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Matthew L. Tripp,Gary Darland,Veera Reddy Konda,Linda M. Pacioretty,Jyh-Lurn Chang,Jeffrey S. Bland,John G. Babish 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.5
Rho iso-alpha acids-rich extract (RIAA) from Humulus lupulus (hops) and proanthocyanidins-rich extracts (PAC) from Acacia nilotica exert anti-inflammatory and anti-diabetic activity in vitro and in vivo. We hypothesized that a combination of these two extracts would exert enhanced effects in vitro on inflammatory markers and insulin signaling, and on nonfasting glucose and insulin in db/db mice. Over 49 tested combinations, RIAA:PAC at 5:1 (6.25 ㎍/mL) exhibited the greatest reductions in TNFα-stimulated lipolysis and IL-6 release in 3T3-L1 adipocytes, comparable to 5 ㎍/mL troglitazone. Pretreatment of 3T3-L1 adipocytes with this combination (5 ㎍/mL) also led to a 3-fold increase in insulin-stimulated glucose uptake that was comparable to 5 ㎍/mL pioglitazone or 901 ㎍/mL aspirin. Finally, db/db mice fed with RIAA:PAC at 5:1 (100 ㎎/㎏) for 7 days resulted in 22% decrease in nonfasting glucose and 19% decrease in insulin that was comparable to 0.5 ㎎/㎏ rosiglitazone and better than 100 ㎎/㎏ metformin. RIAA:PAC mixture may have the potential to be an alternative when conventional therapy is undesirable or ineffective, and future research exploring its long-term clinical application is warranted.
Perception of upper lip augmentation utilizing simulated photography
Gary Linkov,Elizabeth Wick,Dorina Kallogjeri,Collin L. Chen,Gregory H. Branham 대한성형외과학회 2019 Archives of Plastic Surgery Vol.46 No.3
Background No head to head comparison is available between surgical lip lifting and upper lip filler injections to decide which technique yields the best results in patients. Despite the growing popularity of upper lip augmentation, its effect on societal perceptions of attractiveness, successfulness and overall health in woman is unknown. Methods Blinded casual observers viewed three versions of independent images of 15 unique patient lower faces for a total of 45 images. Observers rated the attractiveness, perceived success, and perceived overall health for each patient image. Facial perception questions were answered on a visual analog scale from 0 to 100, where higher scores corresponded to more positive responses. Results Two hundred and seventeen random observers with an average age of 47 years (standard deviation, 15.9) rated the images. The majority of observers were females (n=183, 84%) of white race (n=174, 80%) and had at least some college education (n=202, 93%). The marginal mean score for perceived attractiveness from the natural condition was 1.5 points (95% confidence interval [CI], 0.9–2.18) higher than perceived attractiveness from the simulated upper lip filler injection condition, and 2.6 points higher (95% CI, 1.95–3.24) than the simulated upper lip lift condition. There was a moderate to strong correlation between the scores of the same observer. Conclusions Simulated upper lip augmentation is amenable to social perception analysis. Scores of the same observer for attractiveness, successfulness, and overall health are strongly correlated. Overall, the natural condition had the highest scores in all categories, followed by simulated upper lip filler, and lastly simulated upper lip lift.