심장박동 측정 센서회로 IC 설계에 관한 연구

이우람,이완직,원창수,손상희 청주대학교 산업과학연구소 2008 産業科學硏究 Vol.26 No.1

Interface IC design for heart beat measurement sensor is proposed and executed by using current control schmitt trigger. The function of interface IC is to measure the heart beat using PPG from sensor. This circuit is composed of analog circuit that converts current signal of sensor to voltage and digital circuit that converts it to digital value. Applying OTA to schmitt trigger and oscillator, operation speed is faster and linear error is smaller than the conventional one. Besides, follow features such as low power consumption, simple configuration and high resolution, are realized by IC design.

8.3% Carbamide Peroxide 함유 펜 형 자가미백제인 BIancTis Forte의 색조개선 및 안전성에 관한 임상연구

이진경,민선홍,홍성태,오소람,정신혜,황영혜,유성엽,배광식,백승호,이우철,손원준,금기연 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.2

This clinical study evaluated the whitening effect and safety of polymer based-pen type BlancTis Forte(NIBEC) containing 8.3% carbamide peroxide. Twenty volunteers used the BlancTis Forte whitening agent for 2 hours twice a day for 4 weeks As a control. Whitening Effect Pen (LG) containing 3% hydrogen peroxide was used by 20 volunteers using the same protocol. The change in shade (ΔE^(*) color difference) was measured using Shadepilot™ (DeguDent) before, during and after bleaching (2 weeks, 4 weeks and postbleaching 4 weeks). A clinical examination for any side effects (tooth hypersensitivity or soft tissue complications) was also performed at each check-up. The following results were obtained. 1 Both the experimental and control groups displayed a noticeable change in shade (ΔE) of over 2 No significant differences were found between the two group (p>0.05) implying that the two agents have a similar whitening effect. 2 The whitening effect was mainly due to changes in a and b values rather than in L value (brightness). The experimental group showed a significantly higher change in b value thus yellow shade than the control(p < 0.05) 3 None of the participants complained of tooth hypersensitivity or soft tissue complications confirming the safety of both whitening agents 8.3%의 carbamide peroxide를 함유한 펜형 코팅용 미백제인 BlancTis Forte (NIBEC, Seosul & JinCheon)를 실험군으로, 3% hydrogen peroxide를 함유한글 Whitening Effect Pen (LG. Seoul) 제재를 대조군으로 각각 피험자 20명에게 2시간씩 1일 2회 제조사의 지시대로 치아표면에 4주간 적용하도록 지시하고 색조개선 효능과 안전성을 평가하였다. 미백 효과는 미백 전 및 미백 2주, 4주 및 미백 종료 4주 후에 Shadopilot™을 이용하여 색 변화를 측정하였고, 매 내원시기마다 모든 환자는 치수생활력 검사와 치주 및 치태 검사를 통해 부작용 여부 (치아과민증 및 구감 내 연조직의 부작용)를 기록한 후 다음과 같은 결과를 얻었다. 1.실험군 및 대조군의 색 변화량 (ΔE)은 2이상으로 인지할 수 있는 색 변화를 보였으며, 두 제품 간에는 통계적으로 유의한 차이를 보이지 않아 (p > 0.05) 유사한 미백효능을 나타냄을 알 수 있었다. 2,미백효과는 명도의 개선보다는 주로 a. b값의 변화에 의한 것으로 특히 실험군에서 b값의 변화, 즉 황색조의 개선효과가 대조군에 비해 유의성 있게 높은 것으로 나타났다 (p <0.05). 3.치아나 치은의 과민증이나 이상증상을 호소하는 피험자는 없어 두 제품 모두 안전성을 확인할 수 있었다.

