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Jo, Sooyeon,Na, Hyung Gyun,Choi, Yoon Seok,Bae, Chang Hoon,Song, Si-Youn,Kim, Yong-Dae The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.6
Background: Diesel exhaust particle (DEP) is a harmful kind of particulate matter known to exacerbate pre-existing respiratory diseases. Although their adverse effects on airway pathologies have been widely studied, the mechanistic analysis of signaling pathways and potential targets in reducing DEP-induced mucin secretion and pro-inflammatory cytokine production remain elusive. We, for the first time, investigated the effects of Korean Red Ginseng (KRG) extracts on mucin overproduction and airway inflammation induced by DEP. Methods: The effects of KRG and saponin on DEP-induced expression of MUC5AC and interleukin (IL)-6/8 were examined by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) in human airway epithelial NCI-H292 cells. We conducted Western blotting analysis to analyze the associated signaling pathways. To evaluate the effects of saponin treatment on DEP-induced MUC5AC expression and inflammatory cell infiltrations in ovalbumin (OVA)-sensitized mice, immunohistochemical (IHC) staining and real-time PCR were implemented. Results: The KRG extracts markedly attenuated DEP-induced MUC5AC expression in vitro by inhibiting the TLR4/TRIF/NF-𝛋B pathway. Furthermore, KRG and saponin inhibited DEP-induced pro-inflammatory cytokine IL-6/8 production. The in vivo study revealed that saponin blocked DEP-induced inflammation, mucin production and MUC5AC expression. Conclusion: Our study revealed that KRG extracts have inhibitory effects on DEP-induced expression of MUC5AC and the production of pro-inflammatory cytokines. This finding provides novel insights into the mechanism by which saponin alleviates diesel-susceptible airway inflammation, elucidating its potential as a phytotherapeutic agent for inflammatory pathologies of airway.
Knowledge and behavior regarding sun protection in Korean patients with skin diseases
( Seong Jin Jo ),( Si Hyung Lee ),( Young-joon Seo ),( Hyo Hyun Ahn ),( Jong Hee Lee ),( Sang Ho Oh ),( Ki Heon Jeong ),( Kui Young Park ),( Chul Hwan Bang ),( Min-soo Kim ),( Jae Yoon Jung ),( Young- 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.74 No.1
Cr-doped lithium titanate nanocrystals as Mg ion insertion materials for Mg batteries
Lee, Boeun,Jo, Eunmi,Choi, Jihwan,Kim, Jong Hak,Chang, Wonyoung,Yu, Seungho,Kim, Hyung-Seok,Oh, Si Hyoung The Royal Society of Chemistry 2019 Journal of Materials Chemistry A Vol.7 No.44
<P>Magnesium metal anodes offer significant economic, capacitive, and safety advantages over their lithium counterparts. However, developing viable magnesium batteries remains challenging because of the lack of efficient insertion cathode materials; the presently used materials suffer from lethargic reaction kinetics caused by strong electrostatic interactions between the divalent intercalant ions and the host. Herein, we present a technique integrating physical and chemical approaches toward achieving high intercalation kinetics utilizing lithium titanate (LTO). We demonstrate that reducing the particle size of LTO to 8 nm drastically enhances the utilization of redox-active centers, leading to a 300% higher reversible capacity than the bulk-sized material. Moreover, aliovalent doping of Cr into the LTO structure not only increases the electrical conductivity, facilitating fast charge redistribution at redox centers, but also causes a favorable structural disordering that can enhance the local ion mobility, ensuring good high-rate performance, long-term cycle stability, and rapid completion of initial activation compared to that offered by the undoped LTO. These findings agree with the computational study reporting that the diffusion barriers for Mg<SUP>2+</SUP> and Li<SUP>+</SUP> ions can be reduced significantly upon Cr doping. This study provides an interesting and novel opportunity to improve conventional insertion materials with poor reaction kinetics to unlock excellent electrochemical activity for practical application in magnesium battery cathodes.</P>
治療的 環境에서의 그룹力動에 關한 硏究 : 其Ⅰ. 患者會長을 中心으로 No.1 PATIENT CHAIRMAN
姜炳祚,金政輝,李時炯 大韓神經精神醫學會 1972 신경정신의학 Vol.11 No.2
Dynamic relationship between the patient's chairman and ward environment in the therapeutic milieu has been studied at Department of Neuropsychiatry, K.P.U.H. Ten chairmen, who have been elected between the period of Apr. 1st to Sep. 31'70 are included in this study. Results: 1. Chairmen, who have paranoid personality or predominant paranoid symptom, are evaluated as a poor leader. 2. When the group is well integrated, ward staff tend to be neglecting the patient's group, then group pick a poor leader, as a means of getting attention from the staff. 3. As a poor leader is expected to be picked, ward staff should be participated more actively and should intervene the group activity if necessary, thus prevent further accidents.
Yun Jeong Jo,Si Hoon Lee,Jin Woong Park,Hyung Soo Kim,Sei Hyun Kim,Hyun Hee Lee,Jae Seok Yang,Jae Hyun Chang,Woo Kyung Chung,Se Joong Kim 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Most of the patients with hemorrhagic fever with renal syndrome (HFRS) by Hantaviruses recover completely. However, the prevalence of hypopituitarism as sequel of HFRS may be approximately 10%. However, it is rare for hyponatremia to present as a manifestation of hypopituitarism due to HFRS. A 42-year-old Asian woman presented with anorexia, nausea, and vomiting. She had a history of HFRS 7 years ago. During her first hospital admission, her serum sodium was 103 mmol/L. The rapid adrenocorticotropic hormone (ACTH) stimulation test showed no abnormal findings suggesting the possibility of adrenal insufficiency. After she underwent fluid therapy for 5 days, her serum sodium level was slightly increased to 131 mmol/L, and her clinical symptoms were improving. The next day after she was discharged, she suffered from the same symptoms and was admitted to our hospital again. On the day of her second admission, her serum sodium was 117 mmol/L. A combined pituitary function test showed diminished function of the anterior pituitary gland, which led to secondary adrenal insufficiency. Magnetic resonance imaging findings of her sella were compatible with empty sella turcica. After the replacement of prednisolone, her serum sodium levels returned to normal. Pituitary dysfunction should be included in the differential diagnosis of severe hyponatremia, especially in patients who suffered HFRS. This case also suggests that the rapid ACTH stimulation test has limitations with regard to the differential diagnosis of primary or secondary adrenal insufficiency.