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이정현(Lee, Jeonghyeon),강소리(Kang, Sori),강태연(Kang Taeyeon),최지영(Choi, Jiyoung),박영재(Park Youngjae),김지영(Kim, Jiyoung) 충북대학교 생활과학연구소 2020 생활과학연구논총 Vol.24 No.1
The purpose of this study is to provide examples of design planning which can satisfy the various tastes and needs of consumers through developing fashion designs that combine storytelling and kidults, and that are easy to link in emotional terms. A literature study was conducted in relation to storytelling and kidult fashion, and analyzed the theoretical elements and types of storytelling, as well as looking at the definition of “kidult fashion” and cases thereof. Based on the theoretical analysis, the storytelling of “The town musician of Bremen” was analyzed, and five representative scenes were selected according to stages of plot, a component of storytelling. The design was developed to present lively, diverse kidult fashion designs, which were planned according to two contrasting concepts. Concept One, “A Dark Dream”, utilizes motifs developed in Scenes One and Three, and is a kidult-like pattern, but uses achromatic colors as its main color scheme, an expression found in modern everyday wear. Concept Two, Ride a Balloon , utilizes Scenes Two, Four and Five and uses pink, red and pastel shades as the main colors to emphasize humor and kidult fashion s vivacious and energetic side. Using Adobe Photoshop and Adobe Illustrator, two patterns were developed per scene, with motifs representing the main elements of that scene. Using the patterns thus developed, two color schemes were deployed and implemented in a virtual outfit with 3D mapping, which is presented as the final result.
Pharmacometabolomic Approach to Predict QT Prolongation in Guinea Pigs
( Jeonghyeon Park ),( Keumhan Noh ),( Hae Won Lee ),( Mi Sun Lim ),( Sook Jin Seong ),( Jeong Ju Seo ),( Eun Jung Kim ),( Wonku Kang ),( Young Ran Yoon ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Drug-induced torsades de pointes (TdP), a life-threatening arrhythmia associated with prolongation of the QT interval, has been a significant reason for withdrawal of several medicines from the market. Prolongation of the QT interval is considered as the best biomarker for predicting the torsadogenic risk of a new chemical entity. Because of the difficulty assessing the risk for TdP during drug development, we evaluated the metabolic phenotype for predicting QT prolongation induced by sparfloxacin, and elucidated the metabolic pathway related to the QT prolongation. We performed electrocardiography analysis and liquid chromatography-mass spectroscopy-based metabolic profiling of plasma samples obtained from 15 guinea pigs after administration of sparfloxacin at doses of 33.3, 100, and 300 mg/kg. Principal component analysis and partial least squares modelling were conducted to select the metabolites that substantially contributed to the prediction of QT prolongation. QTc increased significantly with increasing dose (r = 0.93). From the PLS analysis, the key metabolites that showed the highest variable importance in the projection values (>1.5) were selected, identified, and used to determine the metabolic network. In particular, cytidine-5`-diphosphate (CDP), deoxycorticosterone, L-aspartic acid and stearic acid were found to be final metabolomic phenotypes for the prediction of QT prolongation. Metabolomic phenotypes for predicting drug-induced QT prolongation of sparfloxacin were developed and can be applied to cardiac toxicity screening of other drugs. In addition, this integrative pharmacometabolomic approach would serve as a good tool for predicting pharmacodynamic or toxicological effects caused by changes in dose.
Top-phobic heavy Higgs boson as the 750 GeV diphoton resonance
Kang, Sin Kyu,Song, Jeonghyeon American Physical Society 2016 Physical Review D Vol.93 No.11
<P>A hint of a new resonance at a mass of 750 GeV has been shown in the diphoton channel of the Run-2 LHC data. The observed signal rate is usually too large to interpret it as a new scalar boson in the context of weakly coupled renormalizable models. One way is to reduce its total decay rate, which is possible if the CP-even heavy Higgs boson H-0 in the aligned two Higgs doublet model becomes top-phobic. To ensure sufficient gluon fusion production, we introduce vector-like quarks (VLQ). The Higgs precision data as well as the exclusion limits from no excesses in other resonance searches through Z gamma, b (b) over bar, tau(+)tau(-), and jj channels at the Run-1 LHC are comprehensively studied. In Type I, the top-phobic H-0 cannot simultaneously explain the 750 GeV diphoton excess and the Higgs precision data since the same Yukawa couplings of the up-type and down-type VLQs to H-0 always make more contribution to the diphoton signal rate of the standard model Higgs boson than that of H-0. In Type II, small Yukawa coupling of the up-type VLQ but sizable Yukawa coupling of the down-type VLQ is shown to explain the signal while satisfying other LHC exclusion limits.</P>
김정현 ( Jeonghyeon Kim ),이인환 ( Inhwan Lee ),강현식 ( Hyunsik Kang ) 한국운동생리학회(구 한국운동과학회) 2021 운동과학 Vol.30 No.2
PURPOSE: This study aimed to examine the association between estimated cardiorespiratory fitness (eCRF) and sarcopenic obesity in Korean middle-aged and older adults. METHODS: This study used the data from the 2008-2011 Korea National Health and Nutrition Examination Survey involving 8,252 Korean adults aged ≥50 years (56.6% women). Participants were classified into normal, sarcopenia, obesity, and sarcopenic obesity groups based on the presence of sarcopenia and/or obesity phenotypes. eCRF was assessed using sex-specific algorithms and classified as low (lowest 25%), middle (middle 50%), and high (highest 25%) categories. Logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the risk of sarcopenic obesity according to eCRF categories. RESULTS: The middle and low eCRF groups had a significantly higher risk of sarcopenia (OR=1.688, 95% CI=1.438-1.981 and OR=2.877, 95% CI=2.366-3.498; respectively) than the high eCRF group (OR=1), a significantly higher risk of obesity (OR=1.810, 95% CI=1.533-2.137 and OR=5.103, 95% CI=4.234-6.151; respectively) than the high eCRF group (OR=1), and a significantly higher risk of sarcopenic obesity (OR=2.852, 95% CI=2.371-3.429 and OR=12.008, 95% CI=9.866-14.616; respectively) than the high eCRF group (OR=1). The risks of sarcopenia, obesity, and sarcopenic obesity in the middle and low eCRF groups remained statistically significant after adjusting for all the measured covariates. CONCLUSION: The results suggest that eCRF is an independent predictor of sarcopenic obesity in Korean middle-aged and older adults, implying the importance of promotion of CRF as a preventive measure against sarcopenic obesity.