A Case of a Gallbladder Infarction after Transcatheter Arterial Chemoembolization, Recovered with Only Medical Treatment

Yena Kang,Eun-Jung Kim,Young Seok Kim,Sang Gyune Kim,Jae Myeong Lee2,Boo Sung Kim 순천향대학교 순천향의학연구소 2015 Journal of Soonchunhyang Medical Science Vol.21 No.2

Transcatheter arterial chemoembolization (TACE) is suitable treatment method of hepatocellular carcinoma (HCC) for patients with decreased underlying liver function or unresectable disease. But this procedure can induce some embolic events. We report a case of a gallbladder infarction caused by the embolic event in TACE procedure. A 61-year-old man had been going to undergo 6th TACE for marginal recurrence of HCC. After the procedure, gallbladder infarction occurred and was detected by abdominal computed tomography (CT) scan for response evaluation of the treatment at out-patient-clinic. Then, he was treated with oral antibiotics and conservative therapy at out-patient clinic. In 6th week after the event, abdominal CT scan showed improved state of gallbladder.

EEG and EMG recording system for sleep study with a freely moving rat

Youjin Lee,Yena Lee,Seoyoung Hwang,Hee Soo Jeong,Yunjin Kim,Yunbin Lee,Jihoo Lee,Seoyeon Park,Sang Beom Jun 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7

Sleep is known to play an important role in cognitive functions as well as in physical recovery. Especially, high-quality sleep is closely associated with smooth sleep cycles between NREM (non-rapid eye movement) and REM (rapid eye movement) sleep. It is well known that both sleep stages show clear distinction in electroencephalogram (EEG) and electromyogram (EMG) signals. Therefore, as a first step for sleep study with rodents, a sleep monitoring system must be established for stable measurement of EEG and EMG. There are two challenges for the setup. First, animals should be able to freely move without interruption of EEG or EMG recording cable, so that their natural behavior and sleep can occur. Second, long-term EEG and EMG should be recorded stably. Also, the movements of animals can cause a cable tension and moving artifacts. The movement-related artifacts can interfere with judgment of sleep stages. Also, rodent gnawing of the recording cable frequently leads to early termination of sleep study. In this study, in order to overcome these problems, acrylic cages were developed for sleep monitoring which can minimize the interruption of cables and the artifacts. Principle of lever mechanics is applied to rotational cover of the cage, and it rotates vertically in synchronization with rat’s movement. When the rat stand up, the cage cover opens up to prevent the cable from loosening. Therefore, cable tension can be stably maintained, allowing the rat to move freely without causing artifact. As a result, long-term EEG and EMG recordings are successful performed, and specific characteristics of each sleep stages can be extracted due to the high-quality recorded signals. We expected that the developed sleep monitoring setup can be applied to various long-term in vivo experiments with rats.

개의 정서발달을 위한 웨어러블 디바이스, GATWALK

이예나(Yena Lee),이지은(Jieun Lee),이장희(Janghee Lee),조휴담(Hudam Cho),최인홍(Inhong Choi),김진우(Jinwoo Kim) 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.12

국내 애견 관련 산업은 2012 년 기준 이미 2 조원이라는 큰 시장을 형성하였고, 국내의 애완동물을 키우는 인구수는 1,000 만 명에 육박한다. 앞으로도 애견 관련 산업은 지속적으로 성장할 것으로 예상된다. 그런데 많은 애견인들은 바쁜 라이프 스타일 때문에 애견을 충분히 돌보지 못하고 있다. 애견의 분리불안 증세나 우울증 등의 문제를 해결하기 위하여 애견 유치원, 호텔, 애견용 TV 채널 등 다양한 해결책이 나왔으나 아직 획기적인 해결책은 나오지 않았다. 우리는 이 문제에 주목하여 ‘애견의 정서발달을 쉽게 관리할 수 있는 웨어러블 디바이스’인 GATWALK (개 + Network + Walk 의 합성어)를 기획하였다. The market of pet industry is formed as big as about 16 billion dollars, and the population of pet holder reaches 10 million in Korea. And it’s expected to be growing. But many of pet holders are not able to take good care of their pets because of hectic lifestyle. In this context, we designed GATWALK, a wearable device that helps pet to have better emotional status and relationship with the pet owner.

