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다양한 형태의 사물데이터 질의 처리를 위한 단일 색인 및 시각화 방안
한진주(Jinju Han),나철원(Chul-Won Na),이다희(Dahee Lee),이도훈(Do-Hoon Lee),온병원(Byung-Won On),이용(Ryong Lee),박민우(Min-Woo Park),이상환(Sang-Hwan Lee) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.9
Recently, a variety of IoT data is collected by attaching geosensors to many vehicles that are on the road. IoT data basically has time and space information and is composed of various data such as temperature, humidity, fine dust, Co2, etc. Although a certain sensor data can be retrieved using time, latitude and longitude, which are keys to the IoT data, advanced search engines for IoT data to handle high-level user queries are still limited. There is also a problem with searching large amounts of IoT data without generating indexes, which wastes a great deal of time through sequential scans. In this paper, we propose a unified spatial index model that handles both grid and trajectory queries using a cell-based space-filling curve method. also it presents a visualization method that helps user grasp intuitively. The Trajectory query is to aggregate the traffic of the trajectory cells passed by taxi on the road searched by the user. The grid query is to find the cells on the road searched by the user and to aggregate the fine dust. Based on the generated spatial index, the user interface quickly summarizes the trajectory and grid queries for specific road and all roads, and proposes a Web-based prototype system that can be analyzed intuitively through road and heat map visualization.
Jinju Lee,Youngsin Han,조현희,김미란 대한폐경학회 2019 대한폐경학회지 Vol.25 No.2
Sleep disorders are one of the main symptoms of menopause. Symptoms of sleep disorders that menopausal women complain about include falling asleep, frequent awakening and/or early morning awakening. There are many possible causes of sleep disorders in postmenopausal women, including vasomotor symptoms, ovarian hormone changes, restless legs syndrome, periodic leg movement syndrome, and obstructive sleep apnea. In this review, we discuss the relationship between menopause and sleep disorders.
MicroRNA genes are transcribed by RNA polymerase II
Lee, Yoontae,Kim, Minju,Han, Jinju,Yeom, Kyu-Hyun,Lee, Sanghyuk,Baek, Sung Hee,Kim, V Narry Wiley (John WileySons) 2004 The EMBO journal Vol.23 No.20
<P>MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present the first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II). The primary miRNA transcripts (pri-miRNAs) contain cap structures as well as poly(A) tails, which are the unique properties of class II gene transcripts. The treatment of human cells with alpha-amanitin decreased the level of pri-miRNAs at a concentration that selectively inhibits pol II activity. Furthermore, chromatin immunoprecipitation analyses show that pol II is physically associated with a miRNA promoter. We also describe, for the first time, the detailed structure of a miRNA gene by determining the promoter and the terminator of mir-23a approximately 27a approximately 24-2. These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes.</P>
EXIT procedure in congenital chylothorax fetus : case report
( Jinju Lee ),( Me Hong ),( Yong Jin Jang ),( Yun Sung Jo ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Background: The ex-utero intrapartum therapy(EXIT) procedure allows therapeutic interventions on the fetus while maintaining feto-placenta circulation and oxygenation. Case presentation: A 35-year-old, gravida2, para1, at 36+3 weeks gestation, was referred to for evaluation of polyhydramnios and fetal hydrothorax. The mother had symptoms of upper respiratory infection with fever (37.7), nasal stuffiness and mild myalgia, Ultrasound showed Amniotic fluid index was 34 and fetal hydrothorax. The abnormalities of fetal lung didnt founded until ultrasound examination at 34 weeks gestation. Maternal blood examination for culture & congenital infection(TORCH syndrome) was negative study. At 36+5 weeks gestation, by sono-guided Amnioreduction(200ml) & fetal thoracentesis(74ml) & cordocentesis, we found that contents of fetal pleural effusion were chyle. Once congenital chylothorax fetus was diagnoses, our multidisciplinary team(pediatrics, thoracic- cardiovascular surgery, anesthesiology) discussed emergency cesarean section and EXIT procedure. The fetus was delivered, airway was securely intubated and surfactant was administered, then chest tube inserted for drainage of chylothorax during EXIT procedure. (8minutes). The newborn was underwent Thoracoscopic thoracic duct ligation operation at 10days after birth, and died 17days after birth.
