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Kwang-Rim BAEK,Min-Ji KANG,Ye-Rim LEE,Seung-Oh SEO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Probiotic yeast variants including Saccharomyces cerevisiae and Saccharomyces boulardii have proven their effectiveness in the treatment of many gastrointestinal diseases including acute diarrhea and bacterial infection. The yeast cell wall is composed of functional polysaccharides such as b-glucan, mannans, and chitin which have beneficial effects on human health. Particularly, the b-glucans and mannans has gained interest in the food industry as nutritional supplements and ingredients for functional food. Saccharomyces boulardii is believed to be a variant strain of S. cerevisiae and has been commercialized as a food supplement promoting the health of the intestinal tract. To evaluate the health-promoting effects of S. boulardii strains when compared to that of S. cerevisiae, we examined in vitro the immunomodulatory effect of the yeast cell extracts from S. cerevisiae and S. boulardii by measuring the production of IL-6, TNF-ɑ, and nitric oxide (NO) levels in macrophage cell line Raw 264.7.
Improved Production of Heme Porphyrins in Bacillus megaterium by a Cumate-inducible Promoter
Kwang-Rim BAEK,Geun-Hyung KIM,Min-Gyu YANG,Seung-Oh SEO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Heme is a porphyrin derivative consisting of ferrous iron and protoporphyrin IX, hemoglobin. In the food industry, heme derivatives can be used as a food additive for improving color and flavor of alternative meat products. Bacillus megaterium is one of the heme-producing microorganisms with the biosynthetic pathways including hemAXCBDL operon. To increase production of heme porphyrins in B. megaterium, we overexpressed the hemAXCBDL operon by replacing the native promoter in the chromosome with a synthetic cumate-inducible strong promoter. Since the first enzyme of the operon, HemA, acts as a major control point of the pathway, we also introduced a stable version of HemA mutant containing two lysine residues (HemAkk) into the integration cassette. The resulting recombinant strain of B. megaterium harboring the newly constructed hemAkkXCBDL operon in the genome exhibited increased production of heme porphyrins after cumate induction.
정유림(Yu Rim Jeong),박은영(Eun-Young Park),백동재(Dong Jae Baek),방준석(Joon Seok Bang),김광준(Kwang Joon Kim) 대한약학회 2023 약학회지 Vol.67 No.5
Digital therapeutics (DTx) are defined as high-quality software designed to prevent, manage, and treat medical disorders or diseases by providing evidence-based therapeutic interventions. In this study, an investigation was conducted to examine the characteristics of DTx, including their methods, safety-related data, and user evaluations of reSET®, reSET-O®, and Somryst®. These DTx solutions have recently obtained the first FDA approval and the first insurance code registration by government. However, there are limitations in terms of the quantitative scale of patient feedback evaluations and concerns about accuracy, as indicated by research findings. Nevertheless, with the active global development of DTx and the increasing scale of investment, pharmacists need to pay attention to and prepare for this innovative treatment concept.
Geun-Hyung KIM,Min-Gyu YANG,Kwang-Rim BAEK,Seung-Oh SEO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Pathogenic fungi can be a major threat to crop production and food safety by causing crop diseases and food poisoning. To control the growth of pathogenic fungi, chemical substances such as synthetic fungicides are commonly utilized. However, the excessive use of chemical fungicide has resulted in the emergence of fungicide-resistant fungi and negative effects on the environment and human health. For this reason, biocontrol agents such as natural antifungal peptides are attractive options to replace the chemical fungicides for fungal disease management. Antifungal peptides are widespread produced among diverse bacteria. Bacillus species are well-known antifungal peptide producers. In this study, Bacillus strains were isolated from Doenjang, a Korean traditional fermented soybean paste to screen for the strains having antifungal activity. Among the Bacillus isolates, one strain showed strong antifungal activity against Fusarium sp., and was identified as Bacillus velezensis. We characterized the Bacillus velezensis strain and evaluated the antifungal potential as a biocontrol agent under the various conditions.
신생 송아지에 있어서 Theileria sergenti 의 감염에 관한 연구
백병걸,임병무,이우종,김진호,김병수,손동수,이광원,Baek, Byeong-kirl,Rim, Byung-moo,Lee, Woo-jong,Kim, Jin-ho,Kim, Byeong-su,Son, Dong-soo,Lee, Kwang-won 대한수의학회 1993 大韓獸醫學會誌 Vol.33 No.4
The rate of 67 neonatal calves's infection of Theileria sergenti was investigated in random samples on the farms located in Kyeongki, Chonbuk and Jeju districts of Korea. The criteria used in verifying infection with T sergenti included the detection of parasites by giemsa's stain and acridine orange stain in the blood smear slides. Further evidence of current or previous exposure to T sergenti was based on the demonstration of T sergenti-specific antibody and antigen by the western immunoblot and the indirect immunofluorescence antibody test in the peripheral blood of the calves. The prevalence rates were 35%, 50% and 100% in Kyeongki, Chonbuk and Jeju provinces respectively and the overall prevalence in all the farms was 43.2% by means of acridine orange stain. The parasites that were observed in the peripheral blood of calves was shown surely by the western immunoblot to the characteristic 34KD antigen among the proteins of T sergenti (Korean Isolate). And the antibody of the neonatal calves reacted at the very highest titer(1 : >2,520). These data highlight the significance of T sergenti in the neonatal calf disease in Korea.