농식품 환경 분야(PF) : PF-11 ; 인체 혈시료 중 잔류 농약 biomonitoring 주요 현황

이현숙 ( Hyun Sook Lee ),경예나 ( Yena Kyung ),이동석 ( Dong Suk Lee ),이상목 ( Sang Mok Lee ),정지윤 ( Ji Yun Jung ),장문익 ( Moon Ik Chang ),이은주 ( Eun Ju Lee ),이규식 ( Gyu Seek Rhee ) 한국환경농학회 2014 한국환경농학회 학술대회집 Vol.2014 No.-

Biomonitoring using sample derived from human has been conducted in several countries. Most researches have traced organochloride insecticides which were banned since 1970s as endocrine distributor. Recently, researchers has conducted biomonitoring using urine and blood in human. Urine sample is difficult to calculate quantitative amount of pesticide because of metabolism in the kidney. It is also influenced by intake of waters or other factors. Blood is a regulated fluid and its volume does not vary virtually with water intake or other factors. Pesticides in the blood measured at a specified time interval after exposure will remain the same as long as the absorbed amounts are constant. Blood measurement provide and estimation of the dose available for the target site, allowing for prediction of dose-responserelationships. Blood concentrations of the pesticides are usually at a maximum directly after exposure, so if exposure events are known, the preferred time range for sampling may be clearer than with urine. But It has disadvantage also, when we sampling the human blood, it is needed to venipuncture. The amount of blood is influenced by collector’s techniques. In this study, we indicated that the results of biomonitoring researches and its methods using human blood. We also compared abroad and domestic research and its methods. It will contribute to improve domestic researches of residual amounts of pesticides in biomonitoring using human blood.

The SufS-SufU Complex Mediating Extracellular Cysteine-cystine Recycling in Fervidobacterium islandicum AW-1 is Associated with Keratin Degradation

Hyeon-Su JIN,Yena LEE,Immanuel DHANASINGH,Jae Yoon SUNG,Jae Won LA,Eun Mi LEE,Yujin KANG,Do Yup LEE,Sung Haeng LEE,Dong-Woo LEE 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4

Disappearance of contralateral dominant neural activity of auditory cortex after single-sided deafness in adult rats

Lee, Min Young,Kim, Doo Hee,Park, Su-Kyoung,Jun, Sang Beom,Lee, Yena,Choi, Jun-Jae,Yoo, Hyun Ji,Raphael, Yehoash,Oh, Seung-Ha Elsevier/North-Holland 2017 Neuroscience letters Vol.657 No.-

<P><B>Abstract</B></P> <P>Hearing loss in mature ears can cause functional reorganization of the auditory cortex. The functional reorganization is speculated to negatively affect the outcome of hearing rehabilitation. Therefore, once hearing loss occurs, it is important to provide auditory input before extensive reorganization in the auditory pathways. We investigated the neural plasticity in auditory cortex after single-sided deafness (SSD) in an adult rat model. The animals were divided into two groups: a normal hearing (NH) and the SSD group. The neural recordings of the SSD group were conducted at different time points (2, 4, 6 and 8 weeks) after cochlear ablation. The multi-unit activity was discriminated on the sum of spikes, peak amplitude, onset latency, peak latency, and responsive area based on the peak amplitude. The auditory cortical reorganization was observed after SSD. The contralateral dominance of peak amplitude and latency that normally occur in NH group were not present in the SSD group, replaced by higher amplitude and faster response in ipsilateral cortex. According to serial recordings at different time points after SSD, different phases in the response of the auditory cortex were speculated. Compared with normal hearing, alteration of contralateral dominance was observed because of the functional reorganization of the auditory cortex after SSD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Adult rats show plastic changes of both brain hemispheres after single side deafness. </LI> <LI> The plastic change can be summarized as the loss of normal contralateral dominance. </LI> <LI> Serial time point analysis suggests the two different phase after single side deafness. </LI> </UL> </P>

Carbon-Fiber Based Microelectrode Array Embedded with a Biodegradable Silk Support for In Vivo Neural Recording

Lee, Yena,Kong, Chanho,Chang, Jin Woo,Jun, Sang Beom The Korean Academy of Medical Sciences 2019 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.34 No.4

<P><B>Background</B></P><P>Recently, carbon fibers have been utilized to develop a depth-type microelectrode array for chronic neural recording. Since the diameter of carbon fibers is smaller than the conventional electrodes made of metal wires or microfabricated silicon, the carbon fiber electrodes showed an improved capability for chronic neural recording with less tissue damages. However, the carbon fiber based microelectrodes have a limitation of short insertion depth due to a low stiffness.</P><P><B>Methods</B></P><P>We proposed a carbon fiber based microelectrode array embedded with a mechanical support structure to facilitate the penetration into the deeper brain. The support is made of biodegradable silk fibroin to reduce the reactive tissue responses. The 4-channel carbon fiber based microelectrode arrays were fabricated and accessed in terms of electrochemical impedance, recording capability for 1-month implantation in rat hippocampi. The electrodes with tungsten supports were fabricated and tested as a control group. Immunohistochemical analysis was performed to identify the reactive glial responses.</P><P><B>Results</B></P><P>The carbon fiber based electrode arrays with silk supports showed about 2-fold impedance increase 2 weeks after implantation while the number of active electrodes decreased simultaneously. However, after 1 month, the electrode impedance decreased back to its initial value and the percentage of active electrodes also increased above 70%. Immunohistochemical staining clearly showed that the electrodes with silk supports induced less reactive glial responses than that with tungsten supports.</P><P><B>Conclusion</B></P><P>The proposed carbon fiber based microelectrode array is expected to be used for long-term in vivo neural recording from deep brain regions with the minimized reactive tissue response.</P>

Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b-Myb and miRNA34a expression

Lee, Yu-Jin,Kang, Yeong-Rim,Lee, So Young,Jin, Yena,Han, Dong Cho,Kwon, Byoung-Mog Lychnia 2017 International journal of oncology Vol.51 No.4

<P>Ginkgetin has been reported to display antitumor activity. However, the relevant pathway integrating cell cycle regulation and signaling pathways involved in growth inhibition in CRC cells remains to be identified. In this study, ginkgetin-treated HCT116 CRC cells exhibited significant dose-dependent growth inhibition with a GI(50) value of 4.0 mu M for 48-h treatment, together with apoptosis, via G(2)-phase cell cycle arrest. When HCT116 cells were treated with 10 mu M ginkgetin for 48 h, the percentage of cells in G(2)/M phase increased by 2.2-fold (43.25%) versus the untreated control (19.69%). Ginkgetin regulated the expression of genes that are critically involved in G(2) phase arrest cells, such as b-Myb, CDC2 and cyclin B1. Furthermore, we found that the suppression of b-Myb expression by ginkgetin was rescued similar to 5.1-fold by treatment with a miR-34a inhibitor (500 nM) and b-Myb was downregulated by >80% by 100 nM miR-34a mimic. These data suggest that the miRNA34a/b-Myb/cyclin B1 cascade plays a critical role in ginkgetin-induced G(2) cell cycle arrest, as well as in the inhibition of HCT116 cell proliferation. Moreover, the administration of ginkgetin (10 mg/kg) reduced tumor volumes by 36.5% and tumor weight by 37.6% in the mice xenografted with HCT116 cells relative to their vehicle-treated counterparts. Therefore, ginkgetin is the first compound shown to regulate b-Myb by modulating miR-34a, and we suggest the use of ginkgetin as an inducer of G(2) arrest for the treatment of CRC.</P>

Puzzle Taxi: How to Share the Time and Space for Everyone in the Road

( Yena Jo ),( Jungu Sim ),( Jongsik Lee ),( Karim Manaa ),( Sanghong Lee ) 한국감성과학회 2023 한국감성과학회 국제학술대회(ICES) Vol.2023 No.-

This study focuses on the challenge in Seoul's public transportation system where taxis are increasingly used for short distances due to inconvenience during peak times. The rise in taxi fares, dissatisfaction, and traffic congestion caused by singleperson taxis add strain to the system. Public dissatisfaction with high-cost taxis is revealed, leading to a decline in taxi usage, and the study emphasizes the demand for both long and short-distance taxis during rush hours. It proposes the Puzzle Taxi as an innovative solution to reduce costs and traffic congestion. The envisioned service involves shared taxis with flexible boarding, aiming to improve efficiency, service quality, and contribute to a sustainable transportation system. In conclusion, revitalizing public transportation with shared services and introducing additional services in taxis for public benefit is suggested to enhance convenience and satisfaction while addressing issues related to private sharing reluctance.

Coexistence of ZigBee-Based WBAN and WiFi for Health Telemonitoring Systems

Yena Kim,SeungSeob Lee,SuKyoung Lee IEEE 2016 IEEE Journal of Biomedical and Health Informatics Vol.20 No.1

<P>The development of telemonitoring via wireless body area networks (WBANs) is an evolving direction in personalized medicine and home-based mobile health. A WBAN consists of small, intelligent medical sensors which collect physiological parameters such as electrocardiogram, electroencephalography, and blood pressure. The recorded physiological signals are sent to a coordinator via wireless technologies, and are then transmitted to a healthcare monitoring center. One of the most widely used wireless technologies in WBANs is ZigBee because it is targeted at applications that require a low data rate and long battery life. However, ZigBee-based WBANs face severe interference problems in the presence of WiFi networks. This problem is caused by the fact that most ZigBee channels overlap with WiFi channels, severely affecting the ability of healthcare monitoring systems to guarantee reliable delivery of physiological signals. To solve this problem, we have developed an algorithm that controls the load in WiFi networks to guarantee the delay requirement for physiological signals, especially for emergency messages, in environments with coexistence of ZigBee-based WBAN and WiFi. Since WiFi applications generate traffic with different delay requirements, we focus only on WiFi traffic that does not have stringent timing requirements. In this paper, therefore, we propose an adaptive load control algorithm for ZigBee-based WBAN/WiFi coexistence environments, with the aim of guaranteeing that the delay experienced by ZigBee sensors does not exceed a maximally tolerable period of time. Simulation results show that our proposed algorithm guarantees the delay performance of ZigBee-based WBANs by mitigating the effects of WiFi interference in various scenarios.</P>