Lee, Jinju,Ahn, Hyung Jun Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.3
<P><B>Abstract</B></P> <P>Although siRNA-mediated downregulation technology has been highly successful in suppressing the expression of any disease-related gene, systemic delivery of siRNA for the clinical applications remains challenging, especially in the use of cancer therapy. DC-Chol/DOPE cationic liposomes as one of the most attractive vehicles for gene delivery have been widely exploited for transfection of siRNA into cells, but complexity of systemic delivery has allowed only their direct injection into local targets due to the formation of aggregations with negatively-charged blood components. Herein, we demonstrate the effects of PEGylation on DC-Chol/DOPE cationic liposomes for systemic siRNA delivery in cancer therapy. In contrast to non-PEGylated DC-Chol/DOPE-siRNA lipoplexes, PEGylated DC-Chol/DOPE-siRNA lipoplexes reduce the excretion by kidneys and scavenging in liver, prolonging the circulation time <I>in vivo</I>, and ultimately increase their preferential tumor accumulation. Therefore, systemic injection of PEGylated DC-Chol/DOPE liposomes loaded with siRNA against kinesin spindle protein (KSP) gene exhibited a high level of target gene silencing at tumor sites and substantial suppression of tumor growth. Furthermore, systemically administered PEGylated lipoplexes did not lead to any activation of innate immune responses in the immunocompetent mice. These results suggest the potential of PEGylated DC-Chol/DOPE liposomes as a systemic delivery carrier for siRNA-mediated cancer therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Dong-Sung,Ko, Wonmin,Yoon, Chi-Su,Kim, Dong-Cheol,Yun, Jinju,Lee, Jun-Kyung,Jun, Ki-Young,Son, Ilhong,Kim, Dong-Woung,Song, Bong-Keun,Choi, Seulah,Jang, Jun-Hyeog,Oh, Hyuncheol,Kim, Sungchul,Kim, Hindawi Publishing Corporation 2014 Evidence-based Complementary and Alternative Medic Vol.2014 No.-
<P>The brain is vulnerable to oxidative stress and inflammation that can occur as a result of aging or neurodegenerative diseases. Our work has sought to identify natural products that regulate heme oxygenase (HO)-1 and to determine their mechanism of action in neurodegenerative diseases. KCHO-1 is a novel herbal therapeutic containing 30% ethanol (EtOH) extracts from nine plants. In this study, we investigated the antineuroinflammatory effects of KCHO-1 in lipopolysaccharide- (LPS-) treated mouse BV2 microglia. KCHO-1 inhibited the protein expression of inducible nitric oxide synthase (iNOS), iNOS-derived nitric oxide (NO), cyclooxygenase- (COX-) 2, and COX-2-derived prostaglandin E2 (PGE<SUB>2</SUB>) in LPS-stimulated BV2 microglia. It also reduced tumor necrosis factor-<I>α</I> (TNF-<I>α</I>), interleukin-1<I>β</I> (IL-1<I>β</I>), and IL-6 production. This effect was correlated with the suppression of inhibitor of nuclear factor kappa B-<I>α</I> (I<I>κ</I>B-<I>α</I>) phosphorylation and degradation and nuclear factor kappa B (NF-<I>κ</I>B) translocation and DNA binding. Additionally, KCHO-1 upregulated HO-1 expression by promoting nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in mouse BV2 microglia. Tin protoporphyrin (SnPP), an HO activity inhibitor, was used to verify the inhibitory effects of KCHO-1 on proinflammatory mediators and proteins associated with HO-1 expression. Our data suggest that KCHO-1 has therapeutic potential in neurodegenerative diseases caused by neuroinflammation.</P>
Lee Hansol,Gelija Devarajulu,Kim Usik,Lee Jinju,Chung Woon Jin 한국세라믹학회 2024 한국세라믹학회지 Vol.61 No.3
CsPbBr3 perovskite nanocrystal embedded glasses (PNEGs) based on the borosilicate system were synthesized with varying compositions to obtain a chemically stable PNEG compared with a PNEG based on the germanate system. Photo- luminescence (PL) and structural characteristics were examined to fi nd the proper heat-treatment conditions for high quantum effi ciency under a 450 nm blue light emitting diode (LED) excitation. The CsPbBr 3 within the glass matrix was observed by transmission electron microscope (TEM). Comparative studies on the thermal, photonic and water stabilities of the obtained borosilicate PNEG with those of a germanate PNEG were carried out. The borosilicate CsPbBr 3 PNEG was employed as a green phosphor along with K 2SiF6:Mn4+ as a red phosphor to compose a white LED with phosphor in silicone (PiS) and a remote PiS structure, whose color gamut was examined for display applications.