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- 저자 : Junga Koh (검색결과 3 건)
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Kim, Hyunsuk,Koh, Junga,Park, Sue K,Oh, Kook H,Kim, Yeong H,Kim, Yaeni,Ahn, Curie,Oh, Yun K John Wiley Sons Australia, Ltd 2019 Nephrology Vol.24 No.4
<P><B>ABSTRACT</B></P><P><B>Aim</B></P><P>The aim of this study was to describe the baseline characteristics of autosomal‐dominant polycystic kidney disease (ADPKD) in a cohort of Korean patients with chronic kidney disease (CKD).</P><P><B>Methods</B></P><P>From April 2011 to February 2016, patients with CKD stage 1–5 (pre‐dialysis) were enrolled as an ADPKD sub‐cohort of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease. Baseline characteristics, the correlation of kidney and liver volume and kidney function and the factors associated with kidney function were analysed.</P><P><B>Results</B></P><P>A total of 364 ADPKD patients with a mean estimated glomerular filtration rate (eGFR) of 68.1 ± 33.3 mL/min per 1.73 m<SUP>2</SUP> (50.5% male with a mean age of 47.0 ± 10.6 years) were enrolled from nine hospitals in Korea. Initially, 55.8% of the patients were asymptomatic, and pain was the most common symptom (12.9%); 87.6 and 77.5% of the patients had hypertension and hepatic cysts, respectively. The height‐adjusted total kidney volumes (htTKV) were higher in male patients than in female patients. In contrast, the height‐adjusted total liver volumes were higher in female patients than in male patients. The decrease rate of eGFR depending on Log(htTKV) was larger in the group aged between 41 and 50 years than the other age groups. Older age, a higher 24‐h urine protein excretion, larger htTKV and hyperuricemia were independently associated with lower eGFR, whereas using febuxostat was independently associated with higher eGFR.</P><P><B>Conclusion</B></P><P>This sub‐cohort will provide clinical characteristics and outcomes of Korean ADPKD patients, which can be compared with those of other previous cohorts. We have identified factors associated with advanced‐stage CKD in Korean patients with ADPKD.</P><P><B>Summary at a Glance</B></P><P>This paper describes the clinical characteristics and outcomes of an underreported cohort of patients, namely, ethnic Koreans with ADPKD. Older age, proteinuria, larger height‐adjusted total kidney volume and hyperuricemia were independently associated with lower eGFR.</P>
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김현숙,Yeonsil Yu,Kwang Eon Shim,Jin Eop Kim,Junga Koh,Jong-Woo Yoon,안규리,오윤규 전해질고혈압연구회 2018 Electrolytes & Blood Pressure Vol.16 No.1
A 47-year-old female previously diagnosed with ADPKD visited the hospital due to sudden pain in her upper abdomen and back. Esophagogastroduodenoscopy, contrast-enhanced abdominal computed tomography (CT), and CT angiography identified an esophageal artery pseudoaneurysm and hematoma in the esophagus. Urgent angiography and embolization were performed. After the procedure, CT angiography and positron emission tomography were performed due to differences in blood pressure between the arms. The patient was also found to have Takayasu arteritis and subsequently received outpatient follow-up care. The possible mechanisms that cause vascular abnormalities in ADPKD patients include damaged vascular integrity due to abnormal polycystin expression caused by PKD mutations and connective tissue abnormalities. Further research is needed to confirm these mechanisms, and ADPKD patients should be assessed for vascular abnormalities.
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( Yunmi Kim ),( Kyung Don Yoo ),( Hyo Jin Kim ),( Junga Koh ),( Yeonsil Yu ),( Young Joo Kwon ),( Gheun-ho Kim ),( Tae-hyun Yoo ),( Joongyub Lee ),( Dong-chan Jin ),( Bum Soon Choi ),( Yeong Hoon Kim 대한신장학회 2018 Kidney Research and Clinical Practice Vol.37 No.3
Background: We investigated the associations between mineral metabolism parameters and mortality to identify optimal targets in Korean hemodialysis patients. Methods: Among hemodialysis patients registered in the end-stage renal disease registry of the Korean Society of Nephrology between March 2012 and June 2017, those with serum calcium, phosphorus, and intact parathyroid hormone (iPTH) measured at enrollment were included. Association of serum levels of calcium, phosphorus, and iPTH with all-cause mortality was analyzed. Results: Among 21,433 enrolled patients, 3,135 (14.6%) died during 24.8 ± 14.5 months of follow-up. After multivariable adjustment, patients in the first quintile of corrected calcium were associated with lower mortality (hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.71-0.99; P = 0.003), while those in the fifth quintile were associated with higher mortality (HR, 1.39; 95% CI, 1.20-1.61; P < 0.001) compared with those in the third quintile. For phosphorus, only the lowest quintile was significantly associated with increased mortality (HR, 1.24; 95% CI, 1.08-1.43; P = 0.003). The lowest (HR, 1.18; 95% CI, 1.02-1.36; P = 0.026) and highest quintiles of iPTH (HR, 1.24; 95% CI, 1.05-1.46; P = 0.013) were associated with increased mortality. For target counts achieved according to the Kidney Disease Outcomes Quality Initiative guideline, patients who did not achieve any mineral parameter targets hadhigher mortality than those who achieved all three targets (HR, 1.37; 95% CI, 1.12-1.67; P = 0.003). Conclusion: In Korean hemodialysis patients, high serum calcium, low phosphorus, and high and low iPTH levels were associated with increased all-cause mortality.
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