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      • SCOPUSKCI등재

        Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

        ( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

        Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

      • 복싱 선수들의 경기 결과별 귀인형태에 관한 연구

        김진표,천인호 龍仁大學校 1998 용인대학교 논문집 Vol.16 No.-

        The present study was designed to examine the effect of performance outcomes on attributional patterns across male boxers in the athletic setting. Boxers reported causal attributions on the 4-itemed 7-point Attribution-success Scale and 4-itemed 7-point Attributions on the 4-itemed 7-point Attribution-Success Scale and 4-itemed 7-point Attribution-Failure Scale by Carrots(1981). The relationship between the two kinds of variables were examined by pearson's and two-way ANOVA. The implcations of the study are as follows: 1. The outcome performance boxers significntly affected their ability attribution. The mean ability attribution scale scores for the winners was significantly higher than that of losers. 2. The outcome performance boxers significntly affected their effort attribution. The mean effort attribution scale scores for the winners was significantly higher than that of losers. 3. The outcome performance boxers significntly affected their luck attribution. The mean luck attribution scale scores for the winers was significantly lower than that of losers. 4. The outcome performance boxers significntly affected their task difficulty attribution. The mean task difficulty attribution scale scores for the winners was significantly lower than that of losers. In conclusion, winners perceived the causes behind the successful outcome to be more controllable trait.

      • 시멘트 제조사 및 W/C 변화에 따른 콘크리트의 초기 강도발현 특성

        金光華,裵正烈,김규도,이승훈,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

        This study is to investigate the influence of cement manufacturing company and W/C on the properties of fresh concrete, strength of hardened concrete and rebound value of P type Schmidt hammer. According to the result, setting time of concrete is shortened with and increase of W/C, and when cement made in A and B corporation is used in concrete, the final setting time is measured at about 10 hours and 13 hours. Compressive strength increases with elapse of time and decrease of W/C, and concrete using cement made in A corporation shows higher compressive strength and rebound value until 24 hours, but from 3rd day, the contrary tendency is shown. As for the properties of early strength, the strength develop fast with decrease of W/C, and the time when compressive strength of 5MPa is gained and the form can be removed, is about 15, 18, 21 hours and 20, 22, 27 hours at the W/C 40, 45, 50% in concrete using cement made in A and B Co. respectively. The correlativity between compressive strength and the rebound value, which a coefficient of correlation is over 0.97, is very favorable. Therefore this method is effective to estimate the strength of removing the form.

      • KCI등재

        백서 뇌의 정상 노화와 병적 노화 과정의 조직학적 차이 및 약물효과

        전진숙,한호성,장희경,길영기,김순옥 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.1

        Objectives : Besides of malnutrition and neurotoxic effect of alcohol on the prefrontal cortex or subcortical structures, premature aging may be involved in alcohol-induced cognitive disorders. The aims of this study were to evaluate the effect of alcohol on short-term memory function and histology, and to identify the drug responses and an association with aging process to understand a biological mechanism underlying alcoholic dementia. Methods: In experiment 1, T-maze tests were done in 5 aged controls and 5 atropine-treated rats. In experiment 2, T-maze tests were repeated on every week for a month in 5 normal adult and 5 ethanol-treated rats. In experiment 3, T-maze tests were repeated on every week for a month in seven groups of 5 ethanol-treated rats injected with normal saline, fluoxetine, bromocriptine, bethacholine, nimodipine, clonidine and ketamine. After completion of behavioral tests rats were sacrificed by the intracardiac perfusion with phosphate buffered 10% formaldehyde solution, and the brain specimen was stained with hematoxylin-eosin to count cells in prefrontal cortex and hippocampus. Results: 1) Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were reduced in ethanol-treated rats(P<0.05) without significant changes on T-maze tests. 2)Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were recovered by bethacholine(P<0.05), while those of hippocampus raised by bromocriptine and clonidine(P<0.05 respectively). There were no significant changes on T-maze tests. 3) Cell numbers of prefrontal cortex in ethanol-treated rats were correlated with those of atropine-treated(r=0.977,P<0.001), and of normal aged(r=0.448, P<0.05) rats. Conclusions : Alcohol-induced memory disorder might be mainly related with cholinergic system as well as adrenergic or dopaminergic ones. Pathological aging process could be involved in a mechanism underlying alcoholic dementia.

