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Repeated-Dose Toxicity Testing of Scolopendrid Pharmacopuncture in Sprague-Dawley Rats
Jang Jongwon,Seo Wookcheol,Chu Hongmin,Park Kyungtae,Kim SunKyung,Park Ju-Hun,신준영,Choi Dong ho,Kang Hyung Won,김성철 대한침구의학회 2020 대한침구의학회지 Vol.37 No.2
Background: The aim of this pilot study was to assess the safety and dosing of scolopendrid pharmacopuncture (SPP).Methods: A total of 40 healthy Sprague-Dawley rats (males and 20 females 20) were selected following a 7-day inspection and acclimation period. SPP was administered via intramuscular injection, over a 2-week period using 3 doses including a high-dose [0.84 mg of scolopendrid per kg of body weight (BW)], a meddose (0.42 mg/kg BW), and a low-dose (0.21 mg/kg BW). The control group was injected with sterile water into the muscles. Unusual changes caused by administration of the test substance were observed. Weight, feed intake, organ weight, and hematological examinations were compared among the groups. Using the SPSS statistical program, Levene’s test was performed to evaluate the homogeneity of variances, and a one-way ANOVA test was subsequently performed to assess the significance between each test group.Results: During the experiment no animals died. Weight change, food consumption, organ weight, hematological test, and blood biochemical tests showed no significant differences in the treatment groups compared to controls.<br>Conclusion: No toxicological changes related to the administration of test substances were observed. Therefore, the LD<sub>50</sub> (lethal-dose that kills 50%) of scolopendrid pharmacoupuncture in rats was greater than 0.84 mg/kg.
Jang, Hee-Do,Kim, Jongwon,Han, Dong-Chul,Jang, Dong-Young,Ahn, Hyeong-Joon Korean Society for Precision Engineering 2014 International Journal of Precision Engineering and Vol.15 No.12
This paper presents an improvement of the high-speed stability of an aerostatic bearing (ASB) rotor system with an active magnetic bearing (AMB). The AMB can effectively extend the operating range of the ASB-rotor system by adjusting its stiffness and damping through active feedback control. An experimental setup has been built for a rotor supported by both ASB and AMB. Through experiment, we first demonstrated that the fluid induced instability of the rotor bearing system occurs at around 27,000rpm, which conforms to our theoretical analysis. After that, we verified that the AMB can be used to suppress the fluid induced instability of the ASB-rotor system, and to extend its operating speed up to 35,000 rpm.
Current Status of the Heavy-Ion Accelerator Facility RAON
Jongwon Kim,Wookang Kim,Hyun-man JANG,Young Kwon Kim,Ilkyoung SHIN,Bun-sik PARK,Ji-Ho Jang,Jaehong KIM,Sang-il LEE,Suk-jin CHOI,Chul-jin CHOI 한국물리학회 2016 새물리 Vol.66 No.12
The baseline design of the heavy-ion accelerator facility called RAON was completed in 2012, and its construction is scheduled to be completed in 2021. The rare isotope science project (RISP) was organized to establish the facility under the auspices of Institute for Basic Science (IBS). A complex of superconducting (SC) linacs will be used for the accelerations of high-power heavy-ion beams to utilize the technique of in-flight fragmentation for isotope beam production and for the post acceleration of the rare isotope beams produced by using the isotope separation on line (ISOL) method. The ISOL system will be driven by a 70 MeV H$^-$ cyclotron. Many efforts have been directed to developing prototypes of the SC cavities and related components, which are the core parts of the SC linac. Mass production of all the components with proper quality control is a major concern of the project. Recently, a test facility equipped with a 330 W LHe cryoplant was completed, and it has been used to test prototypes of and actual SC-linac components. Progress on RAON construction is described.
Jang, Yun Hee,Hwang, Sungu,Cho, Keunchang,Lim, Manho,Joo, Taiha,Choi, Suhee,Kim, Jongwon,Joo, Sang‐,Woo John Wiley Sons, Ltd. 2011 Surface and interface analysis Vol.43 No.3
<P><B>Abstract</B></P><P>The potential‐induced adsorption change of 2‐amino‐4,5‐imidazoledicarbonitrile (AIDCN) on Ag electrode surfaces has been examined by surface‐enhanced Raman scattering (SERS) in an applied potential range between −1.0 and 0.2 V. Upon adsorption, AIDCN has a substantial interaction with the Ag metal surfaces via its two nitrile groups. The CN stretching peaks at ∼2200 cm<SUP>−1</SUP> appeared to be more intensified and redshifted at a negative potential. The deconvolution peak analysis of the CN bands at various voltages suggests that there should be a change in binding modes of AIDCN on Ag surfaces. This potential‐dependent orientation change appeared to be reversible. The density functional theory (DFT) calculation of AIDCN on Ag cluster atoms is used to explain its potential‐dependent adsorption. Copyright © 2010 John Wiley & Sons, Ltd.</P>
Development of Chemical Accident Classification Codes and Tool for Management in Process Industries
Jang, Namjin,Han, Kyusang,Koo, Jamin,Yoon, Yi,Yong, Jongwon,Yoon, En Sup The Society of Chemical Engineers, Japan 2009 Journal of chemical engineering of Japan Vol.42 No.10
<P>In this study, domestic and international chemical accident databases are analyzed, and a chemical accident reporting system is developed using chemical accident classification codes. These codes are revised by adopting the data collected in 2115 cases of chemical accidents that occurred in S. Korea over the last 20 years. The revised classification codes are composed of 12 upper, 64 middle, and 276 lower classes. The developed database is composed of data input, data list, and data search modules as well as statistic and analysis modules. Module operations help obtain information on relationships between accident data attributes that are not apparent, in addition to simple statistical results. The chemical accident tracking system is available on the Internet, and the data are treated using an on-line analytical system. The records are statistically analyzed to identify type of accidents that occurs frequently in Korean chemical companies, as well as the accident data and materials involved. We expect the results of this study to be useful in reporting for developing a management of system for prevention of chemical accidents, and improve the manageability of the designed system.</P>