Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

인체 대장암 및 자궁경부암에서 PCR-SSCP법을 이용한 Ki-ras 암유전자의 점돌연변이에 관한 연구

박영홍,백낙환,김현찬,김상효,홍관희,김기태,이기영 인제대학교 1994 仁濟醫學 Vol.15 No.2

인체 대장암 20례와 자궁경부암 10례의 암조직을 대상으로 c-Ki-ras 유전자 codon 12와 13에서의 점돌연변이를 알아보고자 polymerase chain reaction(PCR)과 single-strand conformation polymorphism(SSCP) 검사법을 시행하였다. 대장암의 경우 20례중 9례(45%)에서, 자궁경부암의 경우 10례중 1례(10%)에서 양성으로 나왔다. 대장암에서는 codon 12에서 GGT가 TGT로의 치환이 4례로서 가장 많았으며, AGT, CGT로의 치환이 각 1례였고 codon 13에서는 GGC가 GAC로의 치환이 2례, TGC로의 치환이 1례인 것으로 나타났다. 자궁경부암의 경우 codon 12에서 GGT가 AGT로의 치환이 1례인 것으로 나타났다. In an attempt to clarify the role of genetic alteration in the genesis of human colorectal and cervical cancers, tissue specimens from 20 patients with colorectal cancer and 10 patients with cervical cancer were examined for the presence of point mutation in K-ras2 exon 1 by single strand conformation polymorphism analysis of PCR product. Exon I of c-Ki-ras2 was amplified by polymerase chain reaction(PCR) and comparison was made between the normal and mutated genes by nondenaturing polyacrylamide gel electrophoresis(PAGE) of PCR product and nucleotide sequence analysis using asymmetric PCR with direct sequencing. Genomic DNA from white blood cells were used as normal control and those from A427 cell line were used as mutated control. 1.PCR product from A427 cell line showed a distinct migration shift pattern compared to the normal control in PAGE and the direct sequencing indicated that nucleotide sequence of codon 12 was mutated from GGT to GAT. In addition, there was a loss of normal allele in A427 cell line. 2.PCR product from 9 cases(45%) out of a 20 colon cancer patients showed migration shifts in PAGE, and all of these 9 patients invariably demonstrated mutation of ras gene, either in codon 12(6 cases:30%) or 13(3 cases:15%). The base substitutions in codon 12 were: from GGT to AGT(1), CGT(1), or TGT(4). Base changes in codon 13 were from GGC to TGC(1) or GAC(2). 3.PCR product from 1 cases(10%) out of a 10 cervical cancer patients showed migration shrifts in PAGE, Invariably demonstrated mutation of ras gene in codon 12. The base substitutions was from GGT to AGT(1) TQE incidence of point mutation of c-Ki-ras in colon cancer was high, however, it was low in cervical cancer, which showed the relation of ruts gene mutation with colon cancer. PCR -SSCP analysis is a simple, rapid and efficient method of detection of point mutation, especially when dealing with multiple samples.

노인의 정주환경 인식에 관한 연구

김수남,박영호,최창환 東亞大學校 建設技術硏究所 2007 硏究論文集 Vol.31 No.1

The purpose of this study is to not only clarify needs for physical environment improvement and participation in local community but also present results from actual field survey for establishing the policy for the elderly. With this purpose in mind, firstly, we attempt to consider personal characteristic. And then we analyzed the elderly residents' needs for the improvement of residential environment in local community. Second, we attempt to find out trends or settlement consciousness of the elderly and establish the policy considering environment improvement for the elderly. The results are as follows; 1) it is needed to work up to improve the basic actual settlement environment of the elderly, because they want to continually live in recent community. 2) in participation in local community, they are on negative lines and prefer to participation bring about incomes. 3) for the improvement of the quality of the settlement environment for the elderly in community, it is need to maintenance of the physical environment; especially mobility, welfare facilities, housing for the elderly.

황 첨착 활성탄에 의한 구리제거

김영환,박정훈,김정섭,유현철,이봉섭,곽명화,우성훈,박승조 東亞大學校 環境問題硏究所 2005 硏究報告 Vol.27 No.1

This study was carried out to remove copper ion in case of activated carbon impregnated sulphur(ACS) dose and different pH using activated carbon impregnated sulphur that prepared from activated carbon at sulphur dioxide atmosphere. Removal copper ion concentration was increased as increasing the ACS dose when copper ion concentration was 10 mg/L. Optimum dose of ACS 13.3 g ACS/L and maximum removal efficiency was 93%. The results obtained from adsorption experiment in the condition of ACS optimum dose when the pH was 3, 4, 5 respectively was pH 5 was excellent.

低炭素 Dual-Phase鋼의 引張性質과 베이크 硬化性에 關한 硏究

김영환 釜山工業大學校 1984 論文集 Vol.26 No.-

The present investigation was conducted to study the bake-hardenability behavior of iced-water quenched low carbon dual-phase steel with emphasis on the effect of prior tempering treatment on the subsequent bake-hardenability response. The results obtained are as follows; 1) The steels quenched from intercritically annealed range were softened during paint-bake treatment. 2) The quench-tempered steels did not show softening but was hardened during paint-bake treatment. However, in steels tempered from insufficient temperature (e.g., 150℃ for 1 minute) prior to paint-bake treatment, further softening takes place during paint-bake treatment. 3) All the steels showed discontinuous yielding. This phenomenon was explained by the diffusion of solute carbon to mobile dislocation and removal of residual stress. But the steel that has 45 percentage of martensite volume showed continuous yielding. 4) The product of tensile strength and elongation(TS.EL value) was slightly decreased with increasing the volume fraction of martensite but rapidly decreased above 35 percentage of martensite volume. 5) The presense of martensite phase suppressed the change of yield point elongation at room temperature and decreased the increase of yield stress, that is, bake-hardenability above 35 percentage of martensite volume.

