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Kim, Yeonghwan,Jang, Miran,Lim, Sangbin,Won, Hyeran,Yoon, Kyung‐,Sik,Park, Jae‐,Hoon,Kim, Hyo Jong,Kim, Byung‐,Ho,Park, Won‐,Sang,Ha, Joohun,Kim, Sung‐,Soo Wiley Subscription Services, Inc., A Wiley Company 2011 Hepatology Vol.54 No.5
<P><B>Abstract</B></P><P>Cyclophilin B (CypB) performs diverse roles in living cells, but its role in hepatocellular carcinoma (HCC) is largely unclear. To reveal its role in HCC, we investigated the induction of CypB under hypoxia and its functions in tumor cells <I>in vitro</I> and <I>in vivo</I>. Here, we demonstrated that hypoxia‐inducible factor 1α (HIF‐1α) induces CypB under hypoxia. Interestingly, CypB protected tumor cells, even p53‐defective HCC cells, against hypoxia‐ and cisplatin‐induced apoptosis. Furthermore, it regulated the effects of HIF‐1α, including those in angiogenesis and glucose metabolism, via a positive feedback loop with HIF‐1α. The tumorigenic and chemoresistant effects of CypB were confirmed <I>in vivo</I> using a xenograft model. Finally, we showed that CypB is overexpressed in 78% and 91% of the human HCC and colon cancer tissues, respectively, and its overexpression in these cancers reduced patient survival. <I>Conclusions:</I> These results indicate that CypB induced by hypoxia stimulates the survival of HCC via a positive feedback loop with HIF‐1α, indicating that CypB is a novel candidate target for developing chemotherapeutic agents against HCC and colon cancer. (H<SMALL>EPATOLOGY</SMALL> 2011;).</P>
Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy
Kim, Jin-Hwan,Choi, Tae Gyu,Park, Seolhui,Yun, Hyeong Rok,Nguyen, Ngoc Ngo Yen,Jo, Yong Hwa,Jang, Miran,Kim, Jieun,Kim, Joungmok,Kang, Insug,Ha, Joohun,Murphy, Michael P.,Tang, Dean G.,Kim, Sung Soo Nature Publishing Group 2018 Cell death and differentiation Vol.25 No.11
한려해상국립공원 홍도와 태안 난도의 괭이갈매기 번식현황
김미란(Miran Kim),이용순(Yong-soon Lee),최세준(Se-jun Choi),김양모(Yang-mo Kim),김재훈(Jae-hun Kim),황보연(Bo-yeon Hwang),권영수(Young-soo Kwon) 국립공원연구원 2022 국립공원연구지 Vol.13 No.2
전세계적으로 350여종의 바닷새가 있으며 이 중 10여 종이 우리나라에서 번식한다. 바닷새는 개체군이 감소할 경우 느린 성장과 작은 한배산란수로 인해 회복하는데 많은 시간이 소요된다. 본 연구는 천연기념물로 지정된 한려해상국립공원 홍도와 태안군 난도에서 괭이갈매기 집단번식지 관리를 위한 기초자료를 수집하기 위하여 수행되었다. 조사는 2022년 5월에 수행되었으며 괭이갈매기(Black-tailed gulls, Larus crassirostris)의 알크기, 한배산란수, 둥지 밀도 등을 조사하였다. 조사 결과 한배산란수는 홍도에서 1.89±0.57, 난도에서 1.91±0.48로 나타났다. 알크기는 홍도에서 59.22±5.47㎤, 난도에서 59.63±3.96㎤로 유사하였다. 둥지 밀도는 홍도(1.27±0.18개/㎡)가 난도(0.54±0.15개/㎡)보다 유의하게 높았다. 번식 면적으로 추정된 번식개체군 크기는 홍도가 56,729쌍, 난도가 14,112쌍으로 산정되었다. 번식개체군 장기모니터링은 괭이갈매기 번식지 보호를 위해 번식 개체군 변동을 파악하는데 필요하다. Seabirds take a long time to recover if their population decreases due to slow growth and small clutch size. This study was conducted to collect basic data of breeding status of Black-tailed gulls (Larus crassirostris) on Hongdo Island of Hallyeohaesang National Park and and Nando Island. These two breeding colonies are designated as natural monuments. We investigated egg volume, clutch size and nest density in May 2022. As results, clutch size was 1.89±0.57 in Hongdo Island and 1.91±0.48 in Nando Island. The egg volume was also similar between Hongdo Island (59.22±5.47) and Nando Island (59.63±3.96). The nest density was significantly higher in Hongdo Island (1.27±0.18/㎡) than in Nando Island(0.54±0.15/㎡). Breeding population was estimated as 56,729 pairs in Hongdo Island while 14,112 pairs in Nando Island based on the proportion of breeding areas. Long-term monitoring is required to know the trends of Black-tailed gulls to protect breeding colonies.
Expressions indéfinies en français et en coréen -du point de vue de la généricité partitive-
Miran Kim-Gautier 한국프랑스어문교육학회 2019 프랑스어문교육 Vol.64 No.-
Les expressions indéfinies sont en général connues pour ne pas être aptes à exprimer la généricité en français et en coréen. Avant d'aborder les expressions indéfinies des deux langues, nous avons vu que la particule ‘ga’ peut être aussi comptée parmi les marqueurs génériques en coréen. Les déterminants indéfinis certains, plusieurs et quelques constituent un nouveau paradigme des déterminants pour atteindre la généricité. En principe, les déterminants indéfinis ne sont pas aptes à la reprise par ça. Nous avons examiné la possibilité de l'interprétation générique de ces expressions partitives et ensuite avons analysé quelques aspects du quand et du comment elles peuvent se combiner avec le pronom ça. L'adjectif indéfini ‘eotton’ et les numéraux indéfinis ‘yeoreo’ et ‘myeot’ ont encore plus de difficulté à exprimer la généricité. Mais nous avons essayé de trouver leur possibilité de l'interprétation générique et d'analyser leur particularité syntaxico- sémantique dans le cadre de la généricité partitive.
SINGULAR INTEGRALS ON CERTAIN ORLICZ CLASSES AND ZYGMUND SPACES
KIM, DOHIE,CHO, YONG-KUM,KIM, MIRAN,KOH, DOOWON 中央大學校 基礎科學硏究所 1998 基礎科學硏究所 論文集 Vol.12 No.-
In this paper we consider the original versions of Calderon-Zygmund singular integrals and set up a list of boundedness properties on certain Orlicz classes as wel as Zygmund spaces L log L and ??.