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Relaxor Behaviors in xBaTiO₃–(1-x)CoFe₂O₄ Materials
Cao Thi My Dung,Nhu Hoa Tran Thi,Kieu Hanh Thi Ta,Vinh Cao Tran,Bao Thu Le Nguyen,Van Hieu Le,Phuong Anh Do,Anh Tuan Dang,Heongkyu Ju,Bach Thang Phan 한국자기학회 2015 Journal of Magnetics Vol.20 No.4
Dielectric properties of xBaTiO₃–(1-x)CoFe₂O₄ composite materials have been investigated. Dielectric properties of BaTiO₃, CoFe₂O₄ and 0.5BaTiO₃–0.5CoFe₂O₄ samples show frequency dependence, which is classified as relaxor behavior with different relaxing degree. The relaxor behaviors were described using the modified Curier-Weiss and Vogel–Fulcher laws. Among three above samples, the BaTiO₃ sample has highest relaxing degree. Photoluminescence spectral indicated defects, which might in turn control relaxing degree.
Phung, Cao Dai,Nguyen, Hanh Thuy,Choi, Ju Yeon,Pham, Thanh Tung,Acharya, Suman,Timilshina, Maheshwor,Chang, Jae-Hoon,Kim, Ju-Hyun,Jeong, Jee-Heon,Ku, Sae Kwang,Choi, Han-Gon,Yong, Chul Soon,Kim, Jong Elsevier 2019 Journal of controlled release Vol.315 No.-
<P><B>Abstract</B></P> <P>In this study, dual drug-loaded nanoparticles were constructed to co-deliver low-dose doxorubicin (DOX) and miR-200c (DOX/miR-NPs) to inhibit programmed death-1 receptor (PD-L1) expression and trigger immunogenic cell death (ICD) in cancer cells. Two block copolymers, folic acid (FA)-conjugated PLGA-PEG (PLGA-PEG-FA) and PLGA-PEI, were formulated as folate-targeted NPs and loaded with DOX and miR-200c. The NPs, which were formed as nanosize objects (110.4 ± 2.1) with narrow size distribution (0.19 ± 0.02), effectively protected the miR-200c from degradation in serum. Modifying the NPs with FA increased not only their uptake by cancer cells <I>in vitro</I> but also their accumulation in tumor microenvironments <I>in vivo</I>, as compared with those properties of non-FA-modified NPs. The DOX/miR-NPs also exhibited efficacious inhibition of PD-L1 expression and robust induction of ICD in cancer cells <I>in vitro</I> and <I>in vivo</I>, resulting in increased dendritic cell maturation and CD8<SUP>+</SUP> T cell response towards cancer cells. Furthermore, tumor growth was significantly inhibited by folate-targeted NPs loaded with the low-dose DOX/miR-200c combination, but not by treatments with free DOX, miR-NPs or DOX-NPs. Thus, our results suggest that simultaneous PD-L1 inhibition via microRNAs and the induction of an immunogenic tumor microenvironment via low-dose cytotoxic drugs may improve cancer therapy efficacy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A folate receptor-targeted nanoparticle was prepared for co-delivery of doxorubicin and miR-200c (DOX/miR-NPs). </LI> <LI> The DOX/miR-NPs inhibited PD-L1 expression and robustly induced immunogenic cell death in cancer cells <I>in vitro</I> and <I>in vivo</I>. </LI> <LI> The treatment with DOX/miR-NPs significantly increased tumor-infiltrated dendritic cells and cytotoxic T cells. </LI> <LI> The tumor growth was remarkably inhibited by DOX/miR-NPs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
THREE-DIMENSIONAL CORE DESIGN OF A SUPER FAST REACTOR WITH A HIGH POWER DENSITY
Cao, Liangzhi,Oka, Yoshiaki,Ishiwatari, Yuki,Ikejiri, Satoshi,Ju, Haitao Korean Nuclear Society 2010 Nuclear Engineering and Technology Vol.42 No.1
The SuperCritical Water-cooled Reactor (SCWR) pursues high power density to reduce its capital cost. The fast spectrum SCWR, called a super fast reactor, can be designed with a higher power density than thermal spectrum SCWR. The mechanism of increasing the average power density of the super fast reactor is studied theoretically and numerically. Some key parameters affecting the average power density, including fuel pin outer diameter, fuel pitch, power peaking factor, and the fraction of seed assemblies, are analyzed and optimized to achieve a more compact core. Based on those sensitivity analyses, a compact super fast reactor is successfully designed with an average power density of 294.8 W/$cm^3$. The core characteristics are analyzed by using three-dimensional neutronics/thermal-hydraulics coupling method. Numerical results show that all of the design criteria and goals are satisfied.
Three-dimensional Core Design of a Super Fast Reactor with a High Power Density
LIANGZHI CAO,YOSHIAKI OKA,YUKI ISHIWATARI,SATOSHI IKEJIRI,HAITAO JU 한국원자력학회 2010 Nuclear Engineering and Technology Vol.42 No.1
The SuperCritical Water-cooled Reactor (SCWR) pursues high power density to reduce its capital cost. The fast spectrum SCWR, called a super fast reactor, can be designed with a higher power density than thermal spectrum SCWR. The mechanism of increasing the average power density of the super fast reactor is studied theoretically and numerically. Some key parameters affecting the average power density, including fuel pin outer diameter, fuel pitch, power peaking factor, and the fraction of seed assemblies, are analyzed and optimized to achieve a more compact core. Based on those sensitivity analyses, a compact super fast reactor is successfully designed with an average power density of 294.8 W/cm3. The core characteristics are analyzed by using three-dimensional neutronics/thermal-hydraulics coupling method. Numerical results show that all of the design criteria and goals are satisfied.
