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George Belev,Safa Kasap,J.A. Rowlands,David Hunter,Martin Yaffe 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4
Stabilized a-Se lms deposited at suciently low substrate temperatures aren-like in which electrons can drift but holes are deeplytrapped. Such layers can be conveniently incorporated in a multilayer a-Se detector structure to block the injection of holes from thepositive electrode. We have shown that a simple double-layer detector structure based on a cold depositedn-layer (which is thenannealed) on which an i-like layer is grown can have dark current densities lower than 10. 10 Acm. 2 at a eld of 10 V/l m. The darkcurrent depends on the thickness of then-like layer. An a-Se X-ray detector for slot scanning was fabricated by having thein a-Se photo-conductor structure coated onto a CCD chip. The latter detector was shown to have excellent resolution with a modulation transfer func-tion remaining above 0.5 up to a spatial frequency of 11-14 lp mm-¹
Recent advances in X-ray photoconductors for direct conversion X-ray image detectors
S.O. Kasap,M. Zahangir Kabir,J.A. Rowlands 한국물리학회 2006 Current Applied Physics Vol.6 No.3
Recent research on at panel X-ray image detectors has shown their potential for replacing existing X-ray lm/screen cassettes andcapturing X-ray images electronically, thus enabling the clinical transition to digital radiography. The present work examines the imagingproperties of a number of potential X-ray photoconductors for these new X-ray image detectors. The X-ray sensitivity is discussed interms of the absorption eciency, electronhole pair creation energy (ionization energy), and charge transport and trapping limitedattention to stabilized a-Se and HgI2, currently the most promising materials
Witold A. Ferens,Julius Haruna,Rowland Cobbold,Carolyn J. Hovde 대한수의학회 2008 Journal of Veterinary Science Vol.9 No.4
Healthy ruminants carry intestinal Shiga toxin (Stx)- producing Escherichia coli (STEC). Stx has antiviral activities in vitro and STEC numbers correlate with reduced early viremia in sheep experimentally infected with bovine leukemia virus (BLV). This study assessed the impact of intestinal STEC on BLV-induced disease for one year post-BLV-challenge. High STEC scores (CFU/g feces × frequency of STEC-positive samples) correlated with good health, whereas poor weight gain, distress, and tumor development occurred only among animals with low STEC scores. STEC carriage was associated with increased percentages of B cells in peripheral blood.
Genome-wide characterization of the routes to pluripotency
Hussein, Samer M. I.,Puri, Mira C.,Tonge, Peter D.,Benevento, Marco,Corso, Andrew J.,Clancy, Jennifer L.,Mosbergen, Rowland,Li, Mira,Lee, Dong-Sung,Cloonan, Nicole,Wood, David L. A.,Munoz, Javier,Midd Nature Publishing Group, a division of Macmillan P 2014 Nature Vol.516 No.7530
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions about cellular specification, and despite major efforts, we lack a complete molecular characterization of the reprograming process. To address this gap in knowledge, we generated extensive transcriptomic, epigenomic and proteomic data sets describing the reprogramming routes leading from mouse embryonic fibroblasts to induced pluripotency. Through integrative analysis, we reveal that cells transition through distinct gene expression and epigenetic signatures and bifurcate towards reprogramming transgene-dependent and -independent stable pluripotent states. Early transcriptional events, driven by high levels of reprogramming transcription factor expression, are associated with widespread loss of histone H3 lysine 27 (H3K27me3) trimethylation, representing a general opening of the chromatin state. Maintenance of high transgene levels leads to re-acquisition of H3K27me3 and a stable pluripotent state that is alternative to the embryonic stem cell (ESC)-like fate. Lowering transgene levels at an intermediate phase, however, guides the process to the acquisition of ESC-like chromatin and DNA methylation signature. Our data provide a comprehensive molecular description of the reprogramming routes and is accessible through the Project Grandiose portal at http://www.stemformatics.org.