핵의 극한파쇄 연구

김동철,송진섭,윤천실,정성헌,박인곤,김종오,김철수,김태연,이승희,조재희,천병구,김재률,김준원,김태익,박명렬,장한일,임인택 慶尙大學校 기초과학연구소 1992 基礎科學硏究所報 Vol.8 No.-

고에너지 중이온 원자핵과 핵건판의 충돌에서, 200GeV/핵자 유황이온에 의해 생성된 파쇄 헬륨핵(Z=2)의 실험실계의 방출각 분포는 표적핵에 무관한 회귀공식. dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)]로 잘 표현된다. 여기에서 의사신속도 η=-ln[tan(θ/2)]이고, y_b는 실험실계의 입사입자(^32S)의 신속도이다. 이 공식에 의한 적합에서 k=-0.057±0.008로 얻어진다. 즉, 핵건판과 고에너지 중이온의 충돌에서 파쇄 헬륨핵의 exp(η-y_b)의 분포는 "극한파쇄" 현상을 잘 설명하고 있다. The angular distribution of emission angle θ of helium (Z=2) produced in the collisions of incident particles of 200 GeV/nucleon ^32S in nuclear emulsion is well expressed by dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)] where the pseudorapidity is η=-ln[tan(θ/2)], the laboratory system primary rapidity is y_b, and k=-0.057+0.008. The shape of this frequency of occurrence distributions in terms of exp(η-y_b) attests to the validity of the concept of "limiting fragmentation" for helium projectile fragments produced in the projectile fragmentation regions of heavy ion collisions in nuclear emulsion.

사중극 질량 분석기의 이온소스 오염이 이온전류에 미치는 영향

이규찬,박창준,김진태,오은순,홍기성,홍승수,임인태,윤주영,강상우,신용현,Lee, K.C.,Park, C.J.,Kim, J.T.,Oh, E.S.,Hong, K.S.,Hong, S.S.,Lim, I.T.,Yun, J.Y.,Kang, S.W.,Shin, Y.H. 한국진공학회 2009 Applied Science and Convergence Technology Vol.18 No.3

The long term stability of ion current of QMS has been one of key parameters for monitoring gas process in vacuum. The time dependence of ionic current was monitored while the pressure of nitrogen gas was kept at a fixed pressure by introducing the gas into vacuum chamber. The chamber was evacuated to ${\sim}3{\times}10^{-9}\;Torr$ to reduce background signals before the measurement. Two ion sources were tested; one had brownish or black color due to gas contamination and the other one was new, i.e. cleaner. At a nitrogen pressure of $1{\times}10^{-5}\;Torr$, the ionic currents measured by the contaminated ion source decreased faster with time. The decrease rate was respectively ${\sim}46%$ for cleaner one and ${\sim}84%$ for contaminated one after ${\sim}5.5%$ hours. In order to test the effect of filament material on the ion current decrease, we fabricated a tungsten(W) filament which consisted of two parts; one half was made of W and the other was coated with yttria. The similar decrease of ionic currents were shown for the two types of filaments, indicating that slight change of temperature of filament due to material difference i.e. baking effect could not improve the origin of ionic current decrease. Overall the decreasing rate of ionic current is more closely associated with contaminated ion source of QMS rather than its filament materials. 사중극 질량분석기(Quadrupole Mass Spectrometer, QMS) 이온전류의 안정성은 진공공정 가스를 모니터링 하는데 중요한 요소 중 하나이다. 진공챔버에 질소가스를 주입하여 압력을 일정하게 유지하면서 시간에 따른 이온전류의 변화를 모니터링 하였다. 진공챔버는 측정하기 전에 잡음신호를 줄이기 위해 ${\sim}3{\times}10^{-9}\;Torr$ 까지 배기하였고, 두개의 이온소스를 측정했다; 하나는 오염된 것으로 갈색 또는 검은색을 띄고 있고 다른 하나는 새 것이다. 질소 압력 $1{\times}10^{-5}\;Torr$에서, 오염된 이온소스의 이온 전류는 시간이 지남에 따라 더 빨리 감소했다. 대략 5.5 시간이 지난 후, 감소율은 새 것이 ${\sim}46%$이고 오염된 것은 ${\sim}84%$였다. 필라멘트 재질이 이온 전류감소에 미치는 영향을 관찰하기 위해서 텅스텐 선의 반을 산화이트륨($Y_2O_3$)으로 코팅하여 필라멘트를 제작하였다. 유사한 이온전류 감소현상이 재질이 다른 두 필라멘트에서 나타났는데 이것은 필라멘트 재질에 의한 온도의 변화 즉 baking 효과로는 이온전류 감소의 원인을 개선할 수 없다는 것을 의미한다. 전반적으로 이온전류의 감소율은 필라멘트 재질보다 이온소스의 오염과 더 밀접하게 관계되어 있다.