體格(身長, 體重)이 陸上競技 技能에 미치는 影響에 關한 一硏究 : 100m, High Jump, Shot Put을 中心으로 100m Dash, High Jump, Shot Put

金永煥,金基學 경북대학교 교육대학원 1973 논문집 Vol.4 No.-

The following is to revise the result of comparison How the Physique(Height, weight) have an effect on the skill of the Track and Field Sampling the 40 freshmen and Sophomores of the Department of Physical Education. 1. 100m dash and Physique (Height, Weight) ⑴ Height and Weight cause the almost same effect on the Skill of 100m dash respectively. ⑵ X_1'=0.024H+0.0518W+7.8014. σ_1.23=0.4037 2. High Jump and Physique (Height, Weight) ⑴ Height gives more important effect on the skill of the High Jump than Weight. ⑵ X_1'=0.7184H+0.2036W+13.8304. σ_1.23=9.3380. 3. Shot Put and Physique(Height, Weight) ⑴ Weight gives more important effect on the skill of the Shot Put than Weight. ⑵ X_1'=1.4985H+4.3821W+264.8380. σ_1.23=37.0175.

유압 피스톤 펌프의 피스톤과 실린더 사이의 압력분포

김영환,박태조 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

Under the tendency of higher speed and pressure requirements in hydraulic machinery, the clearance between piston and cylinder became gradually smaller. This results in many new tribological problems. Therefore exact understanding of oil pressure distribution in the clearance is vital for designers in reducing the energy losses due to friction and improving its reliability. This paper aimed at measuring oil pressure distribution in the clearance considering the effect of piston speed. We designed a piston-cylinder type test apparatus and measured oil pressure distributions accurately. The results showed that the pressure distributions are highly affected by the piston speed, and present experimental method can be used to enhance the performance of hydraulic piston pumps.

이기종 운영체계에 기반한 고성능 트랜잭션 처리 시스템의 개발

김기형,남영환,조행래 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.2

Recently, workstation clusters have been utilized for high performance transaction processing systems. In such systems, transactions are usually processed by multi-threads. Workstations in the clusters can have heterogeneous operating systems in the viewpoint of the thread processing mechanism. This paper focuses on the portability issues which should be considered from the design stage of the workstation cluster-based transaction processing systems. Especially, this paper analyzes the differences between single-threaded and multi-threaded operating systems. Based on this analysis this paper presents the architecture of a high performance transaction processing system which works on both operating systems.

자동차 드라이브 샤프트의 정적강도 및 피로특성에 관한 연구

金永煥 진주여자전문대학 1998 論文集 Vol.21 No.-

Practically, induction surface hardening is used widely to enhance mechanical strength of vehicle's drive shaft. In this study, the static torsional strength and it's S-N characteristic for various effective case depth specimen of XCD43N is studied experimentally In addition, this is intended to suggest optimal limits of effective case depth for induction hardened drive shafts of XCD43N in a point of view both static strength and fatigue life.

알루미늄기 비정질 와이어의 제조와 그 특성연구

김영환 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

높은 반응성을 가지는 Al-Ni-Y(또는 Ce)합금을 60°각도의 날카로운 edge를 가지는 구리휠을 사용하여 용탕추출법(melt extration)에 의해 연속적인 비정질 와이어를 제조할 수 있었다. 와이어는 원형 단면을 가지고 지름이 35∼50㎛범위였다. 와이어의 열적 성질은 멜트스피닝법으로 제조딘 두께 15㎛인 리본재와 거의 같앗다. 그리고 연성도 우수하고 1020MPa의 커다란 인장강도가 비정질 Al86Nil0Y4합금와이어에서 얻어졌다. 리본재에 비해서 본 제조기술이 높으 응고속도를 가지는 것이 밝혀졌는데, 이것은 체적에 비해서 훨씬 큰 표면적을 가짐으로써 아르곤 가스 분위기하에서 쉽게 과냉이 되기 때문이라고 생각된다. The application of a melt extraction method using a copper wheel with a steep edge to Al-Ni-Y(or Ce) alloys with highly reactive molten states was found to cause the formation of continuous amorphous wire. The wires have circular cross section and the diameters are in the range of 35 to 50㎛. The thermal property of the wire is nearly the same as that of the melt-spun ribbon with the 15㎛ thick. and same composition. The wires have good bending ductility and a tensile strength of 1020 MPa. The high cooling rate for the present pocess is accomplished presumably because the supercooled liquid with a small volume and a large outer area to volume ratio is solidified homogeneously without contact of other substances. The combination of the solidification process with high cooling rate and the good bending ductility into the wire shape allows us to expect that the present process develops as an alternative method to produce amorphous ally wires in various kinds of alloy systems including reactive elements as main components.