      • KCI등재후보

        주의력결핍 과잉행동장애 아동의 지적수준에 따른 정신병리와 실행기능의 차이

        천은진,서완석,이종범,김진성,구본훈,송창진,성형모,배준용,배대석 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

        To investigate psychopathoIogy and executive functions of attention deficit hyperactivity disorder (ADHD) children according to intelligence level, this study included 197 ADHD children who visited the outpatient department of neuropsychiatry of YeungNam University Medical Center, from July 2000 to June 2002. The children were divided into groups based on their intelligence levels. They were compared by the Personality Inventory for Children (PIC), Conncers' Continuous Performence Test (CPT), and Wisconsin Card Sorting Test (WCST). There were significant differences in PIC, on the subscales of verbal development, socialization and autism. In the CPT, there was no significant difference. In the WCST, there were significant differences in the total number of errors, the number of perseverative errors, the number of completed categories and the number of trials needed to complete the first category. Considering these results, the intelligence level of ADHD children is related to their disabilities and behavioral symptoms.Executive functions such as abstract thinking, categorization, working memory and flexibility had significant relationship to the intelligence levels of ADHD children. Therefore, the intelligence level of children with ADHD influences the higher executive functions of regulating attention and information processing rather than attentional functions and capacity alone.

      • CFL법을 이용한 SiCN계 세라믹 패턴의 제조 및 특성 연구

        천진호,김동표 충남대학교 바이오응용화학연구소 2007 응용화학공학 Vol.1 No.1

        액상 고분자 세라믹전구체를 이용하여 모세관력 리소그래피 (CFL) 방법으로 Siliconcarbonitride (SiCN) 세라믹 패턴을 제조하였다. 세라믹 패턴은 과산화물과 같은 열 개시제를 사용하여 낮은 온도(70 ~ 90℃)에서 열가교 후에 아르곤 가스 분위기에서 높은 온도로 (800℃) 열분해하여 제조되었다. SEM, TGA를 이용해 세라믹 패턴의 고온 안정성, 수축 특성, 제조된 패턴의 형태를 분석하였다. 또한 XRD를 이용해 결정구조를 분석하였다. CFL 방법은 대면적과 정교한 패턴의 복제에 적합하다. 그러나 잔류층의 제거는 극복해야 할 문제이다.

      • 한국어 종성 폐쇄음 /k^ㄱ/,/t^ㄱ/,/p^ㄱ/의 음향 음성학적 연구

        김병천,梁鎭宇 안성산업대학교 1994 論文集 Vol.26 No.-

        본 논문은 한국어의 종성 폐쇄음 /k^ㄱ/,/t^ㄱ/,/p^ㄱ/에 대한 음향 음성학적인 분석에 관한 연이다. 본 논문에서는 세 개의 종성 폐쇄음 /k^ㄱ/,/t^ㄱ/,/p^ㄱ/이 8개의 단모음(ㅏ,ㅓ,ㅗ,ㅜ,ㅡ,ㅣ,ㅐ,ㅔ)과 조합되어 형성된 24개의 음절을 선택하여 3인의 성인 남성이 각각 3회씩 발음하여 구성한 216개의 음성 데이터를 사용하여 포만트 주파수를 추출한 연후에 각각의 모음에 대해 종성 폐쇄음의 포만트 주파수가 이동하는 방향을 분석하였다. 실험 걸과 모음에서 종성 폐쇄음으로 이동하는 과도 구간의 최종 포르만트 주파수는 각 모음마다 상당한 차이를 내었으며, 과도 구간에서 각 모음에 따라 각기 다르다는 것을 알 수 있었다. This paper is a study on the acoustic-phonetical analysis of Korean final stops /k^ㄱ/,/t^ㄱ/,/p^ㄱ/. In this paper, I selected twenty four syllables in order to constitute corpora. These syllables are formed by combination of three final stops /k^ㄱ/,/t^ㄱ/,/p^ㄱ/ and eight single vowels /a/,/∂/,/o/,/u/,/?/,/i/,/æ/,/ε/. Three adult men pronounced these corpora three times a man and stored them files. After extraction of the final stop's frequencies from the stored files, I analysed the moving directions of the final stop's final formant frequencies for each vowel. As a result of the analysis, I was able to confirm that the final formant frequencies of transition section moving from the vowels to the final stops were very different for each vowel, and the features of each formant frequencies.

