http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신준영,Jong-Ok Ji,Da-Woon Choi,Sang-Heon Choi,Jong-Gu Choi,Min-Suk Rho,이지윤,이상석 사단법인약침학회 2019 Journal of Acupuncture & Meridian Studies Vol.12 No.1
It is known that the primo vascular system (PVS) includes the primo nodes and vessels. However, the relevant genes in the PVS system for both pathologic and physiologic condition are poorly understood. Here, we first examined the gene expression in primo vessels (PVs) floating in lymphatic endothelium by isolation of PVS and lymphatic vessels (LVs) containing PVS. To investigate therapeutic effects, both PVs and LVs containing PVS were isolated after lipopolysaccharide injection and acupuncture electric stimulation at two acupoints Joksamni (ST36) and Hapgok (LI04) following lipopolysaccharide injection. We used reverse transcriptaseepolymerase chain reaction to examine expression of lymphatic endothelial cell markers and inflammatory related genes. We found that lymphatic endothelial cell markers such as fms-related tyrosine kinase 4(Flt4), lymphatic vessel endothelial receptor (Lyve-1), prospero homeobox protein 1(Prox-1), and podoplanin (Pdpn) were highly expressed in PV compared to that of lymphatic endothelium, suggesting pivotal roles of PV in LV under inflammation. Furthermore, lymphatic-related genes including metal-response element-binding transcription factor 2 (Mtf2), hypoxia inducible factor (Hif1a), angiotensin II type 1 receptor (Agtr1), and angiotensin II type 2 receptor (Agtr2) were also overall increased in PV, and remarkably increased and these genes except peroxisome proliferatoreactivated receptor gamma (Pparg) after acupuncture electric stimulation in two acupoints implying central role of PV by gene activation.
신준영,김희정,김대연,공경엽,조경자 대한병리학회 2019 Journal of Pathology and Translational Medicine Vol.53 No.5
Background: Primary breast sarcoma (PBS) is rare, comprising approximately 1% of breast malignancies. Rhabdomyosarcoma (RMS) accounts for an extremely small proportion of PBSs, often leading to delayed histologic confirmation. Methods: Upon reviewing Asan Medical Center’s pathology database between 2000 and 2018, 41 PBS cases were retrieved, including three cases of primary RMS of the breast. Their clinicopathological features were analyzed, and the literature related to PBS and primary RMS of the breast was reviewed. Results: We identified three primary breast RMS cases from our institution database, comprising 7.3% of PBS: one case each of spindle cell/sclerosing RMS (ssRMS), alveolar RMS (aRMS), and embryonal RMS (eRMS). All cases involved adolescents or young adults (14, 16, and 25 years, respectively) who underwent mastectomy or radiotherapy and were confirmed using immunohistochemical testing for myogenin, desmin, and myogenic differentiation. The ssRMS patient experienced recurrence at the operation site 4 months post-surgery despite undergoing concurrent chemoradiotherapy. The aRMS patient had multiple metastases at diagnosis and showed FAX3-FOXO1 fusion transcripts; she died 22 months after the diagnosis. The eRMS patient had enlarged axillary lymph nodes; post-radiotherapy, the lesion recurred as multiple metastases to the bone and lung. She died 18 months post-diagnosis. Conclusions: Our experience on RMS cases suggests that spindle cell or small round cell malignancy in breasts of young female should raise suspicion for the possibility of primary or secondary RMS. To our knowledge, this is the second report of primary breast ssRMS and it may help clinicians who encounter this rare disease in the future.
신준영 호남대학교 2007 학술논문집 Vol.28 No.1
The term curriculum is used by specialists in the field broadly in two ways: (1) to indicate a plan for the education of learners, and (2) to identify a field of study. Objectives are the centerpiece of an adequate instructional system for curriculum development. In the view of many instructional theorists, a good instructional system is designed to meet a real world need through the coordinated functioning of five elements: real world goals, objectives, content, methods and evaluation. To produce an objective, first derive goals from what students need in the real world. Convert each need into a goal. Second, think of a test in a real situation to reflect the real world performance goal. Third, think of the most realistic simulation of the conditions, behavior, and criteria specified in the real situation test and write a description of that test. That description is the instructional objective. Fourth, based on the objective, create an adequate instructional system. By analyzing the objectives, educators can assess the balance of whole curriculum.
「종합생활기록부제」의 신뢰도와 타당도에 관한 연구: 내신성적이 대학학업성취도에 미치는 영향을 중심으로
신준영 호남대학교 1995 호남대학교 학술논문집 Vol.16 No.2
In an effort to test the reliability and validity of "the Comprehensive High School Record" that is presumed to be used as a data for college student selection from 1997. this study examined the effects of high school achievement on grades in college using data drawn from 604 students enfolled in a private university. The data analysis showed that high school achievement is the most reliable and valid data among various measures. High school academic records showed high correlation coefficiency with college gradepoint averga steadily during five semesters. Contrary to general beliefs, participants College Achivement Test scores showed low correlation coefficiency with college GPA consistently. These findings support the conclusion that high school academic recored is the single most important resource in prediction students success in college. and "the Comprehensive High School Record" can be the most reliable and vablid resource in selecting college students.
면역억제제 중단으로 호전된 거대세포바이러스에 의해 유발된 거대 위궤양 1예
신준영,고은정,방병욱,권계숙,김형길,신용운,김준미,기성호 대한상부위장관ㆍ헬리코박터학회 2015 Korean Journal of Helicobacter Upper Gastrointesti Vol.15 No.1
Cytomegalovirus (CMV) is not a rare infection and is frequently observed in immuoncompromised patients. CMV infection is usually asymptomatic in immunocompetent patients however it can be a major cause of morbidity and mortality in immunocompromised patients. The diagnosis of CMV gastric ulcer is not easy because of the absence of characteristic endoscopic features and the difficulty in the identification of infection by routine histologic examinations. We experienced a case of CMV-associated giant gastric ulcer in a patient receiving immunosuppressive therapy. She was a 45-year-old woman with dermatomyositis and had received steroid therapy to control her disease. Epigastric pain developed during therapy and upper endoscopy revealed a gastric ulcer. Despite proton pump inhibitor therapy, her epigastric pain aggravated and follow-up endoscopy revealed a huge gastric ulcer approximately 10 cm in diameter. Histologic findings showed intracellular inclusion bodies after immunostaining which confirmed CMV-associated gastric ulcer. Steroid therapy was discontinued and she received proton pump inhibitors without antiviral agents. Her symptoms improved and follow-up endoscopy revealed successful healing of the CMV-associated gastric ulcer. If an unusual gastric ulcer develops in the immunocompromised patients, CMV gastric ulcer should be suspected and examination for inclusion bodies using CMV immunostaining should be considered.