내용기반 이미지 검색을 위한 문자-에지 맵의 특징을 이용한 자연이미지에서의 텍스트 영역 추출

박종천,황동국,이우람,권교현,전병민 충북대학교 컴퓨터정보통신 연구소 2006 컴퓨터정보통신연구 Vol.14 No.2

자연이미지에 포함된 텍스트는 많은 중요한 정보를 포함하고 있다. 그러므로 자연이미지에서 텍스트를 추출할 수 있다면 다양한 분야에서 활용될 수 있다. 본 논문에서는 문자-에지 맵 패턴 히스토그램을 분석함으로서 텍스트 영역을 추출하는 방법을 제안한다. 첫 번째 단계로, Canny 에지 검출기로 에지를 추출하여 16가지 에지 맵을 생성하고, 두 번째 단계로 16가지 에지 맵을 조합하여 문자 특징을 갖는 8가지 문자-에지 맵을 생성한다. 세 번째 단계로 8가지 문자-에지 맵과 16가지 에지 맵을 이용하여 텍스트 후보 영역을 추출 하고, 마지막으로 텍스트 후보 영역에 대한 검증은 문자-에지 맵의 패턴 히스토그램 및 텍스트 영역의 구조적 특징을 이용하여 수행하였다. 실험결과 제안한 방법은 복잡한 배경, 다양한 글꼴, 다양한 텍스트 컬러로 구성된 자연이미지에서 텍스트 영역을 효과적으로 추출하였다. The text to be included in the natural images has many important information. Therefore, if we can extract the text in natural images, it can be applied to many important applications. In this paper, we propose a text region extraction method using pattern histogram of character-edge maps. In the first step, we extract edges with the Canny edge detector and create 16 kinds of edge maps from the extracted edges. In the second step, we make 8 kinds of character-edge maps that has a character features with combination of edge maps. In the third step, we extract a text regions using 8 kinds of character-edge maps and 16 kinds of edge maps. Finally, verification about candidate of the text regions uses pattern histogram of character-edge maps and structural features of text regions. The proposed method is experimented with various kinds of natural images. Experimental results show that the proposed method extracts a text regions composed of complex background, various letters, various text colors effectively.

Low-Level Microsatellite Instability as a Potential Prognostic Factor in Sporadic Colorectal Cancer

Lee, Soo Young,Kim, Duck-Woo,Lee, Hye Seung,Ihn, Myong Hoon,Oh, Heung-Kwon,Min, Byung Soh,Kim, Woo Ram,Huh, Jung Wook,Yun, Jung-A.,Lee, Kang Young,Kim, Nam Kyu,Lee, Woo Yong,Kim, Hee Cheol,Kang, Sung- Wolters Kluwer Health 2015 Medicine Vol.94 No.50

<P><B>Abstract</B></P><P>Although microsatellite instability-high (MSI-H) colorectal cancers (CRCs) have been shown to exhibit a distinct phenotype, the clinical value of MSI-low (MSI-L) in CRC remains unclear. We designed this study to examine the clinicopathologic characteristics and oncologic implications associated with MSI-L CRCs.</P><P>We retrospectively reviewed data of CRC patients from 3 tertiary referral hospitals in Korea, who underwent surgical resection between January 2003 and December 2009 and had available MSI testing results. MSI testing was performed using the pentaplex Bethesda panel. Clinicopathologic features and oncologic outcomes were compared between MSI-L and microsatellite stable (MSS) CRCs; prognostic factors for survival were also examined.</P><P>Of the 3019 patients reviewed, 2621 (86.8%) were MSS, and 200 (6.6%) were MSI-L; the remaining 198 (6.6%) were MSI-H. MSI-L and MSS CRCs were comparable in terms of their clinicopathologic features, with the exception of proximal tumor location (MSI-L 30.0% vs MSS 22.1%, <I>P</I> = 0.024) and tumor size (MSI-L 5.2 ± 2.6 cm vs MSS 4.6 ± 2.1 cm, <I>P</I> = 0.001). No differences were detected in either 3-year disease-free survival (MSI-L 87.2% vs MSS 82.6%, <I>P</I> = 0.121) or 5-year overall survival (OS) (MSI-L 74.2% vs MSS 78.3%, <I>P</I> = 0.131) by univariable analysis. However, MSI-L was an independent prognostic factor for poor OS by Cox regression analysis (hazard ratio 1.358, 95% confidence interval 1.014–1.819, <I>P</I> = 0.040).</P><P>MSI-L may be an independent prognostic factor for OS in sporadic CRCs despite their clinicopathologic similarity to MSS. Further studies investigating the significance of MSI-L in the genesis and prognosis of CRCs are needed.</P>

Recovering Color of Dark Images Using Tone Mapping and MSRCR

Woo-Ram Lee,Dong-Guk Hwang,Byoung-Min Jun 보안공학연구지원센터 2014 International Journal of Software Engineering and Vol.8 No.1

Comparative study of oncologic outcomes for laparoscopic vs. open surgery in transverse colon cancer

Woo Ram Kim,Se Jin Baek,Chang Woo Kim,Hyun A Jang,Min Soo Cho,Sung Uk Bae,Hyuk Hur,Byung Soh Min,Seung Hyuk Baik,Kang Young Lee,Nam Kyu Kim,Seung Kuk Sohn 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.1