      • 안정화제를 사용한 회수수의 고형분량 및 방치시간에 따른 시멘트 모르터의 특성

        金光華,김기정,이문환,이세현,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

        This study is intended to investigate the fundamental properties of cement mortar with solid content and leaving time of recycled water that stabilizing agent is added. According to the results, fluidity and air content does not make a big difference with variation of solid content. As the leaving time of recycled water is long, fluidity and air content increases. Setting time is shortened due to fine particle with an increase of solid content and leaving time. Compressive strength and flexural strength increase with an increase of solid content, and they increase at the leaving time of 1 day, but decrease after 2days. Length change by drying shrinkage is smaller than that of plain concrete, and is almost same with variation of solid content. And it is reduced at the leaving time of 1 day, but increases after that. Therefore, it analyzed that the effect of stabilizing agent is best under condition of adding ratio of 0.15%, solid content of 3% and leaving time of 1day, and it also works upto solid content of 5% and leaving time of 2days.

      • KCI등재

        酒精依存에서 血漿 Dopamine 및 Serotonin 濃度 變化의 意味

        田珍淑,金玹壽,吳秉勳 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

        Dopamine and serotonin drew much attention to understand a biological mechanism underlying alchohol dependence. There were three reasons. Frit, behavioral effects governed by them were quite similar with various psychopathology observed in alcoholism. Second, preference to alcohol drinking tended to be related to the genetically transmitted biochemical abnormalities of these neurotransmitters. Finally, reward-mediating brain areas which seemed to be related to alcoholism were include in dopaminergic and serotonergic pathways. The aims of this study were to look for any changes of dopamine and serotonin concentrations in alcohol dependence, to identify what psychopathology was associated with, and to understand a biological mechanisms underlying alcohol-related psychopathology. Subjects were consisted of 25 male patients admitted with alcohol dependence and 25 healthy male volunteers. Samples drawn after 1 to 3 weeks of detoxification were analyzed by HPLC for the measurement of plasma dopamine and serotonin concentrations. Otherwise, precise alcohol history including duration of alcohol drinking, onset age, family history, types of alcoholism, MAST score, and frequency of hospitalization was done. Furthermore, psychopathology was rated by several questionnares like BPRS, MMPI, Sexual Jealousy Questionnaire, BDI and CES-D. 1) Mean concentration of dopamine in alcoholics(61.8±22.6pg/ml) was significantly(p<0.01) lower than in controls(77.4±16.3pg/ml), while serotonin concentration in alcoholics tended to be higher than in controls. 2) Dopamine concentration was negatively correlated with 'hallucinatory behavior' item(p<0.01) and 'unusual thought content' item(p<0.01) of BPRS, and 'hypochondriasis' scale(p<0.05) of MMPI. While serotonin concentration was positively correlated with 'tension' item(p<0.001) of BPRS. 3) Dopamine concentration was negatively correlated with SJQ(p<0.05), while serotonin concentration was positively correlated with frequency of hospitalization(p<0.05) and total score of BPRS(p<0.001). In conclusion, reduced dopamine and increased serotonin concentrations seemed to be associated with psychosis developed in alcohol dependence. Otherwise, impulsivity-aggressivity easily found in alcoholics might be biologically related to decreased dopamine concentration.

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