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Kim, Sunjoo,Kim, Ju-Hyun,Kim, Dong Kyun,Lee, Jaesin,In, Sangwhan,Lee, Hye Suk Korean Society for Mass Spectrometry 2018 Mass spectrometry letters Vol.9 No.3
Methallylescaline, 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethanamine, is a new psychoactive substance with potent agonist of 5-HT receptor, but there is little information on its pharmacological effect, metabolism, and toxicity. It is necessary to characterize the metabolic profiling of methallylescaline in human hepatocytes using liquid chromatography-high resolution mass spectrometry. Methallylescaline was metabolized to three hydroxy-methallylescaline (M1-M3) and dihydroxy-methallylescaline (M4) via hydroxylation in human hepatocytes. CYP2D6, CYP2J2, CYP1A2, and CYP3A4 enzymes were responsible for the metabolism of methallylescaline. The metabolites as well as methallylescaline would be used for monitoring the abuse of methallylescaline.
Spatial Multiplexing Gain for Two Interfering MIMO Broadcast Channels Based on Linear Transceiver
Jaesin Kim,Seok-Hwan Park,Hakjea Sung,Inkyu Lee IEEE 2010 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.9 No.10
<P>In this letter, we provide an expression of spatial multiplexing gain (SMG) for two mutually interfering multiple-input multiple-output (MIMO) broadcast channels, referred to as MIMO-IBC, with linear transceiver. We derive the SMG with respect to user antenna distribution, and compare the systems with and without cooperation among receive antennas in each cell. Additionally, we propose a linear precoding and decoding algorithm for the MIMO-IBC which maximizes the sum rate by extending a solution for single-cell multiple-input single-output broadcast channels. Simulation results confirm the accuracy of our theoretical SMG analysis for the MIMO-IBC.</P>
Blockwise Amplify-and-Forward Relaying Strategies for Multipoint-to-Multipoint MIMO Networks
Jaesin Kim,Jeongho Hwang,Kyoung-Jae Lee,Inkyu Lee IEEE 2011 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.10 No.7
<P>In this letter, we consider a multipoint-to-multipoint transmission system which employs a single relay in wireless networks where all source, destination and relay nodes are equipped with multiple antennas. For amplify-and-forward relay systems, we propose new linear processing strategies for maximizing the sum rate performance by applying a blockwise relaying method combined with convex optimization techniques. To reduce a computational complexity, we first consider a zero-forcing based relay only optimization scheme, which generate a closed-form solution in a non-iterative fashion. In order to further improve the sum rate at low signal-to-noise ratio regimes, we additionally design an enhanced relay filter by exploiting the blockwise relaying method based on a minimum mean-square error criterion. Simulation results show that the proposed relay design strategies outperform the existing conventional schemes in terms of the sum rate.</P>
( Sunjoo Kim ),( Ju-hyun Kim ),( Dong Kyun Kim ),( Jaesin Lee ),( Sangwhan In ),( Hye Suk Lee ) 한국질량분석학회 2018 Mass spectrometry letters Vol.9 No.3
Methallylescaline, 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethanamine, is a new psychoactive substance with potent agonist of 5-HT receptor, but there is little information on its pharmacological effect, metabolism, and toxicity. It is necessary to characterize the metabolic profiling of methallylescaline in human hepatocytes using liquid chromatography- high resolution mass spectrometry. Methallylescaline was metabolized to three hydroxy-methallylescaline (M1-M3) and dihydroxy-methallylescaline (M4) via hydroxylation in human hepatocytes. CYP2D6, CYP2J2, CYP1A2, and CYP3A4 enzymes were responsible for the metabolism of methallylescaline. The metabolites as well as methallylescaline would be used for monitoring the abuse of methallylescaline