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Protective effects of a novel herbal decoction on focal cerebral ischemia in a rodent model
Kim, Myung-Gyou,Choi, Jae-Hwan,Lim, Jong-Pil,Kim, Dae-Keun,Shin, Tae-Yong,Boo, Yungmin,Kim, Sun-Yeou,Kim, Hocheol,Ha, Eunyoung,Park, Hun-Kuk,Kim, Jeongseon,Lim, Ha-Sup,Kim, Ee-Hwa,Kim, Jeung-Beum,Leem Informa UK (TaylorFrancis) 2007 Neurological research Vol.29 No.suppl1
Jeongseon Kim,Mi-Hyeon Jang,김창주,Ee-Hwa Kim,Myung-Gyou Kim,Kang-Hyun Leem 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2
The roots of Platycodon grandiflorum, which belongs to the Campanulaceae family, have been used as a foodmaterial and as a traditional Oriental medicine. The effect of P. grandiflorumagainst lipopolysaccharide (LPS)-stimulated in-flammation was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, reverse transcription-polymerase chain reaction, prostaglandin E2 (PGE2) immunoassay, nitric oxide (NO) detection assay, and interleurkin-8 (IL-8) immunoassay on BV2 microglial cells. The aqueous extract of P. grandiflorumwas shown to suppress PGE2 synthesis andNO production by inhibiting LPS-stimulated cyclooxygenase (COX)-2 activity and expression of inducible NO synthase(iNOS) mRNAs. In addition, the treatment with P. grandiflorumreduced the LPS-induced IL-8 release. These results suggestthat P. grandifloruminhibits PGE2 and NO production through its suppression of LPS-induced COX-2 and iNOS expression,and also reduces IL-8 secretion by microglial cells.
Kim, Jeongseon,Kim, Mi Kyung,Lee, Jae Kwan,Kim, Jae-Hoon,Son, Sung Kyong,Song, Eun-Seop,Lee, Kwang Beom,Lee, Jung Pil,Lee, Jong Min,Yun, Young Mi Routledge 2010 Nutrition and cancer Vol.62 No.2
<P> Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, &bgr; -carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, &bgr; -carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, &bgr; -carotene, and vitamin C: odds ratio (OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.</P>
Kim, Jeongseon,Park, Jun-Young,Kim, Sunggoo The Korean Nutrition Society 2004 Nutritional Sciences Vol.7 No.1
This study was performed to investigate the effect of a raw diet (RD) on blood glucose and immune function in non-diabetic (normal) and streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were assigned to four groups (normal control, normal RD, diabetic control and diabetic RD). The control groups and the RD groups were fed an AIN-diet and RD for four weeks, respectively. Weight gain was statistically lower in the RD groups than in the controls. Fasting plasma glucose was significantly lower in the diabetic RD group than in the diabetic control group. The $CD4^+$ T-cell population was higher along with the $CD4^+/CD8^+$ ratio of the mesenteric lymph nodes in the normal RD group compared to the other groups. It can be concluded that RD may reduce the plasma fasting glucose concentration in diabetic rats and improve mesenteric lymph node immune function in normal rats.
Effects of a Raw Diet on Plasma Glucose and Lipid Levels in Streptozotocin-induced Diabetic Rats
Kim, Jeongseon,Park, Jun-Young,Kim, Sunggoo The Korean Nutrition Society 2003 Nutritional Sciences Vol.6 No.3
This study investigates the effects of a raw diet (RD) on blood glucose and lipid metabolism in non-diabetic (normal) and streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley vats were assigned to four groups (normal control, normal RD, diabetic control, and diabetic RD), for the four-week experimental period. The control groups were fed the AIN diet and the RD groups were fed a diet consisting only of raw materials. Weight gain was statistically lower in the RD group than the control. fasting plasma glucose was significantly lower in the diabetic RD group compared to the diabetic control group. The levels of triglycerides (TG), and of total cholesterol (TC) and LDL-cholesterol in the plasma, were lower in the RD groups than the control groups, but not significantly. There was a statistically significant decrease in the levels of TG and TC in the livers of the diabetic RD group, compared to the diabetic control group. The fecal levels of total lipids, TG, and TC were significantly higher in the RD groups, compared to the non-RD groups. It can be postulated that this raw diet may possess substantial hypoglycemic/hypolipidemic properties in diabetic rats.