디지털 병리 대장암 분화도 예측을 위한 순서학습 기반 비전 트랜스포머 기술
이주천(Ju Cheon Lee),이재웅(Jae Ung Lee),Vuong Thi Le Trinh,Wang Jiamu,JiangKan,변근호(Keunho Byeon),정수민(sumin Jung),Anh Tien Nguyen,Bui Cao Doanh,곽진태(Jin Tae Kwak) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6
We propose a deep learning based digital pathology method that can classify colorectal cancers from digitized whole slide images. The conventional digital pathology methods approach cancer grading as a categorical classification problem, where the goal is to classify them into appropriate classes. However, in the case of cancer cells, the higher the grade or differentiation of each class, the poorer the condition of the cancer is, making simple categorical classification insufficient to address this issue. Therefore, in this paper, we formulate cancer grading as both categorical and ordinal classification problems and conduct two cancer grading tasks simultaneously. To achieve this, we build a deep learning model based on vision transformer and order learning. The proposed method is evaluated using a colorectal tissue dataset. Experimental results show that our method is able to accurately classify cancer grades and outperforms other competing models.
Control of inflorescence architecture in tomato by BTB/POZ transcriptional regulators
Xu, Cao,Park, Soon Ju,Van Eck, Joyce,Lippman, Zachary B. Cold Spring Harbor Laboratory 2016 Genes & development Vol.30 No.18
<P>Plant productivity depends on inflorescences, flower-bearing shoots that originate from the stem cell populations of shoot meristems. Inflorescence architecture determines flower production, which can vary dramatically both between and within species. In tomato plants, formation of multiflowered inflorescences depends on a precisely timed process of meristem maturation mediated by the transcription factor gene TERMINATING FLOWER (TMF), but the underlying mechanism is unknown. We show that TMF protein acts together with homologs of the Arabidopsis BLADE-ON-PETIOLE (BOP) transcriptional cofactors, defined by the conserved BTB (Broad complex, Tramtrack, and Bric-a-brac)/POZ (POX virus and zinc finger) domain. TMF and three tomato BOPs (S1BOPs) interact with themselves and each other, and TMF recruits S1BOPs to the nucleus, suggesting formation of a transcriptional complex. Like TMF, S1BOP gene expression is highest during vegetative and transitional stages of meristem maturation, and CRISPR/Cas9 elimination of S1BOP function causes pleiotropic defects, most notably simplification of inflorescences into single flowers, resembling tmf mutants. Flowering defects are enhanced in higher-order s1bop tmf mutants, suggesting that S1BOPs function with additional factors. In support of this, S1BOPs interact with TMF homologs, mutations in which cause phenotypes like sibop mutants. Our findings reveal a new flowering module defined by S1BOP TMF family interactions that ensures a progressive meristem maturation to promote inflorescence complexity.</P>
Zhao, Zengying,Cao, Lili,Hu, Anhui,Zhang, Weili,Ju, Xiaomei,Zhang, Yuanyuan,Sun, Wei Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
By using ionic liquid 1-hexylpyridinium hexafluorophosphate ($HPPF_6$) based carbon ionic liquid electrode (CILE) as the substrate electrode, a $CoMoO_4$ nanorods and myoglobin (Mb) composite was casted on the surface of CILE with chitosan (CTS) as the film forming material to obtain the modified electrode (CTS/$CoMoO_4$-Mb/CILE). Spectroscopic results indicated that Mb retained its native structures without any conformational changes after mixed with $CoMoO_4$ nanorods and CTS. Electrochemical behaviors of Mb on the electrode were carefully investigated by cyclic voltammetry with a pair of well-defined redox peaks from the heme Fe(III)/Fe(II) redox center of Mb appeared, which indicated that direct electron transfer between Mb and CILE was realized. Electrochemical parameters such as the electron transfer number (n), charge transfer coefficient (${\alpha}$) and electron transfer rate constant ($k_s$) were estimated by cyclic voltammetry with the results as 1.09, 0.53 and 1.16 $s^{-1}$, respectively. The Mb modified electrode showed good electrocatalytic ability toward the reduction of trichloroacetic acid in the concentration range from 0.1 to 32.0 mmol $L^{-1}$ with the detection limit as 0.036 mmol $L^{-1}$ ($3{\sigma}$), and the reduction of $H_2O_2$ in the concentration range from 0.12 to 397.0 ${\mu}mol\;L^{-1}$ with the detection limit as 0.0426 ${\mu}mol\;L^{-1}$ ($3{\sigma}$).
Fu‑xiang Cao,Kun‑kun Deng,Cui‑ju Wang,Kai‑bo Nie,Wei Liang,Jian‑feng Fan 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.12
The 10 μm 10 vol% SiCp/2024Al composites sheet was successfully fabricated by semi-solid stir casting followed withtwo-step deformation (extrusion and rolling). The two-step thermal deformation solves the sheet rolling formability of theSiCp/2024Al composites produced by stir casting. Compared with the SiCp/2024Al composites prepared by traditional powdermetallurgy, this paper innovatively studied the synergistic enhancement between CuAl2phase and SiCpon the mechanicalproperties. The result shows that the two-step deformation can significantly improve the uniformity of the distribution of SiCpand CuAl2phases. At the same time, the average size of the SiCpand CuAl2phase decreases after the two-step deformation. During the hot extrusion, SiCphas an obvious hindrance to the refinement of the CuAl2phase. Moreover, the SiCp/2024Alcomposites sheet exhibits excellent yield strength (295 MPa), ultimate tensile strength (489 MPa), and elongation (10.42%). The performance improvement of SiCp/2024Al after two-step thermal deformation is mainly attributed to the improvedinterface bonding strength of SiCp-2024 Al matrix, the refined SiCpand the more uniform distribution of SiCp.