Purpose: Laparoscopic resection for transverse colon cancer is a technically challenging procedure that has been excluded from various large randomized controlled trials of which the long-term outcomes still need to be verified. The purpose of this study was to evaluate long-term oncologic outcomes for transverse colon cancer patients undergoing laparoscopic colectomy (LAC) or open colectomy (OC). Methods: This retrospective review included patients with transverse colon cancer who received a colectomy between January 2006 and December 2010. Short-term and five-year oncologic outcomes were compared between these groups. Results: A total of 131 patients were analyzed in the final study (LAC, 84 patients; OC, 47 patients). There were no significant differences in age, gender, body mass index, tumor location, operative procedure, or blood loss between groups, but the mean operative time in LAC was significantly longer (LAC, 246.8 minutes vs. OC, 213.8 minutes; P = 0.03). Hospital stay was much shorter for LAC than OC (9.1 days vs. 14.5 days, P < 0.01). Postoperative complication rates were not statistically different between the two groups. In terms of long-term oncologic data, the 5-year disease-free survival and overall survival were not statistically different between both groups, and subgroup analysis according to cancer stage also revealed no differences. Conclusion: LAC for transverse colon cancer is feasible and safe with comparable short- and long-term outcomes.

Exceptional CO ₂ working capacity in a heterodiamine-grafted metal–organic framework

Lee, Woo Ram,Jo, Hyuna,Yang, Li-Ming,Lee, Hanyeong,Ryu, Dae Won,Lim, Kwang Soo,Song, Jeong Hwa,Min, Da Young,Han, Sang Soo,Seo, Jeong Gil,Park, Yong Ki,Moon, Dohyun,Hong, Chang Seop Royal Society of Chemistry 2015 Chemical Science Vol.6 No.7

<▼1><P>The amine functionalized material <B>1-dmen</B> shows a record high working capacity for CO<SUB>2</SUB> capture at low regeneration temperatures compared with other MOFs. Furthermore, this performance is maintained upon exposure to humidity.</P></▼1><▼2><P>An amine-functionalized metal–organic framework (MOF), dmen-Mg<SUB>2</SUB>(dobpdc) (dmen = <I>N</I>,<I>N</I>-dimethylethylenediamine), which contains a heterodiamine with both primary and tertiary amines, was prepared <I>via</I> a post-synthetic method. This material exhibits a significant selectivity factor for CO<SUB>2</SUB> over N<SUB>2</SUB> that is commensurate with top-performing MOFs. It is remarkable that the solid is fully regenerated under vacuum or flowing Ar at low desorption temperatures, and following this can take up CO<SUB>2</SUB> at more than 13 wt%. An exceptionally high working capacity is achieved at low regeneration temperatures and after exposure to humid conditions, which are important parameters for a real post-combustion CO<SUB>2</SUB> capture process.</P></▼2>

Effect of Flow Instability on Pool Boiling and CHF of Thin Flat Plate Heater PCB

Lee, Woo-Ram,Lee, Jae-Young Taylor Francis 2015 Heat transfer engineering Vol.36 No.12

Direct manifestation of topological order in the winding number of the Wannier-Stark ladder

Lee, Woo-Ram,Park, Kwon American Physical Society 2015 Physical review. B, Condensed matter and materials Vol.92 No.19

Metabolomic Approaches for Origin Discrimination of Panax ginseng C. A. Meyer by Multi-Platform Metabolomics

Woo Cheol Shin,Dahye Yoon,Seon Min Oh,Bo-Ram Choi,Yunji Lee,Hyoung-Geun Kim,Nam-In Baek,Geum-Soog Kim,Min-Ho Lee,Dae Young Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Panax ginseng C. A. Meyer is distributed and cultivated in Korea, China, and Japan. Although their genetic information is the same, metabolites are different depending on the environmental factors of the cultivation region, and these metabolite changes cause differences in pharmacological effects. Metabolomics refers to the study of comprehensive metabolic changes occurring in the body. These metabolites may vary depending on disease, organic mutations, or environmental factors. For this reason, metabolites can be used for biomarkers. NMR and UPLC-Q-TOF/MS are the most widely used instruments for metabolite analysis. Recently, in metabolic studies, multi-platform metabolic studies using a combination of various instruments have been actively conducted, and this method can further help interpret metabolic analysis results. In this study, in order to determine the origin of ginseng and analyze biomarkers, metabolites of P. ginseng grown in Korea, China, and Japan were analyzed through multi-platform metabolomics using NMR and UPLC-Q-TOF/MS. The origins of P. ginseng were discriminated using multivariate statistical analysis and the candidate of biomarkers were identified.