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RISS 인기검색어
- 검색키워드
- 저자 : Kamran Tahir (검색결과 5 건)
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Tahir Ali,Kamran Saeed,Muhammad Abdullah,Iram Murtaza 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.6
Objectives: Humans have been using plants as natural medicines since prehistoric times. Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities. The aim of this study is to evaluate the antihematotoxic and antioxidative effects of the differential extracts of B. persicum against leukemic blood induced hematotoxicity in an animal model. Methods: This study was performed on animals, which were divided into several groups: normal control, disease control, and groups that were administered with differential extracts of plants. We measured the concentration of free radical [reactive oxygen species (ROS)] and hematological parameters as blast cells from the tibia and femur in different groups. Results: The ROS level and blast cells count were higher in disease control groups than in groups treated with varying amounts of B. persicum extract and the normal group. Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration. Conclusion: These findings may indicate a possible link between free radicals and hematotoxicity and blast cells, while depicting a potential therapeutic role for B. persicum against ROS-induced hematotoxicity.
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A revival of 2D materials, phosphorene: Its application as sensors
Rabia Irshad,Kamran Tahir,Baoshan Li,Zunaira Sher,Jawad Ali,Sadia Nazir 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-
Black phosphorus, a prototype of phosphorene that has been known for a hundred years, has earned anew premium. Due to its unique properties such as direct band gap and tunable anisotropic properties, BPmayfind its broad applications in energy, sensing, photo-thermal devices and optoelectronics etc. In thisarticle, an inclusive review of some salutary properties of BP for its sensing application, have beenunderlined. However, its practical ability and scale-up applications are enigmatic as of yet and requiresignificant research and investigation. Therefore, this article motivates the researcher’s community todiscover more approaches to enhance the pragmatic ability of BP.
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Shah, Fawad Ali,Zeb, Amir,Ali, Tahir,Muhammad, Tahir,Faheem, Muhammad,Alam, Sayed Ibrar,Saeed, Kamran,Koh, Phil-Ok,Lee, Keun Woo,Kim, Myeong Ok Frontiers Media S.A. 2018 Frontiers in neuroscience Vol.12 No.-
<P>Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss to subsequent membrane depolarization, glutamate excitotoxicity, and calcium overload. Melatonin is a potent antioxidant that exerts protective effects in different experimental stroke models. In this study, melatonin effects were demonstrated by a proteomic and <I>in silico</I> approach. The proteomic study identified differentially expressed proteins by 2D gel electrophoresis in the striatum 24 h after middle cerebral artery occlusion. Proteomic analysis revealed several proteins with aberrant expression and was validated by western blot and immunofluorescence analysis. Homology modeling was performed to build 3D structures for γ-enolase, thioredoxin (TRX), and heat shock 60 (HSP60) by the template crystal structures using a protein data bank as a sequence database. The structure refinement of each model was achieved by energy minimization via molecular dynamic simulation, and the generated models were further assessed for stability by Procheck and ProSA. The models were processed for docking analysis using AutoDock Vina, and post-docking analysis was determined by discovery studio. The proteomic study showed decreased expression of γ-enolase, TRX, and protein phosphatase 2A subunit B and increased expression of collapsin response mediator protein 2 and HSP60 in the striatum after ischemic injury. Treatment with melatonin modulated the expression profiles of these proteins. This study demonstrated the neuroprotective role of melatonin in the ischemic striatum using a proteomic and <I>in silico</I> approach. Collectively, melatonin may act in a multimechanistic way by modulating the expression of several proteins in the ischemic striatum.</P>
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Ionic liquids based fluorination of organic compounds using electrochemical method
Zia Ul Haq Khan,Yongmei Chen,Dondan Kong,Nawshad Muhammad,Arif Ullah Khan,Faheem Ullah Khan,Kamran Tahir,Aftab Ahmad,Lei Wang,Pingyu Wan 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.31 No.-
Ionic liquids due to their advantageous properties gain importance in many fields. This study aims tooverview the use of ionic liquids in the selective partial fluorination of organic compounds throughelectrochemical method. In addition to ionic liquid based fluorination, the earlier approaches offluorination through an electrochemical process have also been highlighted. The factors such aselectrode materials (Pt, Ni, and C), types of solvents (CH3CN, DMC, THF, DME, Sulfone, etc.) and type ofelectrolytes (Et3N 3HF, Et3NF 3HF, py HF, etc.) which affect the electrochemical fluorination of organiccompounds have been reviewed. For electrode preparation, the carbon, platinum and nickel wereconsidered suitable materials to be used as an electrode. In CH3CN media, Et3N 3HF and Et4NF 3HFshowed better efficiency during fluorination of organic compounds. Solvent play an important role inelectrochemical fluorination of organic compounds, with the change of solvent the percentage yield ishighly affected. Py-HF is a convenient solvent-supporting electrolyte medium with a reasonably goodconductivity. The electrolyte containing solvents have some side effects on electrochemical fluorinationof organic compounds as observed in cyclic voltammetric analysis. Therefore electrochemicalfluorination to organic compounds without the use of solvent gained more importance. The ionicliquids have been reported for its dual properties, as solvent as well as a fluorinating agent for organiccompounds in electrochemical processes. It has been concluded that solvents free electrochemicalfluorination of organic compounds gives good results as compare to solvent based. Ionic liquids due tomore oxidative stability were noted to have considerable effect on the yield and selectivity of organiccompound fluorination.
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Shahzad, F.,Abdullah, M.,Chaudhry, A.S.,Bhatti, J.A.,Jabbar, M.A.,Ahmed, F.,Mehmood, T.,Asim, M.,Ahmed, S.,Kamran, Z.,Irshad, I.,Tahir, M.N. Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.3
The study was carried out to explore the effects of replacing wheat straw with fungal treated wheat straw as an ingredient of total mixed ration (TMR) on the growth performance and nutrient digestibility in Nili Ravi buffalo male calves. Fungal treated wheat straw was prepared using Arachniotus sp. Four TMRs were formulated where wheat straw was replaced with 0 (TMR1), 33 (TMR2), 67 (TMR3), and 100% (TMR4) fungal treated wheat straw in TMR. All TMRs were iso-caloric and iso-nitrogenous. The experimental TMRs were randomly assigned to four groups of male calves (n = 6) according to completely randomized design and the experiment continued for four months. The calves fed TMR2 exhibited a significant improve in dry matter intake, average daily weight gain, feed conversion ratio and feed economics compared to other groups. The same group also showed higher digestibility of dry matter, crude protein, neutral-, and acid detergent fibers than those fed on other TMRs. It is concluded that TMR with 33% fungal-treated wheat straw replacement has a potential to give an enhanced growth performance and nutrient digestibility in male Nili Ravi buffalo calves.
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