http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
남부현,김병국,고필준,심장한,박찬일 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1
Post-traumatic cholesteatoma can be originated in the middle ear or mastoid cavity after head trauma such as temporal bone fracture, penetrating injury of the temporal bone or blast injury of the tympanic membrane. It usually takes a long time to develope cholesteatoma after injury, and physicians may overlook its association with previous, trauma. Post-traumatic cholesteatoma can be suspected in patients with head trauma history and atypical cholesteatoma findings. We experienced two cases of cholesteatoma which found behind the intact tympanic membrane in 7 and 13 years old boys with history of head trauma, and we are reporting this with a discussion and literatural review.
RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity
( Jun-pil Jang ),( Mina Jang ),( Toshihiko Nogawa ),( Shunji Takahashi ),( Hiroyuki Osada ),( Jong Seog Ahn ),( Sung-kyun Ko ),( Jae-hyuk Jang ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.3
A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and High-resolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.
Anti-Angiogenesis Effects Induced by Octaminomycins A and B against HUVECs
( Jun-pil Jang ),( Jang Mi Han ),( Hye Jin Jung ),( Hiroyuki Osada ),( Jae-hyuk Jang ),( Jong Seog Ahn ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.8
In the course of studies to discover natural products with anti-angiogenic properties, two cyclic octapeptides, octaminomycins A (1) and B (2), were isolated from the cultures of Streptomyces sp. RK85-270. Octaminomycins suppressed the vascular endothelial growth factor (VEGF)-induced proliferation, adhesion, tube formation, migration, and invasion of HUVECs. Anti-angiogenic activity was futher confirmed in vivo by the chicken chorioallantoic membrane assay. We also identified that 1 and 2 inhibited the phosphorylation of VEGF receptor 2, AKT, and ERK1/2 and the expression and activities of MMP-2 and MMP-9. These results suggest that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to angiogenesis-dependent diseases.
( Jun-pil Jang ),( Min Cheol Kwon ),( Toshihiko Nogawa ),( Shunji Takahashi ),( Hiroyuki Osada ),( Jong Seog Ahn ),( Sung-kyun Ko ),( Jae-Hyuk Jang ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.12
A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. In addition, biological evaluation studies revealed that compounds 1 and 2 both exert neuroprotective activity against 6-hydroxydopamine (6-OHDA)-mediated neurotoxicity by blocking the generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.
Jang, Jun-Pil,Hwang, Gwi Ja,Jang, Mina,Takahashi, Shunji,Ko, Sung-Kyun,Osada, Hiroyuki,Jang, Jae-Hyuk,Ahn, Jong Seog American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.9
<P>A chemical investigation of a culture extract from a soil-derived <I>Streptomyces</I> sp. RK88-1441 led to the isolation and characterization of two new glycosylated anthraquinones, aturanosides A (<B>1</B>) and B (<B>2</B>), and a new anthraquinone derivative, aturanocin (<B>3</B>). The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses. The absolute configurations of the sugar units, based on the magnitudes of the coupling constants, ROESY correlations, and chemical derivatization, from <B>1</B> and <B>2</B> are 6-<I>O</I>-[<I>N</I>-acetyl-α-<SMALL>D</SMALL>-glucosamino-(1→2)-α-<SMALL>L</SMALL>-rhamnoside] and 6-<I>O</I>-α-<SMALL>L</SMALL>-rhamnoside, respectively. Compounds <B>1</B> and <B>2</B> showed no cytotoxicity against human umbilical vein endothelial cells (HUVECs), but significantly suppressed vascular endothelial growth factor (VEGF)-induced tube formation and invasion of HUVECs. The down-regulation of both the phosphorylation of VEGF receptor 2 and the expression of vascular endothelial cadherin at the protein level were also observed.</P> [FIG OMISSION]</BR>
Hygrolansamycins A-D, O-Heterocyclic Macrolides from Streptomyces sp. KCB17JA11
( Jun-pil Jang ),( Byeongsan Lee ),( Kyung Taek Heo ),( Tae Hoon Oh ),( Hyeok-won Lee ),( Sung-kyun Ko ),( Bang Yeon Hwang ),( Jae-hyuk Jang ),( Young-soo Hong ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.10
Six ansamycin derivatives were isolated from the culture broth of Streptomyces sp. KCB17JA11, including four new hygrolansamycins A-D (1-4) and known congeners divergolide O (5) and hygrocin C (6). Compounds 1-5 featured an unusual six-membered O-heterocyclic moiety. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The structures of 1-4 were elucidated using NMR and HRESIMS experiments, and the absolute configuration was established by the Mosher’s method. Compound 2 exhibited mild cytotoxicity against five cancer cell lines with IC<sub>50</sub> values ranging from 24.60 ± 3.37 μM to 49.93 ± 4.52 μM.
Benzomalvin E, an indoleamine 2,3-dioxygenase inhibitor isolated from Penicillium sp. FN070315
Jang, Jun-Pil,Jang, Jae-Hyuk,Soung, Nak-Kyun,Kim, Hye-Min,Jeong, Sook-Jung,Asami, Yukihiro,Shin, Kee-Sun,Kim, Mee Ree,Oh, Hyuncheol,Kim, Bo Yeon,Ahn, Jong Seog Springer Science and Business Media LLC 2012 Journal of antibiotics Vol.65 No.4