Meropenem 내성 Ochrobactrum anthropi 균혈증 1예
김건민,진성준,유정선,김창오,최준용,김준명,송영구 대한감염학회 2009 감염과 화학요법 Vol.41 No.1
Ochrobactrum anthropi is an oxidase-producing, non-lactose-fermenting, gram-negative bacillus that is frequently isolated from the environment including sinks, baths, soil, and hospital water sources. Recently O. anthropi have been reported as an emerging opportunistic pathogen in immunocompromised patients, Particularly in those with indwelling venous catheters. Most O. anthropi were highly resistant to B-lactam antibiotics except carbapenem. We report a case of O. anthropi bacteremia with an unusual pattern of antibiotic resistance compared to previous reports. A 47-year-o1d woman undergoing camptobell/cisplatin chemotherapy via indwelling venous catheter (chemoport) for stage IV ovarian cancer, had septicemia due to O. anthropi of unknown origin. The isolates were resistant to all B-lactams and meropenem and susceptible to aminoglycoside, ciprofloxacin, and trimethoprim-sulfamethoxazole. She recovered from sepsis with combination treatment with imipenem and ciprofloxacin for 3 weeks.
Kim, Jeongseon,Lee, Jung-Sug,Shin, Aesun,Kang, Myung-Hee,Shin, Dong-Soon,Chung, Hae-Rang,Kim, Woo-Kyoung Japan Epidemiological Association 2010 Journal of epidemiology Vol.20 No.3
<P><B>Objective</B></P><P>The use of dietary supplements has been increasing rapidly in Korea over the last decade. The aim of this study was to investigate associations between the pattern of dietary supplement use and the sociodemographic/lifestyle characteristics of Korean consumers.</P><P><B>Methods</B></P><P>Participants were asked to complete a self-administered questionnaire on their sociodemographic and lifestyle characteristics, perceived health status, and regular dietary supplement use.</P><P><B>Results</B></P><P>A total of 697 men and 832 women completed the questionnaire. Of the respondents, 44.3% of the men and 53.2% of the women used some kind of dietary supplement regularly. Dietary supplement users were more likely to be women (<I>P</I> < 0.001), to be older than 50 years (<I>P</I> < 0.001), to have a higher household income (<I>P</I> = 0.003), to engage in moderate or vigorous physical activity (<I>P</I> < 0.032), to perceive themselves as healthy (<I>P</I> = 0.026), and to have received a diagnosis of a chronic disease (<I>P</I> < 0.001). In addition, the type of dietary supplements used varied with respect to sociodemographic and lifestyle factors. Among dietary supplement users, men preferred ginseng, and older respondents were more likely to use carbohydrate supplements and less likely to use lipid supplements. Those who had a lower BMI, were ex-smokers, or were nondrinkers preferred either vitamins or minerals. Those who were highly physical active or were nondrinkers tended to prefer either vitamin/mineral complexes or carbohydrate supplements.</P><P><B>Conclusions</B></P><P>The use of dietary supplements was related to sociodemographic and lifestyle factors in a Korean population.</P>
Dietary Habits and Lifestyle Factors in Relation to Sa-Sang Constitution
Kim Jeongseon,Kang Hye-Jung,Kim Ee-Hwa The Korean Nutrition Society 2005 Nutritional Sciences Vol.8 No.2
According to Sa-Sang constitution, people can be classified into 4 types, Tae-Yang-In, Tae-Eum-In, So-Yang-In, and So-Eum-In. 1he purpose of this study was to examine any significance between types of Sa-Sang constitution and dietary factors. Physical and constitutional examinations as well as a questionnaire survey were conducted on a group of 483 college students. Among the group of 483 college students, only 428 subjects were determined to have identical constitution through both the questionnaire survey and Korean traditional medical doctors' inquiries. Of 428 subjects, $29.7\%$ were determined to be Tae-Eum-Ins; $35.5\%$ were identified as So-Yang-Ins; $34.8\%$ were classified as So-Eum-Ins. Tae-Eum-Ins showed a statistically significant difference in BMI and higher smoking rate in comparison with groups of So-Yang-Ins and So-Eum-Ins. So-Eum-Ins had a tendency to take vegetables and fruits more often but they had lower preferences for balanced diets. Tae-Eum-Ins showed higher propensity to eat a visible fat protein. In terms of degrees of doneness of meat, So-Yang-Ins showed a higher tendency to prefer well-broiled meat Tae-Eum-Ins also tended to have significantly higher iron, potassium, sodium, vitamin $B_1$, niacin, $\beta$-carotene and vitamin E in their diet So-Eum-Ins had significantly lower intakes of protein, phosphorous, and folate. Considering the fact that most chronic degenerative diseases could be developed by any lifestyle factors, it is necessary to conduct educational programs about lifestyles including dietary habits for maintaining good health; On the basis of the results of this study, it is expected that the scientific, objective and accurate diet information depending upon individual's type of constitution will be provided.