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Yanwei Li,Jinhuan Yao,Shengkui Zhong,Zhengguang Zou 한국물리학회 2011 Current Applied Physics Vol.11 No.6
The effect of molecular orientation on the electron transport behavior of single porphyrin sandwiched between two gold (111) electrodes is investigated by density functional theory calculations combined with non-equilibrium Green’s function method. The results show that the porphyrin with parallel connection to gold (111) electrodes is more conductive than the porphyrin with diagonal connection to gold (111) electrodes. The mechanism of the difference of electron transport for these two molecular junctions is analyzed from the transmission spectra and the molecular projected self-consistent Hamiltonian states. It is found that the intrinsic nature of the molecule, such as the π-conjugated framework and the strength of molecule―electrode coupling, are the essential reason for generating this difference of electron transport for the two molecular systems.
Jiaqi Li,Yanwei Li,Jinhuan Yao,Bin Huang,Jiqiong Jiang,Jianwen Yang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
The influence of heat treatment (100 °C, 150 °C, 200 °C, 300 °C, and 400 °C) on the structure and the zinc ion storage performance of V2O5·nH2O is explored. The results show that the interlayer water content, interlayer distance, and V4+ content in V2O5·nH2O can be regulated by heat treatment. Electrochemical characterization demonstrates that the as-prepared vanadium pentoxide without heat treatment shows rather poor cycling stability (only 56 m Ah g−1 after 600 cycles at 0.5 A/g). After being heat treated in the temperature range of 100 to 200 °C, the zinc ion storage performance of vanadium pentoxide can be enhanced dramatically. Particularly, the vanadium pentoxide after being heat-treated at 150 °C exhibits the best cycling stability (179 mA h g−1 after 600 cycles at 0.5 A/g), superior high-rate capability (117 mA h g−1 at 3.0 A/g), and faster electrochemical reaction kinetics. The results reported in this work could provide clues for regulating and optimizing the electrochemical performance of vanadium pentoxide as a cathode material for ZIBs.
Yanwei Li,Wenhan Xu,Jinhuan Yao,Bin Huang,Shunhua Xiao,Jianwen Yang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-
Rational utilization of jarosite residue is significantly important from the view of environmental protectionand resource recycling. Herein, we report a facile preparation of porous amorphous FePO4/reducedgraphene oxide (rGO) composite by utilizing the iron resource in jarosite residue with a selective chemicalprecipitation method, and demonstrate its great potential as a high-performance anode material oflithium-ion batteries (LIBs). The FePO4/rGO composite exhibits superior cyclic performance(812.7 mA h g1 over 300 cycles at 500 mA g1) and high-rate capability (335.2 mA h g1 even at a highcurrent density of 10 A g1) in a half cell. More importantly, the full LIB assembled with FePO4/rGO anodeand commercial Li(Ni0.5Co0.2Mn0.3)O2 (NCM523) cathode still delivers a high and stable capacity of 674. 9/528.7 mA h g1 upon 100/300 cycles at 200/500 mA g1, indicating the great potential of this FePO4/rGO composite as a new anode material with high lithium storage performance. This work proposes asimple, feasible, and cost-effective strategy for the high-valued utilization of jarosite residue and providesa reference for the design and development of FePO4-based anode materials for LIBs.
A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II
Shanshan Zhao,Zhenghui Li,Muxian Zhang,Lingliang Zhang,Honghua Zheng,Jinhuan Ning,Yanyan Wang,Feng-Peng Wang,Xiaobin Zhang,Hexia Gan,Yuanqing Wang,Xian Zhang,Hong Luo,Guojun Bu,Huaxi Xu,Yi Yao,Yun-wu 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Focal cortical dysplasia type II (FCDII) is a cerebral cortex malformation characterized by local cortical structure disorganization, neuronal dysmorphology, and refractory epilepsy. Brain somatic mutations in several genes involved in the PI3K/AKT/mTOR pathway are associated with FCDII, but they are only found in a proportion of patients with FCDII. The genetic causes underlying the development FCDII in other patients remain unclear. Here, we carried out whole exome sequencing and targeted sequencing in paired brain–blood DNA from patients with FCDII and identified a brain somatic doublet mutation c.(A104T, C105A) in the Ras homolog, mTORC1 binding (RHEB) gene, which led to the RHEB p.Y35L mutation in one patient with FCDII. This RHEB mutation carrier had a dramatic increase of ribosomal protein S6 phosphorylation, indicating mTOR activation in the region of the brain lesion. The RHEB p.Y35L mutant protein had increased GTPλS-binding activity compared with wild-type RHEB. Overexpression of the RHEB p. Y35L variant in cultured cells also resulted in elevated S6 phosphorylation compared to wild-type RHEB. Importantly, in utero electroporation of the RHEB p.Y35L variant in mice induced S6 phosphorylation, cytomegalic neurons, dysregulated neuron migration, abnormal electroencephalogram, and seizures, all of which are found in patients with FCDII. Rapamycin treatment rescued abnormal electroencephalograms and alleviated seizures in these mice. These results demonstrate that brain somatic mutations in RHEB are also responsible for the pathogenesis of FCDII, indicating that aberrant activation of mTOR signaling is a primary driver and potential drug target for FCDII.