2-Dehydroemetine hydrochloride(Ro 1-9334)에 依한 肺吸蟲症 臨床治療 成績

임영찬,柳浩濬,金應瑞,金元一,李炫,朴柄宰,蘇鎭卓 中央醫學社 1964 中央醫學 Vol.6 No.2

44 cases of paragonimiasis were admitted in 121 Army Hospital for the clinical trial with the drug, dehydroemetine hydrochloride. Dehydroenietine hydrochloride was administered to 19 cases with the doses of 1 mg/kg of body weight/day for 10 days, and second course of 13 day administration was followed after 12 day rest. The remain of cases were applied as control group for emetine-HCI, astiban, and 5% glucose solution. The result of the trial are summarized as follows; 1) 15 out of 19 cases showed decrease of E.P.D. (egg per day) after the second course. 3 converted. to egg negative and 5 showed complete disappearance of blood sputum. 2) Three cases showed radiological improvement in X-ray picture. 3) Blood pressure, red cell sedimentation rate, and white blood cell count became worse at the beginning of the administration of the drug in several cases with short duration, then continued to be with in the normal range of their values until after the second course. 4) Electrocardiographic changes were very slight in several cases, but recovered to normal in 1-'2 weeks after the administration of the second course. 5) Systemic side effects were practically absent. 6) No improvement of symptoms was observed in 2 cases administered with astiban, 3 cases with emetine-HCI, and 20 cases with 5% glucose as control.

포유자돈용 인큐베이터 개발

임정택,장동일,한원석 한국농업기계학회 2001 바이오시스템공학 Vol.26 No.4

The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells

Kim, S-H,Kim, E-J,Hitomi, M,Oh, S-Y,Jin, X,Jeon, H-M,Beck, S,Jin, X,Kim, J-K,Park, C G,Chang, S-Y,Yin, J,Kim, T,Jeon, Y-j,Song, J,Lim, Y C,Lathia, J D,Nakano, I,Kim, H Macmillan Publishers Limited 2015 CELL DEATH AND DIFFERENTIATION Vol.22 No.9

Glioblastomas (GBMs) maintain their cellular heterogeneity with glioma stem cells (GSCs) producing a variety of tumor cell types. Here we interrogated the oncogenic roles of Lim domain only 2 (LMO2) in GBM and GSCs in mice and human. High expression of LMO2 was found in human patient-derived GSCs compared with the differentiated progeny cells. LMO2 is required for GSC proliferation both in vitro and in vivo, as shRNA-mediated LMO2 silencing attenuated tumor growth derived from human GSCs. Further, LMO2 is sufficient to induce stem cell characteristics (stemness) in mouse premalignant astrocytes, as forced LMO2 expression facilitated in vitro and in vivo growth of astrocytes derived from Ink4a/Arf null mice and acquisition of GSC phenotypes. A subset of mouse and human GSCs converted into vascular endothelial-like tumor cells both in vitro and in vivo, which phenotype was attenuated by LMO2 silencing and promoted by LMO2 overexpression. Mechanistically, the action of LMO2 for induction of glioma stemness is mediated by transcriptional regulation of Jagged1 resulting in activation of the Notch pathway, whereas LMO2 directly occupies the promoter regions of the VE-cadherin gene for a gain of endothelial cellular phenotype. Subsequently, selective ablation of human GSC-derived VE-cadherin-expressing cells attenuated vascular formation in mouse intracranial tumors, thereby significantly prolonging mouse survival. Clinically, LMO2 expression was elevated in GBM tissues and inversely correlated with prognosis of GBM patients. Taken together, our findings describe novel dual roles of LMO2 to induce tumorigenesis and angiogenesis, and provide potential therapeutic targets in GBMs.